J M Rollinger

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi request reprint Strategies for efficient lead structure discovery from natural products
    J M Rollinger
    Institute of Pharmacy Pharmacognosy, Josef Moeller Haus, Innrain 52c, Leopold Franzens University Innsbruck, 6020 Innsbruck, Austria
    Curr Med Chem 13:1491-507. 2006
  2. ncbi request reprint Computer-guided approach to access the anti-influenza activity of licorice constituents
    Ulrike Grienke
    Institute of Pharmacy Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80 82, 6020 Innsbruck, Austria
    J Nat Prod 77:563-70. 2014
  3. pmc Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum
    Sarah K Oettl
    Institute of Pharmacy Pharmacognosy, Center for Molecular Biosciences Innsbruck, Leopold Franzens University of Innsbruck, Innsbruck, Austria
    PLoS ONE 8:e76929. 2013
  4. pmc 2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells
    Angela Ladurner
    Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
    Biochem Pharmacol 84:804-12. 2012
  5. pmc Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum
    Ulrike Grienke
    Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria
    Bioorg Med Chem 19:6779-91. 2011
  6. ncbi request reprint Venturia inaequalis-inhibiting Diels-Alder adducts from Morus root bark
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy, Innrain 52c, and Institute of Organic Chemistry, Innrain 52a, Center for Molecular Biosciences Innsbruck, Leopold Franzens Universitat, A 6020 Innsbruck, Austria
    J Agric Food Chem 54:8432-6. 2006
  7. doi request reprint Structure-based virtual screening for the discovery of natural inhibitors for human rhinovirus coat protein
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy, University of Innsbruck, Innrain 52, A 6020 Innsbruck, Austria
    J Med Chem 51:842-51. 2008
  8. pmc In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens
    Judith M Rollinger
    Institute of Pharmacy, Pharmacognosy, and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria
    Planta Med 75:195-204. 2009
  9. doi request reprint The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52c, A 6020 Innsbruck, Austria
    Med Res Rev 31:42-92. 2011
  10. doi request reprint 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria
    Bioorg Med Chem 18:1507-15. 2010

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Strategies for efficient lead structure discovery from natural products
    J M Rollinger
    Institute of Pharmacy Pharmacognosy, Josef Moeller Haus, Innrain 52c, Leopold Franzens University Innsbruck, 6020 Innsbruck, Austria
    Curr Med Chem 13:1491-507. 2006
    ....
  2. ncbi request reprint Computer-guided approach to access the anti-influenza activity of licorice constituents
    Ulrike Grienke
    Institute of Pharmacy Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80 82, 6020 Innsbruck, Austria
    J Nat Prod 77:563-70. 2014
    ..Compounds 1, 3, 5, and 6 showed antiviral activity, most likely caused by the inhibition of NA. Of these, compounds 1, 3, and 6 were highly ranked in shape-focused virtual screening. ..
  3. pmc Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum
    Sarah K Oettl
    Institute of Pharmacy Pharmacognosy, Center for Molecular Biosciences Innsbruck, Leopold Franzens University of Innsbruck, Innsbruck, Austria
    PLoS ONE 8:e76929. 2013
    ..The potent inhibitory effects on the three identified targets attest 4 and 5 a pronounced multi-target anti-inflammatory profile which warrants further investigation on their pharmacokinetics and in vivo efficacy. ..
  4. pmc 2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells
    Angela Ladurner
    Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
    Biochem Pharmacol 84:804-12. 2012
    ..DPPB enhances eNOS activity and endothelial NO release by raising intracellular Ca(2+) levels and increases signaling through a CaMKKβ-AMPK dependent pathway...
  5. pmc Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum
    Ulrike Grienke
    Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria
    Bioorg Med Chem 19:6779-91. 2011
    ..To rationalize the binding interactions, additional pharmacophore profiling and molecular docking studies were performed, which allowed establishing a first structure-activity relationship of the investigated triterpenes...
  6. ncbi request reprint Venturia inaequalis-inhibiting Diels-Alder adducts from Morus root bark
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy, Innrain 52c, and Institute of Organic Chemistry, Innrain 52a, Center for Molecular Biosciences Innsbruck, Leopold Franzens Universitat, A 6020 Innsbruck, Austria
    J Agric Food Chem 54:8432-6. 2006
    ..The in vitro activity of the most active fraction (A5, IC50 39.0 +/- 4.2 microg/mL) was evaluated in vivo, confirming a distinct antifungal activity against V. inaequalis for the tested natural material...
