M Roden

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. doi request reprint Basal insulin glargine vs prandial insulin lispro in type 2 diabetes
    Michael Roden
    Lancet 372:371; author reply 372. 2008
  2. ncbi request reprint How to detect pheochromocytomas?--the diagnostic relevance of plasma free metanephrines
    Michael Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Wien Klin Wochenschr 114:246-51. 2002
  3. ncbi request reprint Hepatic glucose metabolism in humans--its role in health and disease
    Michael Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Best Pract Res Clin Endocrinol Metab 17:365-83. 2003
  4. ncbi request reprint Relative hypoleptinemia in patients with type 1 and type 2 diabetes mellitus
    M Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Int J Obes Relat Metab Disord 24:976-81. 2000
  5. ncbi request reprint Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans
    M Roden
    Department of Internal Medicine III, University of Vienna Medical School, Austria
    Diabetes 49:701-7. 2000
  6. ncbi request reprint Effects of short-term leptin exposure on triglyceride deposition in rat liver
    M Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Vienna, Austria
    Hepatology 32:1045-9. 2000
  7. ncbi request reprint Quantification of unconjugated metanephrines in human plasma without interference by acetaminophen
    M Roden
    Division of Endocrinology and Metabolism, Department of Medicine III, University of Vienna Medical School, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Clin Chem 47:1061-7. 2001
  8. ncbi request reprint Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans
    M Roden
    Department of Internal Medicine III, Institute for Medical Physics, University of Vienna Medical School, Austria
    Diabetes 48:358-64. 1999
  9. ncbi request reprint Applications of NMR spectroscopy to study muscle glycogen metabolism in man
    M Roden
    Department of Internal Medicine III, University of Vienna Medical School, Austria
    Annu Rev Med 50:277-90. 1999
  10. ncbi request reprint Non-invasive studies of glycogen metabolism in human skeletal muscle using nuclear magnetic resonance spectroscopy
    M Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Curr Opin Clin Nutr Metab Care 4:261-6. 2001

Detail Information

Publications96

  1. doi request reprint Basal insulin glargine vs prandial insulin lispro in type 2 diabetes
    Michael Roden
    Lancet 372:371; author reply 372. 2008
  2. ncbi request reprint How to detect pheochromocytomas?--the diagnostic relevance of plasma free metanephrines
    Michael Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Wien Klin Wochenschr 114:246-51. 2002
    ..In conclusion, it is therefore recommended to use plasma free metanephrines--after meticulous clinical screening--as the first-line biochemical test for detecting pheochromocytomas...
  3. ncbi request reprint Hepatic glucose metabolism in humans--its role in health and disease
    Michael Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Best Pract Res Clin Endocrinol Metab 17:365-83. 2003
    ..These patients also exhibit augmented intracellular lipid accumulation which could hint at a link between deranged glucose and lipid metabolism in insulin-resistant states...
  4. ncbi request reprint Relative hypoleptinemia in patients with type 1 and type 2 diabetes mellitus
    M Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Int J Obes Relat Metab Disord 24:976-81. 2000
    ..To determine the relation between plasma leptin concentrations and metabolic control in human diabetes mellitus...
  5. ncbi request reprint Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans
    M Roden
    Department of Internal Medicine III, University of Vienna Medical School, Austria
    Diabetes 49:701-7. 2000
    ..05 vs. glycerol: 64+/-4%). In conclusion, high plasma FFA concentrations increase the percent contribution of GNG to EGP and may contribute to increased rates of GNG in patients with type 2 diabetes...
  6. ncbi request reprint Effects of short-term leptin exposure on triglyceride deposition in rat liver
    M Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Vienna, Austria
    Hepatology 32:1045-9. 2000
    ..01 mg/g, 25 nmol/L: 0.48 +/- 0.04 mg/g, control: 0.38 +/- 0.03 mg/g; P <.05). In conclusion, hyperleptinemia increases hepatic triglyceride content and may therefore contribute to hepatic steatosis in hyperleptinemic obese patients...
  7. ncbi request reprint Quantification of unconjugated metanephrines in human plasma without interference by acetaminophen
    M Roden
    Division of Endocrinology and Metabolism, Department of Medicine III, University of Vienna Medical School, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Clin Chem 47:1061-7. 2001
    ..We aimed to develop a method to measure unconjugated plasma normetanephrine (NMN) and metanephrine (MN) without interference from acetaminophen, a widely prescribed drug for headaches...
