Research Topics
Species | G WeissSummaryAffiliation: University of Innsbruck Country: Austria Publications
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Detail Information
Publications
Modification of iron regulation by the inflammatory responseGunter Weiss
Department of General Internal Medicine, Clinical Immunology and Infectious Diseases Medical University, Anichstr 35, A 6020 Innsbruck, Austria
Best Pract Res Clin Haematol 18:183-201. 2005....- Pathogenesis and treatment of anaemia of chronic diseaseGunter Weiss
Department of Internal Medicine, University Hospital, Anichstr 35, A 6020 Innsbruck, Austria
Blood Rev 16:87-96. 2002.... - Iron and immunity: a double-edged swordGunter Weiss
Department of Internal Medicine, University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
Eur J Clin Invest 32:70-8. 2002..Thus, the reticulo-endothelial system has evoked sophisticated strategies to control iron metabolism in general and especially the handling of the metal within immune cells... - [Antimicrobial combination therapy]Gunter Weiss
Klinische Abteilung für Allgemeine Innere Medizin, Klinische Infektiologie und Immunologie, Universitatsklinik fur Innere Medizin, Anichstrasse 35, A 6020 Innsbruck
Wien Med Wochenschr 153:153-5. 2003.... - Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietinGunter Weiss
Department of Internal Medicine and Division of Nephrology, University Hospital of Innsbruck, Innsbruck, Austria
Kidney Int 64:572-8. 2003..However, iron catalyzes the formation of toxic radicals, which might promote vascular damage, is a nutrient for microorganisms, and negatively affects immune pathways, thus increasing the risk for severe infections... - Benefits and risks of iron therapy for chronic anaemiasG Weiss
Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Innsbruck, Austria
Eur J Clin Invest 35:36-45. 2005..Thus, it is essential to correctly diagnose the precise cause of anaemia and to consider the benefits and hazards of targeted iron therapy... - Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infectionG Weiss
Department of Internal Medicine, University Hospital, Anichstr 35, A 6020 Innsbruck, Austria
J Infect Dis 180:1452-8. 1999..Our data suggest that an association exists between macrophage activation and hepatic dysfunction, and that iron status may affect the clinical course of HCV infection by modulating Th-1/Th-2 responses in vivo... - Iron and anemia of chronic diseaseG Weiss
Department of Internal Medicine, University Hospital, Innsbruck, Austria
Kidney Int Suppl 69:S12-7. 1999..The role of these factors, as well as the pathophysiological reasons for the development of ACD, is discussed in this review... - Dexrazoxane (ICRF-187)G Weiss
Department of Internal Medicine, University Hospital, Innsbruck, Austria
Gen Pharmacol 32:155-8. 1999.... - Cerebrospinal fluid levels of biopterin, nitric oxide metabolites, and immune activation markers and the clinical course of human cerebral malariaG Weiss
Department of Internal Medicine, University Hospital, University of Innsbruck, Austria
J Infect Dis 177:1064-8. 1998..Local production of NO, most likely by nonimmune mechanisms, may be detrimental in cerebral malaria; however, this appears not to be the case for local Th1-mediated immune pathways... - Modulation of transferrin receptor expression by dexrazoxane (ICRF-187) via activation of iron regulatory proteinG Weiss
Department of Internal Medicine, University Hospital, Innsbruck, Austria
Biochem Pharmacol 53:1419-24. 1997.... - Anemia of chronic diseaseGuenter Weiss
Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
N Engl J Med 352:1011-23. 2005 - [Iron, infection and anemia--a classical triad]Gunter Weiss
Universitatsklinik fur Innere Medizin, Innsbruck, Osterreich
Wien Klin Wochenschr 114:357-67. 2002..The sole application of iron should be strictly avoided due to promotion of pathogen growth and impairment of immune function... 
Serum hepcidin concentration in chronic haemodialysis patients: associations and effects of dialysis, iron and erythropoietin therapyG Weiss
Department of Internal Medicine IV, Nephrology and Hypertension, Medical University Innsbruck, A 6020 Innsbruck, Austria
Eur J Clin Invest 39:883-90. 2009..As hepcidin decreases gastrointestinal iron absorption and recirculation from monocytes, over-expression is associated with the development of anaemia...- Quality of life and immune activation in patients with HIV-infectionK Schroecksnadel
Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Brain Behav Immun 22:881-9. 2008..In HIV-infected patients, depressive mood and impaired QoL appear to be related to clinical parameters like immune activation, haemoglobin values and viral load... - Increased asymmetric dimethylarginine concentrations in stimulated peripheral blood mononuclear cellsK Schroecksnadel
Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Innsbruck, Austria
Scand J Immunol 65:525-9. 2007..Activated PBMC not only release Th1-type cytokine gamma-interferon, which is the most important inducer of nitric oxide synthase, but also ADMA, a natural inhibitor of the enzyme... - Regulatory interactions between iron and nitric oxide metabolism for immune defense against Plasmodium falciparum infectionG Fritsche
Department of Internal Medicine, University Hospital, Anichstr. 35, A-6020 Innsbruck, Austria
J Infect Dis 183:1388-94. 2001..The effect of DFO on the clearance of plasmodia appears to be due to enhanced generation of NO, rather than to limitation of iron availability to the parasite... - Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cellsG Weiss
Department of Internal Medicine, University Hospital, Innsbruck, Austria
Blood 89:680-7. 1997..Our data suggest that sequential administration of Epo and iron might improve the response to Epo therapy in some anemias... - Altered immune responses during septicaemia in patients suffering from haematological malignanciesK Kurz
Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck
