W H Poewe

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Combined assessment of midbrain hyperechogenicity, hyposmia and motor asymmetry improves diagnostic accuracy in early Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, A 6020 Innsbruck, Anichstrasse 35, Austria
    Expert Rev Neurother 12:911-4. 2012
  2. ncbi What is new in movement disorders?
    W Poewe
    Department of Neurology, University of Innsbruck, Austria
    Wien Klin Wochenschr 111:664-71. 1999
  3. ncbi Akathisia, restless legs and periodic limb movements in sleep in Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Neurology 63:S12-6. 2004
  4. doi Dysautonomia and cognitive dysfunction in Parkinson's disease
    Werner Poewe
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 22:S374-8. 2007
  5. ncbi The natural history of Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 253:VII2-6. 2006
  6. ncbi The need for neuroprotective therapies in Parkinson's disease: a clinical perspective
    Werner Poewe
    Department of Neurology, University of Innsbruck, Anichstrasse 35, Innsbruck, Austria
    Neurology 66:S2-9. 2006
  7. ncbi Long-term benefits of rivastigmine in dementia associated with Parkinson's disease: an active treatment extension study
    Werner Poewe
    Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:456-61. 2006
  8. ncbi Treatment of dementia with Lewy bodies and Parkinson's disease dementia
    Werner Poewe
    Department of Neurology, Medical University of Innsbruck, Austria
    Mov Disord 20:S77-82. 2005
  9. ncbi Clinical studies with transdermal rotigotine in early Parkinson's disease
    W Poewe
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Neurology 65:S11-4. 2005
  10. ncbi Role of dopamine transporter imaging in investigation of parkinsonian syndromes in routine clinical practice
    Werner Poewe
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:S16-21. 2003

Detail Information

Publications79

  1. ncbi Combined assessment of midbrain hyperechogenicity, hyposmia and motor asymmetry improves diagnostic accuracy in early Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, A 6020 Innsbruck, Anichstrasse 35, Austria
    Expert Rev Neurother 12:911-4. 2012
    ..The results of this study further support the diagnostic utility of transcranial sonography in diagnosing PD...
  2. ncbi What is new in movement disorders?
    W Poewe
    Department of Neurology, University of Innsbruck, Austria
    Wien Klin Wochenschr 111:664-71. 1999
    ..Nevertheless, symptomatic treatment of movement disorders, as evident in the field of Parkinson's disease, is one of the most rewarding and innovative areas of neurological therapy...
  3. ncbi Akathisia, restless legs and periodic limb movements in sleep in Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Neurology 63:S12-6. 2004
    ..Long-term prospective studies of RLS cohorts will clarify whether or not RLS is associated with an increased risk for development of PD...
  4. doi Dysautonomia and cognitive dysfunction in Parkinson's disease
    Werner Poewe
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 22:S374-8. 2007
    ..This raises the possibility that spread of synuclein pathology to involve neocortical areas producing cognitive decline could be somehow linked to involvement of the autonomic nervous system in PD...
  5. ncbi The natural history of Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 253:VII2-6. 2006
    ..This is now become a realistic possibility with screening tests of olfactory function and subsequent functional imaging. Subjects at risk for Parkinson's disease should be the future focus of neuroprotective trials...
  6. ncbi The need for neuroprotective therapies in Parkinson's disease: a clinical perspective
    Werner Poewe
    Department of Neurology, University of Innsbruck, Anichstrasse 35, Innsbruck, Austria
    Neurology 66:S2-9. 2006
    ..Such future trials will test intervention for their ability to prevent or retard the development of clinically overt PD in at-risk individuals...
  7. ncbi Long-term benefits of rivastigmine in dementia associated with Parkinson's disease: an active treatment extension study
    Werner Poewe
    Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:456-61. 2006
    ..Long-term rivastigmine treatment appeared well tolerated and may provide sustained benefits in dementia associated with PD patients who remain on treatment for up to 48 weeks...
