M Schmuth

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi The effect of LXR activators on AP-1 proteins in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 123:41-8. 2004
  2. ncbi Systemic sarcoidosis and cutaneous lymphoma: is the association fortuitous?
    M Schmuth
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    Br J Dermatol 140:952-5. 1999
  3. ncbi Expression of the C-C chemokine MIP-3 alpha/CCL20 in human epidermis with impaired permeability barrier function
    M Schmuth
    Departments of Dermatology, University of Innsbruck, Innsbruck, Austria
    Exp Dermatol 11:135-42. 2002
  4. ncbi Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero
    Matthias Schmuth
    Departments of Medicine Dermatology, University of California San Francisco, California 94121, USA
    J Invest Dermatol 119:1298-303. 2002
  5. ncbi [Beyond glucocorticoids, retinoids and vitamin D--the evolution of nuclear hormone type transcription factor targeting in the skin]
    Matthias Schmuth
    Universitätsklinik für Dermatologie und Venerologie Karl Franzens Universität Innsbruck
    J Dtsch Dermatol Ges 1:352-62. 2003
  6. ncbi Pathogenesis of the permeability barrier abnormality in epidermolytic hyperkeratosis
    M Schmuth
    Internal Medicine, University of California, San Francisco, USA
    J Invest Dermatol 117:837-47. 2001
  7. ncbi Permeability barrier function of skin exposed to ionizing radiation
    M Schmuth
    Department of Dermatology, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Dermatol 137:1019-23. 2001
  8. ncbi Clear cells in acral melanoma
    M Schmuth
    Department of Dermatology, University of Innsbruck, Austria
    Eur J Dermatol 11:21-4. 2001
  9. ncbi Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study
    M Schmuth
    Department of Dermatology, University of Innsbruck, Austria
    Br J Dermatol 146:983-91. 2002
  10. ncbi Granulomatous slack skin: a distinct disorder or a variant of mycosis fungoides?
    G Topar
    Departments of Dermatology, University of Innsbruck, Austria
    Acta Derm Venereol 81:42-4. 2001

