W R Sperr

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of disease
    Wolfgang R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Int Arch Allergy Immunol 128:136-41. 2002
  2. ncbi request reprint Clinical and biologic diversity of leukemias occurring in patients with mastocytosis
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Leuk Lymphoma 37:473-86. 2000
  3. ncbi request reprint Autoantibody reactivity in a case of Schnitzler's syndrome: evidence for a Th1-like response and detection of IgG2 anti-FcepsilonRIalpha antibodies
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Int Arch Allergy Immunol 122:279-86. 2000
  4. ncbi request reprint Survival analysis and AML development in patients with de novo myelodysplastic syndromes: comparison of six different prognostic scoring systems
    W R Sperr
    Department of Internal Medicine I, University of Vienna, Austria
    Ann Hematol 80:272-7. 2001
  5. ncbi request reprint Treatment concepts for elderly patients with acute myeloid leukemia
    Wolfgang R Sperr
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 115:505-14. 2003
  6. ncbi request reprint Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Blood 98:2200-9. 2001
  7. ncbi request reprint Spectrum of associated clonal hematologic non-mast cell lineage disorders occurring in patients with systemic mastocytosis
    Wolfgang R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Int Arch Allergy Immunol 127:140-2. 2002
  8. ncbi request reprint Tryptase a novel biochemical marker of acute myeloid leukemia
    Wolfgang R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Leuk Lymphoma 43:2257-61. 2002
  9. ncbi request reprint Human leukaemic stem cells: a novel target of therapy
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria
    Eur J Clin Invest 34:31-40. 2004
  10. ncbi request reprint Serum tryptase measurements in patients with myelodysplastic syndromes
    W R Sperr
    Leuk Lymphoma 43:1097-105. 2002

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of disease
    Wolfgang R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Int Arch Allergy Immunol 128:136-41. 2002
    ..The serum tryptase level is used as a diagnostic marker in mastocytosis and is considered to reflect the burden of (neoplastic) mast cells (MC)...
  2. ncbi request reprint Clinical and biologic diversity of leukemias occurring in patients with mastocytosis
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Leuk Lymphoma 37:473-86. 2000
    ..In the present article, the concomitant occurrence of mastocytosis and leukemia is discussed in the light of the literature and of concepts proposed to explain the biologic basis of this phenomenon...
  3. ncbi request reprint Autoantibody reactivity in a case of Schnitzler's syndrome: evidence for a Th1-like response and detection of IgG2 anti-FcepsilonRIalpha antibodies
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Int Arch Allergy Immunol 122:279-86. 2000
    ..Whether such autoantibodies are recurrently produced in patients with Schnitzler's syndrome and play a role in the pathophysiology of the disease remains to be determined...
  4. ncbi request reprint Survival analysis and AML development in patients with de novo myelodysplastic syndromes: comparison of six different prognostic scoring systems
    W R Sperr
    Department of Internal Medicine I, University of Vienna, Austria
    Ann Hematol 80:272-7. 2001
    ..Karyotype-based multiparameter systems appear to be particularly effective in defining MDS patients who are at high risk of transforming to leukemia...
  5. ncbi request reprint Treatment concepts for elderly patients with acute myeloid leukemia
    Wolfgang R Sperr
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 115:505-14. 2003
    ..The therapeutic efficiency and toxicity-profiles of these novel drugs are currently under investigation in clinical trials...
  6. ncbi request reprint Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Blood 98:2200-9. 2001
    ..Blast cell persistence or regrowth was associated with a persistently elevated level or recurrent increase of tryptase. Together, tryptase is expressed in myeloblasts in a group of AML and may serve as a useful disease-related marker...
  7. ncbi request reprint Spectrum of associated clonal hematologic non-mast cell lineage disorders occurring in patients with systemic mastocytosis
    Wolfgang R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Int Arch Allergy Immunol 127:140-2. 2002
    ..No general guidelines for the treatment of patients with SM-AHNMD have been established so far. A reasonable straightforward approach may be to treat the AHNMD in those patients in the same way as if no coexisting SM exists...
  8. ncbi request reprint Tryptase a novel biochemical marker of acute myeloid leukemia
    Wolfgang R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Leuk Lymphoma 43:2257-61. 2002
    ..We hypothesize that tryptase-positive AMLs arise from a leukemic progenitor that exhibits a limited potential to differentiate into mast cells and/or basophils...
  9. ncbi request reprint Human leukaemic stem cells: a novel target of therapy
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria
    Eur J Clin Invest 34:31-40. 2004
    ..The present article gives an overview of our knowledge about AML stem cells, their phenotype, and their role as a 'therapy-target' in new concepts to treat and to cure patients with AML...
  10. ncbi request reprint Serum tryptase measurements in patients with myelodysplastic syndromes
    W R Sperr
    Leuk Lymphoma 43:1097-105. 2002
    ..In addition, serum tryptase levels appear to correlate with MDS variants. Follow up studies should clarify whether an elevated tryptase concentration in MDS is of prognostic significance...