  8. ncbi request reprint Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans
    M Roden
    Department of Internal Medicine III, Institute for Medical Physics, University of Vienna Medical School, Austria
    Diabetes 48:358-64. 1999
    ....
  9. ncbi request reprint Applications of NMR spectroscopy to study muscle glycogen metabolism in man
    M Roden
    Department of Internal Medicine III, University of Vienna Medical School, Austria
    Annu Rev Med 50:277-90. 1999
    ....
  10. ncbi request reprint Non-invasive studies of glycogen metabolism in human skeletal muscle using nuclear magnetic resonance spectroscopy
    M Roden
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Curr Opin Clin Nutr Metab Care 4:261-6. 2001
    ..An elevation of plasma free fatty acids causes similar alterations of muscle glucose metabolism, and could play a central role in the development of impaired muscle glucose transport associated with insulin resistance...
  11. ncbi request reprint NMR and stable isotope techniques for studies of liver metabolism in man
    M Roden
    Department of Internal Medicine III University of Vienna, Austria
    Horm Metab Res 29:340-3. 1997
    ....
  12. ncbi request reprint Lipid-dependent control of hepatic glycogen stores in healthy humans
    H Stingl
    Department of Internal Medicine III, University of Vienna Medical School, Austria
    Diabetologia 44:48-54. 2001
    ..We suggest that this effect is not due to increased availability of glycerol alone but rather to lipid-dependent control of hepatic glycogen stores...
  13. ncbi request reprint Hormonal and metabolic counterregulation during and after high-dose insulin-induced hypoglycemia in diabetes mellitus type 2
    M G Bischof
    Department of Internal Medicine III, University of Vienna Medical School, Austria
    Horm Metab Res 32:417-23. 2000
    ....
  14. doi request reprint Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle
    A Brehm
    First Medical Department, Hanusch Hospital, Vienna, Austria
    Am J Physiol Endocrinol Metab 299:E33-8. 2010
    ..This suggests that lipid-induced insulin resistance results primarily from mechanisms decreasing glucose uptake rather than from direct interference of fatty acid metabolites with mitochondrial function...
  15. doi request reprint Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes
    M Kacerovsky
    Karl Landsteiner Institute for Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria
    J Intern Med 269:189-99. 2011
    ..We hypothesized that patients with long-standing type 1 diabetes may also exhibit insulin resistance as well as lower fATP...
  16. pmc Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism
    C Fürnsinn
    Department of Medicine III, Division of Endocrinology and Metabolism, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Br J Pharmacol 128:1141-8. 1999
    ..8 Further efforts are required to clarify, to what extent other mechanisms besides insulin sensitization via the activation of PPARgamma are involved in the antidiabetic actions of thiazolidinediones...
  17. ncbi request reprint Effect of near physiologic insulin therapy on hypoglycemia counterregulation in type-1 diabetes
    M G Bischof
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Horm Res 56:151-8. 2001
    ..CONCLUSION: Despite long-term near physiologic insulin substitution and the low incidence of hypoglycemia, hormonal hypoglycemia counterregulation was impaired in type-1 diabetic patients after a diabetes duration of more than 10 years...
  18. ncbi request reprint Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans
    M Krebs
    Division of Endocrinology and Metabolism, University of Vienna Medical School, Austria
    J Clin Endocrinol Metab 86:2153-60. 2001
    ..In conclusion, the lack of an increase in muscular G6P along with reduction of whole body glucose clearance indicates that FFA might directly inhibit glucose transport/phosphorylation in skeletal muscle...
  19. ncbi request reprint Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans
    M G Bischof
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Hanusch Hospital, A 1090 Vienna, Austria
    Eur J Clin Invest 36:164-9. 2006
    ..Increased brain glucose uptake during hypoglycaemia or alterations of brain energy metabolism could effect glucose sensing by the brain and thus contribute to hypoglycaemia-associated autonomic failure...
  20. ncbi request reprint Changes in hepatic glycogen cycling during a glucose load in healthy humans
    H Stingl
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Diabetologia 49:360-8. 2006
    ..The percentage contribution of glycogen cycling to glycogen synthesis then equals the difference between the sum of the percentage contributions of the direct and indirect pathways and 100...
