Jan Michael Peters

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Molecular biology. How and when the genome sticks together
    Erwan Watrin
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 317:209-10. 2007
  2. ncbi request reprint The anaphase-promoting complex: proteolysis in mitosis and beyond
    Jan Michael Peters
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mol Cell 9:931-43. 2002
  3. doi request reprint Checkpoint control: the journey continues
    Jan Michael Peters
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 18:R170-2. 2008
  4. ncbi request reprint The anaphase promoting complex/cyclosome: a machine designed to destroy
    Jan Michael Peters
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Mol Cell Biol 7:644-56. 2006
  5. ncbi request reprint Wapl controls the dynamic association of cohesin with chromatin
    Stephanie Kueng
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 127:955-67. 2006
  6. ncbi request reprint TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1
    Hartmut C Vodermaier
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 13:1459-68. 2003
  7. ncbi request reprint Regulation of sister chromatid cohesion between chromosome arms
    Juan F Giménez-Abián
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 14:1187-93. 2004
  8. pmc APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex
    Kristina Uzunova
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Struct Mol Biol 19:1116-23. 2012
  9. ncbi request reprint Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression
    Erwan Watrin
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 16:863-74. 2006
  10. pmc Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads
    Johann Holzmann
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    J Proteome Res 10:780-9. 2011

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Molecular biology. How and when the genome sticks together
    Erwan Watrin
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 317:209-10. 2007
  2. ncbi request reprint The anaphase-promoting complex: proteolysis in mitosis and beyond
    Jan Michael Peters
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mol Cell 9:931-43. 2002
    ....
  3. doi request reprint Checkpoint control: the journey continues
    Jan Michael Peters
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 18:R170-2. 2008
    ..Mad2 and p31(comet) are components of the spindle assembly checkpoint which controls the fidelity of chromosome segregation. Two recent structural studies reveal new insight into how these proteins achieve this difficult task...
  4. ncbi request reprint The anaphase promoting complex/cyclosome: a machine designed to destroy
    Jan Michael Peters
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Mol Cell Biol 7:644-56. 2006
    ..5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates...
  5. ncbi request reprint Wapl controls the dynamic association of cohesin with chromatin
    Stephanie Kueng
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 127:955-67. 2006
    ..Wapl depletion also increases the residence time of cohesin on chromatin in interphase. Our data indicate that Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin...
  6. ncbi request reprint TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1
    Hartmut C Vodermaier
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 13:1459-68. 2003
    ..The APC is a ubiquitin ligase composed of at least 11 subunits. The interaction of APC2 and APC11 with E2 enzymes is sufficient for ubiquitination reactions, but the functions of most other subunits are unknown...
  7. ncbi request reprint Regulation of sister chromatid cohesion between chromosome arms
    Juan F Giménez-Abián
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 14:1187-93. 2004
    ..This loss is prevented by proteasome inhibitors, implying that it depends on separase activation. Separase may therefore be able to cleave cohesin at centromeres and on chromosome arms...
  8. pmc APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex
    Kristina Uzunova
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Struct Mol Biol 19:1116-23. 2012
    ..We propose that APC15 and Mnd2 negatively regulate APC/C coactivators and report generation of recombinant human APC/C...
  9. ncbi request reprint Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression
    Erwan Watrin
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 16:863-74. 2006
    ..Mutation of Scc2 orthologs causes defects in cohesion, transcription, and development, resulting in Cornelia de Lange syndrome in humans...
  10. pmc Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads
    Johann Holzmann
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    J Proteome Res 10:780-9. 2011
    ..In summary, we show that the protease elution protocol increases the recovery from affinity beads and is compatible with quantitative measurements such as the stoichiometry determination of protein complexes...
  11. ncbi request reprint Regulation of human separase by securin binding and autocleavage
    Irene Waizenegger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030, Vienna, Austria
    Curr Biol 12:1368-78. 2002
    ..In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated...
  12. pmc Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2
    Silke Hauf
    Research Institute of Molecular Pathology, Vienna, Austria
    PLoS Biol 3:e69. 2005
    ..The similarity of the phenotype obtained after expression of nonphosphorylatable SA2 in human cells to that seen after the depletion of Plk1 suggests that SA2 is the critical target of Plk1 in the cohesin dissociation pathway...
  13. doi request reprint A new acid mix enhances phosphopeptide enrichment on titanium- and zirconium dioxide for mapping of phosphorylation sites on protein complexes
    Michael Mazanek
    Institute of Molecular Biotechnology, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    J Chromatogr B Analyt Technol Biomed Life Sci 878:515-24. 2010
    ....
  14. doi request reprint Sororin mediates sister chromatid cohesion by antagonizing Wapl
    Tomoko Nishiyama
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 143:737-49. 2010
    ..The mechanism we describe here may therefore be widely conserved among different species...