  11. ncbi request reprint A novel effective and safe consolidation for patients over 60 years with acute myeloid leukemia: intermediate dose cytarabine (2 x 1 g/m2 on days 1, 3, and 5)
    Wolfgang R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Institute of Medical Biology, and Institute of Medical and Laboratory Medicine, Medical University of Vienna, Vienna, Austria
    Clin Cancer Res 10:3965-71. 2004
    ..High-dose intermittent cytarabine is an effective postremission treatment for patients with acute myeloid leukemia (AML). This regimen is a safe approach in patients < 60 years but produced severe neurotoxicity in the elderly...
  12. ncbi request reprint Kit ligand/mast cell growth factor-independent differentiation of mast cells in myelodysplasia and chronic myeloid leukemic blast crisis
    P Valent
    Department of Internal Medicine, University of Vienna, Austria
    Blood 84:4322-32. 1994
    ....
  13. ncbi request reprint Diagnostic criteria and classification of mastocytosis: a consensus proposal
    P Valent
    Department of Internal Medicine I, Division of Hematology, University of Vienna, Währinger Gürtel 18 20 Vienna, Austria
    Leuk Res 25:603-25. 2001
    ..Criteria proposed in this article should be helpful in this regard...
  14. ncbi request reprint Specific activation of human mast cells by the ligand for c-kit: comparison between lung, uterus and heart mast cells
    W R Sperr
    Department of Internal Medicine I, University of Vienna, Austria
    Int Arch Allergy Immunol 102:170-5. 1993
    ..Furthermore, MCs could be desensitized specifically by pre-incubation of MCs with rhSCF in Ca-free medium. Together, these data suggest that SCF triggers mediator secretion from MCs in various organs via binding to the c-kit receptor...
  15. ncbi request reprint Monocytes do not make mast cells when cultured in the presence of SCF. Characterization of the circulating mast cell progenitor as a c-kit+, CD34+, Ly-, CD14-, CD17-, colony-forming cell
    H Agis
    Department of Internal Medicine I, University of Vienna, Austria
    J Immunol 151:4221-7. 1993
    ..This is the first definitive demonstration that mast cells are replenished directly from early hemopoietic progenitors and thus form a unique cell lineage within the hemopoietic system...
  16. ncbi request reprint Variable expression of activation-linked surface antigens on human mast cells in health and disease
    P Valent
    Department of Internal Medicine I, University of Vienna, Austria
    Immunol Rev 179:74-81. 2001
    ..The present article gives an overview of MC phenotypes in health and disease, and attempts to provide explanations for the phenotypic variability of MC...
  17. ncbi request reprint Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, , 1090 Vienna, Austria
    Leuk Res 25:529-36. 2001
    ..These data suggest that cytomorphological assessment of bm MC in SM is an important diagnostic approach that may help to delineate between variants of the disease...
  18. ncbi request reprint Myelomastocytic overlap syndromes: biology, criteria, and relationship to mastocytosis
    P Valent
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Leuk Res 25:595-602. 2001
    ..Whether these neoplasms display aberrant gene expression (or gene defects) or represent 'pre-pre-mast cell leukemias', remains unknown...
  19. ncbi request reprint Effects of various statins on cytokine-dependent growth and IgE-dependent release of histamine in human mast cells
    M T Krauth
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Allergy 61:281-8. 2006
    ..In the present study, we examined the in vitro effects of five different statins on primary human mast cells (MCs), MC progenitors, and the human MC line HMC-1...
  20. ncbi request reprint Purification of human basophils and mast cells by multistep separation technique and mAb to CDw17 and CD117/c-kit
    M Willheim
    Institute of General and Experimental Pathology, University of Vienna, Neubau AKH, Austria
    J Immunol Methods 182:115-29. 1995
    ..Thus, by combining isolation techniques including elutriation, magnetic cell depletion and cell sorting with mAb, functionally intact normal human basophils and mast cells can be enriched to homogeneity...
  21. ncbi request reprint Quantitative, phenotypic, and functional evaluation of basophils in myelodysplastic syndromes
    W Füreder
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, The University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur J Clin Invest 31:894-901. 2001
    ..However, little is known so far about basophil granulocytes in MDS...
  22. ncbi request reprint Molecular, immunological, and structural characterization of Phl p 6, a major allergen and P-particle-associated protein from Timothy grass (Phleum pratense) pollen
    S Vrtala
    Institute of General and Experimental Pathology, Vienna General Hospital, University of Vienna, Austria
    J Immunol 163:5489-96. 1999
    ....