  21. ncbi request reprint Characterization of hepatic and brain metabolism in young adults with glycogen storage disease type 1: a magnetic resonance spectroscopy study
    D Weghuber
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Am J Physiol Endocrinol Metab 293:E1378-84. 2007
    ..Therefore, hepatic defects of glucose metabolism persist in young adult GSD1 patients. Upregulation of the glucose and lactate transport at the blood-brain barrier could be responsible for the amelioration of hypoglycemic symptoms...
  22. ncbi request reprint Direct and indirect effects of amino acids on hepatic glucose metabolism in humans
    M Krebs
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Diabetologia 46:917-25. 2003
    ..The study was designed to examine the contribution of direct (substrate-mediated) and indirect (hormone-mediated) effects of amino acids on hepatic glucose metabolism in healthy men...
  23. ncbi request reprint Quantitative ATP synthesis in human liver measured by localized 31P spectroscopy using the magnetization transfer experiment
    A I Schmid
    Karl Landsteiner Institute of Endocrinology and Metabolism, Hanusch Hospital, Vienna, Austria
    NMR Biomed 21:437-43. 2008
    ..In conclusion, 31P MRS at 3 T provides sufficient sensitivity to detect magnetization transfer effects and can therefore be used to assess ATP synthesis in human liver...
  24. ncbi request reprint Brain energy metabolism during hypoglycaemia in healthy and type 1 diabetic subjects
    M G Bischof
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Austria
    Diabetologia 47:648-51. 2004
    ..This study aimed to examine brain energy metabolism during moderate insulin-induced hypoglycaemia in Type 1 diabetic patients and healthy volunteers...
  25. ncbi request reprint Troglitazone directly inhibits CO(2) production from glucose and palmitate in isolated rat skeletal muscle
    C Fürnsinn
    Department of Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, Austria
    J Pharmacol Exp Ther 293:487-93. 2000
    ..The results demonstrate direct and acute inhibition of fuel oxidation to CO(2) by troglitazone in rat skeletal muscle in vitro...
  26. ncbi request reprint Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression
    B Brunmair
    Department of Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Austria
    Diabetes 50:2309-15. 2001
    ..In summary, our findings provided good evidence that direct inhibition of mitochondrial fuel oxidation in isolated skeletal muscle is a group-specific effect of TZDs and is independent of PPAR-gamma-mediated gene expression...
  27. ncbi request reprint Nuclear magnetic resonance studies of hepatic glucose metabolism in humans
    M Roden
    Department of Internal Medicine III, University of Vienna Medical School, Austria
    Recent Prog Horm Res 56:219-37. 2001
    ....
  28. ncbi request reprint Free fatty acids exert a greater effect on ocular and skin blood flow than triglycerides in healthy subjects
    M Bayerle-Eder
    University of Vienna, Vienna, Austria
    Eur J Clin Invest 34:519-26. 2004
    ..This study was designed to discriminate whether FFA or TG independently induce hyperperfusion by measuring regional and systemic haemodynamics...
  29. ncbi request reprint Adiponectin concentrations increase during acute FFA elevation in humans treated with rosiglitazone
    K Krzyzanowska
    Department of Internal Medicine I, Rudolfstiftung Hospital, Vienna, Austria
    Horm Metab Res 39:769-72. 2007
    ..CRP and resistin were not affected by rosiglitazone or FFAs. The acute increase in circulating adiponectin concentrations during acutely elevated FFA depends on PPAR gamma activation in healthy subjects...
  30. ncbi request reprint Metabolic response to anisoosmolarity of rat skeletal muscle in vitro
    B Brunmair
    Department of Medicine II, University of Vienna, Austria
    Horm Metab Res 32:251-5. 2000
    ....
  31. doi request reprint Three-dimensional high-resolution magnetic resonance spectroscopic imaging for absolute quantification of 31P metabolites in human liver
    M Chmelik
    Karl Landsteiner Institute for Endocrinology and Metabolism, Vienna, Austria
    Magn Reson Med 60:796-802. 2008
    ..This method allows for examination of regional deviations of energy metabolism in human liver diseases...
  32. ncbi request reprint Acute and chronic exposure to tumor necrosis factor-alpha fails to affect insulin-stimulated glucose metabolism of isolated rat soleus muscle
    C Fürnsinn
    Department of Medicine III, University of Vienna, Austria
    Endocrinology 138:2674-9. 1997
    ..The obtained data favor the concept that TNF alpha-dependent muscle insulin resistance in vivo depends on indirect effects rather than direct interaction of the peptide with skeletal muscle...
