J Tauscher

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Previous treatment as a confounding variable in studies with novel antipsychotics: two cases of high dopamine-2 receptor occupancy with quetiapine
    J Tauscher
    Department of General Psychiatry, University of Vienna, Austria
    Psychopharmacology (Berl) 133:102-5. 1997
  2. ncbi request reprint Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol
    Johannes Tauscher
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Psychopharmacology (Berl) 162:42-9. 2002
  3. ncbi request reprint Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635
    Johannes Tauscher
    PET Centre, Toronto, Ontario
    Arch Gen Psychiatry 59:514-20. 2002
  4. ncbi request reprint Significant dissociation of brain and plasma kinetics with antipsychotics
    Johannes Tauscher
    Schizophrenia PET program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mol Psychiatry 7:317-21. 2002
  5. ncbi request reprint Inverse relationship between serotonin 5-HT(1A) receptor binding and anxiety: a [(11)C]WAY-100635 PET investigation in healthy volunteers
    J Tauscher
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Am J Psychiatry 158:1326-8. 2001
  6. ncbi request reprint In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment
    J Tauscher
    Department of General Psychiatry, University Hospital of Vienna, Austria
    Eur Neuropsychopharmacol 9:177-9. 1999
  7. ncbi request reprint In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol
    J Tauscher
    Department of General Psychiatry, University of Vienna, Austria
    Psychopharmacology (Berl) 141:175-81. 1999
  8. ncbi request reprint A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophrenia
    N P Verhoeff
    PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, ON, M5T 1R8, Toronto, Canada
    Psychiatry Res 99:123-35. 2000
  9. ncbi request reprint Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET
    J Tauscher
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neuropsychopharmacology 24:522-30. 2001
  10. ncbi request reprint In vivo (123)I IBZM SPECT imaging of striatal dopamine 2 receptor occupancy in schizophrenic patients
    C Barnas
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Psychopharmacology (Berl) 157:236-42. 2001

Detail Information

Publications34

  1. ncbi request reprint Previous treatment as a confounding variable in studies with novel antipsychotics: two cases of high dopamine-2 receptor occupancy with quetiapine
    J Tauscher
    Department of General Psychiatry, University of Vienna, Austria
    Psychopharmacology (Berl) 133:102-5. 1997
    ..This might be of importance for the design of clinical trials and brain imaging studies in the future...
  2. ncbi request reprint Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol
    Johannes Tauscher
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Psychopharmacology (Berl) 162:42-9. 2002
    ..Extrapyramidal symptoms (EPS) are common with conventional antipsychotics. Clozapine and other novel antipsychotic substances with lower in vitro affinity for dopamine-2 (D(2)) receptors have a lower propensity to induce EPS...
  3. ncbi request reprint Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635
    Johannes Tauscher
    PET Centre, Toronto, Ontario
    Arch Gen Psychiatry 59:514-20. 2002
    ....
  4. ncbi request reprint Significant dissociation of brain and plasma kinetics with antipsychotics
    Johannes Tauscher
    Schizophrenia PET program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mol Psychiatry 7:317-21. 2002
    ..Our results question the current reliance on plasma kinetics as the main basis for dosing regimens of antipsychotics. Studies of brain kinetics may provide a sounder basis for determining dosing schedules of psychotropic medications...
  5. ncbi request reprint Inverse relationship between serotonin 5-HT(1A) receptor binding and anxiety: a [(11)C]WAY-100635 PET investigation in healthy volunteers
    J Tauscher
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Am J Psychiatry 158:1326-8. 2001
    ..The authors investigated the relationship between anxiety--a facet of the Revised NEO Personality Inventory dimension of neuroticism--and serotonin 5-HT(1A) receptor binding potential...
  6. ncbi request reprint In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment
    J Tauscher
    Department of General Psychiatry, University Hospital of Vienna, Austria
    Eur Neuropsychopharmacol 9:177-9. 1999
    ..Four hours after injection of the tracer more than 40% of serotonin transporters were blocked. To our knowledge, this is the first direct documentation of the pharmacodynamic action of fluoxetine in the human brain in vivo...