  23. ncbi request reprint A case of 'smouldering' mastocytosis with high mast cell burden, monoclonal myeloid cells, and C-KIT mutation Asp-816-Val
    J H Jordan
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria
    Leuk Res 25:627-34. 2001
    ..Because of the 'intermediate' clinical signs and absence of progression to aggressive disease, we proposed the term 'smouldering mastocytosis'...
  24. ncbi request reprint Prognostic value of lactate dehydrogenase activity in myelodysplastic syndromes
    F Wimazal
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, , A-1090, Vienna, Austria
    Leuk Res 25:287-94. 2001
    ..The LDH activity should be considered as an important prognostic factor in MDS...
  25. ncbi request reprint Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination
    M Focke
    Department of Pathophysiology, Vienna General Hospital, AKH, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
    FASEB J 15:2042-4. 2001
    ..We thus demonstrate that synthetic hypoallergenic peptides derived from B cell epitopes of major allergens represent safe vaccine candidates for the treatment of IgE- mediated allergies...
  26. ncbi request reprint Clinical and prognostic significance of histamine monitoring in patients with CML during treatment with imatinib (STI571)
    H Agis
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Center of Excellence for Clinical and Experimental Oncology CLEXO, Medical University of Vienna, Austria
    Ann Oncol 18:1834-41. 2007
    ..Therefore, monitoring of minimal residual disease (MRD) during treatment with imatinib is important. However, most MRD-parameters are expensive and require special technology. We determined the value of histamine as MRD-marker in CML...
  27. ncbi request reprint Numbers of colony-forming progenitors in patients with systemic mastocytosis: potential diagnostic implications and comparison with myeloproliferative disorders
    J H Jordan
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur J Clin Invest 33:611-8. 2003
    ..In the present study, we measured the levels of peripheral blood (pb) and bone marrow (bm) CFU in patients with different categories of SM, and compared them with those obtained in MPD patients and healthy controls...
  28. ncbi request reprint Immunohistochemical properties of bone marrow mast cells in systemic mastocytosis: evidence for expression of CD2, CD117/Kit, and bcl-x(L)
    J H Jordan
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria
    Hum Pathol 32:545-52. 2001
    ..Apart from these, CD2 may be a novel useful marker because MCs in mastocytosis frequently express this antigen, whereas MCs in other pathologic conditions are CD2 negative...
  29. ncbi request reprint Expression of the target receptor CD33 in CD34+/CD38-/CD123+ AML stem cells
    A W Hauswirth
    Department of Medicine I, Medical University of Vienna, Austria
    Eur J Clin Invest 37:73-82. 2007
    ..In the present study, we asked whether leukaemic stem cells in patients with AML express CD33...
  30. ncbi request reprint Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms
    P Samorapoompichit
    Institute of Histology and Embryology, Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Blood 98:2580-3. 2001
    ..Therefore, tryptase should not be regarded as specific for mast cells when neoplastic myeloid cells are analyzed...
  31. ncbi request reprint Interleukin-3 promotes the expression of E-NPP3/CD203C on human blood basophils in healthy subjects and in patients with birch pollen allergy
    A W Hauswirth
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria
    Int J Immunopathol Pharmacol 20:267-78. 2007
    ..Compared to FcepsilonRI-mediated cell activation, IL-3-induced upregulation of CD203c is a late(r) event and is not accompanied by upregulation of CD63...
  32. doi request reprint Prognostic significance of serial determinations of lactate dehydrogenase (LDH) in the follow-up of patients with myelodysplastic syndromes
    F Wimazal
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Ann Oncol 19:970-6. 2008
    ..In a screen program searching for dynamic prognostic determinants, we have identified lactate dehydrogenase (LDH) as a most suitable follow-up parameter...
  33. ncbi request reprint Non-anaphylactic surface-exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination
    M Focke
    Department of Pathophysiology, Vienna General Hospital, Medical University of Vienna, Austria
    Clin Exp Allergy 34:1525-33. 2004
    ..Almost 100 million allergic patients are sensitized to the major birch pollen allergen, Bet v 1, a 17 kDa protein containing most of the IgE epitopes present in pollens of trees belonging to the Fagales order and plant-derived food...
  34. ncbi request reprint On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts
    P Valent
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria
    Eur J Clin Invest 34:41-52. 2004
    ..The therapeutic potential of target-specific approaches in malignant mast cell disorders should be evaluated in forthcoming clinical trials in the near future...
  35. ncbi request reprint Evaluation of neoplastic human mast cells by tryptase-immunoelectron microscopy
    P Samorapoompichit
    Centre of Anatomy and Cell Biology, Institute of Histology and Embryology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Histopathology 48:247-57. 2006
    ..To analyse and characterize the ultrastructural morphology of normal tissue mast cells (MC) and neoplastic bone marrow MC...
