H Sinzinger

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Flu-like response on statins
    Helmut Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group ASF, Vienna, Austria
    Med Sci Monit 8:CR384-8. 2002
  2. ncbi request reprint Atorvastatin reduces microalbuminuria in patients with familial hypercholesterolemia and normal glucose tolerance
    Helmut Sinzinger
    Institute for Diagnosis and Treatment of Lipid Disorders and Atherosclerosis ATHOS, Vienna, Austria
    Med Sci Monit 9:PI88-92. 2003
  3. ncbi request reprint Radiation alarm at an airport after radioiodine therapy
    Helmut Sinzinger
    ISOTOPIX Institute for Nuclear Medicine, Vienna, Austria
    Nucl Med Commun 26:67-8. 2005
  4. pmc Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems
    H Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group ASF Vienna, Institute for Diagnosis and Treatment of Atherosclerosis and Lipid Disorders ATHOS, Vienna, Austria
    Br J Clin Pharmacol 57:525-8. 2004
  5. ncbi request reprint Statin-induced myositis migrans
    Helmut Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group ASF, Institute for Diagnosis and Treatment of Lipid Disorders and Atherosclerosis ATHOS, Vienna, Austria
    Wien Klin Wochenschr 114:943-4. 2002
  6. ncbi request reprint Variable influence of statins on isoprostanes in hyperlipidemia
    Helmut Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group, Vienna, Austria
    Adv Exp Med Biol 525:209-12. 2003
  7. ncbi request reprint Enhanced accumulation of the isoprostane, 8-epi-PGF2 alpha, in human aortic and pulmonary valves of patients with coronary heart disease
    M R Mehrabi
    Department of Cardiology, University of Vienna, Wahringer Gurtel 18 20, Postfach 120, A 1097 Vienna, Austria
    Histol Histopathol 17:1053-9. 2002
  8. ncbi request reprint The isoprostane 8-epi-PGF(2alpha) is a valuable indicator of oxidative injury in human heart valves
    M R Mehrabi
    Department of Cardiology, University of Vienna, Wahringer Gurtel 18 20, Postfach 120, A 1097, Vienna, Austria
    Cardiovasc Pathol 10:241-5. 2001
  9. ncbi request reprint Prevalence and relevance of thyroid dysfunction in 1922 cholesterol screening participants
    C Pirich
    Department of Nuclear Medicine, University Hospital of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    J Clin Epidemiol 53:623-9. 2000
  10. ncbi request reprint Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia--a pilot study
    Roswitha M Wolfram
    Department of Angiology, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 114:840-6. 2002

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Flu-like response on statins
    Helmut Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group ASF, Vienna, Austria
    Med Sci Monit 8:CR384-8. 2002
    ..We are reporting on a so far unknown flu-like response on statins with very severe symptoms of exhaustion, weakness, aching muscles and joints elevated acute phase response markers and sometimes even subfebrile body temperature...
  2. ncbi request reprint Atorvastatin reduces microalbuminuria in patients with familial hypercholesterolemia and normal glucose tolerance
    Helmut Sinzinger
    Institute for Diagnosis and Treatment of Lipid Disorders and Atherosclerosis ATHOS, Vienna, Austria
    Med Sci Monit 9:PI88-92. 2003
    ..We therefore examined whether treatment with the most potent LDL-lowering drug available (atorvastatin) has a similar effect on the level of microalbuminuria...
  3. ncbi request reprint Radiation alarm at an airport after radioiodine therapy
    Helmut Sinzinger
    ISOTOPIX Institute for Nuclear Medicine, Vienna, Austria
    Nucl Med Commun 26:67-8. 2005
    ..Screening for radioactive material at borders may become more widely introduced in order to prevent illegal transport. All the alarms at Vienna airport so far have been due to recent applications of radionuclides for medical reasons...
  4. pmc Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems
    H Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group ASF Vienna, Institute for Diagnosis and Treatment of Atherosclerosis and Lipid Disorders ATHOS, Vienna, Austria
    Br J Clin Pharmacol 57:525-8. 2004
    ..Muscular problems are the major group of side-effects during statin treatment. They are known to occur much more frequently during and after exercise...
  5. ncbi request reprint Statin-induced myositis migrans
    Helmut Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group ASF, Institute for Diagnosis and Treatment of Lipid Disorders and Atherosclerosis ATHOS, Vienna, Austria
    Wien Klin Wochenschr 114:943-4. 2002
    ..The clinical consequence (to withdraw the drug or not) of these milder statin side effects are discussed...