  7. ncbi request reprint In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol
    J Tauscher
    Department of General Psychiatry, University of Vienna, Austria
    Psychopharmacology (Berl) 141:175-81. 1999
    ..No clinical relevant EPS occurred during treatment with olanzapine or clozapine. There was no correlation between the degree of striatal D2 receptor occupancy and clinical improvement...
  8. ncbi request reprint A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophrenia
    N P Verhoeff
    PET Centre and Schizophrenia and Continuing Care Division, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, ON, M5T 1R8, Toronto, Canada
    Psychiatry Res 99:123-35. 2000
    ..Thus, in agreement with the previous ROI studies, voxel-by-voxel analysis confirmed the lack of substantial 5-HT(2A)R BP differences between schizophrenic patients and control subjects...
  9. ncbi request reprint Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET
    J Tauscher
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neuropsychopharmacology 24:522-30. 2001
    ..Hence, careful age matching may be recommended for future studies using PET and [11C]WAY-100635 to examine 5-HT1A receptors...
  10. ncbi request reprint In vivo (123)I IBZM SPECT imaging of striatal dopamine 2 receptor occupancy in schizophrenic patients
    C Barnas
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Psychopharmacology (Berl) 157:236-42. 2001
    ..Single photon emission computed tomography (SPECT) using (123)I iodobenzamide (IBZM) as tracer substance has been shown to be a useful tool to visualize dopamine 2 (D2) receptor occupancy...
  11. ncbi request reprint [123I] beta-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa
    J Tauscher
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Biol Psychiatry 49:326-32. 2001
    ....
  12. ncbi request reprint No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism
    M Willeit
    Department of General Psychiatry, Vienna University, Vienna, Austria
    Biol Psychiatry 50:8-12. 2001
    ..CONCLUSIONS: Our data provide no evidence for in vivo functional regulation of 5-HTT availability by 5-HTTLPR in the thalamus-hypothalamus and mesencephalon-pons of healthy subjects...
  13. ncbi request reprint Dopamine- and serotonin-receptors in schizophrenia: results of imaging-studies and implications for pharmacotherapy in schizophrenia
    S Kasper
    Department of General Psychiatry, University of Vienna, Wien, Austria
    Eur Arch Psychiatry Clin Neurosci 249:83-9. 1999
    ..g. 5-HT1A) will further shed light on the pathophysiology of schizophrenia as well as possible psychopharmacological treatment perspectives...
  14. ncbi request reprint In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in healthy subjects administered different doses of escitalopram or citalopram
    N Klein
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel, 18 20A 1090, Vienna, Austria
    Psychopharmacology (Berl) 188:263-72. 2006
    ..The novel radioligand [123I]ADAM and single photon emission computer tomography (SPECT) were used to measure midbrain SERT occupancies for different doses of escitalopram and citalopram...
  15. ncbi request reprint Effects of tryptophan depletion in drug-free depressed patients who responded to total sleep deprivation
    A Neumeister
    Department of General Psychiatry, Vienna University, Austria
    Arch Gen Psychiatry 55:167-72. 1998
    ..We investigated the effects of short-term tryptophan depletion (TD) on depressed patients who responded to a single night of total SD...
  16. ncbi request reprint Quetiapine: efficacy and tolerability in schizophrenia
    S Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 11:S405-13. 2001
    ....
  17. ncbi request reprint Choosing the right dose of antipsychotics in schizophrenia: lessons from neuroimaging studies
    J Tauscher
    Schizophrenia PET program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    CNS Drugs 15:671-8. 2001
    ..This seems to be particularly important in individuals experiencing a first episode of schizophrenia, as they appear to be especially responsive to pharmacotherapy and quite sensitive to adverse effects...
  18. ncbi request reprint Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans
    N P L G Verhoeff
    Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Mol Psychiatry 7:233, 322-8. 2002
    ..Thus, while DA depletion "uncovers" D(2)receptors, it does not do so for D(1) receptors. The implications of this finding for measuring endogenous DA and its effects on in vivo receptor binding in humans are discussed...