  36. doi request reprint Treatment responses to cladribine and dasatinib in rapidly progressing aggressive mastocytosis
    K J Aichberger
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria
    Eur J Clin Invest 38:869-73. 2008
    ..Cladribine (2CdA) and dasatinib are two drugs that counteract the in vitro growth of neoplastic mast cells in SM. However, only little is known about the in vivo effects of these drugs in SM...
  37. ncbi request reprint Increase and redistribution of cardiac mast cells in auricular thrombosis. Possible role of kit ligand
    H C Bankl
    Department of Internal Medicine I, University of Vienna, Austria
    Circulation 91:275-83. 1995
    ..The role of redistributed MC and their mediators in the pathophysiology of atrial thrombosis requires further investigation...
  38. ncbi request reprint Detection of differentiation- and activation-linked cell surface antigens on cultured mast cell progenitors
    G H Schernthaner
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Allergy 60:1248-55. 2005
    ..Depending on the stage of maturation and the environment, MC variably express differentiation- and activation-linked antigens. Little is known, however, about the regulation of expression of such antigens in immature human MC...
  39. doi request reprint Comorbidity as prognostic variable in MDS: comparative evaluation of the HCT-CI and CCI in a core dataset of 419 patients of the Austrian MDS Study Group
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, A 1090 Vienna, Austria
    Ann Oncol 21:114-9. 2010
    ..The evaluation of comorbidity is of increasing importance in patients with hematologic disorders...
  40. ncbi request reprint CD203c is overexpressed on neoplastic mast cells in systemic mastocytosis and is upregulated upon IgE receptor cross-linking
    A W Hauswirth
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Int J Immunopathol Pharmacol 21:797-806. 2008
    ..In conclusion, CD203c is a novel activation-linked surface antigen on MC that is upregulated in response to IgE receptor cross-linking and is overexpressed on neoplastic MC in patients with SM...
  41. doi request reprint Mixed-lineage eosinophil/basophil crisis in MDS: a rare form of progression
    F Wimazal
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria
    Eur J Clin Invest 38:447-55. 2008
    ..Basophilic crisis and eosinophilia are well recognized features of advanced chronic myeloid leukaemia. In other myeloid neoplasms, however, transformation with marked basophilia and eosinophilia is considered unusual...
  42. pmc Purification, biochemical, and immunological characterisation of a major food allergen: different immunoglobulin E recognition of the apo- and calcium-bound forms of carp parvalbumin
    A Bugajska-Schretter
    Institute of Medical and Chemical Laboratory Diagnostics, AKH, University of Vienna, Austria
    Gut 46:661-9. 2000
    ..Almost 4% of the population suffer from food allergy which is an adverse reaction to food with an underlying immunological mechanism...
  43. doi request reprint Targeting of mTOR is associated with decreased growth and decreased VEGF expression in acute myeloid leukaemia cells
    A Bohm
    Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 39:395-405. 2009
    ..Three mTOR-targeting drugs, rapamycin, everolimus (RAD001) and CCI-779, were applied. The effects of these drugs on growth, survival, apoptosis and VEGF expression in primary AML cells and various AML cell lines were examined...
  44. ncbi request reprint Impact of cytogenetics on the prognosis of adults with de novo AML in first relapse
    A Weltermann
    Department of Internal Medicine I, Division of Haematology and Haemostasis, Vienna University Hospital, Vienna, Austria
    Leukemia 18:293-302. 2004
    ..In conclusion, our results indicate that both karyotype and the duration of first CR are independent prognostic factors for patients with de novo AML in first relapse...
  45. ncbi request reprint Expression of homing receptors and related molecules on human mast cells and basophils: a comparative analysis using multi-color flow cytometry and toluidine blue/immunofluorescence staining techniques
    F Wimazal
    Department of Internal Medicine I, University of Vienna, Austria
    Tissue Antigens 54:499-507. 1999
    ..In summary, Ba and MC express a unique profile of homing molecules. Apparently, Ba differ from MC in expression of recognition receptors relevant for binding to endothelium and consecutive transmigration...
  46. doi request reprint Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology
    W R Sperr
    Medical University of Vienna, A 1090 Vienna, Austria
    Eur J Clin Invest 39:914-23. 2009
    ..Recent data suggest that tryptase, a mast cell enzyme, is expressed in neoplastic cells in myeloid leukaemias. In several of these patients, increased serum tryptase levels are detectable...
  47. doi request reprint Serum CD44 levels predict survival in patients with low-risk myelodysplastic syndromes
    J Loeffler-Ragg
    Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Crit Rev Oncol Hematol 78:150-61. 2011
    ..037) and in the IPSS intermediate-1-risk group (p=0.015). The CD44s-adjusted IPSS defines a cohort of MDS patients with unfavorable prognosis, which might be helpful in risk stratification and in therapeutic algorithms...
  48. doi request reprint Deferasirox induces regression of iron overload in patients with myelodysplastic syndromes
    F Wimazal
    Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 39:406-11. 2009
    ..A major disadvantage of deferoxamine is that the drug has to be applied as continuous subcutaneous infusion. Therefore, novel oral agents have been developed. One of these drugs is deferasirox (Exjade)...