  33. ncbi request reprint Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature
    M Krebs
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Diabetes Obes Metab 7:621-32. 2005
    ..This review focuses on the effects of increased lipid availability on the regulation of glucose metabolism in skeletal muscle and liver as well as on vascular function...
  34. ncbi request reprint Nutrient-induced insulin resistance in human skeletal muscle
    M Krebs
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Austria
    Curr Med Chem 11:901-8. 2004
    ..Therefore, glucotoxicity might be in part indirectly caused by lipotoxicity (glucolipotoxicity). In conclusion, different nutrients affect common metabolic pathways and thereby induce insulin resistance in humans...
  35. ncbi request reprint Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with Type 2 diabetes mellitus
    M Roden
    I Medical Department, Hanusch Hospital, Vienna, Austria
    Diabet Med 22:1101-6. 2005
    ....
  36. ncbi request reprint Exercise induces excessive normetanephrine responses in hypertensive diabetic patients
    W Raber
    University of Vienna, Vienna, Austria
    Eur J Clin Invest 33:480-7. 2003
    ....
  37. ncbi request reprint Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetes
    M Roden
    Medical Department, Hanusch Hospital, Vienna, Austria
    Int J Obes (Lond) 29:S111-5. 2005
    ..In humans, the causal relationships between obesity and insulin resistance were examined in detail over the last years...
  38. ncbi request reprint Effects of free fatty acids on carbohydrate metabolism and insulin signalling in perfused rat liver
    C Anderwald
    Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 37:774-82. 2007
    ..Thus, we aimed to investigate acute direct effects of specific FFAs on fasting HGP, lactate uptake, and insulin signalling...
  39. ncbi request reprint Acute myopathy in a type 2 diabetic patient on combination therapy with metformin, fenofibrate and rosiglitazone
    M Ledl
    First Medical Department, Hanusch Hospital, Heinrich Collin Strasse 30, A 1140, Vienna, Austria
    Diabetologia 48:1996-8. 2005
    ..This report describes the case of a 75-year-old male type 2 diabetic Caucasian who was admitted to the clinical ward because of acute pain and cramps in both calf muscles...
  40. ncbi request reprint 1H NMR relaxation times of skeletal muscle metabolites at 3 T
    M Krssak
    Division of Endocrinology and Metabolism, Department of Internal Medicine 3, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    MAGMA 16:155-9. 2004
    ..28+/-1 ms, p<0.05). These data can be applied to relaxation correction for the absolute quantification of skeletal muscle metabolite concentrations and further sequence optimization...
  41. ncbi request reprint Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism
    M Artwohl
    Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria
    Diabetologia 48:586-94. 2005
    ....
  42. doi request reprint The impact of risk factors and more stringent diagnostic criteria of gestational diabetes on outcomes in central European women
    A Kautzky-Willer
    Department of Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    J Clin Endocrinol Metab 93:1689-95. 2008
    ....
  43. ncbi request reprint Intracellular calcium in the isolated rat liver: correlation to glucose release, K(+) balance and bile flow
    R Wurzinger
    Department of Pathophysiology, University of Vienna, Austria
    Cell Calcium 30:403-12. 2001
    ..Vasopressin (2 nM) exerts qualitatively similar effects. The transient rise of bile flow is attributed to Ca(2+)-mediated contraction of the pericanalicular actin-myosin web of hepatocytes...
  44. doi request reprint Sex-related psychological effects on metabolic control in type 2 diabetes mellitus
    G Kacerovsky-Bielesz
    Medical Department, Hanusch Hospital, Vienna, Austria
    Diabetologia 52:781-8. 2009
    ..We tested the hypothesis that there are sex-specific differences in glucometabolic control, and in social and psychological factors. We also examined the influence of these factors on glucometabolic control...
  45. ncbi request reprint Transcapillary insulin transfer in human skeletal muscle
    H Herkner
    Department of Clinical Pharmacology, University of Vienna, Medical School, Vienna, Austria
    Eur J Clin Invest 33:141-6. 2003
    ..Transcapillary insulin transfer is considered a rate-limiting step in insulin action at supraphysiological insulin concentrations. However, it remains unclear whether this concept also applies for physiological conditions...
  46. doi request reprint Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults
    Christian Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Heart 96:1191-200. 2010
    ....