  6. ncbi request reprint Variable influence of statins on isoprostanes in hyperlipidemia
    Helmut Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group, Vienna, Austria
    Adv Exp Med Biol 525:209-12. 2003
  7. ncbi request reprint Enhanced accumulation of the isoprostane, 8-epi-PGF2 alpha, in human aortic and pulmonary valves of patients with coronary heart disease
    M R Mehrabi
    Department of Cardiology, University of Vienna, Wahringer Gurtel 18 20, Postfach 120, A 1097 Vienna, Austria
    Histol Histopathol 17:1053-9. 2002
    ..Considering the data presented in this study, we suggest that 8-epi-PGF2 alpha is a valuable indicator of oxidative injury in human semilunar valves...
  8. ncbi request reprint The isoprostane 8-epi-PGF(2alpha) is a valuable indicator of oxidative injury in human heart valves
    M R Mehrabi
    Department of Cardiology, University of Vienna, Wahringer Gurtel 18 20, Postfach 120, A 1097, Vienna, Austria
    Cardiovasc Pathol 10:241-5. 2001
    ..30+/-58.77 pg/mg protein in aortic valves, P=.09). Considering the data presented in this study, we suggest that 8-epi-PGF(2alpha) is a valuable indicator of oxidative injury in human semilunar valves...
  9. ncbi request reprint Prevalence and relevance of thyroid dysfunction in 1922 cholesterol screening participants
    C Pirich
    Department of Nuclear Medicine, University Hospital of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    J Clin Epidemiol 53:623-9. 2000
    ..These results argue against indiscriminate measurements of TSH concentrations in clinically healthy subjects either with normocholesterolemia or hypercholesterolemia...
  10. ncbi request reprint Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia--a pilot study
    Roswitha M Wolfram
    Department of Angiology, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 114:840-6. 2002
    ..Aim of this pilot study was to assess the effect of prickly pear consumption on glucose- and lipid metabolism...
  11. ncbi request reprint 8-Epi-PGF2alpha and 6-oxo-PGF1alpha in human (varicose) veins: influence of age, sex, and risk factors
    Susan Meghdadi
    Department of Nuclear Medicine, University of Vienna, Vienna, Austria
    Angiology 54:317-24. 2003
    ..Lower 8-epi-PGF2alpha in varicose veins may shift the venous tone toward vasodilatation and contribute to development and progression of varicosis...
  12. ncbi request reprint Prostaglandins and lipid modification
    G Sobal
    Department of Nuclear Medicine, University of Vienna, Vienna, Austria
    Curr Pharm Des 7:461-74. 2001
    ..The influence of various eicosanoids on lipoprotein modification, however, has not been assessed yet...
  13. ncbi request reprint Comparative binding of 125I-and 99mTc-d-labeled native and glycated low-density lipoprotein to human microvascular endothelial cells-potential for atherosclerosis imaging?
    Grazyna Sobal
    Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
    J Recept Signal Transduct Res 26:693-707. 2006
    ..We conclude that for in vitro binding studies as well as for potential in vivo imaging, only 125I-labeled goLDL should be used, whereas nLDL may be applied as 125I-or 99mTc-labeled ligand...
  14. ncbi request reprint Enhanced oxidative stress in coronary heart disease and chronic heart failure as indicated by an increased 8-epi-PGF(2alpha)
    Roswitha Wolfram
    Department of Angiology, Medical University of Vienna, Vienna, Austria
    Eur J Heart Fail 7:167-72. 2005
    ....
  15. ncbi request reprint Oxidation injury in patients receiving HMG-CoA reductase inhibitors: occurrence in patients without enzyme elevation or myopathy
    Helmut Sinzinger
    Wilhelm Auerswald Atherosclerosis Research Group ASF, Vienna, Austria
    Drug Saf 25:877-83. 2002
    ..Several lines of evidence indicate that even mild forms of myopathy during statin treatment may be associated with in vivo oxidation injury. In contrast, statin therapy has been shown to be associated with a decrease in oxidation injury...
  16. ncbi request reprint Radioiodine therapy induces dose-dependent in vivo oxidation injury: evidence by increased isoprostane 8-epi-PGF(2 alpha)
    Roswitha M Wolfram
    Department of Angiology, University of Vienna, Vienna, Austria
    J Nucl Med 43:1254-8. 2002
    ..The aim of this study was to investigate the possible induction of oxidative stress as a consequence of (131)I therapy...
