G Weiss

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi request reprint Modification of iron regulation by the inflammatory response
    Gunter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Best Pract Res Clin Haematol 18:183-201. 2005
  2. ncbi request reprint [Antimicrobial combination therapy]
    Gunter Weiss
    Klinische Abteilung für Allgemeine Innere Medizin, Klinische Infektiologie und Immunologie, Universitatsklinik fur Innere Medizin, Anichstrasse 35, A 6020 Innsbruck
    Wien Med Wochenschr 153:153-5. 2003
  3. ncbi request reprint Pathogenesis and treatment of anaemia of chronic disease
    Gunter Weiss
    Department of Internal Medicine, University Hospital, Anichstr 35, A 6020 Innsbruck, Austria
    Blood Rev 16:87-96. 2002
  4. ncbi request reprint Iron and immunity: a double-edged sword
    Gunter Weiss
    Department of Internal Medicine, University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur J Clin Invest 32:70-8. 2002
  5. ncbi request reprint Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietin
    Gunter Weiss
    Department of Internal Medicine and Division of Nephrology, University Hospital of Innsbruck, Innsbruck, Austria
    Kidney Int 64:572-8. 2003
  6. ncbi request reprint Anemia of chronic disease
    Guenter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
    N Engl J Med 352:1011-23. 2005
  7. ncbi request reprint Benefits and risks of iron therapy for chronic anaemias
    G Weiss
    Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Innsbruck, Austria
    Eur J Clin Invest 35:36-45. 2005
  8. ncbi request reprint Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infection
    G Weiss
    Department of Internal Medicine, University Hospital, Anichstr 35, A 6020 Innsbruck, Austria
    J Infect Dis 180:1452-8. 1999
  9. ncbi request reprint Iron and anemia of chronic disease
    G Weiss
    Department of Internal Medicine, University Hospital, Innsbruck, Austria
    Kidney Int Suppl 69:S12-7. 1999
  10. ncbi request reprint Dexrazoxane (ICRF-187)
    G Weiss
    Department of Internal Medicine, University Hospital, Innsbruck, Austria
    Gen Pharmacol 32:155-8. 1999

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Modification of iron regulation by the inflammatory response
    Gunter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Best Pract Res Clin Haematol 18:183-201. 2005
    ....
  2. ncbi request reprint [Antimicrobial combination therapy]
    Gunter Weiss
    Klinische Abteilung für Allgemeine Innere Medizin, Klinische Infektiologie und Immunologie, Universitatsklinik fur Innere Medizin, Anichstrasse 35, A 6020 Innsbruck
    Wien Med Wochenschr 153:153-5. 2003
    ....
  3. ncbi request reprint Pathogenesis and treatment of anaemia of chronic disease
    Gunter Weiss
    Department of Internal Medicine, University Hospital, Anichstr 35, A 6020 Innsbruck, Austria
    Blood Rev 16:87-96. 2002
    ....
  4. ncbi request reprint Iron and immunity: a double-edged sword
    Gunter Weiss
    Department of Internal Medicine, University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur J Clin Invest 32:70-8. 2002
    ..Thus, the reticulo-endothelial system has evoked sophisticated strategies to control iron metabolism in general and especially the handling of the metal within immune cells...
  5. ncbi request reprint Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietin
    Gunter Weiss
    Department of Internal Medicine and Division of Nephrology, University Hospital of Innsbruck, Innsbruck, Austria
    Kidney Int 64:572-8. 2003
    ..However, iron catalyzes the formation of toxic radicals, which might promote vascular damage, is a nutrient for microorganisms, and negatively affects immune pathways, thus increasing the risk for severe infections...
  6. ncbi request reprint Anemia of chronic disease
    Guenter Weiss
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
    N Engl J Med 352:1011-23. 2005
  7. ncbi request reprint Benefits and risks of iron therapy for chronic anaemias
    G Weiss
    Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Innsbruck, Austria
    Eur J Clin Invest 35:36-45. 2005
    ..Thus, it is essential to correctly diagnose the precise cause of anaemia and to consider the benefits and hazards of targeted iron therapy...
  8. ncbi request reprint Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infection
    G Weiss
    Department of Internal Medicine, University Hospital, Anichstr 35, A 6020 Innsbruck, Austria
    J Infect Dis 180:1452-8. 1999
    ..Our data suggest that an association exists between macrophage activation and hepatic dysfunction, and that iron status may affect the clinical course of HCV infection by modulating Th-1/Th-2 responses in vivo...
  9. ncbi request reprint Iron and anemia of chronic disease
    G Weiss
    Department of Internal Medicine, University Hospital, Innsbruck, Austria
    Kidney Int Suppl 69:S12-7. 1999
    ..The role of these factors, as well as the pathophysiological reasons for the development of ACD, is discussed in this review...
  10. ncbi request reprint Dexrazoxane (ICRF-187)
    G Weiss
    Department of Internal Medicine, University Hospital, Innsbruck, Austria
    Gen Pharmacol 32:155-8. 1999
    ....
