Alexander Schleiffer

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners
    Alexander Schleiffer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mol Cell 11:571-5. 2003
  2. pmc Molecular processes during fat cell development revealed by gene expression profiling and functional annotation
    Hubert Hackl
    Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
    Genome Biol 6:R108. 2005
  3. ncbi request reprint Wapl controls the dynamic association of cohesin with chromatin
    Stephanie Kueng
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 127:955-67. 2006
  4. doi request reprint Sororin mediates sister chromatid cohesion by antagonizing Wapl
    Tomoko Nishiyama
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 143:737-49. 2010
  5. doi request reprint Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans
    Stefan Westermann
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Trends Cell Biol 23:260-9. 2013
  6. pmc Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4
    Cornelia Rumpf
    Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    Cell Cycle 9:3997-4004. 2010
  7. ncbi request reprint Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression
    Erwan Watrin
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 16:863-74. 2006
  8. pmc From a single double helix to paired double helices and back
    Kim Nasmyth
    Research Institute for Molecular Biology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Philos Trans R Soc Lond B Biol Sci 359:99-108. 2004
  9. ncbi request reprint CENP-T proteins are conserved centromere receptors of the Ndc80 complex
    Alexander Schleiffer
    IMP IMBA Bioinformatics Core Facility, Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nat Cell Biol 14:604-13. 2012
  10. pmc Systematic analysis of human protein complexes identifies chromosome segregation proteins
    James R A Hutchins
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 328:593-9. 2010

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners
    Alexander Schleiffer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mol Cell 11:571-5. 2003
    ..Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure. Since these are the only domains conserved among kleisins, we suggest that ring formation with SMC proteins may define this family...
  2. pmc Molecular processes during fat cell development revealed by gene expression profiling and functional annotation
    Hubert Hackl
    Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
    Genome Biol 6:R108. 2005
    ..We evaluated the extent to which molecular processes can be revealed by expression profiling and functional annotation of genes that are differentially expressed during fat cell development...
  3. ncbi request reprint Wapl controls the dynamic association of cohesin with chromatin
    Stephanie Kueng
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 127:955-67. 2006
    ..Wapl depletion also increases the residence time of cohesin on chromatin in interphase. Our data indicate that Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin...
  4. doi request reprint Sororin mediates sister chromatid cohesion by antagonizing Wapl
    Tomoko Nishiyama
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 143:737-49. 2010
    ..The mechanism we describe here may therefore be widely conserved among different species...
  5. doi request reprint Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans
    Stefan Westermann
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Trends Cell Biol 23:260-9. 2013
    ..Together, these findings contribute to a unified view of how centromeric chromatin functions as a regulated scaffold for kinetochore assembly...
  6. pmc Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4
    Cornelia Rumpf
    Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    Cell Cycle 9:3997-4004. 2010
    ..Finally, we show that Pcs1/Mde4 complex shares similar features with the conserved kinetochore complex Spc24/Spc25 suggesting that these two complexes may occupy a similar functional niche...
  7. ncbi request reprint Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression
    Erwan Watrin
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 16:863-74. 2006
    ..Mutation of Scc2 orthologs causes defects in cohesion, transcription, and development, resulting in Cornelia de Lange syndrome in humans...
  8. pmc From a single double helix to paired double helices and back
    Kim Nasmyth
    Research Institute for Molecular Biology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Philos Trans R Soc Lond B Biol Sci 359:99-108. 2004
    ..Cohesion between sister chromatids is destroyed at the metaphase to anaphase transition by proteolytic cleavage of cohesin's Scc1 subunit by a thiol protease called separase, which severs the ring and thereby releases sister DNAs...
  9. ncbi request reprint CENP-T proteins are conserved centromere receptors of the Ndc80 complex
    Alexander Schleiffer
    IMP IMBA Bioinformatics Core Facility, Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nat Cell Biol 14:604-13. 2012
    ..Our results reveal the molecular function of CENP-T proteins and demonstrate how the Ndc80 complex is anchored to centromeres in a manner that couples chromosome movement to spindle dynamics...
  10. pmc Systematic analysis of human protein complexes identifies chromosome segregation proteins
    James R A Hutchins
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 328:593-9. 2010
    ..The approaches we describe here are generally applicable to high-throughput follow-up analyses of phenotypic screens in mammalian cells...
  11. ncbi request reprint Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion
    Dmitri Ivanov
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:323-8. 2002
    ..In vitro Eco1 acetylates itself and components of the cohesin complex but not histones. Thus, the establishment of cohesion between sister chromatids appears to be regulated, directly or indirectly, by a specific acetyltransferase...
  12. pmc A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A
    Peter Hornung
    Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria
    J Cell Biol 206:509-24. 2014
    ..This two-step mechanism may protect against inappropriate kinetochore assembly similar to rate-limiting nucleation steps used by cytoskeletal polymers. ..
  13. pmc DOUTfinder--identification of distant domain outliers using subsignificant sequence similarity
    Maria Novatchkova
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nucleic Acids Res 34:W214-8. 2006
    ..DOUTfinder is available at http://mendel.imp.ac.at/dout/...
  14. doi request reprint Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins
    Alexander Heuck
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    J Mol Biol 406:659-66. 2011
    ..Thus, BamB could simultaneously bind to BamA and prefolded β-barrel proteins, thereby enhancing the folding and membrane insertion capability of the Bam complex...
  15. pmc High-throughput knockout screen in fission yeast
    Juraj Gregan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nat Protoc 1:2457-64. 2006
    ..Here, we present our protocol with detailed instructions. Using this protocol, one person can knock out 96 S. pombe genes in 8 days...