  8. ncbi Treatment of dementia with Lewy bodies and Parkinson's disease dementia
    Werner Poewe
    Department of Neurology, Medical University of Innsbruck, Austria
    Mov Disord 20:S77-82. 2005
    ..Clozapine and quetiapine are the drugs most commonly used and, contrary to classic neuroleptics, risperidone or olanzapine do not seem to cause severe side effects according to published data...
  9. ncbi Clinical studies with transdermal rotigotine in early Parkinson's disease
    W Poewe
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Neurology 65:S11-4. 2005
  10. ncbi Role of dopamine transporter imaging in investigation of parkinsonian syndromes in routine clinical practice
    Werner Poewe
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:S16-21. 2003
    ..DAT-SPECT facilitates differential diagnosis of the different parkinsonian syndromes that cannot be reliably separated on clinical grounds and it can thus provide valuable diagnostic information in early disease...
  11. ncbi Psychosis in Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Mov Disord 18:S80-7. 2003
    ..Cholinesterase inhibitors may prove an additional option in psychotic PD patients with dementia...
  12. ncbi Treatment options for depression and psychosis in Parkinson's disease
    W Poewe
    Department of Neurology, University Hospital Innsbruck, Austria
    J Neurol 248:III12-21. 2001
    ..5 to 15 mg/d seems to aggravate motor symptoms with lesser effect on psychosis compared to clozapine. Currently, clozapine is the atypical neuroleptic of choice for the treatment of drug-induced psychosis in Parkinson's disease...
  13. ncbi Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal levodopa response: a 6-month randomized placebo-controlled double-blind study in Germany and Austria (Celomen study)
    W H Poewe
    Department of Neurology, University Hospital, Innsbruck, Austria
    Acta Neurol Scand 105:245-55. 2002
    ..To determine the efficacy and safety of the catechol-O-methyltransferase (COMT) inhibitor entacapone, used as an adjunct to levodopa, in Parkinson's disease (PD) patients...
  14. doi The clinical progression of Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Parkinsonism Relat Disord 15:S28-32. 2009
    ....
  15. doi Treatments for Parkinson disease--past achievements and current clinical needs
    Werner Poewe
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Neurology 72:S65-73. 2009
    ..As understanding of preclinical markers for PD develops, there is new hope for neuropreventive strategies to target "at risk" populations before clinical onset of disease...
  16. ncbi The differential diagnosis of Parkinson's disease
    W Poewe
    Department of Neurology, University Hospital, Innsbruck, Austria
    Eur J Neurol 9:23-30. 2002
    ..Early diagnosis of atypical parkinsonian disorders is important not only because of prognostic implications, but also because of variable therapeutic targets such as autonomic failure, apraxia or dementia...
  17. pmc Diagnosis and management of Parkinson's disease dementia
    W Poewe
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Int J Clin Pract 62:1581-7. 2008
    ....
  18. ncbi Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy)
    Laura Mantoan
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
    Acta Neuropathol 109:191-7. 2005
    ....
  19. doi The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels
    Birgit Frauscher
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Sleep Med 10:611-5. 2009
    ..The aim of the study was to prospectively examine all patients with a diagnosis of RLS consulting a sleep disorders clinic and to assess RLS severity and augmentation and their associations, including ferritin levels...
  20. ncbi Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007
    ....
  21. doi When a Parkinson's disease patient starts to hallucinate
    Werner Poewe
    Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Pract Neurol 8:238-41. 2008
    ..Visual hallucinations in Parkinson's disease patients with dementia can also be improved by treatment with the cholinesterase inhibitor rivastigmine...
  22. doi Striatal transplantation in a rodent model of multiple system atrophy: effects on L-Dopa response
    Martin Köllensperger
    Section for Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 87:1679-85. 2009
    ..Therefore, striatal transplantation should be further defined preclinically as a possible therapeutic option for patients with MSA-P and a failing L-Dopa response...
  23. doi Red flags for multiple system atrophy
    Martin Köllensperger
    Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 23:1093-9. 2008
    ..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P...
  24. ncbi Evaluation of striatal dopamine transporter function in rats by in vivo beta-[123I]CIT pinhole SPECT
    Christoph Scherfler
    Department of Neurology, The Leopold Franzens University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Neuroimage 17:128-41. 2002
    ..Depending on SPECT ligand availability, a wide range of other CNS receptors may be imaged as well using the presented in vivo technique...