  15. pmc The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
    Silke Hauf
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    J Cell Biol 161:281-94. 2003
    ..Together, our data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling...
  16. ncbi request reprint Distinct functions of condensin I and II in mitotic chromosome assembly
    Toru Hirota
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    J Cell Sci 117:6435-45. 2004
    ..These results reveal that condensin II and I associate with chromosomes sequentially and have distinct functions in mitotic chromosome assembly...
  17. doi request reprint Wapl is an essential regulator of chromatin structure and chromosome segregation
    Antonio Tedeschi
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nature 501:564-8. 2013
    ....
  18. pmc Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells
    Barry E McGuinness
    Research Institute of Molecular Pathology, Vienna, Austria
    PLoS Biol 3:e86. 2005
    ..Centromeric cohesion is one of the hallmarks of mitotic chromosomes. Our results imply that it is not an intrinsically stable property, because it can easily be destroyed by mitotic kinases, which are kept in check by shugoshin...
  19. ncbi request reprint The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase
    Izabela Sumara
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mol Cell 9:515-25. 2002
    ..Cohesin phosphorylation depends on Polo-like kinase and reduces the ability of cohesin to bind to chromatin. These results suggest that Polo-like kinase regulates the dissociation of cohesin from chromosomes early in mitosis...
  20. ncbi request reprint Roles of polo-like kinase 1 in the assembly of functional mitotic spindles
    Izabela Sumara
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 14:1712-22. 2004
    ....
  21. ncbi request reprint The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1
    Peter Lenart
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Curr Biol 17:304-15. 2007
    ..Cdk1 and Aurora kinase studies have been facilitated by small-molecule inhibitors, but few if any potent Plk1 inhibitors have been identified...
  22. doi request reprint Systematic phosphorylation analysis of human mitotic protein complexes
    Björn Hegemann
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Sci Signal 4:rs12. 2011
    ..Combination of the results of the cellular studies with Scansite motif prediction enabled us to identify 14 sites on six proteins as direct candidate substrates of AURKB or PLK1...
  23. pmc Mitotic regulation of the human anaphase-promoting complex by phosphorylation
    Claudine Kraft
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    EMBO J 22:6598-609. 2003
    ..Plk1 depletion neither prevents APC phosphorylation nor cyclin A destruction in vivo. These observations imply that APC activation is initiated by Cdk1 already in the nuclei of late prophase cells...
  24. pmc Systematic analysis of human protein complexes identifies chromosome segregation proteins
    James R A Hutchins
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 328:593-9. 2010
    ..The approaches we describe here are generally applicable to high-throughput follow-up analyses of phenotypic screens in mammalian cells...
  25. pmc Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin
    Tomoko Nishiyama
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 110:13404-9. 2013
    ..We propose that the stepwise loss of cohesion between chromosome arms and centromeres is caused by local regulation of Wapl activity, which is controlled by the phosphorylation state of Sororin. ..
  26. pmc Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome
    Karin Grosstessner-Hain
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    Mol Cell Proteomics 10:M111.008540. 2011
    ..Analysis of amino acid sequence motifs among phosphorylation sites down-regulated under PLK1 inhibition in this data set identified two potential novel variants of the PLK1 consensus motif...
  27. ncbi request reprint Methods to measure ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex
    Claudine Kraft
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Methods 38:39-51. 2006
    ..We also describe procedures to analyze the ubiquitination activity associated with recombinant Apc11...
  28. ncbi request reprint Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase
    Julia Schmitz
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 17:630-6. 2007
    ..Our data indicate that sororin interacts with chromatin-bound cohesin and functions during the establishment or maintenance of cohesion in S or G2 phase, respectively...
  29. ncbi request reprint Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes
    Jesse J Lipp
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    J Cell Sci 120:1245-55. 2007
    ..Our data indicate that Aurora B contributes to chromosome rigidity and segregation by promoting the binding of condensin I to chromatin. We have also addressed how Aurora B might mediate the dissociation of cohesin from chromosome arms...
  30. ncbi request reprint The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates
    Claudine Kraft
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mol Cell 18:543-53. 2005
    ..Our data imply that APC/C is activated by the association of Cdh1 with Cdc27, which enables APC/C to recognize the D box of substrates via Cdh1's propeller domain...
  31. doi request reprint Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1
    Bettina A Buschhorn
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Nat Struct Mol Biol 18:6-13. 2011
    ..Our results suggest that substrates are recruited to the APC/C by binding to a bipartite substrate receptor composed of a coactivator protein and Doc1...
  32. doi request reprint Cohesin mediates transcriptional insulation by CCCTC-binding factor
    Kerstin S Wendt
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nature 451:796-801. 2008
    ..We propose that cohesin functions as a transcriptional insulator, and speculate that subtle deficiencies in this function contribute to 'cohesinopathies' such as Cornelia de Lange syndrome...
