Maria Sibilia

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development
    M Sibilia
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 102:211-20. 2000
  2. ncbi request reprint Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart
    Maria Sibilia
    Department of Dermatology and Biomolecular Therapeutics BMT, University of Vienna, Medical School, Brunnerstr 59, A 1235 Vienna, Austria
    Development 130:4515-25. 2003
  3. pmc Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes
    Bettina Wagner
    Department of Dermatology DIAID, Medical University of Vienna, Vienna Competence Center VCC, Vienna, Austria
    EMBO J 25:752-62. 2006
  4. ncbi request reprint c-Jun regulates eyelid closure and skin tumor development through EGFR signaling
    Rainer Zenz
    Research Institute of Molecular Pathology IMP, A 1030, Vienna, Austria
    Dev Cell 4:879-89. 2003
  5. pmc Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells
    Barbara Drobits
    Institute for Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
    J Clin Invest 122:575-85. 2012
  6. pmc Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis
    Mircea Winter
    Max F Perutz Laboratories, Department of Medical Biochemistry, Vienna Biocenter, Medical University of Vienna, Vienna, Austria
    EMBO J 32:3176-91. 2013
  7. ncbi request reprint Raf-1 addiction in Ras-induced skin carcinogenesis
    Karin Ehrenreiter
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria
    Cancer Cell 16:149-60. 2009
  8. doi request reprint Skin inflammation is not sufficient to break tolerance induced against a novel antigen
    Martin Holcmann
    Institute for Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, Vienna, Austria
    J Immunol 183:1133-43. 2009
  9. doi request reprint Methods to study MAP kinase signalling in the central nervous system
    Bettina Wagner
    APEIRON Biologics AG, Vienna, Austria
    Methods Mol Biol 661:481-95. 2010
  10. doi request reprint hVps37A Status affects prognosis and cetuximab sensitivity in ovarian cancer
    Michael Wittinger
    Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Clin Cancer Res 17:7816-27. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development
    M Sibilia
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 102:211-20. 2000
    ..Therefore, EGFR functions as a survival factor in oncogenic transformation and provides a valuable target for therapeutic intervention in a broader range of tumors than anticipated...
  2. ncbi request reprint Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart
    Maria Sibilia
    Department of Dermatology and Biomolecular Therapeutics BMT, University of Vienna, Medical School, Brunnerstr 59, A 1235 Vienna, Austria
    Development 130:4515-25. 2003
    ..These results demonstrate that mice humanised for EGFR display tissue-specific hypomorphic phenotypes and describe a novel function for EGFR in bone development...
  3. pmc Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes
    Bettina Wagner
    Department of Dermatology DIAID, Medical University of Vienna, Vienna Competence Center VCC, Vienna, Austria
    EMBO J 25:752-62. 2006
    ..These spatial differences in astrocyte composition provide a mechanism for the region-specific neurodegeneration in EGFR(-/-) mice...
  4. ncbi request reprint c-Jun regulates eyelid closure and skin tumor development through EGFR signaling
    Rainer Zenz
    Research Institute of Molecular Pathology IMP, A 1030, Vienna, Austria
    Dev Cell 4:879-89. 2003
    ..Thus, using three experimental systems, we show that EGFR and HB-EGF are regulated by c-Jun, which controls eyelid development, keratinocyte proliferation, and skin tumor formation...
  5. pmc Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells
    Barbara Drobits
    Institute for Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
    J Clin Invest 122:575-85. 2012
    ..Our results demonstrate that imiquimod treatment leads to CCL2-dependent recruitment of pDCs and their transformation into a subset of killer DCs able to directly eliminate tumor cells...
  6. pmc Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis
    Mircea Winter
    Max F Perutz Laboratories, Department of Medical Biochemistry, Vienna Biocenter, Medical University of Vienna, Vienna, Austria
    EMBO J 32:3176-91. 2013
    ..Our data reveal a crucial function of HDAC1/HDAC2 in the control of lineage specificity and a novel role of HDAC1 as a tumour suppressor in the epidermis. ..
  7. ncbi request reprint Raf-1 addiction in Ras-induced skin carcinogenesis
    Karin Ehrenreiter
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria
    Cancer Cell 16:149-60. 2009
    ..These data link the Raf-1:Rok-alpha complex to STAT3/Myc activation and delineate a pathway crucial for cell fate decision in Ras-induced tumorigenesis...
  8. doi request reprint Skin inflammation is not sufficient to break tolerance induced against a novel antigen
    Martin Holcmann
    Institute for Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, Vienna, Austria
    J Immunol 183:1133-43. 2009
    ....
  9. doi request reprint Methods to study MAP kinase signalling in the central nervous system
    Bettina Wagner
    APEIRON Biologics AG, Vienna, Austria
    Methods Mol Biol 661:481-95. 2010
    ....
  10. doi request reprint hVps37A Status affects prognosis and cetuximab sensitivity in ovarian cancer
    Michael Wittinger
    Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Clin Cancer Res 17:7816-27. 2011
    ..hVps37A was originally described as a member of the membrane-trafficking ESCRT-I complex mediating the internalization and degradation of ubiquitinated membrane receptors...
  11. doi request reprint Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome
    Arshad Muhammad
    Department of Molecular Immunology, Centre for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    J Immunol 182:7672-80. 2009
    ..CD48 in turn shuttles the transmembrane adapter molecule LAT...
  12. ncbi request reprint The epidermal growth factor receptor: from development to tumorigenesis
    Maria Sibilia
    Department of Medicine I, Institute for Cancer Research, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
    Differentiation 75:770-87. 2007
    ....
  13. doi request reprint Haploinsufficiency of senescence evasion factor causes defects of hematopoietic stem cells functions
    Elisabeth Schraml
    Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, 8010 Graz, Austria
    Stem Cells Dev 17:355-66. 2008
    ..These data suggest that the expression of SNEV is closely associated with the growth of murine HSCs and determines the proliferative and repopulating capacity of phenotypically defined HSC subsets...
  14. ncbi request reprint Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod
    Francesca Palamara
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Austria
    J Immunol 173:3051-61. 2004
    ..Therefore, strategies aimed at activating and directing these cells into neoplastic tissues may be a promising and novel approach for the immunotherapy of various types of cancer...
  15. pmc The EGF receptor is required for efficient liver regeneration
    Anuradha Natarajan
    Department of Dermatology, Division of Immunology, Allergy, and Infectious Diseases, and Institute for Cancer Research, Department of Medicine 1, Vienna Competence Center, Medical University of Vienna, Lazarettgasse 19, A 1090 Vienna, Austria
    Proc Natl Acad Sci U S A 104:17081-6. 2007
    ..Our studies demonstrate that EGFR is a critical regulator of hepatocyte proliferation in the initial phases of liver regeneration...
  16. pmc Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver
    Axel Behrens
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    EMBO J 21:1782-90. 2002
    ..These studies identify c-Jun as a critical regulator of hepatocyte proliferation and survival during liver development and regeneration...
  17. pmc Early embryonic lethality of mice lacking the essential protein SNEV
    Klaus Fortschegger
    Institute of Applied Microbiology, Muthgasse 18, A 1190 Vienna, Austria
    Mol Cell Biol 27:3123-30. 2007
    ..Our experiments demonstrate that the SNEV protein is essential, functionally nonredundant, and indispensable for mouse development...