G Wiche

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Role of plectin in cytoskeleton organization and dynamics
    G Wiche
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, Austria
    J Cell Sci 111:2477-86. 1998
  2. ncbi request reprint Unusual 5' transcript complexity of plectin isoforms: novel tissue-specific exons modulate actin binding activity
    P Fuchs
    Vienna Biocenter, Institute of Biochemistry and Molecular Cell Biology, University of Vienna, A 1030 Vienna, Austria
    Hum Mol Genet 8:2461-72. 1999
  3. ncbi request reprint Plectin transcript diversity: identification and tissue distribution of variants with distinct first coding exons and rodless isoforms
    C E Elliott
    Vienna Biocenter, Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Austria
    Genomics 42:115-25. 1997
  4. pmc M-phase-specific phosphorylation and structural rearrangement of the cytoplasmic cross-linking protein plectin involve p34cdc2 kinase
    R Foisner
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Austria
    Mol Biol Cell 7:273-88. 1996
  5. ncbi request reprint Dose-dependent linkage, assembly inhibition and disassembly of vimentin and cytokeratin 5/14 filaments through plectin's intermediate filament-binding domain
    F A Steinböck
    Institute of Biochemistry, University of Vienna, Vienna Biocenter, Austria
    J Cell Sci 113:483-91. 2000
  6. ncbi request reprint The mouse and rat MAP1B genes: genomic organization and alternative transcription
    W Kutschera
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Austria
    Genomics 49:430-6. 1998
  7. pmc Not just scaffolding: plectin regulates actin dynamics in cultured cells
    K Andra
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, 1030 Vienna, Austria
    Genes Dev 12:3442-51. 1998
  8. ncbi request reprint High-pressure freezing of epithelial cells on sapphire coverslips
    S Reipert
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Vienna Biocenter, 1030 Vienna, Austria
    J Microsc 213:81-5. 2004
  9. ncbi request reprint Analysis of the mouse MAP1B gene identifies a highly conserved 4.3 kb 3' untranslated region and provides evidence against the proposed structure of DBI-1 cDNA
    A Meixner
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Dr Bohr Gasse 9, A 1030, Vienna, Austria
    Biochim Biophys Acta 1445:345-50. 1999
  10. pmc MAP1B is required for axon guidance and Is involved in the development of the central and peripheral nervous system
    A Meixner
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 151:1169-78. 2000

Collaborators

  • R Foisner
  • H Lassmann
  • S Reipert
  • B Becker
  • W Zauner
  • P A Coulombe
  • P Traub
  • R E Bittner
  • E Fuchs
  • F Propst
  • A Meixner
  • G A Rezniczek
  • B Nikolic
  • K Andra
  • M J Castanon
  • J W Bauer
  • L Janda
  • R Hauptmann
  • F A Steinböck
  • P Fuchs
  • I Linhartova
  • W Kutschera
  • S Oehler
  • M Tögel
  • C E Elliott
  • N Malecz
  • C G Liu
  • E Yaoita
  • R Hametner
  • B Kofler
  • A Huber
  • A Klausegger
  • I Kornacker
  • F Rouan
  • H Hintner
  • W Muss
  • J Uitto
  • G Pohla-Gubo
  • S Haverkamp
  • S Fuhrer
  • J Thalhammer
  • H Wassle
  • N Kropf
  • D Spazierer
  • M Repitz
  • M Nemec
  • P Draber
  • M Zörer
  • M Stöcher
  • D Drenckhahn
  • S Shorny
  • R Fassler
  • C Stadler
  • T Yamamoto
  • I Kihara
  • E Mac Nulty
  • K Kawasaki
  • C Maercker
  • B Mir

