Alexander Tzankov

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Idiopathic myelofibrosis with nodal, serosal and parenchymatous infiltration. Case report and review of the literature
    Alexander Tzankov
    Institute of Pathology, University of Innsbruck, Austria
    Acta Haematol 107:173-6. 2002
  2. ncbi Congo red-positive cardiac kappa-AL amyloidosis in plasmacytoma -- case report and review of the literature
    A Tzankov
    Institute of Pathology, University of Innsbruck
    Acta Med Austriaca 30:29-32. 2003
  3. ncbi Prognostic significance of CD20 expression in classical Hodgkin lymphoma: a clinicopathological study of 119 cases
    Alexandar Tzankov
    Institute of Pathology, University of Innsbruck, A 6020 Innsbruck, Austria
    Clin Cancer Res 9:1381-6. 2003
  4. pmc Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis
    Ellen C Obermann
    Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
    BMC Cancer 5:162. 2005
  5. ncbi Marginal zone lymphoma of the lacrimal gland spreading to the lung and the bone marrow 11 years after first symptoms
    Annette Zimpfer
    Institute of Pathology, University of Basel, Basel, Switzerland
    Virchows Arch 448:361-5. 2006
  6. ncbi Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence
    Van An Nguyen
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Mod Pathol 19:291-8. 2006
  7. ncbi Myelodysplastic/myeloproliferative disease with erythropoietic hyperplasia (erythroid preleukemia) and the unique translocation (8;9)(p23;p24): first description of a case
    Simone Heiss
    Institute of Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria
    Hum Pathol 36:1148-51. 2005
  8. ncbi Hodgkin's disease variant of Richter's syndrome clonally related to chronic lymphocytic leukemia arises in ZAP-70 negative mutated CLL
    Alexandar Tzankov
    Institute of Pathology, Medical University of Innsbruck, Mullerstrasse 44, A 6020 Innsbruck, Austria
    Med Hypotheses 66:577-9. 2006
  9. ncbi Unilateral breast enlargement 5 years after reduction mammaplasty
    Petra Pülzl
    Department of Plastic and Reconstructive Surgery, University Hospital Innsbruck, Anichstrasse, 35, A 6020 Innsbruck, Austria
    Aesthetic Plast Surg 29:404-6. 2005
  10. ncbi Age and hemoglobin level emerge as most important clinical prognostic parameters in patients with osteomyelofibrosis: introduction of a simplified prognostic score
    Kathrin Strasser-Weippl
    First Medical Department with Medical Oncology, Wilhelminen Hospital, Vienna, Austria
    Leuk Lymphoma 47:441-50. 2006

Collaborators

Detail Information

Publications51

  1. ncbi Idiopathic myelofibrosis with nodal, serosal and parenchymatous infiltration. Case report and review of the literature
    Alexander Tzankov
    Institute of Pathology, University of Innsbruck, Austria
    Acta Haematol 107:173-6. 2002
    ..The present case demonstrates that IMF not only can progress to acute leukemia but can also spread uncontrollably, or 'metastasize' with extensive sclerosing hematopoietic tumors throughout the body...
  2. ncbi Congo red-positive cardiac kappa-AL amyloidosis in plasmacytoma -- case report and review of the literature
    A Tzankov
    Institute of Pathology, University of Innsbruck
    Acta Med Austriaca 30:29-32. 2003
    ..The present case is remarkable as it demonstrates that carpal tunnel syndrome and congestive heart failure could be symptoms of plasma cell dyscrasia-associated amyloidoses...
  3. ncbi Prognostic significance of CD20 expression in classical Hodgkin lymphoma: a clinicopathological study of 119 cases
    Alexandar Tzankov
    Institute of Pathology, University of Innsbruck, A 6020 Innsbruck, Austria
    Clin Cancer Res 9:1381-6. 2003
    ..There is very little, and controversial, information on the prognostic significance of CD20 expression in cHL with regard to failure-free (FFS) and overall survival (OS)...
  4. pmc Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis
    Ellen C Obermann
    Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
    BMC Cancer 5:162. 2005
    ....
  5. ncbi Marginal zone lymphoma of the lacrimal gland spreading to the lung and the bone marrow 11 years after first symptoms
    Annette Zimpfer
    Institute of Pathology, University of Basel, Basel, Switzerland
    Virchows Arch 448:361-5. 2006
    ..The elaboration of this case emphasizes the importance of the combined use of modern diagnostic methods for establishment of correct diagnosis of MALT lymphomas at late relapses, which is essential for proper patient management...