  47. doi request reprint Mitochondrial fitness and insulin sensitivity in humans
    J Szendroedi
    First Medical Department, Hanusch Hospital Teaching Hospital of the Medical University of Vienna, Vienna, Austria
    Diabetologia 51:2155-67. 2008
    ..in mitochondrial biogenesis; (3) which geno/phenotypes are associated with both insulin resistance and mitochondrial abnormalities; and (4) which are the most promising targets for improving mitochondrial fitness in insulin resistance?..
  48. ncbi request reprint Elevated serum free fatty acid concentrations inhibit T lymphocyte signaling
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, Austria
    FASEB J 14:939-47. 2000
    ..In conclusion, our data emphasize that serum FFA elevation is able to exert immunosuppressive effects in vivo...
  49. ncbi request reprint Ocular hyperperfusion following onset of intensified insulin therapy is inversely correlated with plasma endothelin-1 in Type I diabetes
    G Fuchsjager-Mayrl
    Department of Clinical Pharmacology, University of Vienna, Vienna, Austria
    Diabetologia 45:883-9. 2002
    ..We hypothesized that these changes in ocular blood flow could be associated with alterations of plasma insulin, glucose or endothelin concentration...
  50. ncbi request reprint In vivo magnetic resonance micro-imaging of the human toe at 3 Tesla
    J C Szeles
    Department of Vascular Surgery, University of Vienna Medical School, Vienna, Austria
    Magn Reson Imaging 19:1235-8. 2001
    ..Thus, high resolution MR micro-imaging at 3 Tesla may provide improved morphologic information in distal extremities of humans in vivo...
  51. doi request reprint Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes
    A Tura
    Metabolic Unit, Institute of Biomedical Engineering ISIB CNR, Padua, Italy
    Diabet Med 29:351-8. 2012
    ..Here, we examined the response of non-esterified fatty acid dynamics to oral glucose loading (oral glucose tolerance test)...
  52. ncbi request reprint News in gut-brain communication: a role of peptide YY (PYY) in human obesity and following bariatric surgery?
    U Hanusch-Enserer
    3rd Medical DepartmentHospital Lainz, Vienna, Austria
    Eur J Clin Invest 35:425-30. 2005
    ..Controversial results on the effect of exogenous administration of PYY(3-36) opened the discussion on the respective roles of PYY and/or PYY(3-36) in body weight homeostasis in man...
  53. ncbi request reprint Modulation by leptin of proliferation and apoptosis in vascular endothelial cells
    M Artwohl
    Department of Internal Medicine III, University of Vienna, Austria
    Int J Obes Relat Metab Disord 26:577-80. 2002
    ..The present study was designed to further examine, whether leptin's proliferative, proangiogenic activity relates to a yet uncovered anti-apoptotic effect...
  54. ncbi request reprint Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans
    W R Sperr
    Department of Cardiology, University of Vienna, Austria
    Thromb Res 90:117-23. 1998
    ..Thus, no significant association between the polymorphisms of any of the studied HPA systems and the development of CAD can be found in central Europeans...
  55. ncbi request reprint The role of intramyocellular lipids during hypoglycemia in patients with intensively treated type 1 diabetes
    Elisabeth Bernroider
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Austria
    J Clin Endocrinol Metab 90:5559-65. 2005
    ..Endocrine defensive mechanisms provide for energy supply during hypoglycemia. Intramyocellular lipids (IMCL) were recently shown to contribute to energy supply during exercise...
  56. ncbi request reprint Insulin glargine in combination with oral antidiabetic drugs as a cost-equivalent alternative to conventional insulin therapy in type 2 diabetes mellitus
    Monika Lechleitner
    University Clinic for Internal Medicine, Innsbruck, Austria
    Wien Klin Wochenschr 117:593-8. 2005
    ..The aim of this observational study was to evaluate the treatment costs of insulin glargine in combination with oral antidiabetic drugs (OADs) compared with conventional insulin therapy in T2DM in everyday clinical practice...
  57. ncbi request reprint The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests
    Attila Brehm
    Division of Endocrinology and Metabolism, Department of Internal Medicine 3, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Clin Endocrinol Metab 91:2272-8. 2006
    ..During insulin-modified frequently sampled iv glucose tolerance tests (IM-FSIGT), which allow assessment of insulin action, plasma glucose can markedly decrease...
  58. ncbi request reprint Reduction of plasma leptin concentrations by arginine but not lipid infusion in humans
    Harald Stingl
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Obes Res 10:1111-9. 2002
    ..We examined short-term effects of arginine infusion on plasma leptin in diabetic and healthy subjects...