Collaborators

Detail Information

Publications45

  1. ncbi The effect of LXR activators on AP-1 proteins in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 123:41-8. 2004
    ..These results indicate that oxysterols induce specific AP-1 proteins, thereby activating involucrin, one of the genes required for epidermal differentiation...
  2. ncbi Systemic sarcoidosis and cutaneous lymphoma: is the association fortuitous?
    M Schmuth
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    Br J Dermatol 140:952-5. 1999
    ..We review the cases reported in the literature and discuss a possible causal and temporal relationship as well as the role of IFN alpha in the development of sarcoidosis...
  3. ncbi Expression of the C-C chemokine MIP-3 alpha/CCL20 in human epidermis with impaired permeability barrier function
    M Schmuth
    Departments of Dermatology, University of Innsbruck, Innsbruck, Austria
    Exp Dermatol 11:135-42. 2002
    ..Its upregulation may represent a danger signal for increased immunosurveillance in barrier disrupted skin and inflammatory skin conditions with impaired barrier function to counteract potential antigen invasion...
  4. ncbi Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero
    Matthias Schmuth
    Departments of Medicine Dermatology, University of California San Francisco, California 94121, USA
    J Invest Dermatol 119:1298-303. 2002
    ..The transient and incomplete nature of the developmental delay, however, is consistent with regulation of the late stages of epidermal development by multiple factors...
  5. ncbi [Beyond glucocorticoids, retinoids and vitamin D--the evolution of nuclear hormone type transcription factor targeting in the skin]
    Matthias Schmuth
    Universitätsklinik für Dermatologie und Venerologie Karl Franzens Universität Innsbruck
    J Dtsch Dermatol Ges 1:352-62. 2003
    ..Therefore, these compounds have important implications for dermatological therapy. In this review, the clinical implications of the more recently discovered members of the nuclear hormone receptor family are discussed...
  6. ncbi Pathogenesis of the permeability barrier abnormality in epidermolytic hyperkeratosis
    M Schmuth
    Internal Medicine, University of California, San Francisco, USA
    J Invest Dermatol 117:837-47. 2001
    ....
  7. ncbi Permeability barrier function of skin exposed to ionizing radiation
    M Schmuth
    Department of Dermatology, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Dermatol 137:1019-23. 2001
    ..To characterize the epidermal permeability barrier function of skin during exposure to ionizing radiation...
  8. ncbi Clear cells in acral melanoma
    M Schmuth
    Department of Dermatology, University of Innsbruck, Austria
    Eur J Dermatol 11:21-4. 2001
    ..Recognition of clear cell features is important since differential diagnosis includes a variety of other clear cell malignancies, among them metastasis from renal cell carcinoma, clear cell sarcoma and hidradenocarcinoma...
  9. ncbi Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study
    M Schmuth
    Department of Dermatology, University of Innsbruck, Austria
    Br J Dermatol 146:983-91. 2002
    ..Radiation dermatitis is a common side-effect of radiation therapy, but there is no current consensus about its appropriate therapy...
  10. ncbi Granulomatous slack skin: a distinct disorder or a variant of mycosis fungoides?
    G Topar
    Departments of Dermatology, University of Innsbruck, Austria
    Acta Derm Venereol 81:42-4. 2001
    ....
  11. ncbi Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 122:971-83. 2004
    ..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes...
  12. ncbi Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function
    Sandrine Dubrac
    Department of Dermatology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Immunol 178:4362-72. 2007
    ..In conclusion, PPARalpha activation by endogenous ligands may provide a molecular signal that allows LC to remain in an immature state within the epidermis for extended periods of time despite minor environmental stimuli...
  13. ncbi Lymphocytic infiltration of the skin is a photosensitive variant of lupus erythematosus: evidence by phototesting
    F Weber
    Department of Dermatology and Venereology, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Br J Dermatol 144:292-6. 2001
    ..Lymphocytic infiltration of the skin (LIS) is a disorder in which photosensitivity has been suspected but never proven...
  14. ncbi Healing of burns after treatment with 670-nanometer low-power laser light
    A Schlager
    Department of Anesthesia and General Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria
    Plast Reconstr Surg 105:1635-9. 2000
    ..In the present study, irradiation of burns with a 250-mW/670-nm laser light produced no beneficial effects on wound-healing processes...
  15. ncbi A model system using tape stripping for characterization of Langerhans cell-precursors in vivo
    Sandra Holzmann
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 122:1165-74. 2004
    ..We conclude that this experimental system may serve as a valuable tool for the further characterization of LC-precursors and the conditions necessary for LC-immigration into the epidermis...
  16. ncbi Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation
    Man Mao-Qiang
    Department of Dermatology, University of California, San Francisco and VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 123:305-12. 2004
    ..These observations suggest that thiazolidindiones and perhaps other PPAR-gamma activators maybe useful in the treatment of cutaneous disorders...
  17. ncbi (P)PARsing epidermal development
    Sandrine Dubrac
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    J Invest Dermatol 126:241-2. 2006
    ..5 to birth). In contrast, pharmacologic activation of PPAR-alpha inhibits proliferation and induces differentiation in mouse epidermis regardless of developmental stage. Thus, PPAR-alpha is an important regulator of epidermal homeostasis...
  18. ncbi Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides
    Florian Weber
    Clinical Department of Dermatology and Venereology, Medical University of Innsbruck, Innsbruck, Austria
    Acta Derm Venereol 85:329-32. 2005
    ..5) weeks. We conclude that bath-water PUVA therapy with 8-MOP is a valuable photo-therapeutic alternative, which should be considered for patients in whom systemic psoralen cannot be used...
  19. ncbi Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation
    Mao Qiang Man
    Department of Dermatology, University of California San Francisco and VA Medical Center San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 128:370-7. 2008
    ..Together, these results further demonstrate that PPARbeta/delta in the epidermis: (1) is required for permeability barrier homeostasis; (2) regulates keratinocyte proliferation; and (3) modulates cutaneous inflammation...
  20. ncbi Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    Ashley J Fowler
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 120:246-55. 2003
    ..LXR activators could provide a new class of therapeutic agents for the treatment of cutaneous inflammatory disorders...
  21. doi Modulation of T lymphocyte function by the pregnane X receptor
    Sandrine Dubrac
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    J Immunol 184:2949-57. 2010
    ..In summary, these results reveal a novel immune-regulatory role of PXR in T lymphocytes and identify suppressor of cytokine signaling 1 as an early signal in PXR-mediated T lymphocyte suppression...
  22. ncbi Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
    Mary Y Sheu
    Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA
    J Invest Dermatol 118:94-101. 2002
    ....
