Affiliation: University of Graz
- Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism?Oksana Tehlivets
Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50 II, 8010 Graz, Austria
J Lipids 2011:702853. 2011..In this review a model of deregulation of lipid metabolism in response to accumulation of AdoHcy in Hcy-associated pathology is proposed...
- S-adenosyl-L-homocysteine hydrolase and methylation disorders: yeast as a model systemOksana Tehlivets
Institute of Molecular Biosciences, University of Graz, Graz, Austria
Biochim Biophys Acta 1832:204-15. 2013..Inhibition of S-adenosyl-L-homocysteine hydrolase is also linked to antiviral effects. In this review the advantages of yeast as an experimental system to understand pathologies associated with AdoHcy accumulation will be discussed...
- S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosisNermina Malanovic
Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50 II, Graz, Austria
J Biol Chem 283:23989-99. 2008..The addition of homocysteine, by the reversal of the Sah1-catalyzed reaction, also leads to TG accumulation in yeast, providing an attractive model for the role of homocysteine as a risk factor of atherosclerosis in humans...
- Fatty acid synthesis and elongation in yeastOksana Tehlivets
Institute of Molecular Biosciences, University of Graz, A8010 Graz, Austria
Biochim Biophys Acta 1771:255-70. 2007..In this review, we summarize what is currently known about enzymes involved in cellular fatty acid synthesis and elongation, and discuss potential links between fatty acid metabolism, physiology and cellular regulation...
- S-adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesisOksana Tehlivets
Institute of Molecular Biosciences, SFB Biomembrane Research Center, University of Graz, Schubertstrasse 1, 8010 Graz, Austria
FEBS Lett 577:501-6. 2004..Profound changes in cellular lipid composition upon depletion of Sah1p support the notion of a tight interaction between lipid metabolism and Sah1p function...