  11. ncbi request reprint Cerebrospinal fluid levels of biopterin, nitric oxide metabolites, and immune activation markers and the clinical course of human cerebral malaria
    G Weiss
    Department of Internal Medicine, University Hospital, University of Innsbruck, Austria
    J Infect Dis 177:1064-8. 1998
    ..Local production of NO, most likely by nonimmune mechanisms, may be detrimental in cerebral malaria; however, this appears not to be the case for local Th1-mediated immune pathways...
  12. ncbi request reprint Modulation of transferrin receptor expression by dexrazoxane (ICRF-187) via activation of iron regulatory protein
    G Weiss
    Department of Internal Medicine, University Hospital, Innsbruck, Austria
    Biochem Pharmacol 53:1419-24. 1997
    ....
  13. ncbi request reprint [Iron, infection and anemia--a classical triad]
    Gunter Weiss
    Universitatsklinik fur Innere Medizin, Innsbruck, Osterreich
    Wien Klin Wochenschr 114:357-67. 2002
    ..The sole application of iron should be strictly avoided due to promotion of pathogen growth and impairment of immune function...
  14. doi request reprint Serum hepcidin concentration in chronic haemodialysis patients: associations and effects of dialysis, iron and erythropoietin therapy
    G Weiss
    Department of Internal Medicine IV, Nephrology and Hypertension, Medical University Innsbruck, A 6020 Innsbruck, Austria
    Eur J Clin Invest 39:883-90. 2009
    ..As hepcidin decreases gastrointestinal iron absorption and recirculation from monocytes, over-expression is associated with the development of anaemia...
  15. doi request reprint Immunomodulatory effects in vitro of vitamin K antagonist acenocoumarol
    S Schroecksnadel
    Division of Biological Chemistry, Medical University, Innsbruck, Austria
    Thromb Res 131:e264-9. 2013
    ..Interestingly, NF-κB expression was super-induced in the LPS treated cells. Data suggest that the immunomodulatory capacity of acenocoumarol contributes to its therapeutic efficacy...
  16. doi request reprint Quality of life and immune activation in patients with HIV-infection
    K Schroecksnadel
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain Behav Immun 22:881-9. 2008
    ..In HIV-infected patients, depressive mood and impaired QoL appear to be related to clinical parameters like immune activation, haemoglobin values and viral load...
  17. ncbi request reprint Regulatory interactions between iron and nitric oxide metabolism for immune defense against Plasmodium falciparum infection
    G Fritsche
    Department of Internal Medicine, University Hospital, Anichstr. 35, A-6020 Innsbruck, Austria
    J Infect Dis 183:1388-94. 2001
    ..The effect of DFO on the clearance of plasmodia appears to be due to enhanced generation of NO, rather than to limitation of iron availability to the parasite...
  18. ncbi request reprint Increased asymmetric dimethylarginine concentrations in stimulated peripheral blood mononuclear cells
    K Schroecksnadel
    Division of Biological Chemistry, Biocentre, Innsbruck Medical University, Innsbruck, Austria
    Scand J Immunol 65:525-9. 2007
    ..Activated PBMC not only release Th1-type cytokine gamma-interferon, which is the most important inducer of nitric oxide synthase, but also ADMA, a natural inhibitor of the enzyme...
  19. ncbi request reprint Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells
    G Weiss
    Department of Internal Medicine, University Hospital, Innsbruck, Austria
    Blood 89:680-7. 1997
    ..Our data suggest that sequential administration of Epo and iron might improve the response to Epo therapy in some anemias...
  20. ncbi request reprint Altered immune responses during septicaemia in patients suffering from haematological malignancies
    K Kurz
    Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck
    Int J Immunopathol Pharmacol 25:147-56. 2012
    ..Septic patients with HM showed an impaired pro-inflammatory immune response compared to patients with non-haematological diseases...
  21. ncbi request reprint Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP
    G Werner-Felmayer
    Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    J Biol Chem 268:1842-6. 1993
    ..Thus, cytokines indirectly stimulate the activity of constitutive NO synthase in HUVEC by upregulating production of the cofactor tetrahydrobiopterin...
  22. doi request reprint Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis
    M Seifert
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Immunobiology 213:767-78. 2008
    ..fumigatus affects the regulation of macrophage iron homeostasis and innate immune effector pathways via its siderophore system. The changes in immune response may be a consequence of macrophage iron restriction...
  23. ncbi request reprint Pyopneumothorax due to Streptococcus milleri
    Philipp Eller
    Department of Internal Medicine, Medical University Innsbruck, Austria
    Wien Klin Wochenschr 118:207. 2006
  24. doi request reprint [Antibiotic therapy in elderly patients]
    R Bellmann-Weiler
    Klinische Abteilung für Allgemeine Innere Medizin, Klinische Infektiologie und Immunologie, Medizinische Universitat Innsbruck
    Dtsch Med Wochenschr 133:350-3. 2008
  25. ncbi request reprint Indoleamine-2, 3-dioxygenase and other interferon-gamma-mediated pathways in patients with human immunodeficiency virus infection
    Katharina Schroecksnadel
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Curr Drug Metab 8:225-36. 2007
    ....