  7. doi request reprint Structure-based virtual screening for the discovery of natural inhibitors for human rhinovirus coat protein
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy, University of Innsbruck, Innrain 52, A 6020 Innsbruck, Austria
    J Med Chem 51:842-51. 2008
    ..0 microg/mL) and its virtually predicted constituents 2 (IC50 = 2.5 microM) and 3 (IC50 = 2.6 microM). Modeling studies helped to rationalize the retrieved results...
  8. pmc In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens
    Judith M Rollinger
    Institute of Pharmacy, Pharmacognosy, and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria
    Planta Med 75:195-204. 2009
    ..GRAVEOLENS on three different proteins has shown promise as an IN SILICO tool for rational target fishing and pharmacological profiling of extracts and single chemical entities in natural product research...
  9. doi request reprint The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52c, A 6020 Innsbruck, Austria
    Med Res Rev 31:42-92. 2011
    ..This review will (i) summarize existing structural knowledge about HRV, (ii) focus on mechanisms of anti-HRV agents from synthetic and natural origin, and (iii) demonstrate strategies for efficient lead structure discovery...
  10. doi request reprint 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria
    Bioorg Med Chem 18:1507-15. 2010
    ..The mechanism of action elucidated in the present work together with the previously determined pharmacological activities provides these natural products with an astonishing multi-targeted anti-diabetic profile...
  11. pmc Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy, Center for Molecular Biosciences Innsbruck, Innrain 52c, Leopold Franzens Universitat, A 6020 Innsbruck, Austria
    J Nat Prod 69:1341-6. 2006
    ....
  12. ncbi request reprint Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus
    J M Rollinger
    Institute of Pharmacy Pharmacognosy, Josef Moeller Haus, Innrain 52c, Austria
    Curr Drug Discov Technol 2:185-93. 2005
    ..The two isolates were correctly predicted within the virtual screening process which corroborates the potential of the computer-assisted in combo screening approach for the discovery of the anti-cholinesterase compounds from C. intybus...
  13. ncbi request reprint Lignans, phenylpropanoids and polyacetylenes from Chaerophyllum aureum L. (Apiaceae)
    Judith M Rollinger
    Institut fur Pharmazie, Abteilung Pharmakognosie, Universitat Innsbruck, Josef Moeller Haus, Innrain 52, A 6020 Innsbruck, Austria
    Z Naturforsch C 58:553-7. 2003
    ..In bioautographic tests on TLC plates the dichloromethane extract showed a significant antimicrobial activity. Falcarindiol was identified as the main active principle whereas the phenylpropanoids and lignans showed no activity...
  14. ncbi request reprint New insights into the acetylcholinesterase inhibitory activity of Lycopodium clavatum
    Judith M Rollinger
    Institute of Pharmacy, Pharmacognosy, Leopold Franzens University of Innsbruck, Austria
    Planta Med 71:1040-3. 2005
    ..Bioassay-guided fractionation of L. clavatum resulted in the isolation of lyclavatol (2), showing a weak, but dose-dependent inhibitory effect on AChE. (1)H- and (13)C NMR shift assignments for 1 and 2 are presented and discussed...
  15. ncbi request reprint Crystal forms of torasemide: new insights
    Judith Maria Rollinger
    Institute of Pharmacy Pharmacognosy, University of Innsbruck, Innrain 52, Josef Moeller Haus, A 6020 Innsbruck, Austria
    Eur J Pharm Biopharm 53:75-86. 2002
    ..The present results give a thorough physicochemical characterization of the crystal forms of torasemide. They clearly indicate a mistaken identity of mod. II with crystal form A in formerly published articles...
  16. ncbi request reprint Discovering COX-inhibiting constituents of Morus root bark: activity-guided versus computer-aided methods
    Judith M Rollinger
    Institute of Pharmacy, Department of Pharmacognosy, Leopold Franzens University of Innsbruck, Innsbruck, Austria
    Planta Med 71:399-405. 2005
    ..Structure-activity relationships of the isolated compounds are discussed as well as potential pitfalls and advantages of the applied strategies...
  17. ncbi request reprint Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products
    Judith M Rollinger
    Department of Pharmacognosy, Leopold Franzens University of Innsbruck, A 6020 Innsbruck, Austria
    J Med Chem 47:6248-54. 2004
    ..At the same concentration, the positive control galanthamine increased the ACh concentration to about the same level as 1. These are the first in vivo results indicating an effect of coumarins on brain ACh...