  6. ncbi Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence
    Van An Nguyen
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Mod Pathol 19:291-8. 2006
    ..In addition, the lack of lymphatic endothelial cell-specific markers implies that infantile hemangiomas are tumors of blood vessels without lymphatic competence...
  7. ncbi Myelodysplastic/myeloproliferative disease with erythropoietic hyperplasia (erythroid preleukemia) and the unique translocation (8;9)(p23;p24): first description of a case
    Simone Heiss
    Institute of Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria
    Hum Pathol 36:1148-51. 2005
    ....
  8. ncbi Hodgkin's disease variant of Richter's syndrome clonally related to chronic lymphocytic leukemia arises in ZAP-70 negative mutated CLL
    Alexandar Tzankov
    Institute of Pathology, Medical University of Innsbruck, Mullerstrasse 44, A 6020 Innsbruck, Austria
    Med Hypotheses 66:577-9. 2006
    ..These empirical data suggest that the histological and clinical diversity of Richter's transformation could be to a part explained by the different origin of CLL, with Hodgkin's disease variants arising probably only in V(H) mutated CLL...
  9. ncbi Unilateral breast enlargement 5 years after reduction mammaplasty
    Petra Pülzl
    Department of Plastic and Reconstructive Surgery, University Hospital Innsbruck, Anichstrasse, 35, A 6020 Innsbruck, Austria
    Aesthetic Plast Surg 29:404-6. 2005
    ..Histologic examination confirmed the diagnosis of a fibrocystic breast disease in both breasts. The most common differential diagnoses are juvenile fibroadenoma, virginal hypertrophy, fibrocystic disease, and cystosarcoma phylloides...
  10. ncbi Age and hemoglobin level emerge as most important clinical prognostic parameters in patients with osteomyelofibrosis: introduction of a simplified prognostic score
    Kathrin Strasser-Weippl
    First Medical Department with Medical Oncology, Wilhelminen Hospital, Vienna, Austria
    Leuk Lymphoma 47:441-50. 2006
    ..This is in contrast to previous prognostic scores, in which the poor prognosis group was often very small and/or could not be consistently differentiated from patients with an intermediate prognosis...
  11. ncbi Perivascular treatment with azathioprine reduces neointimal hyperplasia in experimental vein grafts
    Thomas Schachner
    Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria
    Heart Surg Forum 9:E515-7. 2006
    ..We investigated whether local treatment with azathioprine can inhibit neointimal hyperplasia in experimental vein grafts...
  12. ncbi Complete recovery after the removal of an ectopic testicle in a case of primary reninism and retroperitoneal hemangioma
    Bernhard Glodny
    Department of Radiology, Medical University of Innsbruck, Innsbruck 6020, Austria
    Asian J Androl 8:247-50. 2006
    ....
  13. pmc Angiogenesis in nodal B cell lymphomas: a high throughput study
    Alexandar Tzankov
    Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria
    J Clin Pathol 60:476-82. 2007
    ....
  14. pmc Cell cycle phase distribution analysis in chronic lymphocytic leukaemia: a significant number of cells reside in early G1-phase
    Ellen C Obermann
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    J Clin Pathol 60:794-7. 2007
    ..Chronic lymphocytic leukaemia (CLL) is a frequent non-Hodgkin lymphoma characterised by a heterogeneous clinical course. Assessment of cell cycle phase kinetics might be important for prediction of clinical behaviour and prognosis...
  15. ncbi Prognostic and diagnostic relevance of hnRNP A2/B1, hnRNP B1 and S100 A2 in non-small cell lung cancer
    Veronika F E Zech
    Department of Internal Medicine, Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Cancer Detect Prev 30:395-402. 2006
    ..Since previous studies using paraffin-embedded tissues indicated a high potential of these markers for diagnosis and screening the present analysis intended to validate these data applying cryostat sections...
  16. ncbi Combined transplantation of skeletal myoblasts and angiopoietic progenitor cells reduces infarct size and apoptosis and improves cardiac function in chronic ischemic heart failure
    Nikolaos Bonaros
    Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria
    J Thorac Cardiovasc Surg 132:1321-8. 2006
    ..Although several studies have shown encouraging results in acute myocardial infarction, the efficacy of cell therapy using skeletal myoblasts and angiopoietic progenitor cells in chronic ischemic heart disease remains undetermined...