  49. doi request reprint Evaluation of antileukaemic effects of rapamycin in patients with imatinib-resistant chronic myeloid leukaemia
    C Sillaber
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 38:43-52. 2008
    ..Recent data suggest that the mammalian target of rapamycin (mTOR) is involved in the regulation of growth of neoplastic cells in chronic myeloid leukaemia (CML)...
  50. ncbi request reprint A molecular model of type I allergy: identification and characterization of a nonanaphylactic anti-human IgE antibody fragment that blocks the IgE-FcepsilonRI interaction and reacts with receptor-bound IgE
    S Laffer
    Department of Pathophysiology, AKH, University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 108:409-16. 2001
    ..CONCLUSION: Fab12 represents a candidate molecule for therapy of atopy and asthma because it can be used for the depletion of circulating IgE antibodies, as well as for the depletion of IgE-bearing cells...
  51. ncbi request reprint New aspects in thrombosis research: possible role of mast cells as profibrinolytic and antithrombotic cells
    P Valent
    Department of Internal Medicine I, The University of Vienna, Austria
    Thromb Haemost 87:786-90. 2002
    ..Whether an altered availability of components of this cellular repair system can predispose for thrombophilia remains to be determined...
  52. ncbi request reprint Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria
    P Valent
    Department of Internal Medicine I, Division of Haematology and Haemostaseology, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 37:435-53. 2007
    ..Resulting recommendations and algorithms should greatly facilitate the management of patients with mastocytosis in clinical practice, selection of patients for therapies, and the conduct of clinical trials...
  53. doi request reprint Quantitative monitoring of BCR/ABL1 mutants for surveillance of subclone-evolution, -expansion, and -depletion in chronic myeloid leukaemia
    S Preuner
    Children s Cancer Research Institute, Vienna, Austria
    Eur J Cancer 48:233-6. 2012
    ..Recent data indicate that detection of BCR/ABL1 mutant subclones does not permit prediction of their expansion dynamics and their potential to become drivers of resistant disease...
  54. doi request reprint Prognostic impact of age and gender in 897 untreated patients with primary myelodysplastic syndromes
    T Nösslinger
    Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna, Austria
    Ann Oncol 21:120-5. 2010
    ..The aim of this analysis was to study age and gender as interacting variables for individualized prognostication...
  55. ncbi request reprint The KIT D816V allele burden predicts survival in patients with mastocytosis and correlates with the WHO type of the disease
    G Hoermann
    Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
    Allergy 69:810-3. 2014
    ..05). To conclude, the KIT D816V burden correlates with the variant of mastocytosis, predicts survival, and is a valuable follow-up parameter in SM...
  56. ncbi request reprint Circulating myeloid colony-forming cells predict survival in myelodysplastic syndromes
    A Berer
    Department of Internal Medicine I, Division of Hematology, University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Ann Hematol 82:271-7. 2003
    ..018) to predict survival in our patients. After inclusion of the IPSS risk categories, mCFU levels remained a highly predictive parameter for survival ( p=0.0056) and acute myeloblastic leukemia (AML) transformation ( p=0.0003)...
  57. ncbi request reprint The Hsp32 inhibitors SMA-ZnPP and PEG-ZnPP exert major growth-inhibitory effects on D34+/CD38+ and CD34+/CD38- AML progenitor cells
    H Herrmann
    Ludwig Boltzmann Cluster Oncology, Vienna, Austria
    Curr Cancer Drug Targets 12:51-63. 2012
    ..Together, our data suggest that Hsp32 plays an important role as a survival factor in leukemic stem cells and as a potential new target in AML...
  58. ncbi request reprint Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukaemia occurring during imatinib therapy
    K J Aichberger
    Medical University of Vienna, Austria
    Eur J Clin Invest 37:808-13. 2007
    ..The BCR/ABL tyrosine kinase inhibitor imatinib is highly effective in patients with CML, but hardly crosses the blood-brain barrier...
  59. ncbi request reprint Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen
    M Binder
    Division of Specific Prophylaxis and Tropical Medicine and Immunopathology, Department of Pathophysiology, University of Vienna, Vienna, Austria
    J Immunol 167:5470-7. 2001
    ..Recombinant arginine kinase may be used to identify a group of polysensitized indoor allergic patients and for immunotherapy of these individuals...
  60. ncbi request reprint Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    N Mothes
    Department of Pathophysiology, Vienna General Hospital, University of Vienna, Vienna, Austria
    Clin Exp Allergy 33:1198-208. 2003
    ..The allergen extract-based analyses of immunotherapy-induced effects yielded highly controversial results regarding a beneficial role of therapy-induced IgG antibodies...