  33. ncbi request reprint Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex
    Jan Michael Peters
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Mol Cell 11:1420-1. 2003
    ..and Margottin-Goguet et al. in the June issue of Developmental Cell now show that Emi1 degradation in early mitosis is mediated by beta-Trcp1, an adaptor protein that recruits proteins to the SCF ubiquitin ligase...
  34. ncbi request reprint Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin
    Toru Hirota
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Nature 438:1176-80. 2005
    ..H3 phosphorylation by Aurora B is therefore part of a 'methyl/phos switch' mechanism that displaces HP1 and perhaps other proteins from mitotic heterochromatin...
  35. doi request reprint How cohesin and CTCF cooperate in regulating gene expression
    Kerstin S Wendt
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Chromosome Res 17:201-14. 2009
    ..Here we review what is known about the roles of cohesin and CTCF in regulating gene expression in mammalian cells, and we discuss how cohesin might mediate the insulator function of CTCF...
  36. pmc Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression
    Karin G Wirth
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    J Cell Biol 172:847-60. 2006
    ..Separase depletion in bone marrow causes aplasia and the presumed death of hematopoietic cells other than erythrocytes. Destruction of sister chromatid cohesion by Separase may be a universal feature of mitosis in eukaryotic cells...
  37. ncbi request reprint Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noise
    Nedim Mujezinovic
    Research Institute of Molecular Pathology, Vienna, Austria
    Proteomics 6:5117-31. 2006
    ..The approach is based on numerical spectral analysis and signal detection methods. The algorithm has been implemented in a stand-alone computer program called MS Cleaner that can be obtained from the authors upon request...
  38. pmc The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells
    Erwan Watrin
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    EMBO J 28:2625-35. 2009
    ..We propose that accumulation of cohesin at DNA break sites is not only needed to mediate DNA repair, but also facilitates the recruitment of checkpoint proteins, which activate the intra-S and G2/M checkpoints...
  39. pmc Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex
    Franz Herzog
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Science 323:1477-81. 2009
    ..These observations clarify the structural basis for the inhibition of APC/C by spindle checkpoint proteins...
  40. ncbi request reprint Checkpoint activation: don't get mad too much
    Peter Lenart
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 16:R412-4. 2006
    ..The Mad2 protein is required to delay sister chromatid separation until all chromosomes have been aligned on the mitotic spindle. Two recent studies provide new insights into how Mad2 contributes to this remarkable task...
  41. doi request reprint Cohesin acetylation: from antiestablishment to establishment
    Jan Michael Peters
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell 34:1-2. 2009
    ..In a recent issue of Molecular Cell, Rowland et al. (2009) report that acetylation of cohesin in S phase transiently counteracts an intrinsic "antiestablishment" activity and, thus, enables establishment of sister chromatid cohesion...
  42. ncbi request reprint Identification of cell cycle-dependent phosphorylation sites on the anaphase-promoting complex/cyclosome by mass spectrometry
    Franz Herzog
    Research Institute of Molecular Pathology IMP, 1030 Vienna, Austria
    Methods Enzymol 398:231-45. 2005
    ....
  43. ncbi request reprint Cohesin and DNA damage repair
    Erwan Watrin
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Exp Cell Res 312:2687-93. 2006
    ..We discuss how cohesin and sister chromatid cohesion might facilitate the repair of damaged DNA...
  44. ncbi request reprint The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells
    Birgit Koch
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Chromosoma 117:199-210. 2008
    ..Our data indicate that the Suv39h-HP1 pathway is not essential for enrichment and mitotic protection of cohesin at centromeres in mammalian cells...
  45. doi request reprint The cohesin complex and its roles in chromosome biology
    Jan Michael Peters
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Genes Dev 22:3089-114. 2008
    ....
  46. ncbi request reprint Cyclin degradation: don't mes(s) with meiosis
    Jan Michael Peters
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Curr Biol 15:R461-3. 2005
    ..A recent study in fission yeast shows that, during exit from meiosis I, the Mes1 protein partially inhibits cyclin degradation and thereby allows entry into meiosis II without an intervening S phase...
  47. ncbi request reprint Titanium dioxide as a chemo-affinity solid phase in offline phosphopeptide chromatography prior to HPLC-MS/MS analysis
    Michael Mazanek
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Protoc 2:1059-69. 2007
    ..These agents also improve the binding of phosphorylated peptides and block the binding of non-phosphorylated ones. This enrichment procedure takes 30 min, followed by a 100-min HPLC program, including washing and an elution gradient...
  48. ncbi request reprint Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A
    Foong May Yeong
    Institute of Medical Biochemistry, Division of Molecular Biology, Vienna Biocenter, University of Vienna, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    Curr Biol 13:2058-64. 2003
    ..hHCP-6 is therefore part of a condensin-related complex that associates with chromosomes in mitosis and may be regulated by PP2A...