  25. ncbi Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
    Klaus Seppi
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Mov Disord 19:1438-45. 2004
    ..Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM-SPECT in the differential diagnosis of MSA-P versus PD...
  26. pmc Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005
    ..Our results indicate that combined mitochondrial inhibition and overexpression of oligodendroglial alpha-SYN generates a novel model of MSA that may be useful for evaluating both pathogenesis and treatment strategies...
  27. ncbi Progression of parkinsonism in multiple system atrophy
    Klaus Seppi
    Department of Neurology, University Hospital, Innsbruck, Austria
    J Neurol 252:91-6. 2005
    ..However, it may also be subject to considerable variation. Prospective natural history studies using validated rating scales are required to accurately determine the progression of parkinsonism in MSA...
  28. ncbi Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy
    Zoe Puschban
    Experimental Neurodegeneration Laboratory, Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain Res Bull 68:54-8. 2005
    ..e. early stage disease with limited striatal dysfunction...
  29. ncbi Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:353-8. 2007
    ..593; P = 0.01) in the stepping test. These findings contribute further to the behavioral characterization of the double lesion rat model of MSA, improving its value in the evaluation of future neurorestorative strategies...
  30. ncbi High dose levodopa therapy is not toxic in multiple system atrophy: experimental evidence
    Nadia Stefanova
    Clinical Neurobiology Unit, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:969-73. 2007
    ..These findings support the idea that high dose levodopa therapy in MSA is not detrimental to the underlying neuropathological process...
  31. ncbi Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort): a population-based study
    Gregor K Wenning
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Lancet Neurol 4:815-20. 2005
    ..We sought to assess the prevalence of all common categories of movement disorders in a population, accounting for sex differences and age trends...
  32. ncbi Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG)
    Felix Geser
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:179-86. 2006
    ..Our data contribute to the ongoing validation process of UMSARS, and they facilitate the planning and implementation of future neuroprotective intervention trials...
  33. doi Long-term antidyskinetic efficacy of amantadine in Parkinson's disease
    Elisabeth Wolf
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 25:1357-63. 2010
    ..2 (95% CI, 2.1-4.4) to follow-up 3.6 (95% CI, 2.3-4.8) in patients staying on amantadine. These findings argue for long-term antidyskinetic efficacy of amantadine in PD patients with LID's...
  34. doi Restless legs syndrome in Parkinson's disease
    Cecilia M Peralta
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:2076-80. 2009
    ..7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD...
  35. doi Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy?
    Nadia Stefanova
    Department of Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 219:368-71. 2009
    ..Our data suggest that the presence of MSA-like alpha-synuclein oligodendrogliopathy and related to it pro-inflammatory microenvironment may compromise the connectivity and neurorestorative outcome of striatal grafts...
  36. ncbi Cortical atrophy in the cerebellar variant of multiple system atrophy: a voxel-based morphometry study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:159-65. 2006
    ..We observed a volume loss shared by both disorders comprising the cerebellum, vermis, pons, mesencephalon, orbitofrontal, mid-frontal, and temporomesial cortex of both hemispheres as well as the left insular cortex...
  37. ncbi Topography of dopamine transporter availability in progressive supranuclear palsy: a voxelwise [123I]beta-CIT SPECT analysis
    Klaus Seppi
    Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Neurol 63:1154-60. 2006
    ..Most previous SPECT studies have adopted region-of-interest methods for analysis, which are subjective and operator dependent...
  38. ncbi Restless legs syndrome and motor activity during sleep in spinocerebellar ataxia type 6
    Sylvia M Boesch
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Sleep Med 7:529-32. 2006
    ..We investigated the frequency of restless legs syndrome (RLS) and sleep disturbance in spinocerebellar ataxia type 6 (SCA6)...