  17. ncbi Increased angiogenesis in chronic idiopathic myelofibrosis: vascular endothelial growth factor as a prominent angiogenic factor
    Michael Steurer
    Division of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Hum Pathol 38:1057-64. 2007
    ..Moreover, we found significantly elevated VEGF expression correlating with MVD, thus suggesting VEGF to play a prominent angiogenic role and representing a novel potential therapeutic target in CIMF...
  18. ncbi Tissue microarray technology: principles, pitfalls and perspectives--lessons learned from hematological malignancies
    Alexandar Tzankov
    The Institutes of Pathology, Medical University of Innsbruck, Muellerstr 44, A 6020 Innsbruck, Austria
    Exp Gerontol 40:737-44. 2005
    ..Based on recent observations from molecular profiling of hematological malignancies, we review potential TMA applications assessing molecular targets in large collectives of tissue specimens...
  19. ncbi Rare expression of T-cell markers in classical Hodgkin's lymphoma
    Alexandar Tzankov
    Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria
    Mod Pathol 18:1542-9. 2005
    ..Therefore, T-cell antigen expression on Hodgkin's and Reed-Sternberg cells is aberrant in the majority of cases and only infrequently classical Hodgkin's lymphomas are of T-cell origin...
  20. ncbi Longer failure-free survival interval of Epstein-Barr virus-associated classical Hodgkin's lymphoma: a single-institution study
    Jens Krugmann
    Institute of Pathology, University of Innsbruck, Austria
    Mod Pathol 16:566-73. 2003
    ..In accordance with results of similar studies, the presence of Epstein-Barr virus has a beneficial effect on the length of failure-free survival despite the higher frequency of risk factors such as higher tumor stage or advanced age...
  21. ncbi Primary gastric follicular lymphoma with parafollicular monocytoid B-cells and lymphoepithelial lesions, mimicking extranodal marginal zone lymphoma of MALT
    Alexandar Tzankov
    Institute of Pathology, University of Innsbruck, Mullerstr 44, Austria
    Virchows Arch 441:614-7. 2002
    ..In equivocal cases, a careful morphological examination, supported by specific immunohistochemical and molecular findings, should lead to the correct diagnosis...
  22. ncbi Local application of rapamycin inhibits neointimal hyperplasia in experimental vein grafts
    Thomas Schachner
    Department of Cardiac Surgery, Innsbruck University, Innsbruck, Austria
    Ann Thorac Surg 77:1580-5. 2004
    ..We investigated whether rapamycin can reduce neointima formation in a mouse model of vein graft disease...
  23. ncbi Burkitt's lymphoma of the stomach: a case report with molecular cytogenetic analysis
    Jens Krugmann
    Institute of Pathology, University of Innsbruck, Austria
    Leuk Lymphoma 45:1055-9. 2004
    ....
  24. ncbi Detection of apoptoses in gastro-intestinal graft-versus-host disease and cytomegalovirus colitis by a commercially available antibody against caspase-3
    Alexandar Tzankov
    Institute of Pathology, University of Innsbruck, Austria
    Pathol Res Pract 199:337-40. 2003
    ..Staining for CSP3 may be helpful in distinguishing these two conditions, as apoptotic count would be excessive in GvHD...
  25. ncbi Atypical Carney's triad with coincidental clear cell renal carcinoma in an 84-year old patient-a finding at autopsy
    Alexandar Tzankov
    Institute of Pathology, University of Innsbruck, Mullerstr 44, A 6020, Innsbruck, Austria
    Cancer Detect Prev 27:256-8. 2003
    ..To our knowledge, this is the first report of a coincidental clear cell renal carcinoma in a patient with an atypical Carney's triad...
  26. ncbi Retinoic acid-induced Golgi apparatus disruption in F2000 fibroblasts: a model for enhanced intracellular retrograde transport
    Alexandar Tzankov
    Institute of Pathology, University of Innsbruck, Mullerstr 44, A 6020 Innsbruck, Austria
    J Biochem Mol Biol 36:265-8. 2003
    ..Exposure to PMA made cells resistant to the Golgi-disturbing effects of RA, indicating that protein kinase C plays an important role in this process...