  26. doi request reprint Accuracy of bedside antigen tests in the diagnosis of new influenza A/H1N1v infection
    R Bellmann-Weiler
    Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria
    Clin Microbiol Infect 17:235-7. 2011
    ..Although a positive RITD is mostly confirmatory, a negative result in the presence of high clinical likelihood of infection should be interpreted with caution and be re-evaluated by PCR...
  27. doi request reprint Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications
    Igor Theurl
    Department of Internal Medicine I, Medical University of Innsbruck, Austria
    Blood 113:5277-86. 2009
    ..Hepcidin determination may aid to differentiate between ACD and ACD/IDA and in selecting appropriate therapy for these patients...
  28. pmc Atorvastatin suppresses interferon-gamma -induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines
    G Neurauter
    Institute of Medical Chemistry and Biochemistry, Leopold Franzens University, Department of Internal Medicine, Innsbruck, Austria
    Clin Exp Immunol 131:264-7. 2003
    ..In addition we demonstrate that atorvastatin directly inhibits IFN-gamma-mediated pathways in monocytic cells, suggesting that both immunoreactivity of T cells and of monocyte-derived macrophages are down-regulated by this statin...
  29. ncbi request reprint Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload
    H Zoller
    Department of Internal Medicine, Innsbruck, Austria
    Gastroenterology 120:1412-9. 2001
    ..CONCLUSIONS: DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload...
  30. ncbi request reprint The role of immune activation in endotoxin-induced atherogenesis
    C J Wiedermann
    Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Innsbruck, Austria
    J Endotoxin Res 7:322-6. 2001
    ..The study provides epidemiological evidence that the atherogenic potential of endotoxemia is affected by concomitant immune activation...
  31. ncbi request reprint Pronounced postprandial lipemia impairs endothelium-dependent dilation of the brachial artery in men
    H Gaenzer
    Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Cardiovasc Res 52:509-16. 2001
    ..In the present study the influence of a standardized fatty meal with its ensuing postprandial lipemia of highly varying magnitude on endothelium-dependent dilation (EDD) was investigated...
  32. ncbi request reprint Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation
    Guenter Weiss
    Department of Internal Medicine, Leopold Franzens University, Innsbruck, Austria
    Eur J Haematol 72:130-4. 2004
    ....
  33. ncbi request reprint Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability
    Susanne Ludwiczek
    Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Mol Med (Berl) 82:373-82. 2004
    ....
  34. ncbi request reprint New pharmacological concepts for the treatment of iron overload disorders
    Sabine M Mair
    Medicinal University of Innsbruck, Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck, Austria
    Curr Med Chem 16:576-90. 2009
    ..This review discusses established, approaching and future putative treatment strategies and concepts for combating iron metabolism disorders...
  35. ncbi request reprint Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3
    Igor Theurl
    Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    J Infect Dis 190:819-25. 2004
    ..The translation initiation factor 3 (eIF3) is essential for HCV translation, and thus the effects that iron perturbations have on eIF3 expression and HCV translation were studied here...
  36. doi request reprint Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
    Milan Theurl
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Anichstr 35, 6020, Innsbruck, Austria
    J Mol Med (Berl) 86:825-35. 2008
    ....
  37. ncbi request reprint Pathways underlying iron accumulation in human nonalcoholic fatty liver disease
    Elmar Aigner
    Department of Internal Medicine, General Hospital Oberndorf, Oberndorf, Austria
    Am J Clin Nutr 87:1374-83. 2008
    ..Mild iron overload is frequently observed in nonalcoholic fatty liver disease (NAFLD)...
  38. ncbi request reprint Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
    Susanne Ludwiczek
    Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Nat Med 13:448-54. 2007
    ..Modulation of DMT-1 function by L-type calcium channel blockers emerges as a new pharmacological therapy for the treatment of iron overload disorders...
  39. pmc The kinase inhibitor imatinib mesylate inhibits TNF-{alpha} production in vitro and prevents TNF-dependent acute hepatic inflammation
    Anna Maria Wolf
    Department of Gastroenterology and Hepatology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 102:13622-7. 2005
    ..These findings suggest a potent antiinflammatory role of imatinib by modulation of TNF-alpha production in monocytes/macrophages. This observation might be of therapeutic value for the treatment of TNF-mediated diseases...
  40. ncbi request reprint Occult celiac disease prevents penetrance of hemochromatosis
    Andreas Geier
    Department of Internal Medicine III, Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    World J Gastroenterol 11:3323-6. 2005
    ..To report a patient with C282Y homozygocity, depleted body iron and intestinal atrophy caused by celiac disease (CD) who experienced resolution of the enteropathy with subsequent normalization of iron metabolism upon gluten-free diet...