  18. ncbi request reprint Polymorphism of racemic felodipine and the unusual series of solid solutions in the binary system of its enantiomers
    J M Rollinger
    Institute of Pharmacy Pharmacognosy, University of Innsbruck, Innrain 52, Josef Moeller Haus, A 6020 Innsbruck, Austria
    J Pharm Sci 90:949-59. 2001
    ..Because its crystallization is badly reproducible, the use of mod. II is not advisable for processing. However, desolvation of S(Ac) leads to a profitable crystal shape of mod. I, representing a pseudoracemate by definition...
  19. ncbi request reprint Combining ethnopharmacology and virtual screening for lead structure discovery: COX-inhibitors as application example
    Judith M Rollinger
    Institute of Pharmacy, Department of Pharmacognosy, Leopold Franzens University of Innsbruck, Innrain 52, Josef Moeller Haus, A 6020 Innsbruck, Austria
    J Chem Inf Comput Sci 44:480-8. 2004
    ..The statistical benefit of a combination of an ethnopharmacological approach with the potential of computer aided drug discovery by in silico screening was demonstrated exemplified on the applied targets COX-1 and COX-2...
  20. doi request reprint Influenza neuraminidase: a druggable target for natural products
    Ulrike Grienke
    Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
    Nat Prod Rep 29:11-36. 2012
    ..This work addresses the latest developments in theoretical and experimental research on properties of NA that are and will be driving anti-influenza drug development now and in the near future...
  21. ncbi request reprint Integrated in silico tools for exploiting the natural products' bioactivity
    J M Rollinger
    Institute of Pharmacy Pharmacognosy, Leopold Franzens University Innsbruck, Innsbruck, Austria
    Planta Med 72:671-8. 2006
    ..Thus, integrated computer-assisted strategies may help to process the huge amount of available structural and biological information in a reasonably short time for a straightforward search of bioactive natural products...
  22. pmc Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: brain ACh increasing and memory improving properties
    Ariane Hornick
    Institute of Pharmacy, Pharmacology and Toxicology, University of Innsbruck, A 6020 Innsbruck, Austria
    Biochem Pharmacol 76:236-48. 2008
    ..Taken together, isocomene and related constituents of L. alpinum deserve further interest as potential antidementia agents in brain diseases associated with cholinergic deficits...
  23. ncbi request reprint Natural products in structure-assisted design of molecular cancer therapeutics
    P H Pfisterer
    Institute of Pharmacy Pharmacognosy, University of Innsbruck, Innsbruck, Austria
    Curr Pharm Des 16:1718-41. 2010
    ..Examples of applications are provided focusing on innovative targets such as protein kinases, tumour vasculature, epigenetic modulators, heat shock protein (Hsp) 90, and direct apoptosis enhancers...
  24. ncbi request reprint Virtual screening for the discovery of bioactive natural products
    Judith M Rollinger
    Institute of Pharmacy Pharmacognosy, Leopold Franzens University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria
    Prog Drug Res 65:211, 213-49. 2008
    ..Such integrated virtual screening workflows are outlined here and shall help to motivate NP researchers to dare a step towards this powerful in silico tool...
  25. doi request reprint Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai
    Ulrike Grienke
    Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria
    J Med Chem 53:778-86. 2010
    ....
  26. pmc The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory
    A Hornick
    Institute of Pharmacy Pharmacology and Toxicology, University of Innsbruck, Peter Mayr Str 1, A 6020 Innsbruck, Austria
    Neuroscience 197:280-92. 2011
    ..Therefore, SCT might be able to rescue impaired cholinergic functions by enhancing nAChR-mediated release of neurotransmitters and promoting neural plasticity in hippocampus...
  27. ncbi request reprint Energy/temperature diagram and compression behavior of the polymorphs of D-mannitol
    A Burger
    Institut fur Pharmakognosie der Universitat Innsbruck, Josef Moeller Haus, Innrain 52, A 6020 Innsbruck, Austria
    J Pharm Sci 89:457-68. 2000
    ..In addition, compaction studies of these crystal forms were performed by means of an instrumented hydraulic press. The results show that mod. III should have the best tableting behavior under these conditions...
  28. doi request reprint Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors
    Daniela Schuster
    Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck and Center for Molecular Biosciences Innsbruck CMBI, Innrain 52a c, A 6020 Innsbruck, Austria
    Bioorg Med Chem 18:5071-80. 2010
    ..The most active compounds were biochemically tested for their activity on mu, delta, and kappa opioid receptors...
  29. pmc Applications of integrated data mining methods to exploring natural product space for acetylcholinesterase inhibitors
    Daniela Schuster
    Department of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, Austria
    Comb Chem High Throughput Screen 13:54-66. 2010
    ..Finally, in vitro testing of selected compounds led to the identification of forsythoside A and (+)-sesamolin as novel AChE inhibitors...