J M Peters

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Subunits and substrates of the anaphase-promoting complex
    J M Peters
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, Vienna, A 1030, Austria
    Exp Cell Res 248:339-49. 1999
  2. ncbi request reprint SCF and APC: the Yin and Yang of cell cycle regulated proteolysis
    J M Peters
    Research Institute of Molecular Pathology IMP Dr Bohr Gasse 7 A 1030 Vienna Austria
    Curr Opin Cell Biol 10:759-68. 1998
  3. pmc Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
    C Gieffers
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 96:11317-22. 1999
  4. pmc The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
    M Gmachl
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 97:8973-8. 2000
  5. pmc Characterization of vertebrate cohesin complexes and their regulation in prophase
    I Sumara
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    J Cell Biol 151:749-62. 2000
  6. ncbi request reprint Splitting the chromosome: cutting the ties that bind sister chromatids
    K Nasmyth
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 288:1379-85. 2000
  7. ncbi request reprint Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex
    R Grossberger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Biol Chem 274:14500-7. 1999
  8. ncbi request reprint Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
    S Hauf
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 293:1320-3. 2001
  9. ncbi request reprint Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family
    E R Kramer
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Curr Biol 8:1207-10. 1998
  10. pmc A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
    C S Sørensen
    Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen Ø, Denmark
    Mol Cell Biol 21:3692-703. 2001

Collaborators

  • F Uhlmann
  • W Zachariae
  • Peter K Jackson
  • K S Wendt
  • K Nasmyth
  • M Hengstschlager
  • C Gieffers
  • E R Kramer
  • C Lukas
  • C S Sørensen
  • J Bartek
  • J Lukas
  • J D Reimann
  • I C Waizenegger
  • P V Jallepalli
  • S Geley
  • S Hauf
  • I Sumara
  • C S Sorensen
  • E Kramer
  • B O Petersen
  • M Gmachl
  • M Mann
  • A V Podtelejnikov
  • B H Peters
  • R Grossberger
  • R W King
  • Y L Juang
  • H Yu
  • M W Kirschner
  • J R Harris
  • B Vogelstein
  • K W Kinzler
  • J Gannon
  • J Y Hsu
  • F Bunz
  • P Dube
  • S Langer
  • C Lengauer
  • M R Speicher
  • T Hunt
  • H Stark
  • E Freed
  • F Marinoni
  • E Lazzerini Denchi
  • C Wagener
  • K Helin
  • C Matteucci
  • M Melixetian
  • E Vorlaufer
  • C Rabouille
  • E Santoni-Rugiu
  • C Lindeneg
  • A Schleiffer
  • C G Dotti
  • G Hölzl
  • M E McLaughlin
  • C Y Tai
  • D Pellman
  • J Huang
  • R J Deshaies
  • T P Levine
  • G Warren