  39. ncbi Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson's disease
    Michael F H Schocke
    Department of Radiology, University of Innsbruck, Austria
    Neuroimage 21:1443-51. 2004
    ..Because rADCs in one direction are dependent on the slice orientation relative to the directions of fiber tracts, Trace(D) imaging appears to be more accurate in the separation of MSA-P from PD...
  40. ncbi Low concentrations of STI571 in the cerebrospinal fluid: a case report
    Andreas L Petzer
    Abteilung für Hämatologie and Onkologie, Universitatsklinik Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Br J Haematol 117:623-5. 2002
    ..These are the first data demonstrating a low penetration of orally administered STI571 into the CSF in humans...
  41. ncbi Active and passive smoking, chronic infections, and the risk of carotid atherosclerosis: prospective results from the Bruneck Study
    Stefan Kiechl
    Department of Neurology, Innsbruck University Hospital, Innsbruck, Austria
    Stroke 33:2170-6. 2002
    ..The present study sought to estimate the contribution of chronic infections to the variability of atherosclerosis severity among smokers...
  42. ncbi Progression of brain atrophy in multiple system atrophy. A longitudinal VBM study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 254:191-6. 2007
    ..The UPDRS-III score was not significantly correlated with any brain region. Our data suggest that cortical atrophy is prominent in MSA-P and early degeneration of the basal ganglia drives late onset cortical atrophy...
  43. ncbi Allergic rhinitis, asthma, and atherosclerosis in the Bruneck and ARMY studies
    Michael Knoflach
    Department of Pathophysiology, Innsbruck Medical University, Innsbruck, Austria
    Arch Intern Med 165:2521-6. 2005
    ..Several diseases characterized by chronic inflammation and immune activation have been linked to enhanced risk for atherosclerosis. The potential association between allergies and atherosclerosis, however, remains to be defined...
  44. ncbi Diffusion weighted imaging best discriminates PD from MSA-P: A comparison with tilt table testing and heart MIBG scintigraphy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:1771-6. 2007
    ..6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P...
  45. ncbi The role of COMT inhibition in the treatment of Parkinson's disease
    Werner Poewe
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Neurology 62:S31-8. 2004
    ..Studies to determine if administering levodopa in combination with entacapone will delay the development of dyskinesia and motor fluctuations are eagerly awaited...
  46. ncbi Linguistic and neuropsychological deficits in crossed conduction aphasia. Report of three cases
    Lisa Bartha
    Universitaetsklinik fuer Neurologie, Anichstrasse 35, Innsbruck A 6020, Austria
    Brain Lang 88:83-95. 2004
    ..As a result, lesion-behaviour relationships in our study sample indicate both dominant and non-dominant qualities of the right hemisphere...
  47. ncbi Increased daytime sleepiness in Parkinson's disease: a questionnaire survey
    Birgit Hogl
    Department of Neurology, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Mov Disord 18:319-23. 2003
    ..Increased daytime sleepiness is more frequent in patients with PD than in elderly controls. Similar to controls, increased daytime sleepiness in PD patients is correlated with heavy snoring...
  48. ncbi Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
    Christian Brenneis
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:1132-8. 2003
    ..Further studies are required to determine clinical and/or subclinical correlates of cortical atrophy in MSA-P...
  49. doi Rasagiline is neuroprotective in a transgenic model of multiple system atrophy
    Nadia Stefanova
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 210:421-7. 2008
    ..5 mg/kg rasagiline. The results of the study indicate that rasagiline confers neuroprotection in a transgenic mouse model of MSA and may therefore be considered a promising disease-modifying candidate for human MSA...
  50. ncbi Atrophy pattern in SCA2 determined by voxel-based morphometry
    Christian Brenneis
    Department of Neurology, University Hospital of Innsbruck, Innsbruck, Australia
    Neuroreport 14:1799-802. 2003
    ..Two mechanisms could contribute to the observed cortical atrophy. It could be either the result of primary supratentorial degeneration as part of the disease process and/or secondary atrophy due to cerebellar deafferentation...
