Christoph Scherfler

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Evaluation of striatal dopamine transporter function in rats by in vivo beta-[123I]CIT pinhole SPECT
    Christoph Scherfler
    Department of Neurology, The Leopold Franzens University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Neuroimage 17:128-41. 2002
  2. ncbi Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 129:538-42. 2006
  3. ncbi Upregulation of dopamine D2 receptors in dopaminergic drug-naive patients with Parkin gene mutations
    Christoph Scherfler
    MRC Clinical Science Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:783-8. 2006
  4. ncbi Topography of cerebral monoamine transporter availability in families with SCA2 mutations: a voxel-wise [123I]beta-CIT SPECT analysis
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:1084-90. 2006
  5. ncbi Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
  6. ncbi Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats
    Christoph Scherfler
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Neuroimage 24:822-31. 2005
  7. ncbi Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuroimage 31:240-5. 2006
  8. doi Red flags for multiple system atrophy
    Martin Köllensperger
    Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 23:1093-9. 2008
  9. doi Nigrostriatal dysfunction in homozygous and heterozygous parkin gene carriers: an 18F-dopa PET progression study
    Nicola Pavese
    MRC Clinical Science Centre, Imperial College, London, United Kingdom nicola pavese csc mrc ac uk
    Mov Disord 24:2260-6. 2009
  10. ncbi Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson's disease
    Michele T M Hu
    MRC Clinical Sciences Centre, Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:299-305. 2006