  59. ncbi request reprint [Future targets in the treatment of type 2 diabetes]
    Harald Stingl
    Klinische Abteilung für Endokrinologie und Stoffwechsel, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Osterreich
    Wien Klin Wochenschr 116:217-29. 2004
    ..The direct modulation of insulin signal transduction is still limited to experimental studies...
  60. ncbi request reprint Mechanisms of Disease: hepatic steatosis in type 2 diabetes--pathogenesis and clinical relevance
    Michael Roden
    First Medical Department 1 Diabetology, Gastroenterology, Nephrology, Hanusch Hospital, Heinrich Collin Strasse 30, A 1140 Vienna, Austria
    Nat Clin Pract Endocrinol Metab 2:335-48. 2006
    ..In conclusion, liver fat is a critical determinant of metabolic fluxes and inflammatory processes, thereby representing an important therapeutic target in insulin resistance and type 2 diabetes mellitus...
  61. ncbi request reprint Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscle
    Christian Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Austria
    Diabetes 51:3025-32. 2002
    ....
  62. ncbi request reprint Reduction of hepatic glycogen synthesis and breakdown in patients with agenesis of the dorsal pancreas
    Harald Stingl
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
    J Clin Endocrinol Metab 87:4678-85. 2002
    ..3 vs. 2.8 +/- 1.0 ml/kg.min) were increased in all patients. In conclusion, patients with complete agenesis of the dorsal pancreas exhibit marked defects in hepatic glycogen metabolism, which are present even in the nondiabetic offspring...
  63. ncbi request reprint Hepatic autoregulation: response of glucose production and gluconeogenesis to increased glycogenolysis
    Peter Staehr
    Medical Endocrinological Department, Odense University Hospital, Odense, Denmark
    Am J Physiol Endocrinol Metab 292:E1265-9. 2007
    ..While the compensatory response to the galactose administration was not complete, since GP increased, hepatic autoregulation is operative in healthy humans during prolonged fasting...
  64. ncbi request reprint A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects
    Martin O Weickert
    Dept of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Am J Physiol Endocrinol Metab 293:E1078-84. 2007
    ....
  65. ncbi request reprint Muscle type-specific fatty acid metabolism in insulin resistance: an integrated in vivo study in Zucker diabetic fatty rats
    Anja Beha
    Sanofi Aventis Deutschland, Frankfurt Main, Germany
    Am J Physiol Endocrinol Metab 290:E989-97. 2006
    ....
  66. ncbi request reprint Plasma ghrelin in obesity before and after weight loss after laparoscopical adjustable gastric banding
    Ursula Hanusch-Enserer
    Department of Internal Medicine, Wilhelminspital, A 1160 Vienna, Austria
    J Clin Endocrinol Metab 89:3352-8. 2004
    ..In conclusion, prolonged weight loss results in a rise of fasting ghrelin concentrations that correlates with fasting insulin concentrations but not improvement of insulin sensitivity...
  67. ncbi request reprint Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes
    Martin Krssak
    Department of Internal Medicine, Medical University of Vienna, Vienna, Austria
    Diabetes 53:3048-56. 2004
    ....
  68. ncbi request reprint Renal hemodynamic effects of somatostatin are not related to inhibition of endogenous insulin release
    Alice Schmidt
    Department of Clinical Pharmacology, Division of Nephrology and Dialysis, and Institute of Medical Physics, University of Vienna, Vienna, Austria
    Kidney Int 61:1788-93. 2002
    ..Since insulin can cause vasodilation, we hypothesized that removal of basal insulin release by somatostatin may contribute to somatostatin-induced renal vasoconstriction...
  69. ncbi request reprint [Therapy with oral antidiabetic drugs]
    Alexandra Kautzky-Willer
    Klinische Abteilung für Endokrinologie und Stoffwechsel, Univ Klinik für Innere Medizin III, Medizinische Universität Wien, Wien, Osterreich
    Acta Med Austriaca 31:162-3. 2004
    ..The present article represents the recommendations of the Austrian Diabetes Association for the practical use of oral antidiabetic drugs according to current scientific evidence...
  70. ncbi request reprint Thiazolidinediones influence plasma steroids of male obese Zucker rats
    Clemens Fürnsinn
    Department of Medicine III, Division of Endocrinology and Metabolism, University of Vienna, A 1090 Vienna, Austria
    Endocrinology 143:327. 2002
    ....