  51. ncbi Neurological outcome of septic cardioembolic stroke after infective endocarditis
    Elfriede Ruttmann
    Department of Cardiac Surgery, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Stroke 37:2094-9. 2006
    ..The aim of this study was to evaluate mortality and neurological outcomes of cardioembolic cerebral stroke in infective endocarditis (IE) patients requiring cardiac surgery...
  52. ncbi Number processing and basal ganglia dysfunction: a single case study
    Margarete Delazer
    Universitätsklinik für Neurologie, Anichstrasse 35, Innsbruck A 6020, Austria
    Neuropsychologia 42:1050-62. 2004
    ..This study shows that not only parietal lesions may lead to severe deficits in conceptual understanding, but that basal ganglia lesions leading to frontal dysfunction may have a devastating effect...
  53. ncbi Therapeutic strategies in multiple system atrophy
    Gregor K Wenning
    Innsbruck Medical University, Clinical Department of Neurology, Austria
    Mov Disord 20:S67-76. 2005
    ..Because no drug treatment consistently benefits patients with this disease in the long-term, palliative therapies are all the more important. Novel symptomatic and neuroprotective therapies are urgently required...
  54. ncbi In vitro models of multiple system atrophy
    Nadia Stefanova
    Neurological Research Laboratory, Department of Neurology, University Hospital of Innsbruck, Austria
    Mov Disord 20:S53-6. 2005
    ..With this simplified system, we have demonstrated that alpha-synuclein significantly affects the survival of glia and its vulnerability to environmental stress, which might represent a major step in the pathogenesis of MSA...
  55. ncbi How to diagnose dementia with Lewy bodies: state of the art
    Felix Geser
    Clinical Department of Neurology, Medical University Innsbruck, Austria
    Mov Disord 20:S11-20. 2005
    ..We review the present state of the best practice in the clinical diagnosis of DLB. Future modifications of diagnostic criteria would ideally include the full range of clinical presentations that can be associated with LB disease...
  56. ncbi Abnormalities of dopaminergic neurotransmission in SCA2: a combined 123I-betaCIT and 123I-IBZM SPECT study
    Sylvia M Boesch
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1320-5. 2004
    ..Both slowness of limb movements as well as dystonia in the ataxic SCA2 phenotype may reflect dysfunction not only at cerebellar but also at basal ganglia level...
  57. ncbi Voxel-based morphometry in narcolepsy
    Christian Brenneis
    Department of Neurology, Medical University Innsbruck, Anichstr 35, 6020 Innsbruck, Austria
    Sleep Med 6:531-6. 2005
    ..Recent studies using this technique reported controversial results in patients with narcolepsy...
  58. ncbi Diffusion-weighted imaging in Huntington's disease
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1043-7. 2006
    ..Diffusion-weighted imaging appears to be a promising surrogate marker for disease severity in HD. Sensitivity to change remains to be established longitudinally...
  59. ncbi Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
    ..We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]beta-CIT SPECT in patients with uncertain parkinsonism...
  60. ncbi Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats
    Christoph Scherfler
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Neuroimage 24:822-31. 2005
    ..SPECT-MRI-based estimation of regional [123I]IBZM uptake provides a cost effective and widely available in vivo imaging technique for assessing striatal integrity in animal studies...
  61. ncbi Oxcarbazepine in glossopharyngeal neuralgia: clinical response and effect on serum lipids
    Gerhard Luef
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, A 6020, Austria
    Neurology 63:2447-8. 2004
  62. ncbi Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
    Gregor K Wenning
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1391-402. 2004
    ..Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients...
  63. ncbi Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration
    Nadia Stefanova
    Neurodegeneration Research Laboratory, Innsbruck MSA Study Group, Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 78:87-91. 2004
    ..We conclude that despite its astrocytic and microglial suppression, minocycline failed to attenuate lesion-induced neuronal damage in the SND rat model...
  64. ncbi Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 129:538-42. 2006
    ..Whether DWI can be used as a marker to identify individuals at risk to develop this disease remains to be shown...
  65. ncbi Homocysteine and serum markers of immune activation in primary dystonia
    Ulf J Muller
    University Hospital of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 20:1663-7. 2005
    ..HCY is a neuronal excitotoxic amino acid and hyperhomocysteinemia is considered an independent vascular risk factor. Further studies are required to define the background of hyperhomocysteinemia in primary dystonia...