Detail Information

Publications37

  1. ncbi Evaluation of striatal dopamine transporter function in rats by in vivo beta-[123I]CIT pinhole SPECT
    Christoph Scherfler
    Department of Neurology, The Leopold Franzens University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Neuroimage 17:128-41. 2002
    ..Depending on SPECT ligand availability, a wide range of other CNS receptors may be imaged as well using the presented in vivo technique...
  2. ncbi Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 129:538-42. 2006
    ..Whether DWI can be used as a marker to identify individuals at risk to develop this disease remains to be shown...
  3. ncbi Upregulation of dopamine D2 receptors in dopaminergic drug-naive patients with Parkin gene mutations
    Christoph Scherfler
    MRC Clinical Science Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:783-8. 2006
    ..Parkin-positive patients appear to have a greater susceptibility to the exposure to dopaminergic medication than IPD patients, which in turn might be an indirect effect of their genetic mutation...
  4. ncbi Topography of cerebral monoamine transporter availability in families with SCA2 mutations: a voxel-wise [123I]beta-CIT SPECT analysis
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:1084-90. 2006
    ..To this end, nine patients were studied with [(123)I]beta-CIT SPECT...
  5. ncbi Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
    ..We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]beta-CIT SPECT in patients with uncertain parkinsonism...
  6. ncbi Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats
    Christoph Scherfler
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Neuroimage 24:822-31. 2005
    ..SPECT-MRI-based estimation of regional [123I]IBZM uptake provides a cost effective and widely available in vivo imaging technique for assessing striatal integrity in animal studies...
  7. ncbi Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuroimage 31:240-5. 2006
    ....
  8. doi Red flags for multiple system atrophy
    Martin Köllensperger
    Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 23:1093-9. 2008
    ..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P...
  9. doi Nigrostriatal dysfunction in homozygous and heterozygous parkin gene carriers: an 18F-dopa PET progression study
    Nicola Pavese
    MRC Clinical Science Centre, Imperial College, London, United Kingdom nicola pavese csc mrc ac uk
    Mov Disord 24:2260-6. 2009
    ..Although subclinical reductions of striatal (18)F-dopa uptake are common in carriers of a single parkin mutation their slow rate of progression suggests that few if any of these will develop clinical parkinsonism...
  10. ncbi Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson's disease
    Michele T M Hu
    MRC Clinical Sciences Centre, Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:299-305. 2006
    ....
  11. doi Correlation of dopaminergic terminal dysfunction and microstructural abnormalities of the basal ganglia and the olfactory tract in Parkinson's disease
    Christoph Scherfler
    1 Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain 136:3028-37. 2013
    ..Since increases in nigral mean diffusivity signal also correlated with motor dysfunction, diffusion tensor imaging may serve as a surrogate marker for disease progression in future studies of putative disease modifying therapies. ..
  12. ncbi Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism
    Christoph Scherfler
    MRC Clinical Science Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Brain 127:1332-42. 2004
    ..Cortical reductions in D2 binding may contribute to the behavioural problems reported in parkin patients...
  13. ncbi Topography of dopamine transporter availability in progressive supranuclear palsy: a voxelwise [123I]beta-CIT SPECT analysis
    Klaus Seppi
    Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Neurol 63:1154-60. 2006
    ..Most previous SPECT studies have adopted region-of-interest methods for analysis, which are subjective and operator dependent...
  14. ncbi Cortical atrophy in the cerebellar variant of multiple system atrophy: a voxel-based morphometry study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:159-65. 2006
    ..We observed a volume loss shared by both disorders comprising the cerebellum, vermis, pons, mesencephalon, orbitofrontal, mid-frontal, and temporomesial cortex of both hemispheres as well as the left insular cortex...
  15. ncbi Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
    Klaus Seppi
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Mov Disord 19:1438-45. 2004
    ..Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM-SPECT in the differential diagnosis of MSA-P versus PD...
  16. ncbi Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:847-52. 2006
    ..Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI...
  17. ncbi Diffusion weighted imaging best discriminates PD from MSA-P: A comparison with tilt table testing and heart MIBG scintigraphy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:1771-6. 2007
    ..6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P...
  18. doi A novel computer-assisted image analysis of [123I]β-CIT SPECT images improves the diagnostic accuracy of parkinsonian disorders
    Georg Goebel
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schöpfstrasse 41 2, A 6020, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 38:702-10. 2011
    ....
  19. doi In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study
    Nicola Pavese
    MRC Clinical Science Centre and Division of Neuroscience and Mental Health, Imperial College, London, UK
    Exp Neurol 222:120-4. 2010
    ..These findings suggest that parkin patients and IPD patients with similar striatal dysfunction have different patterns of monoaminergic involvement, with more widespread dysfunction in IPD...
  20. doi Left hemispheric predominance of nigrostriatal dysfunction in Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck, Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain 135:3348-54. 2012
    ....
  21. doi Progression of dopamine transporter decline in patients with the Parkinson variant of multiple system atrophy: a voxel-based analysis of [123I]β-CIT SPECT
    Michael Nocker
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 39:1012-20. 2012
    ....
  22. ncbi Health-related quality of life in multiple system atrophy
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 21:809-15. 2006
    ....
  23. doi Diagnostic accuracy of the magnetic resonance Parkinsonism index and the midbrain-to-pontine area ratio to differentiate progressive supranuclear palsy from Parkinson's disease and the Parkinson variant of multiple system atrophy
    Anna Hussl
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 25:2444-9. 2010
    ..6%) compared with the MRPI (77.3%). Both the m/p-ratio and the MRPI may assist the clinical differential diagnosis in neurodegenerative parkinsonism...
  24. ncbi Progression of brain atrophy in multiple system atrophy. A longitudinal VBM study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 254:191-6. 2007
    ..The UPDRS-III score was not significantly correlated with any brain region. Our data suggest that cortical atrophy is prominent in MSA-P and early degeneration of the basal ganglia drives late onset cortical atrophy...
  25. doi Substantia nigra hyperechogenicity as a marker for Parkinson's disease: a population-based study
    Philipp Mahlknecht
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Neurodegener Dis 12:212-8. 2013
    ..According to hospital-based studies, an enlarged echogenicity in the area of the substantia nigra (SN) assessed with transcranial sonography (TCS) may represent a useful biomarker in the diagnosis of PD...
  26. pmc White and gray matter abnormalities in narcolepsy with cataplexy
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Sleep 35:345-51. 2012
    ....
  27. ncbi Parkinsonism and nigrostriatal dysfunction are associated with spinocerebellar ataxia type 6 (SCA6)
    Naheed L Khan
    Department of Molecular Neurosciences, Institute of Neurology, London, United Kingdom
    Mov Disord 20:1115-9. 2005
    ..We suggest that SCA6, in common with SCA2 and SCA3, may be associated with Parkinsonism attributable to nigral loss and dopaminergic dysfunction. Moreover, isolated cases may be confused with multiple system atrophy...
  28. ncbi Role of dopamine transporter imaging in investigation of parkinsonian syndromes in routine clinical practice
    Werner Poewe
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:S16-21. 2003
    ..DAT-SPECT facilitates differential diagnosis of the different parkinsonian syndromes that cannot be reliably separated on clinical grounds and it can thus provide valuable diagnostic information in early disease...
  29. doi White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometry study
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Austria
    Ann Neurol 69:400-7. 2011
    ....
  30. ncbi Small animal imaging using a conventional gamma camera exemplified in studies on the striatal dopaminergic system
    Christoph Scherfler
    Department of Neurology, Department of Nuclear Medicine, Innsbruck Medical University, Austria
    Nucl Med Rev Cent East Eur 9:6-11. 2006
    ..In order to precisely estimate brain regions of low radioligand uptake, single photon emission computed tomography (SPECT) images were coregistered onto an MRI template...
  31. pmc Prevalence and burden of gait disorders in elderly men and women aged 60-97 years: a population-based study
    Philipp Mahlknecht
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    PLoS ONE 8:e69627. 2013
    ..Although gait disorders are common in the elderly, the prevalence and overall burden of these disorders in the general community is not well defined...
  32. ncbi Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG)
    Felix Geser
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:179-86. 2006
    ..Our data contribute to the ongoing validation process of UMSARS, and they facilitate the planning and implementation of future neuroprotective intervention trials...
  33. doi Dopamine transporter SPECT: how to remove subjectivity?
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Mov Disord 24:S721-4. 2009
    ..Their potential as tools to improve the diagnostic accuracy in patients presenting with parkinsonian features is reviewed here...
  34. ncbi The human premotor cortex is 'mirror' only for biological actions
    Yen F Tai
    Division of Neuroscience, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College, London W12 0NN, United Kingdom
    Curr Biol 14:117-20. 2004
    ..This result indicates for the first time that in humans the mirror system is biologically tuned. This system appears to be the neural substrate for biological preference during action coding...
  35. ncbi Role of DAT-SPECT in the diagnostic work up of parkinsonism
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:1229-38. 2007
    ..This review addresses the value of DAT-SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression...
  36. pmc An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes
    Philipp Mahlknecht
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Proteome Sci 10:71. 2012
    ..abstract:..
  37. ncbi Encephalitis lethargica following Bartonella henselae infection
    Christian Brenneis
    J Neurol 254:546-7. 2007