Detail Information

Publications23

  1. ncbi request reprint Subunits and substrates of the anaphase-promoting complex
    J M Peters
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, Vienna, A 1030, Austria
    Exp Cell Res 248:339-49. 1999
    ..The APC also mediates the ubiquitin-dependent proteolysis of several other mitotic regulators, including other protein kinases, APC activators, spindle-associated proteins, and inhibitors of DNA replication...
  2. ncbi request reprint SCF and APC: the Yin and Yang of cell cycle regulated proteolysis
    J M Peters
    Research Institute of Molecular Pathology IMP Dr Bohr Gasse 7 A 1030 Vienna Austria
    Curr Opin Cell Biol 10:759-68. 1998
    ..Both complexes are now known to exist in different forms that target different substrates for ubiquitin-dependent proteolysis...
  3. pmc Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
    C Gieffers
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 96:11317-22. 1999
    ..On the basis of these results, we propose that the functions of APC(CDH1) are not restricted to controlling cell-cycle progression but may include the ubiquitination of yet unidentified substrates in differentiated cells...
  4. pmc The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
    M Gmachl
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 97:8973-8. 2000
    ..These results suggest that APC11 and UBC4 catalyze the formation of isopeptide bonds in APC-mediated ubiquitination reactions...
  5. pmc Characterization of vertebrate cohesin complexes and their regulation in prophase
    I Sumara
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    J Cell Biol 151:749-62. 2000
    ..These results suggest that vertebrate cohesins are regulated by a novel prophase pathway which is distinct from the APC pathway that controls cohesins in yeast...
  6. ncbi request reprint Splitting the chromosome: cutting the ties that bind sister chromatids
    K Nasmyth
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 288:1379-85. 2000
    ..Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's subunits may trigger sister separation at the onset of anaphase...
  7. ncbi request reprint Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex
    R Grossberger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Biol Chem 274:14500-7. 1999
    ..DOC domains may therefore be important for reactions catalyzed by several types of ubiquitin-protein ligases...
  8. ncbi request reprint Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
    S Hauf
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 293:1320-3. 2001
    ..Our results indicate that cohesin cleavage by separase is essential for sister chromatid separation and for the completion of cytokinesis...
  9. ncbi request reprint Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family
    E R Kramer
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Curr Biol 8:1207-10. 1998
    ..The temporally distinct association of hCDC20 and hCDH1 with APC suggests that these proteins are, respectively, mitosis-specific and G1-specific activating subunits of APC...
  10. pmc A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
    C S Sørensen
    Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen Ø, Denmark
    Mol Cell Biol 21:3692-703. 2001
    ..Collectively, these data provide a mechanistic explanation for the mutual functional interplay between cyclin A-Cdk2 and APC-Cdh1 and the first evidence that Cdh1 may activate the APC by binding specific substrates...
  11. ncbi request reprint Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex
    J D Reimann
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 105:645-55. 2001
    ..Our results suggest that Emi1 regulates progression through early mitosis by preventing premature APC activation, and may help explain the well-known delay between cyclin B/Cdc2 activation and cyclin B destruction...
  12. ncbi request reprint Three-dimensional structure of the anaphase-promoting complex
    C Gieffers
    Research Institute of Molecular Pathology (IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Mol Cell 7:907-13. 2001
    ..This cage hypothesis could help to explain the great subunit complexity of the APC...
  13. pmc Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
    S Geley
    Imperial Cancer Research Fund Clare Hall Laboratories, South Mimms, Herts EN6 3LD, United Kingdom
    J Cell Biol 153:137-48. 2001
    ..Overexpression of wild-type cyclin A delayed the metaphase to anaphase transition, whereas expression of cyclin A mutants lacking a D-box arrested cells in anaphase...
  14. pmc Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis
    C S Sorensen
    Danish Cancer Society, Institute of Cancer Biology, DK 2100 Copenhagen O, Denmark
    Mol Cell Biol 20:7613-23. 2000
    ....
  15. pmc Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1
    B O Petersen
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Genes Dev 14:2330-43. 2000
    ..The APC-CDH1-dependent proteolysis of CDC6 in early G(1) and in quiescent cells suggests that this process is part of a mechanism that ensures the timely licensing of replication origins during G(1)...
  16. ncbi request reprint Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex
    K S Wendt
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Nat Struct Biol 8:784-8. 2001
    ..We further provide biochemical evidence that the C-terminus of APC10 binds to CDC27/APC3, an APC subunit that contains multiple tetratrico peptide repeats...
  17. ncbi request reprint Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
    C Lukas
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen
    Nature 401:815-8. 1999
    ..These results implicate an E2F-dependent, cyclin A/Cdk2-mediated phosphorylation of Cdh1 in the timely accumulation of cyclin B1 and the coordination of cell-cycle progression during the post-restriction point period...
  18. ncbi request reprint How proteolysis drives the cell cycle
    R W King
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Science 274:1652-9. 1996
    ..Proteolysis therefore drives cell cycle progression not only by regulating CDK activity, but by directly influencing chromosome and spindle dynamics...
  19. ncbi request reprint Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation
    H Yu
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 6:455-66. 1996
    ..A similar activity (E2-C) has also been observed in clams. However, the molecular identity of Xenopus UBCx or clam E2-C has not been established...
  20. ncbi request reprint APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle
    Y L Juang
    Department of Pediatric Oncology, The Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 275:1311-4. 1997
    ..In addition, loss of ASE1 function destabilized telophase spindles, and expression of a nondegradable Ase1 mutant delayed spindle disassembly. APC-mediated proteolysis therefore appears to regulate both spindle assembly and disassembly...
  21. ncbi request reprint Securin is required for chromosomal stability in human cells
    P V Jallepalli
    The Johns Hopkins Oncology Center, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cell 105:445-57. 2001
    ..These results illuminate the function of mammalian securin and show that it is essential for the maintenance of euploidy...
  22. ncbi request reprint Splitting the chromosome: cutting the ties that bind sister chromatids
    K Nasmyth
    Research Institute of Molecular Pathology (IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Novartis Found Symp 237:113-33; discussion 133-8, 158-63. 2001
    ..In this review we discuss how these proteins may connect sister chromatids and how they are removed from chromosomes to allow sister chromatid separation at the onset of anaphase...
  23. ncbi request reprint An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments
    C Rabouille
    Cell Biology Laboratory, Imperial Cancer Research Fund, London, England
    Cell 82:905-14. 1995
    ..The morphology of cisternae regrown with p97 and NSF-SNAPs-p115 differed, suggesting that they play distinct roles in rebuilding Golgi cisternae after mitosis...