  61. doi request reprint Comorbidity predicts survival in myelodysplastic syndromes or secondary acute myeloid leukaemia after allogeneic stem cell transplantation
    A Boehm
    Department of Internal Medicine I, Bone Marrow Transplantation Unit, Medical University of Vienna, Austria
    Eur J Clin Invest 38:945-52. 2008
    ..Recent data suggest that, among other factors, comorbidity may be an important prognostic variable in patients with myelodysplastic syndromes (MDS) who are eligible for haematopoietic stem cell transplantation (SCT)...
  62. pmc Iron overload in myelodysplastic syndromes (MDS) - diagnosis, management, and response criteria: a proposal of the Austrian MDS platform
    P Valent
    Department of Internal Medicine I, Division of Haematology and Haemostaseology, Medical University of Vienna, Austria
    Eur J Clin Invest 38:143-9. 2008
    ..These recommendations should facilitate and assist in recognition of iron overload, selection of patients, timing of treatment, drug selection and the measurement of treatment responses...
  63. ncbi request reprint Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis
    R Fritsche-Polanz
    Department of Laboratory Medicine, Division of Endocrinology and Metabolism, University of Vienna, Vienna, Austria
    Br J Haematol 113:357-64. 2001
    ..The C-KIT 1642A-->C polymorphism is not associated with myelodysplastic syndrome or systemic mastocytosis...
  64. ncbi request reprint Serum thrombopoietin levels and anti-thrombopoietin antibodies in systemic lupus erythematosus
    W Füreder
    Department of Internal Medicine I, University of Vienna, Austria
    Lupus 11:221-6. 2002
    ..01), but thrombopoietin levels were not significantly different. Taken together, thrombopoietin levels are significantly higher in the sera of SLE patients than in healthy controls and anti-thrombopoietin antibodies are frequently found...
  65. ncbi request reprint Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells
    W Füreder
    Department of Internal Medicine, University of Vienna, Austria
    J Immunol 155:3152-60. 1995
    ....
  66. ncbi request reprint Neoplastic stem cells: a novel therapeutic target in clinical oncology
    Axel Schulenburg
    Bone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Cancer 107:2512-20. 2006
    ....
  67. ncbi request reprint Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome
    Karoline Sonneck
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 142:158-64. 2007
    ..Patients with mastocytosis may suffer from severe hypotension after wasp or bee stings. In these patients, no specific IgE is detectable, but they usually have skin lesions and an elevated serum tryptase level...
  68. ncbi request reprint Induction of apoptosis in the human mast cell leukemia cell line HMC-1 by various antineoplastic drugs
    Puchit Samorapoompichit
    Institute of Histology and Embryology, The University of Vienna, Vienna, Austria
    Leuk Lymphoma 44:509-15. 2003
    ..Whether these drugs, alone or in combination, are also effective in patients with MCL, remains to be determined...
  69. ncbi request reprint Immunological characterization and antibacterial function of persisting granulocytes in leukemic patients receiving pulse cytosine arabinoside-consolidation chemotherapy on days 1, 3, and 5
    Maria T Krauth
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Center of Excellence in Clinical and Experimental Oncology, Vienna, Austria
    J Immunol 176:1759-68. 2006
    ..IDAC is a superior protocol in this regard and may therefore be most suitable for elderly patients and those at high risk for severe infections...
  70. ncbi request reprint A patient with de novo AML M1 and t(16;21) with karyotype evolution
    Andrea Zatkova
    Leuk Res 31:1319-21. 2007
  71. ncbi request reprint Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference
    Peter Valent
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Leuk Res 31:727-36. 2007
    ..Respective algorithms and recommendations should facilitate diagnostic and prognostic evaluations in MDS, selection of patients for therapies, and the conduct of clinical trials...
  72. ncbi request reprint Idiopathic cytopenia of undetermined significance (ICUS) versus low risk MDS: the diagnostic interface
    Friedrich Wimazal
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Leuk Res 31:1461-8. 2007
    ..The phrase "idiopathic cytopenia of undetermined significance (ICUS)", as also suggested by Mufti and co-workers, is proposed and long term follow-up is recommended to assess the evolution...
  73. ncbi request reprint Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3
    Yasamin Majlesi
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Leukoc Biol 73:107-17. 2003
    ..Together, these data identify cerivastatin and atorvastatin as novel inhibitors of growth and activation of human basophils...
  74. ncbi request reprint Immunohistochemical detection of VEGF in the bone marrow of patients with acute myeloid leukemia. Correlation between VEGF expression and the FAB category
    Minoo Ghannadan
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria
    Am J Clin Pathol 119:663-71. 2003
    ..In summary, VEGF expression in the bone marrow is restricted to certain stages of differentiation and maturation of myeloid cells and correlates with the FAB category...