Detail Information

Publications20

  1. ncbi request reprint Role of plectin in cytoskeleton organization and dynamics
    G Wiche
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, Austria
    J Cell Sci 111:2477-86. 1998
    ..Based on its versatile functions and structural diversification plectin emerges as a prototype cytolinker protein among a family of proteins sharing partial structural homology and functions...
  2. ncbi request reprint Unusual 5' transcript complexity of plectin isoforms: novel tissue-specific exons modulate actin binding activity
    P Fuchs
    Vienna Biocenter, Institute of Biochemistry and Molecular Cell Biology, University of Vienna, A 1030 Vienna, Austria
    Hum Mol Genet 8:2461-72. 1999
    ..This fine tuning mechanism based on alternative splicing is likely to optimize the proposed biological role of plectin as a cytolinker opposing intense mechanical forces in tissues like striated muscle...
  3. ncbi request reprint Plectin transcript diversity: identification and tissue distribution of variants with distinct first coding exons and rodless isoforms
    C E Elliott
    Vienna Biocenter, Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Austria
    Genomics 42:115-25. 1997
    ..This study provides first insights into a complex plectin gene regulatory machinery with similarities to that of dystrophin...
  4. pmc M-phase-specific phosphorylation and structural rearrangement of the cytoplasmic cross-linking protein plectin involve p34cdc2 kinase
    R Foisner
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Austria
    Mol Biol Cell 7:273-88. 1996
    ..Together, our data suggest that a mitosis-specific phosphorylation involving p34cdc2 kinase regulates plectin's cross-linking activities and association with intermediate filaments during the cell cycle...
  5. ncbi request reprint Dose-dependent linkage, assembly inhibition and disassembly of vimentin and cytokeratin 5/14 filaments through plectin's intermediate filament-binding domain
    F A Steinböck
    Institute of Biochemistry, University of Vienna, Vienna Biocenter, Austria
    J Cell Sci 113:483-91. 2000
    ..Our results suggest an involvement of plectin not only in crosslinking and stabilization of cytoskeletal IF networks, but also in regulation of their dynamics...
  6. ncbi request reprint The mouse and rat MAP1B genes: genomic organization and alternative transcription
    W Kutschera
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Austria
    Genomics 49:430-6. 1998
    ..The detection of alternative transcripts has implications for the interpretation of conflicting results recently obtained in MAP1B knockout mice...
  7. pmc Not just scaffolding: plectin regulates actin dynamics in cultured cells
    K Andra
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, 1030 Vienna, Austria
    Genes Dev 12:3442-51. 1998
    ..These results reveal a novel role of plectin as regulator of cellular processes involving actin filament dynamics that goes beyond its proposed role in scaffolding and mechanical stabilization of cells...
  8. ncbi request reprint High-pressure freezing of epithelial cells on sapphire coverslips
    S Reipert
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Vienna Biocenter, 1030 Vienna, Austria
    J Microsc 213:81-5. 2004
    ....
  9. ncbi request reprint Analysis of the mouse MAP1B gene identifies a highly conserved 4.3 kb 3' untranslated region and provides evidence against the proposed structure of DBI-1 cDNA
    A Meixner
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Dr Bohr Gasse 9, A 1030, Vienna, Austria
    Biochim Biophys Acta 1445:345-50. 1999
    ..However, further analysis suggested that the published structure of DBI-1 cDNA is most likely the result of fortuitous joining of unrelated cDNA fragments during cloning...
  10. pmc MAP1B is required for axon guidance and Is involved in the development of the central and peripheral nervous system
    A Meixner
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 151:1169-78. 2000
    ..Our results demonstrate an essential role of MAP1B in development and function of the nervous system and resolve a previous controversy over its importance...
  11. pmc Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions
    B Nikolic
    Vienna Biocenter, Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Austria
    J Cell Biol 134:1455-67. 1996
    ....
  12. pmc Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture
    K Andra
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, 1030 Vienna, Austria
    Genes Dev 11:3143-56. 1997
    ..Plectin (-/-) mice will provide a useful tool for the study of EBS-MD, and possibly other types of plectin-related myopathies involving skeletal and cardiac muscle, in an organism amenable to genetic manipulation...
  13. ncbi request reprint Plectin repeats and modules: strategic cysteines and their presumed impact on cytolinker functions
    L Janda
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Austria
    Bioessays 23:1064-9. 2001
    ..This article contains supplementary material that may be viewed at the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/23/v23_11.1064.html...
  14. ncbi request reprint Conserved domains and lack of evidence for polyglutamine length polymorphism in the chicken homolog of the Machado-Joseph disease gene product ataxin-3
    I Linhartova
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Dr Bohr Gasse 9, A 1030, Vienna, Austria
    Biochim Biophys Acta 1444:299-305. 1999
    ..In the first such analysis in a non-primate species we found that in contrast to primates, the chicken CAG repeat is short and genetically stable...
  15. pmc Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain
    M Tögel
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 143:695-707. 1998
    ....
  16. pmc Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24)
    C G Liu
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna Biocenter, Austria
    Proc Natl Acad Sci U S A 93:4278-83. 1996
    ..Detailed knowledge of the structure of the plectin gene and its chromosome localization will aid in the elucidation of whether this or any other pathological conditions are linked to alterations in the plectin gene...
  17. ncbi request reprint Cryofixation of epithelial cells grown on sapphire coverslips by impact freezing
    S Reipert
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Vienna Biocenter, 1030 Vienna, Austria
    J Microsc 209:76-80. 2003
    ..The structural preservation of Lowicryl HM20-embedded cells has been assessed as being free of damage by large ice crystals...
  18. ncbi request reprint Identification of plectin as a substrate of p34cdc2 kinase and mapping of a single phosphorylation site
    N Malecz
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Biocenter, Dr Bohrgasse 9, A 1030 Vienna, Austria
    J Biol Chem 271:8203-8. 1996
    ..Protein kinase A, phosphorylating plectin also within repeat 6, targeted sites that were clearly different from those of p34cdc2 kinase...
  19. pmc Perinuclear distribution of plectin characterizes visceral epithelial cells of rat glomeruli
    E Yaoita
    Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Am J Pathol 149:319-27. 1996
    ..These findings indicate that the perinuclear distribution of plectin may play an important role in the differentiation of VECs...
  20. pmc A compound heterozygous one amino-acid insertion/nonsense mutation in the plectin gene causes epidermolysis bullosa simplex with plectin deficiency
    J W Bauer
    Department of Dermatology, Children s Hospital Salzburg, Austria
    Am J Pathol 158:617-25. 2001
    ..These results describe for the first time the functional consequences of an in-frame insertion mutation in humans...