  27. ncbi Rapamycin treatment is associated with an increased apoptosis rate in experimental vein grafts
    Thomas Schachner
    Department of Cardiac Surgery, Medical University Innsbruck, Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Cardiothorac Surg 27:302-6. 2005
    ..Apoptosis is one mechanism counterbalancing cellular proliferation. We therefore investigated the role of apoptosis in rapamycin treated vein grafts in a mouse model...
  28. ncbi Perivascular application of C-type natriuretic peptide attenuates neointimal hyperplasia in experimental vein grafts
    Thomas Schachner
    Department of Cardiac Surgery, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur J Cardiothorac Surg 25:585-90. 2004
    ..We investigated the effects of perivascularly applied CNP in a mouse model of vein graft disease...
  29. pmc Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
    Miriam Erlacher
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Exp Med 203:2939-51. 2006
    ..Their combined loss promotes spontaneous tumorigenesis, causing the malignancies observed in Bcl-2 transgenic mice, but does not exacerbate the autoimmunity observed in the absence of Bim...
  30. ncbi Deletion of C-MYC in the spectrum of transformed follicular lymphoma grade 3b
    Alexandar Tzankov
    Hum Pathol 38:191-2; author reply 192-3. 2007
  31. ncbi High-resolution ultrasound of peripheral neurogenic tumors
    Hannes Gruber
    Department of Radiology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
    Eur Radiol 17:2880-8. 2007
    ....
  32. ncbi Severe cold agglutinin disease caused by recurrent monomorphic Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD), clonally related to an EBV-negative plasmacytic hyperplasia in a pediatric multivisceral organ transpla
    Barbara Brunner
    Department of Pediatrics II, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Pediatr Transplant 11:547-51. 2007
    ..Summarizing, PTLD may be accompanied by cold agglutinin disease, and both may be successfully treated by immuno-chemotherapy. The appearance of cold agglutinins in transplant patients may indicate PTLD development...
  33. doi Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma
    Alexandar Tzankov
    Department of Pathology, University Hospital Basel, Schoenbeinstr 40, CH 4031 Basel, Switzerland
    Haematologica 93:193-200. 2008
    ..The tumor microenvironment is important for the behavior of cancer. We assessed the distribution and biological significance of FOXP3(+) regulatory T-cells (Treg) in lymphomas...
  34. doi Modern techniques for the diagnostic evaluation of the trephine bone marrow biopsy: methodological aspects and applications
    Falko Fend
    Institute of Pathology, Technical University Munich, Ismaningerstrasse 22, D 81675 Munich, Germany
    Prog Histochem Cytochem 42:203-52. 2008
    ..This review tries to give an overview of techniques suitable for trephine biopsies, as well as diagnostic and research applications...
  35. doi Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers
    Andrea Brunner
    Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria
    Pathobiology 75:25-33. 2008
    ..We investigated the value of multiple cell cycle markers for their prognostic impact on overall survival and recurrence-free survival in urothelial carcinoma (UC)...
  36. doi Cytokeratin expression in hematological neoplasms: a tissue microarray study on 866 lymphoma and leukemia cases
    Heiner Adams
    Institute for Pathology, University Hospital Basel, Schoenbeinstrasse 40, 4031 Basel, Switzerland
    Pathol Res Pract 204:569-73. 2008
    ..Aberrant CK expression can be encountered in a small subset of otherwise characteristic B- and T-cell lymphomas, but not in acute leukemias, which should be considered in difficult differential diagnostic settings...
  37. doi Identification of the rare EGFR mutation p.G796S as somatic and germline mutation in white patients with squamous cell carcinoma of the head and neck
    Ilona Schwentner
    Department of Otorhinolaryngology, Innsbruck Medical University, Innsbruck, Austria
    Head Neck 30:1040-4. 2008
    ..Mutational screening predominantly focuses on the analysis of hotspot regions of EGFR (exons 19 and 21)...
  38. ncbi High-throughput tissue microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1
    Alexandar Tzankov
    Institute of Pathology, University of Innsbruck, Austria
    J Pathol 199:201-7. 2003
    ..Thus, the overexpression of CCNE could be caused by profound changes in HRS cell-cycle regulation that could contribute to the malignant phenotype...
