T M Stulnig

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Biol Chem 272:19242-7. 1997
  2. ncbi request reprint Immunomodulation by polyunsaturated fatty acids: mechanisms and effects
    Thomas M Stulnig
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, and Center of Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria
    Int Arch Allergy Immunol 132:310-21. 2003
  3. ncbi request reprint 11beta-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes
    T M Stulnig
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Diabetologia 47:1-11. 2004
  4. ncbi request reprint Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Mol Pharmacol 62:1299-305. 2002
  5. ncbi request reprint Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Diabetes 51:2426-33. 2002
  6. pmc Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
    J Cell Biol 143:637-44. 1998
  7. ncbi request reprint Elevated serum free fatty acid concentrations inhibit T lymphocyte signaling
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, Austria
    FASEB J 14:939-47. 2000
  8. ncbi request reprint Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids
    J Huber
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
    Int J Obes (Lond) 31:1004-13. 2007
  9. ncbi request reprint The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse
    M Zeyda
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria
    Transplant Proc 37:1970-1. 2005
  10. ncbi request reprint Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids
    J Todoric
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Diabetologia 49:2109-19. 2006

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Biol Chem 272:19242-7. 1997
    ..These results suggest that cellular cholesterol is an important prerequisite for signal transduction via GPI-anchored proteins beyond formation of membrane domains...
  2. ncbi request reprint Immunomodulation by polyunsaturated fatty acids: mechanisms and effects
    Thomas M Stulnig
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, and Center of Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria
    Int Arch Allergy Immunol 132:310-21. 2003
    ..In addition, the effects of PUFAs on the immune system in general are summarized, as are clinical effects in rheumatoid arthritis, inflammatory bowel disease and sepsis...
  3. ncbi request reprint 11beta-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes
    T M Stulnig
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Diabetologia 47:1-11. 2004
    ....
  4. ncbi request reprint Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Mol Pharmacol 62:1299-305. 2002
    ....
  5. ncbi request reprint Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Diabetes 51:2426-33. 2002
    ..In conclusion, LXR ligands could mediate beneficial metabolic effects in insulin resistance syndromes including type 2 diabetes by interfering with peripheral glucocorticoid activation...
  6. pmc Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
    J Cell Biol 143:637-44. 1998
    ..In conclusion, PUFA enrichment selectively modifies the cytoplasmic layer of DRMs and this alteration could underlie the inhibition of T cell signal transduction by PUFAs...
  7. ncbi request reprint Elevated serum free fatty acid concentrations inhibit T lymphocyte signaling
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, Austria
    FASEB J 14:939-47. 2000
    ..In conclusion, our data emphasize that serum FFA elevation is able to exert immunosuppressive effects in vivo...
  8. ncbi request reprint Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids
    J Huber
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
    Int J Obes (Lond) 31:1004-13. 2007
    ..As polyunsaturated fatty acids (PUFA) appear to inhibit diabetes development, we investigated PUFA effects on markers of matrix remodeling in white adipose tissue...
  9. ncbi request reprint The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse
    M Zeyda
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria
    Transplant Proc 37:1970-1. 2005
    ....
  10. ncbi request reprint Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids
    J Todoric
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Diabetologia 49:2109-19. 2006
    ..In this study, we investigated how PUFA affect white adipose tissue inflammation and gene expression in obese diabetic animals...
  11. ncbi request reprint Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production
    M Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Int J Obes (Lond) 31:1420-8. 2007
    ..Macrophages exist in separate types of differentiation, but the nature of ATMs is largely unknown...
  12. doi request reprint Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression
    M Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
    Int J Obes (Lond) 34:1684-94. 2010
    ..This study aimed at identifying and characterizing ATM populations in obesity...
  13. ncbi request reprint Liver X receptors in cardiovascular and metabolic disease
    R Geyeregger
    Clin Div of Endocrinology and Metabolism, Dept of Internal Med III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Cell Mol Life Sci 63:524-39. 2006
    ..This review summarizes the multiple physiological and pathophysiological implications of LXRs and observations that identify LXRs as potential targets for therapeutic interventions in human cardiovascular and metabolic disease...
  14. ncbi request reprint Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
    J Biol Chem 276:37335-40. 2001
    ..In conclusion, these data provide strong evidence that displacement of acylated proteins from rafts in PUFA-treated T cells is predominantly due to altered raft lipid composition...
  15. ncbi request reprint Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    Biochem Biophys Res Commun 310:589-93. 2003
    ..These results indicate a role of LXR in early developmental stages of adipose tissue...
  16. ncbi request reprint Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    J Mol Endocrinol 33:609-22. 2004
    ..These results indicate novel biological roles of the LXR including regulation of energy metabolism, glycolysis and steroidogenesis in the adrenals via alteration of expression profiles of putative target genes...