  17. ncbi request reprint Simvastatin increases bone mineral density in hypercholesterolemic postmenopausal women
    Graziana Lupattelli
    Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of, Perugia, Italy
    Metabolism 53:744-8. 2004
    ..860 +/- 0.110 v 0.853 +/- 0.096 and 0.847 +/- 0.095; P <.05). In conclusion, as partly suggested by retrospective or observational data, this longitudinal study indicates that simvastatin treatment exerts a beneficial effect on BMD...
  18. ncbi request reprint Side effects of statins--prevalence, relevance, consequences
    Helmut Sinzinger
    Wien Klin Wochenschr 114:887-8. 2002
  19. ncbi request reprint Muscular side effects of statins
    Helmut Sinzinger
    Department of Nuclear Medicine, University of Vienna, A 1090 Vienna, Austria
    J Cardiovasc Pharmacol 40:163-71. 2002
    ..Much more research should be directed onto the pathophysiological (genetic?) background to finally evaluate possible therapeutic consequences rather than simply to withdraw or change the respective statin...
  20. ncbi request reprint Passive incorporation of radioisotopes and airport security
    Helmut Sinzinger
    Nucl Med Commun 28:423. 2007
  21. ncbi request reprint Metabolites of arachidonic acid in activating platelets and their estimation by radionuclide techniques
    Helmut Sinzinger
    Hell J Nucl Med 9:111; author reply 111-2. 2006
  22. pmc Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy
    Ulrike Resch
    Medical University of Vienna, Wilhelm Auerswald Atherosclerosis Research Group, Vienna, Austria
    Br J Clin Pharmacol 61:262-74. 2006
    ..To examine the effect of 24 weeks' rosuvastatin treatment on oxidative stress and changes in immune response to oxidized low-density lipoprotein (LDL)...
  23. ncbi request reprint Effect of simvastatin on the oxidation of native and modified lipoproteins
    Grazyna Sobal
    Department of Nuclear Medicine, Medical University of Vienna, Austria
    Biochem Pharmacol 70:1185-91. 2005
    ..0 and 2.3, respectively, but no changes in the presence of simvastatin were observed. These data show that simvastatin besides its lipid-lowering action has also significant antioxidative properties...
  24. ncbi request reprint Antiplatelet activity of semotiadil fumarate
    Roswitha M Wolfram
    Department of Angiology, University of Vienna, A 1090 Vienna, Austria
    Thromb Res 106:187-90. 2002
    ..No difference between platelets derived from healthy volunteers and hypertensive patients was noted. These findings indicate potent antiplatelet activity of the new calcium antagonist semotiadil...
  25. ncbi request reprint Prickly pear induces upregulation of liver LDL binding in familial heterozygous hypercholesterolemia
    Barbara Palumbo
    Institute of Nuclear Medicine, University of Perugia, Italy
    Nucl Med Rev Cent East Eur 6:35-9. 2003
    ..Beside the beneficial effects on lipid metabolism, oxidation injury and platelet function has been claimed in experimental animals. We recently found an upregulation of apo-B/E receptor...
  26. ncbi request reprint Comments on Elevated urinary 8-isoprostaglandin F2 alpha in females with Graves' hyperthyroidism: K.M. Kim, K.-J. PaƩng, J.R. Hahm, D.R. Kim, B.C. Chung. Prostagl. Leukotr. and Essent. Fatty Acids 71 (2004) 143-147
    Hossein Ahmadzadehfar
    Wilhelm Auerswald Atherosclerosis Research Group ASF Vienna, Nadlergasse 1, 1090 Vienna, Austria
    Prostaglandins Leukot Essent Fatty Acids 71:409-10. 2004
  27. ncbi request reprint Radioidine therapy temporarily increases circulating endothelial cells and decreases endothelial progenitor cells
    Barbara Palumbo
    The Institute of Nuclear Medicine, University of Perugia, Italy
    Nucl Med Rev Cent East Eur 6:123-6. 2003
    ..Radiotherapy can cause vascular injury. No data on radioiodine therapy and vascular damage are available...
  28. ncbi request reprint Zinc as antiperoxidative agent following iodine-131 induced changes on the antioxidant system and the morphology of red blood cells
    Hossein Ahmadzadehfar
    Hell J Nucl Med 10:35; author reply 35-6. 2007