  39. ncbi Prognostic relevance of cytogenetics determined by fluorescent in situ hybridization in patients having myelofibrosis with myeloid metaplasia
    Kathrin Strasser-Weippl
    First Medical Department, Center for Oncology and Hematology, Wilhelminen Hospital, Vienna, Austria
    Cancer 107:2801-6. 2006
    ..Interphase fluorescent in situ hybridization (FISH) can partly overcome these limitations and increase the sensitivity of cytogenetic assessment in MF...
  40. ncbi Pathobiology of classical Hodgkin lymphoma
    Alexandar Tzankov
    Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria
    Pathobiology 73:107-25. 2006
    ..HRSC are further characterized by profound cell cycle deregulation with futile replication, multinucleation and poly- and aneuploidy. Here, we review pathobiological aspects of cHL with respect to lymphomagenesis and routine diagnostics...
  41. pmc Age-related loss of naïve T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes
    Lutfan Lazuardi
    Immunology Division of the Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, A 6020 Innsbruck, Austria
    Immunology 114:37-43. 2005
    ..In summary our findings demonstrate characteristic effects of aging on human lymph node tissue, the most striking feature being the depletion of naive T cells and the apparent dysregulation of T-cell/B-cell interactions in old age...
  42. ncbi Subtotal tongue necrosis in delayed diagnosed giant-cell arteritis: a case report
    Matthias Oliver Biebl
    Department of Vascular Surgery, University Hospital, Innsbruck, Austria
    Am J Otolaryngol 25:438-41. 2004
    ..In any case of unclear ischemic symptoms in an elderly patient, one must keep GCA in mind as the possible culprit disease...
  43. ncbi Cyclin B1 expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma
    Ellen C Obermann
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Oncol Rep 14:1461-7. 2005
    ....
  44. ncbi Over-expression of tumor necrosis factor-alpha in bone marrow biopsies from patients with myelodysplastic syndromes: relationship to anemia and prognosis
    Gerald Stifter
    Division of Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Eur J Haematol 75:485-91. 2005
    ....
  45. ncbi Aberrant expression of cell cycle regulators in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma
    Alexandar Tzankov
    Institute of Pathology, Medical University of Innsbruck, Austria
    Mod Pathol 18:90-6. 2005
    ..In contrast to other tumors, expression of PCNA or cyclin A had no prognostic value for patient survival...
  46. ncbi Cancer-associated carbohydrate identification in Hodgkin's lymphoma by carbohydrate array profiling
    Charles H Lawrie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, UK
    Int J Cancer 118:3161-6. 2006
    ..271). We suggest that this technique could provide a powerful tool for identifying novel carbohydrates in other cancers...
  47. ncbi Expression of B-cell markers in classical hodgkin lymphoma: a tissue microarray analysis of 330 cases
    Alexandar Tzankov
    Institute of Pathology, University of Basel, Basel, Switzerland
    Mod Pathol 16:1141-7. 2003
    ..The use of two cores per tissue sample renders the tissue microarray technology effectively representative and thus very useful for high-throughput evaluation of heterogeneously expressed markers in classical Hodgkin lymphoma...
  48. ncbi Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma
    Judith Loeffler-Ragg
    Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur J Cancer 42:109-11. 2006
    ..Similar to reports in lung cancer, EGFR kinase domain mutations in HNSCC patients seem to show a lower incidence in patients of Caucasian origin...
  49. ncbi Complete or partial trisomy 3 in gastro-intestinal MALT lymphomas co-occurs with aberrations at 18q21 and correlates with advanced disease stage: a study on 25 cases
    Jens Krugmann
    World J Gastroenterol 11:7384-5. 2005
  50. ncbi Hodgkin's disease variant of Richter's syndrome in chronic lymphocytic leukaemia patients previously treated with fludarabine
    Dominic Fong
    Division of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Br J Haematol 129:199-205. 2005
    ..The majority present with B-symptoms and CLL treatment-resistant lymphadenopathy, are of the MC type, clonally related to CLL and might be triggered by an EBV infection...
  51. doi Primary diffuse large B-cell lymphomas of the bone: prognostic relevance of protein expression and clinical factors
    Heiner Adams
    Institute of Pathology, University Hospital, Basel, Switzerland
    Hum Pathol 39:1323-30. 2008
    ..In summary, poor survival in PB-DLBCL was clearly predicted in patients older than 53, who had not received chemotherapy, and who demonstrated MUM1 expression and nongerminal center phenotype...