Int J Immunopathol Pharmacol 25:147-56. 2012..Septic patients with HM showed an impaired pro-inflammatory immune response compared to patients with non-haematological diseases... - Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasisM Seifert
Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstr 35, A 6020 Innsbruck, Austria
Immunobiology 213:767-78. 2008..fumigatus affects the regulation of macrophage iron homeostasis and innate immune effector pathways via its siderophore system. The changes in immune response may be a consequence of macrophage iron restriction... - Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMPG Werner-Felmayer
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria
J Biol Chem 268:1842-6. 1993..Thus, cytokines indirectly stimulate the activity of constitutive NO synthase in HUVEC by upregulating production of the cofactor tetrahydrobiopterin... - Pyopneumothorax due to Streptococcus milleriPhilipp Eller
Department of Internal Medicine, Medical University Innsbruck, Austria
Wien Klin Wochenschr 118:207. 2006 - Accuracy of bedside antigen tests in the diagnosis of new influenza A/H1N1v infectionR Bellmann-Weiler
Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
Clin Microbiol Infect 17:235-7. 2011..Although a positive RITD is mostly confirmatory, a negative result in the presence of high clinical likelihood of infection should be interpreted with caution and be re-evaluated by PCR... - Indoleamine-2, 3-dioxygenase and other interferon-gamma-mediated pathways in patients with human immunodeficiency virus infectionKatharina Schroecksnadel
Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Curr Drug Metab 8:225-36. 2007.... - Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implicationsIgor Theurl
Department of Internal Medicine I, Medical University of Innsbruck, Austria
Blood 113:5277-86. 2009..Hepcidin determination may aid to differentiate between ACD and ACD/IDA and in selecting appropriate therapy for these patients... - Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overloadH Zoller
Department of Internal Medicine, Innsbruck, Austria
Gastroenterology 120:1412-9. 2001..CONCLUSIONS: DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload... - The role of immune activation in endotoxin-induced atherogenesisC J Wiedermann
Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Innsbruck, Austria
J Endotoxin Res 7:322-6. 2001..The study provides epidemiological evidence that the atherogenic potential of endotoxemia is affected by concomitant immune activation... 
Atorvastatin suppresses interferon-gamma -induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell linesG Neurauter
Institute of Medical Chemistry and Biochemistry, Leopold Franzens University, Department of Internal Medicine, Innsbruck, Austria
Clin Exp Immunol 131:264-7. 2003..In addition we demonstrate that atorvastatin directly inhibits IFN-gamma-mediated pathways in monocytic cells, suggesting that both immunoreactivity of T cells and of monocyte-derived macrophages are down-regulated by this statin...- Pronounced postprandial lipemia impairs endothelium-dependent dilation of the brachial artery in menH Gaenzer
Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
Cardiovasc Res 52:509-16. 2001..In the present study the influence of a standardized fatty meal with its ensuing postprandial lipemia of highly varying magnitude on endothelium-dependent dilation (EDD) was investigated... - Possible role of cytokine-induced tryptophan degradation in anaemia of inflammationGuenter Weiss
Department of Internal Medicine, Leopold Franzens University, Innsbruck, Austria
Eur J Haematol 72:130-4. 2004.... - Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availabilitySusanne Ludwiczek
Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
J Mol Med 82:373-82. 2004.... - Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1Susanne Ludwiczek
Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
Nat Med 13:448-54. 2007..Modulation of DMT-1 function by L-type calcium channel blockers emerges as a new pharmacological therapy for the treatment of iron overload disorders... - Pathways underlying iron accumulation in human nonalcoholic fatty liver diseaseElmar Aigner
Department of Internal Medicine, General Hospital Oberndorf, Oberndorf, Austria
Am J Clin Nutr 87:1374-83. 2008..Mild iron overload is frequently observed in nonalcoholic fatty liver disease (NAFLD)... - Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expressionMilan Theurl
Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Anichstr 35, 6020, Innsbruck, Austria
J Mol Med (Berl) 86:825-35. 2008.... - New pharmacological concepts for the treatment of iron overload disordersSabine M Mair
Medicinal University of Innsbruck, Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck, Austria
Curr Med Chem 16:576-90. 2009..This review discusses established, approaching and future putative treatment strategies and concepts for combating iron metabolism disorders... - Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3Igor Theurl
Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
J Infect Dis 190:819-25. 2004..Modulation of the affinity of eIF3 to bind to HCV mRNA may be a promising target for the treatment of chronic HCV infection... - The kinase inhibitor imatinib mesylate inhibits TNF-{alpha} production in vitro and prevents TNF-dependent acute hepatic inflammationAnna Maria Wolf
Department of Gastroenterology and Hepatology, Innsbruck Medical University, 6020 Innsbruck, Austria
Proc Natl Acad Sci U S A 102:13622-7. 2005..These findings suggest a potent antiinflammatory role of imatinib by modulation of TNF-alpha production in monocytes/macrophages. This observation might be of therapeutic value for the treatment of TNF-mediated diseases... - Occult celiac disease prevents penetrance of hemochromatosisAndreas Geier
Department of Internal Medicine III, Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
World J Gastroenterol 11:3323-6. 2005..To report a patient with C282Y homozygocity, depleted body iron and intestinal atrophy caused by celiac disease (CD) who experienced resolution of the enteropathy with subsequent normalization of iron metabolism upon gluten-free diet...