  19. ncbi request reprint Inverse relation between stimulus intensity and seizure duration: implications for ECT procedure
    R Frey
    Department of General Psychiatry, University Hospital of Psychiatry, University of Vienna, Austria
    J ECT 17:102-8. 2001
    ..Furthermore, focus on seizure duration led to frequent high-dose restimulation in the elderly. The titration method obviates inadequate or excessive charges because the seizure threshold must first be determined...
  20. ncbi request reprint Reduced serotonin-1A receptor binding in social anxiety disorder
    Rupert R Lanzenberger
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 61:1081-9. 2007
    ..The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD)...
  21. ncbi request reprint Striatal D(2) receptor occupancy in bipolar patients treated with olanzapine
    Trawat Attarbaschi
    Department of General Psychiatry, Medical University Vienna, Vienna, Austria
    Eur Neuropsychopharmacol 17:102-7. 2007
    ..Although we did not find an increased vulnerability for acute EPS in bipolar patients receiving olanzapine at clinical relevant doses, this needs to be replicated with larger sample sizes...
  22. ncbi request reprint Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosis
    Sitra Tauscher-Wisniewski
    Department of Neuropsychiatry for Children and Adolescents, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Psychiatr Res 39:365-70. 2005
    ..441). In contrast to previous studies in patients treated with typical neuroleptics, this cross-sectional MRI study did not find significant differences in CNV of neuroleptic-naive first-episode patients compared to healthy controls...
  23. ncbi request reprint Therapy of treatment resistant depression: focus on the management of TRD with atypical antipsychotics
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, A 1090 Vienna, Austria
    CNS Spectr 9:823-32. 2004
    ..This review especially focuses on the augmentation of the antidepressant therapy with atypical antipsychotics...
  24. ncbi request reprint Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics
    Johannes Tauscher
    University of Toronto Department of Psychiatry, Schizophrenia Program
    Am J Psychiatry 161:1620-5. 2004
    ....
  25. ncbi request reprint Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    J Clin Psychiatry 63:992-7. 2002
    ..We treated patients experiencing their first episode of schizophrenia with a single daily dose of quetiapine to achieve a transient daily peak of D(2) receptor blockade, to determine if this would lead to an antipsychotic response...
  26. ncbi request reprint Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder
    Dietmar Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Eur Neuropsychopharmacol 13:129-34. 2003
    ..Due to methodological limitations our results need to be replicated in controlled double-blind randomized clinical trials...
  27. ncbi request reprint Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 3:133-46. 2002
    ..Our data provide insight into the pathophysiology of neuropsychiatric disorders and may guide future psychopharmacological drug developments...
  28. ncbi request reprint Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up study
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 58:185-8. 2002
    ..Both groups demonstrated a significant 9% decline in caudate volume. We were unable to replicate previous reports of caudate enlargement in patients receiving antipsychotic treatment...
  29. ncbi request reprint The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuropsychopharmacology 33:259-69. 2008
    ..These promising results in monkey justify studying this radioligand in human subjects...
  30. ncbi request reprint Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study
    Nikolas Klein
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Psychopharmacology (Berl) 191:333-9. 2007
    ..In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioligand [(123)I]ADAM and single photon emission computed tomography (SPECT)...
  31. ncbi request reprint Relationship between power spectra of the awake EEG and psychomotor activity patterns measured by short-term actigraphy
    Dietmar Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Austria
    Neuropsychobiology 48:176-81. 2003
    ..Our results, while preliminary, suggest that short-term actigraphy may be apt to reflect central nervous system arousal...
  32. ncbi request reprint Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 188:119-27. 2006
    ..Previous positron emission tomography (PET) studies had failed to demonstrate the feasibility of measuring a dose-dependent and saturable NET occupancy in human brain using [11C]MeNER...
  33. ncbi request reprint Binding kinetics of 123I[ADAM] in healthy controls: a selective SERT radioligand
    Julia Sacher
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Int J Neuropsychopharmacol 10:211-8. 2007
    ..Our data suggest that the acquisition time for the SPECT scan is optimally, under pseudo-equilibrium conditions, between 205-320 min post-bolus injection of the tracer...
  34. pmc Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents
    Garth Terry
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuroimage 41:690-8. 2008
    ..Radiometabolites of [11C]MePPEP in brain caused distribution volume to be overestimated by approximately 13%...