Nigel Whittle

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. pmc Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model
    Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innrain 80 82 III, A 6020 Innsbruck, Austria
    Neuropharmacology 64:414-23. 2013
  2. doi request reprint Different fear states engage distinct networks within the intercalated cell clusters of the amygdala
    Daniela Busti
    Department of Pharmacology, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Neurosci 31:5131-44. 2011
  3. pmc Rescue of impaired fear extinction and normalization of cortico-amygdala circuit dysfunction in a genetic mouse model by dietary zinc restriction
    Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
    J Neurosci 30:13586-96. 2010
  4. doi request reprint Changes in brain protein expression are linked to magnesium restriction-induced depression-like behavior
    Nigel Whittle
    Department of Pharmacology and Toxicology and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
    Amino Acids 40:1231-48. 2011
  5. ncbi request reprint Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development
    Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
    Pediatrics 120:e1465-71. 2007
  6. pmc HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?
    Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innrain 80 82 III, A 6020 Innsbruck, Austria
    Biochem Soc Trans 42:569-81. 2014
  7. ncbi request reprint Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission
    Karl Ebner
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck CMBI, Leopold Franzens University of Innsbruck, Innsbruck, Austria
    Neuropsychopharmacology 33:1929-41. 2008

Collaborators

Detail Information

Publications7

  1. pmc Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model
    Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innrain 80 82 III, A 6020 Innsbruck, Austria
    Neuropharmacology 64:414-23. 2013
    ..This article is part of a Special Issue entitled 'Cognitive Enhancers'...
  2. doi request reprint Different fear states engage distinct networks within the intercalated cell clusters of the amygdala
    Daniela Busti
    Department of Pharmacology, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Neurosci 31:5131-44. 2011
    ....
  3. pmc Rescue of impaired fear extinction and normalization of cortico-amygdala circuit dysfunction in a genetic mouse model by dietary zinc restriction
    Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
    J Neurosci 30:13586-96. 2010
    ..Our findings reveal a novel role for Zn in fear extinction and further support the utility of the S1 model for identifying extinction facilitating drugs...
  4. doi request reprint Changes in brain protein expression are linked to magnesium restriction-induced depression-like behavior
    Nigel Whittle
    Department of Pharmacology and Toxicology and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
    Amino Acids 40:1231-48. 2011
    ..Collectively, these findings provide first evidence of low magnesium-induced alteration in brain protein levels and biochemical pathways, contributing to central dysregulation in affective disorders...
  5. ncbi request reprint Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development
    Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
    Pediatrics 120:e1465-71. 2007
    ..However, mechanisms that underlie the observed dysfunctional brain development in Down syndrome are not clear...
  6. pmc HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?
    Nigel Whittle
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innrain 80 82 III, A 6020 Innsbruck, Austria
    Biochem Soc Trans 42:569-81. 2014
    ..Taken together, HDAC inhibitors display promising potential as pharmacological adjuncts to augment the efficacy of exposure-based approaches in anxiety and trauma therapy. ..
  7. ncbi request reprint Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission
    Karl Ebner
    Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck CMBI, Leopold Franzens University of Innsbruck, Innsbruck, Austria
    Neuropsychopharmacology 33:1929-41. 2008
    ....