  17. doi request reprint Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue
    M Zeyda
    Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria
    Int J Obes (Lond) 37:658-65. 2013
    ..IL-33 and ST2 have been shown to be expressed in human and murine adipose tissue. Our objective was to investigate alterations in obesity and a possible role of IL-33 in adipose tissue inflammation...
  18. doi request reprint Diminished upregulation of visceral adipose heme oxygenase-1 correlates with waist-to-hip ratio and insulin resistance
    S Shakeri-Manesch
    Department of Surgery, Medical University of Vienna, Vienna, Austria
    Int J Obes (Lond) 33:1257-64. 2009
    ....
  19. ncbi request reprint Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback
    Maria Nilsson
    Department of Biosciences and Nutrition, Karolinska Institutet, S 14157 Huddinge, Sweden
    Mol Endocrinol 21:126-37. 2007
    ..In conclusion, LXRs independently interfere with the hypothalamic-pituitary-adrenal axis regulation at the level of the pituitary and the adrenal gland...
  20. ncbi request reprint Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin
    Rene Geyeregger
    Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Austria
    Blood 109:4288-95. 2007
    ..Due to the central position of DCs in immunity, LXRalpha could be a potential novel target for immunomodulation...
  21. ncbi request reprint Blood glucose-lowering nuclear receptor agonists only partially normalize hepatic gene expression in db/db mice
    Michael Loffler
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Austria
    J Pharmacol Exp Ther 316:797-804. 2006
    ..These results suggest that diabetes-induced gene expression is minimally reversed by potent blood glucose-lowering nuclear receptor agonists...
  22. ncbi request reprint Improved metabolic control by depletion of Liver X Receptors in mice
    Gertrud U Schuster
    Department of Biosciences and Nutrition, Karolinska University Hospital, Novum, Karolinska Institutet, S 141 57 Huddinge, Sweden
    Biochem Biophys Res Commun 348:176-82. 2006
    ..LXRalpha(-/-)beta(-/-) mice responded to this diet by induction of SREBP-1c. Our study suggests that in LXRalpha(-/-)beta(-/-) mice, glucose utilization seems to be privileged possibly due to reduced circulating free fatty acid levels...
  23. ncbi request reprint Prospective randomised cross-over comparison of three LDL-apheresis systems in statin pretreated patients with familial hypercholesterolaemia
    S Schmaldienst
    Third Department of Internal Medicine, University of Vienna, Austria
    Atherosclerosis 151:493-9. 2000
    ..No side effects were recorded in the total of 96 treatments performed during the study. Long-term observations have yet to prove whether these differences in efficacy may be of clinical relevance...
  24. ncbi request reprint The malononitrilamide FK778 inhibits activation of NF-kappaB in human dendritic cells
    M Zeyda
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine, Medical University of Vienna, Vienna, Austria
    Transplant Proc 37:1968-9. 2005
    ..Hence, FK778 could exert its immunosuppressive effects via inhibition of activation and thus function of the central antigen-presenting cell, ie, DC...
  25. doi request reprint Local anesthetics have a major impact on viability of preadipocytes and their differentiation into adipocytes
    Maike Keck
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria
    Plast Reconstr Surg 126:1500-5. 2010
    ..The aim of this study was to investigate the influence of different local anesthetics frequently used in clinical practice on the viability of preadipocytes and their ability to differentiate into adipocytes...
  26. ncbi request reprint Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations
    Florian W Kiefer
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Endocrinology 149:1350-7. 2008
    ..In conclusion, our data point toward a specific local role of OPN in obese AT. Therefore, OPN could be a critical regulator in obesity induced AT inflammation and insulin resistance...
  27. ncbi request reprint Immunomodulation by polyunsaturated fatty acids: impact on T-cell signaling
    Thomas M Stulnig
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Lipids 39:1171-5. 2004
    ..These recent results add considerably to the understanding of mechanisms of PUFA actions, but their relevance in the in vivo situation must still be elucidated...
  28. ncbi request reprint Suppression of T cell signaling by polyunsaturated fatty acids: selectivity in inhibition of mitogen-activated protein kinase and nuclear factor activation
    Maximilian Zeyda
    Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism and Institute of Immunology, University of Vienna Medical School, Vienna, Austria
    J Immunol 170:6033-9. 2003
    ..In conclusion, PUFA treatment of T cells inhibits selectively c-Jun NH(2)-terminal kinase and NF-AT activation, resulting in diminished production of IL-2 and IL-13...
