Gerhard Wiche


Affiliation: University of Vienna
Country: Austria


  1. Raith M, Valencia R, Fischer I, Orthofer M, Penninger J, Spuler S, et al. Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers. Skelet Muscle. 2013;3:14 pubmed publisher
    ..This novel role of plectin throws a bridge between extra-sarcomeric cytoarchitecture and metabolism of muscle fibers. Our study thus provides new insights into pathomechanisms of plectinopathies and muscular dystrophies in general. ..
  2. Wiche G, Osmanagic Myers S, Castañón M. Networking and anchoring through plectin: a key to IF functionality and mechanotransduction. Curr Opin Cell Biol. 2015;32:21-9 pubmed publisher
    ..The far reaching consequences of IFs not being well-connected for skin and muscular integrity, migration, and mechanotransduction are highlighted. ..
  3. Rezniczek G, Winter L, Walko G, Wiche G. Functional and Genetic Analysis of Plectin in Skin and Muscle. Methods Enzymol. 2016;569:235-59 pubmed publisher
    ..Foremost, however, we aim to give the readers some good pointers to available tools and into the existing literature. ..
  4. Osmanagic Myers S, Rus S, Wolfram M, Brunner D, Goldmann W, Bonakdar N, et al. Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks. J Cell Sci. 2015;128:4138-50 pubmed publisher
    ..Our study opens a new perspective on cytoskeleton-controlled vascular permeability, where a plectin-organized vimentin scaffold keeps actomyosin contractility 'in-check' and maintains AJ homeostasis. ..
  5. Gregor M, Osmanagic Myers S, Burgstaller G, Wolfram M, Fischer I, Walko G, et al. Mechanosensing through focal adhesion-anchored intermediate filaments. FASEB J. 2014;28:715-29 pubmed publisher
    ..Our data provide important new insights into molecular mechanisms underlying cytoskeleton-regulated mechanosensing, a feature that is fundamental for controlled cell movement and tumor progression...
  6. Mihailovska E, Raith M, Valencia R, Fischer I, Al Banchaabouchi M, Herbst R, et al. Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes. Mol Biol Cell. 2014;25:4130-49 pubmed publisher
    ..Our study demonstrates that linkage to desmin IF networks via plectin is crucial for formation and maintenance of AChR clusters, postsynaptic NMJ organization, and body locomotion. ..
  7. Winter L, Kuznetsov A, Grimm M, Zeöld A, Fischer I, Wiche G. Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle. Hum Mol Genet. 2015;24:4530-44 pubmed publisher
    ..Our results show that the depletion of distinct plectin isoforms affects mitochondrial network organization and function in different ways. ..
  8. Staszewska I, Fischer I, Wiche G. Plectin isoform 1-dependent nuclear docking of desmin networks affects myonuclear architecture and expression of mechanotransducers. Hum Mol Genet. 2015;24:7373-89 pubmed publisher
    ..Our results open a new perspective on cytoskeleton-nuclear crosstalk via specific cytolinker proteins. ..