  75. ncbi request reprint BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
    Matthias Mayerhofer
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, The University of Vienna, Austria
    Blood 100:3767-75. 2002
    ..Together, our data show that BCR/ABL induces VEGF- and HIF-1alpha gene expression through a pathway involving PI3-kinase and mTOR. BCR/ABL-induced VEGF expression may contribute to the pathogenesis and increased angiogenesis in CML...
  76. ncbi request reprint Recombinant allergens promote expression of CD203c on basophils in sensitized individuals
    Alexander W Hauswirth
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 110:102-9. 2002
    ..During the past few years, several attempts have been made to refine diagnostic assays in clinical allergy by introducing recombinant allergens and novel markers of IgE-dependent cell activation...
  77. pmc Increased angiogenesis in the bone marrow of patients with systemic mastocytosis
    Friedrich Wimazal
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria
    Am J Pathol 160:1639-45. 2002
    ..The notion that SM is associated with increased BM angiogenesis and vascular endothelial growth factor expression may have implications for the biology of disease and development of new treatment strategies...
  78. ncbi request reprint Stem cell factor-induced bone marrow mast cell hyperplasia mimicking systemic mastocytosis (SM): histopathologic and morphologic evaluation with special reference to recently established SM-criteria
    John Hendrik Jordan
    Department of Internal Medicine 1, University of Vienna, Wahringer Gurtel, Austria
    Leuk Lymphoma 43:575-82. 2002
    ..Based on our case and similar cases mimicking mastocytosis, it seems of importance to apply recently established SM criteria in order to discriminate between reactive MC hyperplasia and true mastocytosis with certainty...
  79. ncbi request reprint A case of smouldering mastocytosis with peripheral blood eosinophilia and lymphadenopathy
    Alexander W Hauswirth
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria
    Leuk Res 26:601-6. 2002
    ..These data show that some patients with SM can remain in a clinically indolent smouldering state over years even when presenting with marked eosinophilia and lymphadenopathy...
  80. ncbi request reprint Detection of novel CD antigens on the surface of human mast cells and basophils
    Minoo Ghannadan
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Int Arch Allergy Immunol 127:299-307. 2002
    ..Mast cells (MC) and basophils are effector cells of allergic reactions. Growth and function of these cells are regulated by a network of cytokines, other ligands, and respective cell surface membrane receptors...
  81. ncbi request reprint Myelomastocytic leukemia: myeloid neoplasm characterized by partial differentiation of mast cell-lineage cells
    Peter Valent
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Hematol J 3:90-4. 2002
    ..In the few patients recorded so far, a complex karyotype without recurring anomaly was found. The prognosis appears to be grave, although complete remission in response to chemotherapy has been described...
  82. doi request reprint Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease
    Alexander W Hauswirth
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria
    Hum Pathol 39:917-24. 2008
    ..The KIT mutation D816V was detected in sorted CD34(+) cells and unfractionated marrow cells but not in CD5(+) SLL cells, confirming the coexistence of 2 distinct neoplasms...
  83. ncbi request reprint Splenic mastocytosis: report of two cases and detection of the transforming somatic C-KIT mutation D816V
    Friedrich Wimazal
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria
    Leuk Lymphoma 45:723-9. 2004
    ..In summary, our data show that the spleen can be a primary site of disease in rare cases of SM. Mastocytosis should therefore be considered as a (rare) differential diagnosis in patients with splenomegaly of unknown etiology...
  84. ncbi request reprint Evaluation of biologic activity of tryptase secreted from blast cells in acute myeloid leukemia
    Karoline Sonneck
    Department of Internal Medicine I, Division of Hematology and Hemostaseology the Center of Excellence for Clinical and Experimental Oncology CLEXO, Medical University of Vienna, Austria
    Leuk Lymphoma 47:897-906. 2006
    ..Together, tryptase is secreted from AML blasts as a biologically active molecule that may exhibit paracrine rather than autocrine effects in AML...
  85. ncbi request reprint C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils
    Johann Wojta
    Department of Internal Medicine II, University of Vienna, Austria
    Blood 100:517-23. 2002
    ....
  86. ncbi request reprint Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib
    Stefan Florian
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Leuk Res 30:1201-5. 2006
    ..Because of the availability of a superior targeted drug (imatinib), it is of importance to screen for FIP1L1/PDGFRalpha in suspected CEL with or without co-existing SM...
  87. pmc Evaluation of angiogenesis and vascular endothelial growth factor expression in the bone marrow of patients with aplastic anemia
    Wolfgang Füreder
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1097 Vienna, Austria
    Am J Pathol 168:123-30. 2006
    ..05). Taken together, these data show that aplastic anemia is associated with reduced angiogenesis and reduced VEGF expression...
  88. ncbi request reprint Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes
    Stefan Florian
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 136:273-80. 2005
    ..In those who lack skin lesions, mastocytosis is often overlooked or confused with endocrinologic, allergic, or other internal disorders...