  29. ncbi request reprint LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T cell signaling by polyunsaturated fatty acids
    Maximilian Zeyda
    Department of Internal Medicine III and the Institute of Immunology, University of Vienna, A 1090 Vienna, Austria
    J Biol Chem 277:28418-23. 2002
    ..These data reveal LAT displacement from lipid rafts as a molecular mechanism by which PUFAs inhibit T cell signaling and underline the predominant importance of LAT localization in rafts for efficient T cell activation...
  30. ncbi request reprint Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154
    Marcus D Saemann
    Institute of Immunology, Vienna, Austria
    Transplantation 75:1864-72. 2003
    ..Recent evidence, however, indicates a critical role for JAK3 in signaling linked to the T-cell antigen receptor...
  31. pmc Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    J Clin Invest 115:468-75. 2005
    ..These data show that THP is a regulatory factor of innate and adaptive immunity and therefore could have significant impact on host immunity in the urinary tract...
  32. pmc Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance
    Florian W Kiefer
    Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Diabetes 59:935-46. 2010
    ..Here, we studied OPN effects in obesity-induced inflammation and insulin resistance by targeting OPN action in vivo...
  33. ncbi request reprint Polyunsaturated fatty acids interfere with formation of the immunological synapse
    Rene Geyeregger
    Department of Internal Medicine, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Leukoc Biol 77:680-8. 2005
    ....
  34. ncbi request reprint Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts
    Gunther Staffler
    Institute of Immunology, University of Vienna, Vienna, Austria
    J Immunol 171:1707-14. 2003
    ..These results indicate that negative regulating signals can modulate microdomains and suggest a general mechanism for inhibition of receptor signaling...
  35. ncbi request reprint Adipose tissue macrophages
    Maximilian Zeyda
    Department of Internal Medicine III, Clin Div Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Immunol Lett 112:61-7. 2007
    ..Strategies to interfere with ATM recruitment and adverse activation could give rise to novel options for treatment and prevention of insulin resistance and type 2 diabetes mellitus...
  36. ncbi request reprint Obesity, inflammation, and insulin resistance--a mini-review
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Gerontology 55:379-86. 2009
    ..Moreover, novel approaches for treatment and prevention of insulin resistance and type 2 diabetes by targeting obesity-induced inflammatory processes are discussed here...
  37. ncbi request reprint Lipid Rafts & Co.: an integrated model of membrane organization in T cell activation
    Maximilan Zeyda
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria
    Prog Lipid Res 45:187-202. 2006
    ..Further research has to elucidate the relative contribution and interrelation of different modes of membrane organization in productive T cell activation...
  38. ncbi request reprint Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver
    Steven P Anderson
    Investigative Toxicology and Pathology Group, Safety Assessment, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 66:1440-52. 2004
    ....
  39. ncbi request reprint Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors
    J Christopher Corton
    Toxicogenomics, Chapel Hill, North Carolina 27514, USA
    J Biol Chem 279:46204-12. 2004
    ..These results demonstrate that PPARalpha mediates some of the effects of CR and indicate that a pharmacological approach to mimicking many of the beneficial effects of CR may be possible...
  40. pmc Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression
    Jong Bae Seo
    School of Biological Sciences Marine Biotechnology Laboratory, School of Earth and Environmental Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Cell Biol 24:3430-44. 2004
    ..Taken together, these results suggest that LXR plays a role in the execution of adipocyte differentiation by regulation of lipogenesis and adipocyte-specific gene expression...
  41. ncbi request reprint Lipid raft-associated GTPase signaling controls morphology and CD8+ T cell stimulatory capacity of human dendritic cells
    Silvia Jaksits
    Center of Molecular Medicine of the Austrian Academy of Sciences, and Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Austria
    J Immunol 173:1628-39. 2004
    ..We conclude that Cdc42 and Rac1 signaling controls DC morphology and conditions DCs for efficient CD8(+) T cell stimulation...
  42. doi request reprint CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity
    Joakim Huber
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Clin Endocrinol Metab 93:3215-21. 2008
    ..Obesity is associated with a low-grade inflammation, insulin resistance, and macrophage infiltration of adipose tissue. The role of CC chemokines and their respective receptors in human adipose tissue inflammation remains to be determined...
  43. ncbi request reprint Early nutrition and immunity - progress and perspectives
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 96:774-90. 2006
    ..This report summarizes the content of the lectures and the subsequent discussions...
  44. ncbi request reprint Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-kappaB activation
    Maximilian Zeyda
    Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Biol Chem 280:14293-301. 2005
    ..These data demonstrate a unique interference with DC activation and function that could significantly contribute to the well known anti-inflammatory effects of PUFAs...
  45. ncbi request reprint Glucocorticoids alter the lipid and protein composition of membrane rafts of a murine T cell hybridoma
    Francois Van Laethem
    Laboratoire de Physiologie Animale, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    J Immunol 170:2932-9. 2003
    ....