  66. ncbi Topography of cerebral monoamine transporter availability in families with SCA2 mutations: a voxel-wise [123I]beta-CIT SPECT analysis
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:1084-90. 2006
    ..To this end, nine patients were studied with [(123)I]beta-CIT SPECT...
  67. ncbi Basal forebrain atrophy is a distinctive pattern in dementia with Lewy bodies
    Christian Brenneis
    Department of Neurology, University Hospital of Innsbruck, Anichstr 35, 6020 Innsbruck, Austria
    Neuroreport 15:1711-4. 2004
    ..Atrophy of insular cortex was found in both patient groups...
  68. ncbi Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuroimage 31:240-5. 2006
    ....
  69. ncbi Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease
    Stefan Kiechl
    Department of Neurology, University Clinic, Anichstrasse 35, A 6020 Innsbruck, Austria
    Circulation 109:2175-80. 2004
    ..Recent experimental research has implicated osteoprotegerin in atherogenesis, but epidemiological confirmation of this concept is sparse...
  70. ncbi Restless legs syndrome
    Birgit Hogl
    Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
    Curr Opin Neurol 18:405-10. 2005
    ..Those with the most significant findings were selected and will be reviewed...
  71. ncbi Health-related quality of life in multiple system atrophy
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 21:809-15. 2006
    ....
  72. ncbi Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004
    Christopher G Goetz
    Department of Neurological Sciences, Department of Pharmacology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 20:523-39. 2005
    ..We consider a 3-year period a reasonable time frame for published updates and are working to establish a Web-based mechanism to update the report in an ongoing manner...
  73. ncbi Ten-year follow-up of Parkinson's disease patients randomized to initial therapy with ropinirole or levodopa
    Robert A Hauser
    Parkinson s Disease and Movement Disorders Center, University of South Florida, Tampa, Florida 33606, USA
    Mov Disord 22:2409-17. 2007
    ..Early treatment decisions for individual patients depend largely on the anticipated risk of side effects and long-term complications. Both ropinirole and levodopa are viable treatment options in early PD...
  74. ncbi Parkinsonism in multiple system atrophy: natural history, severity (UPDRS-III), and disability assessment compared with Parkinson's disease
    Francois Tison
    Federation de Neurologie, Epidémiologie et Biostatistiques Centre Hospitalo Universitaire de Bordeaux, Bordeaux, France
    Mov Disord 17:701-9. 2002
    ..It also indicates that the UPDRS-III provides a useful severity measure of parkinsonism in MSA, albeit contaminated by additional cerebellar dysfunction...
  75. pmc Depression rating scales in Parkinson's disease: critique and recommendations
    Anette Schrag
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Mov Disord 22:1077-92. 2007
    ..The complex and time-consuming task of developing a new scale to measure depression specifically for patients with PD is currently not warranted...
  76. doi Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Kassel, Germany
    Lancet Neurol 7:595-604. 2008
    ..Continuous administration of a dopamine agonist could be used to treat patients with restless legs syndrome. Our aim was to investigate the efficacy of transdermal rotigotine in the treatment of idiopathic restless legs syndrome...
  77. ncbi Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    ..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...
  78. ncbi [Dementia with Lewy Bodies and its differentiation from Alzheimer's disease]
    Gerhard Ransmayr
    Neurologische Universitätsklinik Graz, Medizinische Universitat Graz
    Neuropsychiatr 21:63-74. 2007
    ..We also guide in the management of DLB as pharmacological treatment can pose difficult dilemmas for the treating clinician...
  79. ncbi Effects of rivastigmine on tremor and other motor symptoms in patients with Parkinson's disease dementia: a retrospective analysis of a double-blind trial and an open-label extension
    Wolfgang Oertel
    Department of Neurology, Philipps University, Marburg, Germany
    Drug Saf 31:79-94. 2008
    ..The current analyses were performed to examine the potential of rivastigmine to affect tremor and other motor symptoms in patients with PDD...