  89. ncbi request reprint Symptomatic venous thromboembolism in acute leukemia. Incidence, risk factors, and impact on prognosis
    Sophie Ziegler
    Division of Haematology and Haemostasis, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Res 115:59-64. 2005
    ..In contrast to solid tumors, venous thromboembolism before or at diagnosis of acute leukemia is not associated with poor prognosis...
  90. ncbi request reprint Detection of trisomy 8 in donor-derived Ph- cells in a patient with Ph+ chronic myeloid leukemia successfully treated with Imatinib (STI571) in relapse after allogeneic transplantation
    Hermine Agis
    Department of Internal Medicine I, Medical University of Vienna, Austria
    Leuk Lymphoma 45:1453-8. 2004
    ..These data suggest that Imatinib is a useful agent for long term treatment of relapsed CML after allogeneic SCT...
  91. ncbi request reprint Bone marrow microvessel density and its prognostic significance in AML
    Werner Rabitsch
    Department of Internal Medicine I, Vienna, Austria
    Leuk Lymphoma 45:1369-73. 2004
    ..05). Together, our data suggest that the BM-MVD could be a prognostic parameter concerning survival in patients with AML undergoing allogeneic BMT...
  92. ncbi request reprint Chronic myeloid leukemia: pathophysiology, diagnostic parameters, and current treatment concepts
    Christian Sillaber
    Abteilung für Hämatologie und Hämostaseologie, Universitätsklinik für Innere Medizin I, AKH Wien, Austria
    Wien Klin Wochenschr 115:485-504. 2003
    ..Whether these strategies will lead to curative drug therapy in CML in the future remains at present unknown...
  93. ncbi request reprint Pathogenesis, classification, and treatment of myelodysplastic syndromes (MDS)
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 115:515-36. 2003
    ..Recently established scoring systems aimed at predicting survival and evolution of leukemia in MDS may be helpful in this regard...
  94. ncbi request reprint Molecular disease eradication is a prerequisite for long-term remission in patients with t(8;21) positive acute myeloid leukemia: a single center study
    Margit Mitterbauer
    Department of Medicine I, Bone Marrow Transplantation Unit, University Hospital of Vienna, Vienna, Austria
    Leuk Lymphoma 45:971-7. 2004
    ..In this situation quantitative RT-PCR might help to define individual relapse risk and to improve as well as facilitate clinical decision-making...
  95. ncbi request reprint Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms
    Peter Valent
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 114:3-11; quiz 12. 2004
    ..The current review provides an overview of mastocytosis and its subvariants and a practical guide that might help to delineate mastocytosis from unrelated systemic disorders...
  96. ncbi request reprint Mast cell proliferative disorders: current view on variants recognized by the World Health Organization
    Peter Valent
    Department of Internal Medicine 1, Division of Hematology and Hemostaseology, University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Hematol Oncol Clin North Am 17:1227-41. 2003
    ..In patients with SM-AHNMD, the SM should be treated as if no AHNMD is present, and the AHNMD should be treated as if no SM had been diagnosed...
  97. ncbi request reprint Assays for measuring in vitro basophil activation induced by recombinant allergens
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, The University of Vienna, Vienna, Austria
    Methods 32:265-70. 2004
    ..In the current article, the biochemical, functional, and technical background of these basophil tests is discussed...
  98. ncbi request reprint Molecular characterization of polygalacturonases as grass pollen-specific marker allergens: expulsion from pollen via submicronic respirable particles
    Ines Swoboda
    Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    J Immunol 172:6490-500. 2004
    ..Our finding that rabbit anti-rPhl p 13 Abs blocked patients' IgE binding to the allergen suggests that rPhl p 13 may be used for immunotherapy of sensitized patients...
  99. ncbi request reprint Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia
    Matthias Mayerhofer
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Cancer Res 64:3148-54. 2004
    ..Together, our data identify HO-1 as a novel BCR/ABL-driven survival molecule and potential target in leukemic cells in patients with CML. The pathogenetic and clinical implications of this observation remain to be elucidated...
  100. ncbi request reprint Normal bone marrow function over 6 years in a patient with dysplastic hematopoiesis and a complex karyotype
    Peter Valent
    Department of Internal Medicine I, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Leuk Res 28:651-5. 2004
    ..This exceptional case supports the notion that complex chromosomes are not invariably associated with rapid disease evolution in MDS...
  101. ncbi request reprint Evaluation of normal and neoplastic human mast cells for expression of CD172a (SIRPalpha), CD47, and SHP-1
    Stefan Florian
    Department of Internal Medicine, Division of Hematology and Hemostaseology, Medical University of Vienna, Austria
    J Leukoc Biol 77:984-92. 2005
    ..It is hypothesized that CD172 and CD47 contribute to MC clustering and that the "lack" of SHP-1 in MC may facilitate KIT-dependent signaling in a subgroup of patients...