  71. ncbi request reprint Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia
    Martin G Bischof
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Diabetes 51:49-54. 2002
    ..05. In conclusion, combined long- and short-term intensified insulin substitution normalizes rates of hepatic glycogen synthesis but not the contribution of gluconeogenesis to glycogen synthesis in type 1 diabetes...
  72. ncbi request reprint Mechanism of amino acid-induced skeletal muscle insulin resistance in humans
    Michael Krebs
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Diabetes 51:599-605. 2002
    ..05). In conclusion, plasma amino acid elevation induces skeletal muscle insulin resistance in humans by inhibition of glucose transport/phosphorylation, resulting in marked reduction of glycogen synthesis...
  73. ncbi request reprint Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients
    Christian Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Diabetes 52:1792-8. 2003
    ..These findings indicate an indirect effect of insulin via ghrelin on the suppression of hunger sensation and appetite...
  74. pmc Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes
    Julia Szendroedi
    Department of Internal Medicine 3, University of Vienna, Vienna, Austria
    PLoS Med 4:e154. 2007
    ..We hypothesized that alterations in insulin action and mitochondrial function should be present even in nonobese patients with well-controlled type 2 diabetes mellitus (T2DM)...
  75. ncbi request reprint Inhibition of glucose production and stimulation of bile flow by R (+)-alpha-lipoic acid enantiomer in rat liver
    Christian Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Austria
    Liver 22:355-62. 2002
    ..Because detailed information of RLA action on carbohydrate metabolism in intact liver is lacking, we examined concentration-dependent effects of RLA on hepatic glucose production...
  76. ncbi request reprint The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans
    Martin Krssak
    Division of Endocrinology and Metabolism, Department of Internal Medicine 3, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Rev Endocr Metab Disord 5:127-34. 2004
  77. ncbi request reprint Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2
    Christian Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Austria A 1090
    Mol Endocrinol 16:1612-28. 2002
    ..In conclusion, leptin both alone and in combination with insulin reduces hepatic glucose production by decreasing the synthesis of the key enzyme of gluconeogenesis, PEPCK, which results mainly from the stimulation of the IRS-2 pathway...
  78. ncbi request reprint Muscular mitochondrial dysfunction and type 2 diabetes mellitus
    Vera B Schrauwen-Hinderling
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 10:698-703. 2007
    ..Here, we review human studies that investigated various aspects of mitochondrial function in relation to muscular insulin sensitivity and/or diabetes...
  79. ncbi request reprint Ectopic fat and insulin resistance
    Angelika Lettner
    Medical Department, Hanusch Hospital, Karl Landsteiner Institute of Endocrinology and Metabolism, Heinrich Collin Strasse 30, A 1140 Vienna, Austria
    Curr Diab Rep 8:185-91. 2008
    ..Consequently, ectopic lipid concentrations, particularly in the liver, decrease with lifestyle- or drug-induced improvement of insulin sensitivity...
  80. ncbi request reprint Rosiglitazone prevents free fatty acid-induced vascular endothelial dysfunction
    Friedrich Mittermayer
    Department of Clinical Pharmacology, Medical University Vienna, AKH Wien, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Clin Endocrinol Metab 92:2574-80. 2007
    ..The peroxisome proliferator-activated receptor gamma agonist rosiglitazone acts as insulin sensitizer and could exert vasoprotective properties by preservation of endothelium-dependent vasodilation...
  81. ncbi request reprint The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
    Michael Krebs
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Diabetes 56:1600-7. 2007
    ..In conclusion, rapamycin stimulates insulin-mediated glucose uptake in man under conditions known to activate the mTOR/S6K pathway...
  82. ncbi request reprint [Diabetes mellitus--definition, classification and diagnosis]
    Michael Roden
    Medizinische Abteilung, Hanusch Krankenhaus, Wien, Osterreich
    Acta Med Austriaca 31:156-7. 2004
    ..These data form the basis of the recommendations of the Austrian Diabetes Association for the clinical practice in diabetes...
  83. ncbi request reprint [Therapy with insulin]
    Alexandra Kautzky-Willer
    Klinische Abteilung für Endokrinologie und Stoffwechsel, Univ Klinik für Innere Medizin III, Medizinische Universität Wien, Wien, Osterreich
    Acta Med Austriaca 31:164-5. 2004
    ..The present article represents the recommendations of the Austrian Diabetes Association for the practical use of insulin according to current scientific evidence...