  23. ncbi Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis
    Laszlo G Komuves
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 118:25-34. 2002
    ..The ability of oxysterols to reverse epidermal hyperplasia suggests that these agents could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or altered differentiation...
  24. ncbi Detection of myocardial involvement in systemic lupus erythematosus: mismatch between normal perfusion scans with 201Thallium and pathological 18FDG uptake
    R Moncayo
    Department of Nuclear Medicine, University of Innsbruck, Innsbruck, Austria
    Int Angiol 20:314-21. 2001
    ..Systemic lupus erythematosus (SLE) patients can frequently present cardiac symptoms, however its etiology is not well known...
  25. ncbi Nuclear hormone receptors in human skin
    M Schmuth
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Horm Metab Res 39:96-105. 2007
    ..The various receptors exert differential effects in skin and can be rationally chosen as drug targets for the treatment of cutaneous pathologies...
  26. ncbi Reduced number of CD1a+ cells in cutaneous B-cell lymphoma
    M Schmuth
    Dept of Dermatology, University of Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria
    Am J Clin Pathol 116:72-8. 2001
    ..Our study demonstrates a distinct pattern of CD1a staining in the infiltrates of B-cell lymphoma and pseudolymphoma that may be of value in the differential diagnosis of these skin disorders...
  27. doi Langerhans cells are critical in the development of atopic dermatitis-like inflammation and symptoms in mice
    Andreas Elentner
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    J Cell Mol Med 13:2658-72. 2009
    ..These results demonstrate that LC are required for the development of AD in mouse models of AD involving epidermal TSLP overexpression...
  28. doi PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation
    Yan J Jiang
    Department of Veterans Affairs Medical Center, Metabolism Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 130:511-9. 2010
    ..These studies show that PPARdelta has a role in SC formation and permeability barrier development...
  29. doi Increased pachyonychia congenita severity in patients with concurrent keratin and filaggrin mutations
    R Gruber
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Br J Dermatol 161:1391-5. 2009
    ..R2447X, which was inherited from the father. This observation suggests that coinheritance of mutations in KRT16 and FLG may aggravate the PC phenotype and that FLG could serve as a genetic modifier in PC...
  30. pmc Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders
    Matthias Schmuth
    Department of Dermatology, University of California, VAMC Metabolism 111F, 4150 Clement Street, San Francisco, CA 94121, USA
    Adv Dermatol 23:231-56. 2007
  31. doi Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology
    Matthias Schmuth
    Department of Dermatology, University of California, San Francisco, CA, USA
    J Lipid Res 49:499-509. 2008
    ..Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, atopic dermatitis, and skin cancer...
  32. doi Atopic dermatitis: the role of Langerhans cells in disease pathogenesis
    Sandrine Dubrac
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    Immunol Cell Biol 88:400-9. 2010
    ..In this review, we describe findings in mouse models and in humans separately. We focus on recent findings that underscore the importance of Langerhans cells in initial mechanisms of skin inflammation in AD...
  33. ncbi Dropping lipids for epidermal defense
    Matthias Schmuth
    Department of Dermatology, University of Innsbruck, Austria
    J Invest Dermatol 121:xi. 2003
  34. ncbi Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)
    Matthias Schmuth
    Dermatology and Metabolism Medicine Services, Veterans Affairs Medical Center, San Francisco, USA
    J Invest Dermatol 122:909-22. 2004
    ..But in contrast to lamellar ichthyosis, the CE scaffold partially normalizes in the outer SC in loricrin keratoderma...
  35. ncbi The regulation of permeability barrier homeostasis
    Kenneth R Feingold
    Department of Medicine, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 127:1574-6. 2007
    ..Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis...
  36. pmc Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens
    Tiffany C Scharschmidt
    Department of Dermatology, Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 124:496-506, 506.e1-6. 2009
    ..Yet additional acquired stressors might be necessary because the same mutations can result in a noninflammatory disorder, ichthyosis vulgaris...
  37. ncbi Differential expression of fatty acid transport proteins in epidermis and skin appendages
    Matthias Schmuth
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    J Invest Dermatol 125:1174-81. 2005
    ..Together, these findings indicate that FATP are not only expressed by different cell types within the skin, but also that their localization is dynamically regulated during development...
  38. pmc Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Veterans Affairs Medical Center, Department of Dermatology, University of California, San Francisco, 94121, USA
    Curr Opin Allergy Clin Immunol 9:437-46. 2009
    ..We will review here emerging evidence that the inflammation in atopic dermatitis results from inherited and acquired insults to the barrier and the therapeutic implications of this new paradigm...
  39. ncbi Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects
    Reinhard Ackerl
    Department of Molecular Cell Biology, Max F Perutz Laboratories, University of Vienna, 1030 Vienna, Austria
    J Cell Sci 120:2435-43. 2007
    ..Our study explains the early lethality of plectin-deficient mice and provides a model to ablate plectin in adult animals which could be used for developing gene or pharmacological therapies...
  40. pmc Epiplakin is dispensable for skin barrier function and for integrity of keratin network cytoarchitecture in simple and stratified epithelia
    Daniel Spazierer
    Department of Molecular Cell Biology, Max F Perutz Laboratories, University of Vienna, Dr Bohrgasse 9, A 1030 Vienna, Austria
    Mol Cell Biol 26:559-68. 2006
    ....
  41. pmc Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Lipid Res 49:697-714. 2008
    ..The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation...
  42. ncbi Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome
    Jean Pierre Hachem
    Dienst Dermatologie, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium
    J Invest Dermatol 126:1609-21. 2006
    ..These studies provide a mechanistic basis for phenotypic variations in NS, and describe compensatory mechanisms that permit survival of NS patients in the face of unrelenting SP attack...
  43. ncbi Filaggrin mutations p.R501X and c.2282del4 in ichthyosis vulgaris
    Robert Gruber
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Eur J Hum Genet 15:179-84. 2007
    ..In a control population from west-Austria a combined p.R501X and c.2282del4 carrier frequency of 6/110 (5.45%) was observed. We confirm that these FLG variants are common, but our results point to the existence of additional modifiers...
  44. ncbi Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
    Aileen Sandilands
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 39:650-4. 2007
    ..i. = 20-1,136)). We found three additional rare null mutations in this case series, suggesting that the genetic architecture of filaggrin-related atopic dermatitis consists of both prevalent and rare risk alleles...
  45. ncbi Basis for the permeability barrier abnormality in lamellar ichthyosis
    Peter M Elias
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Exp Dermatol 11:248-56. 2002
    ....