  49. ncbi request reprint Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle
    Mark Petronczki
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Dev Cell 12:713-25. 2007
    ..We propose that late mitotic Plk1 activity promotes recruitment of Ect2 to the central spindle, triggering the initiation of cytokinesis and contributing to cleavage plane specification in human cells...
  50. ncbi request reprint APC activators caught by their tails?
    Hartmut C Vodermaier
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, Austria
    Cell Cycle 3:265-6. 2004
    ..In this article, we discuss the implications of these findings on our current understanding of APC activation...
  51. doi request reprint Preventing carryover of peptides and proteins in nano LC-MS separations
    Goran Mitulovic
    Institute of Molecular Biotechnology of the Austrian Academy of Science, Dr Bohr Gasse 3, A 1030 Vienna, Austria
    Anal Chem 81:5955-60. 2009
    ..By application of this method, a significant reduction in carryover was achieved without any loss in the amount of proteins and peptides identified by MS...
  52. ncbi request reprint Large-scale purification of the vertebrate anaphase-promoting complex/cyclosome
    Franz Herzog
    Research Institute of Molecular Pathology IMP, 1030 Vienna, Austria
    Methods Enzymol 398:175-95. 2005
    ..5 mg of APC/C. This procedure should facilitate biochemical, biophysical, and structural analyses of the APC/C that will be needed for a better mechanistic understanding of its function and regulation...
  53. ncbi request reprint The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation
    Endre Mathe
    Cancer Research UK Cell Cycle Genetics Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Curr Biol 14:1723-33. 2004
    ..Substrate specificity and temporal activity of the APC/C has been thought to lie primarily with its two activators, Cdc20/Fizzy and Cdh1/Fizzy-related...
  54. pmc Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
    Anja Hagting
    Wellcome Cancer Research UK Institute, Cambridge CB2 1QR, United Kingdom
    J Cell Biol 157:1125-37. 2002
    ..Thus, defects in securin destruction alter chromosome segregation and may be relevant to the development of aneuploidy in cancer...
  55. ncbi request reprint Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells
    Daniel Gerlich
    Gene Expression and Cell Biology Biophysics Programmes, EMBL, 69117 Heidelberg, Germany
    Curr Biol 16:333-44. 2006
    ..Their function under physiological conditions still needs to be defined...
  56. doi request reprint Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1
    Mark Petronczki
    Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, United Kingdom
    Dev Cell 14:646-59. 2008
    ..In particular, we highlight new work on the role of Plk1 in cytokinesis in human cells. Finally, we describe how better understanding of Plk1 functions allows critical evaluation of Plk1 as a potential drug target for cancer therapy...
  57. doi request reprint Polo and Aurora kinases: lessons derived from chemical biology
    Stephen Taylor
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Manchester, UK
    Curr Opin Cell Biol 20:77-84. 2008
    ..These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission...
  58. ncbi request reprint The complete removal of cohesin from chromosome arms depends on separase
    Masato Nakajima
    Department of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research JFCR, Tokyo, Japan
    J Cell Sci 120:4188-96. 2007
    ....
  59. ncbi request reprint How APC/C orders destruction
    Bettina A Buschhorn
    Nat Cell Biol 8:209-11. 2006
  60. ncbi request reprint Cell biology: the checkpoint brake relieved
    Jan Michael Peters
    Nature 446:868-9. 2007
  61. ncbi request reprint Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication
    Daniel Gerlich
    Gene Expression Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Curr Biol 16:1571-8. 2006
    ....
  62. ncbi request reprint BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo
    Martin Steegmaier
    Boehringer Ingelheim Austria GmbH, Dr Boehringer Gasse 5 11, A 1121 Vienna, Austria
    Curr Biol 17:316-22. 2007
    ..For addressing the therapeutic potential of Plk1 inhibition, BI 2536 has progressed into clinical studies in patients with locally advanced or metastatic cancers...
  63. ncbi request reprint Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C
    Prakash Dube
    Max Planck Institute for Biophysical Chemistry, Goettingen, Germany
    Mol Cell 20:867-79. 2005
    ..We have further identified a large flexible domain in APC/C that adopts a different orientation upon Cdh1 binding. Cdh1 may thus activate APC/C both by recruiting substrates and by inducing conformational changes...
  64. doi request reprint Twenty years of cell-cycle conferences in Roscoff
    Isabelle Vernos
    Center for Genomic Regulation CRG, UPF, Barcelona, Spain
    Nat Cell Biol 10:877-80. 2008
    ..At the end of April 2008, the cell-cycle community celebrated the twentieth anniversary of the Jacques-Monod cell-cycle conferences in Roscoff (France), where the discovery of Cdk1 as a key cell-cycle regulator was first discussed in 1988...