  84. ncbi request reprint Hepatic leptin signaling in obesity
    Georg Brabant
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    FASEB J 19:1048-50. 2005
    ..Thus, the liver seems to play a major role in the modulation of the leptin signal and insulin resistance in obesity...
  85. ncbi request reprint Plasma adiponectin, insulin sensitivity, and subclinical inflammation in women with prior gestational diabetes mellitus
    Christine Winzer
    Department of Medicine III, Vienna University Hospital, Vienna, Austria
    Diabetes Care 27:1721-7. 2004
    ....
  86. pmc Differences in troglitazone action on glucose metabolism in freshly isolated vs long-term incubated rat skeletal muscle
    Florian Gras
    Department of Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Austria
    Br J Pharmacol 138:1140-6. 2003
    ..5. The observed differences in troglitazone action on freshly isolated vs long-term incubated muscle suggest that findings on muscle tissue subject to prolonged maintenance in vitro cannot be extrapolated to native muscle in vivo...
  87. ncbi request reprint Increased plasma levels of plasminogen activator inhibitor-1 and soluble vascular cell adhesion molecule after triacylglycerol infusion in man
    Michael Krebs
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
    Thromb Haemost 90:422-8. 2003
    ..PAI-1 then could contribute to the development of atherothrombotic vascular disease...
  88. ncbi request reprint Ghrelin concentrations in morbidly obese patients after adjustable gastric banding
    Ursula Hanusch-Enserer
    N Engl J Med 348:2159-60. 2003
  89. ncbi request reprint Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle
    Attila Brehm
    First Medical Department, Hanusch Hospital, Heinrich Collin Strasse 30, A 1140 Vienna, Austria
    Diabetes 55:136-40. 2006
    ..0 +/- 0.9 vs. CON 14.6 +/- 1.2 micromol . g muscle(-1) . min(-1), P < 0.05). Physiologically increased plasma FFA concentrations reduce insulin-stimulated muscle ATP synthase flux in parallel with induction of insulin resistance...
  90. ncbi request reprint Diabetic LDL triggers apoptosis in vascular endothelial cells
    Michaela Artwohl
    Department of Internal Medicine III, Division of Clinical Endocrinology and Metabolism, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Diabetes 52:1240-7. 2003
    ..The observed behavior of LDL(D) versus LDL(iv) could be of clinical importance and well relate to differences in structure and cellular uptake of LDL(D) compared with LDL(iv)...
  91. ncbi request reprint Adipotoxicity and the insulin resistance syndrome
    Christian Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Vienna Medical University, Vienna, Austria
    Pediatr Endocrinol Rev 1:310-9. 2004
    ..In conclusion, increased fat intake and expanded body fat are now held responsible for increased FFA availability and hormonal changes which may lead to insulin resistance and type- 2 diabetes...
  92. ncbi request reprint Increased intramyocellular lipid concentration identifies impaired glucose metabolism in women with previous gestational diabetes
    Alexandra Kautzky-Willer
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Austria
    Diabetes 52:244-51. 2003
    ..IMCL could serve as an additional parameter of increased diabetes risk because it identifies insulin-resistant pGDM and those who were diagnosed earlier and/or required insulin during pregnancy...
  93. ncbi request reprint Free fatty acids normalize a rosiglitazone-induced visfatin release
    Dominik G Haider
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Am J Physiol Endocrinol Metab 291:E885-90. 2006
    ..In conclusion, release of the insulin-mimetic visfatin may represent a major mechanism of metabolic TZD action. The presence of FFA antagonizes this action, which may have implications for visfatin bioactivity...
  94. ncbi request reprint C-peptide does not affect ocular blood flow in patients with type 1 diabetes
    Elzbieta Polska
    Department of Clinical Pharmacology, Division of Opthalmo Pharmacology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Diabetes Care 29:2034-8. 2006
    ..The aim of the present study was to investigate the effect of intravenous C-peptide infusion on ocular blood flow in patients with type 1 diabetes under euglycemic conditions...
  95. ncbi request reprint Public health aspects of diabetes mellitus--epidemiology, prevention strategies, policy implications: the first Austrian diabetes report
    Thomas Dorner
    Institute of Social Medicine, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 118:513-9. 2006
  96. ncbi request reprint Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?
    Barbara Brunmair
    Department of Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, Austria
    Diabetes 53:1052-9. 2004
    ..05 each). As both metformin and TZDs inhibit complex I activity and cell respiration in vitro, similar mitochondrial actions could contribute to their antidiabetic effects...