Petronel Tuluc

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. doi request reprint Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels
    Petronel Tuluc
    Department of Physiology and Medical Physics, Medical University Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Innrain 80 82, A 6020 Innsbruck, Austria Electronic address
    Structure 24:261-71. 2016
  2. doi request reprint Divergent biophysical properties, gating mechanisms, and possible functions of the two skeletal muscle Ca(V)1.1 calcium channel splice variants
    Petronel Tuluc
    Department of Physiology and Medical Physics, Medical University Innsbruck, Fritz Pregl Str 3, 6020, Innsbruck, Austria
    J Muscle Res Cell Motil 32:249-56. 2011
  3. pmc A CaV1.1 Ca2+ channel splice variant with high conductance and voltage-sensitivity alters EC coupling in developing skeletal muscle
    Petronel Tuluc
    Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria
    Biophys J 96:35-44. 2009
  4. doi request reprint Auxiliary Ca(2+) channel subunits: lessons learned from muscle
    Gerald J Obermair
    Division of Physiology, Department of Physiology and Medical Physics, Medical University Innsbruck, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Curr Opin Pharmacol 8:311-8. 2008
  5. pmc Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavalpha1S-subunit
    Antonella Pirone
    Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Am J Physiol Cell Physiol 299:C1345-54. 2010
  6. pmc Physiological and pharmacological modulation of the embryonic skeletal muscle calcium channel splice variant CaV1.1e
    Bruno Benedetti
    Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria
    Biophys J 108:1072-80. 2015
  7. pmc Stable incorporation versus dynamic exchange of β subunits in a native Ca2+ channel complex
    Marta Campiglio
    Department of Physiology and Medical Physics, Medical University Innsbruck, A 6020 Innsbruck, Austria
    J Cell Sci 126:2092-101. 2013
  8. pmc CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type calcium channels
    Alexandra Pinggera
    Department of Pharmacology and Toxicology, Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
    Biol Psychiatry 77:816-22. 2015
  9. pmc Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling
    Petronel Tuluc
    Department of Physiology and Medical Physics, Division of Physiology, Medical University Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 104:11091-6. 2007

Collaborators

Detail Information

Publications9

  1. doi request reprint Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels
    Petronel Tuluc
    Department of Physiology and Medical Physics, Medical University Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Innrain 80 82, A 6020 Innsbruck, Austria Electronic address
    Structure 24:261-71. 2016
    ..These interactions facilitate the final transition into the activated state and critically determine the voltage sensitivity and current amplitude of these CaV channels. ..
  2. doi request reprint Divergent biophysical properties, gating mechanisms, and possible functions of the two skeletal muscle Ca(V)1.1 calcium channel splice variants
    Petronel Tuluc
    Department of Physiology and Medical Physics, Medical University Innsbruck, Fritz Pregl Str 3, 6020, Innsbruck, Austria
    J Muscle Res Cell Motil 32:249-56. 2011
    ..Moreover, the availability of these two structurally similar but functionally distinct channel variants facilitates the analysis of the molecular mechanisms underlying the unique current properties of the classical Ca(V)1.1a channel...
  3. pmc A CaV1.1 Ca2+ channel splice variant with high conductance and voltage-sensitivity alters EC coupling in developing skeletal muscle
    Petronel Tuluc
    Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria
    Biophys J 96:35-44. 2009
    ..1 Delta 29 splice variant revealed the structural bases underlying the specific gating properties of skeletal muscle Ca(2+) channels, and it suggests the existence of a distinct mode of EC coupling in developing muscle...
  4. doi request reprint Auxiliary Ca(2+) channel subunits: lessons learned from muscle
    Gerald J Obermair
    Division of Physiology, Department of Physiology and Medical Physics, Medical University Innsbruck, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Curr Opin Pharmacol 8:311-8. 2008
    ..Whether these specific functions in muscle indicate similar roles of alpha(2)delta and beta subunits as functional modulator and structural organizer, respectively, in neurons is being discussed...
  5. pmc Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavalpha1S-subunit
    Antonella Pirone
    Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Am J Physiol Cell Physiol 299:C1345-54. 2010
    ....
  6. pmc Physiological and pharmacological modulation of the embryonic skeletal muscle calcium channel splice variant CaV1.1e
    Bruno Benedetti
    Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria
    Biophys J 108:1072-80. 2015
    ..It might block the excessive calcium influx resulting from the aberrant expression of the embryonic splice variant CaV1.1e in the skeletal muscles of myotonic dystrophy patients. ..
  7. pmc Stable incorporation versus dynamic exchange of β subunits in a native Ca2+ channel complex
    Marta Campiglio
    Department of Physiology and Medical Physics, Medical University Innsbruck, A 6020 Innsbruck, Austria
    J Cell Sci 126:2092-101. 2013
    ..The distinct binding properties are not determined by differences in the I-II loop sequences of the α1 subunits, but are intrinsic properties of the β subunit isoforms...
  8. pmc CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type calcium channels
    Alexandra Pinggera
    Department of Pharmacology and Toxicology, Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
    Biol Psychiatry 77:816-22. 2015
    ..G407R. Both mutations are present only in the probands and not in their unaffected parents or siblings...
  9. pmc Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling
    Petronel Tuluc
    Department of Physiology and Medical Physics, Division of Physiology, Medical University Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 104:11091-6. 2007
    ....