J Mair

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Cardiac troponin I and troponin T: are enzymes still relevant as cardiac markers?
    J Mair
    Institut für Medizinische Chemie and Biochemie, University of Innsbruck, Austria
    Clin Chim Acta 257:99-115. 1997
  2. ncbi Natriuretic peptides as markers of mild forms of left ventricular dysfunction: effects of assays on diagnostic performance of markers
    Angelika Hammerer-Lercher
    Department of Medical Chemistry and Biochemistry, Division of Clinical Biochemistry, Innsbruck Medical University, Innsbruck, Austria
    Clin Chem 50:1174-83. 2004
  3. ncbi Quality specifications for B-type natriuretic peptide assays
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 51:486-93. 2005
  4. ncbi Monitoring of patients with heart failure
    Johannes Mair
    Clinical Division of Cardiology, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Scand J Clin Lab Invest Suppl 240:99-106. 2005
  5. ncbi NT-proBNP concentrations indicate cardiac disease in pediatric patients
    Ralf Geiger
    Int J Cardiol 123:63-5. 2007
  6. ncbi The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure
    J Mair
    Department of Internal Medicine, University of Innsbruck School of Medicine, Austria
    Clin Chem Lab Med 39:571-88. 2001
  7. ncbi Markers for perioperative myocardial ischemia: what both interventional cardiologists and cardiac surgeons need to know
    Johannes Mair
    Clinical Division of Cardiology, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Heart Surg Forum 8:E319-25. 2005
  8. ncbi Tissue release of cardiac markers: from physiology to clinical applications
    J Mair
    Department of Internal Medicine, University of Innsbruck, Austria
    Clin Chem Lab Med 37:1077-84. 1999
  9. ncbi Glycogen phosphorylase isoenzyme BB to diagnose ischaemic myocardial damage
    J Mair
    Institut für Medizinische Chemie und Biochemie, Innsbruck, Austria
    Clin Chim Acta 272:79-86. 1998
  10. ncbi Markers of activated coagulation for early diagnosis of acute myocardial infarction
    J Mair
    Department of Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    Clin Chim Acta 267:239-45. 1997

Collaborators

Detail Information

Publications48

  1. ncbi Cardiac troponin I and troponin T: are enzymes still relevant as cardiac markers?
    J Mair
    Institut für Medizinische Chemie and Biochemie, University of Innsbruck, Austria
    Clin Chim Acta 257:99-115. 1997
    ....
  2. ncbi Natriuretic peptides as markers of mild forms of left ventricular dysfunction: effects of assays on diagnostic performance of markers
    Angelika Hammerer-Lercher
    Department of Medical Chemistry and Biochemistry, Division of Clinical Biochemistry, Innsbruck Medical University, Innsbruck, Austria
    Clin Chem 50:1174-83. 2004
    ....
  3. ncbi Quality specifications for B-type natriuretic peptide assays
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 51:486-93. 2005
    ....
  4. ncbi Monitoring of patients with heart failure
    Johannes Mair
    Clinical Division of Cardiology, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Scand J Clin Lab Invest Suppl 240:99-106. 2005
    ..BNP and NT-proBNP are suitable for heart failure monitoring, and BNP and NT-proBNP changes >50% from baseline correlated well with clinical course and a reduction of mortality in heart failure patients...
  5. ncbi NT-proBNP concentrations indicate cardiac disease in pediatric patients
    Ralf Geiger
    Int J Cardiol 123:63-5. 2007
    ..The presence of heart failure (p<0.0001) had a significant impact on NT-proBNP concentrations. CONCLUSIONS: NT-proBNP measurement is a helpful addition to identify pediatric patients with heart disease...
  6. ncbi The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure
    J Mair
    Department of Internal Medicine, University of Innsbruck School of Medicine, Austria
    Clin Chem Lab Med 39:571-88. 2001
    ..For the cardiologists the natriuretic peptides are helpful for guidance of therapy and monitoring disease course in heart failure patients and for risk stratification in heart failure and myocardial infarction...
  7. ncbi Markers for perioperative myocardial ischemia: what both interventional cardiologists and cardiac surgeons need to know
    Johannes Mair
    Clinical Division of Cardiology, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Heart Surg Forum 8:E319-25. 2005
    ..After elective percutaneous coronary interventions, only troponin increases >8-fold the upper reference limit were associated with increased mortality in long-term follow-up...
  8. ncbi Tissue release of cardiac markers: from physiology to clinical applications
    J Mair
    Department of Internal Medicine, University of Innsbruck, Austria
    Clin Chem Lab Med 37:1077-84. 1999
    ..Smaller molecules, such as myoglobin, also pass the glomerular membranes of the kidneys and are reabsorbed and subsequently metabolized in tubular epithelial cells...
  9. ncbi Glycogen phosphorylase isoenzyme BB to diagnose ischaemic myocardial damage
    J Mair
    Institut für Medizinische Chemie und Biochemie, Innsbruck, Austria
    Clin Chim Acta 272:79-86. 1998
    ..The diagnostic specificity of GPBB in non-traumatic chest pain patients was comparable to creatine kinase MB. These results indicate that GPBB is a sensitive marker for ischaemic myocardial damage...
  10. ncbi Markers of activated coagulation for early diagnosis of acute myocardial infarction
    J Mair
    Department of Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    Clin Chim Acta 267:239-45. 1997
    ..However, TAT increases give no information about the location of clot formation in the body, and the diagnosis of AMI must be subsequently verified by an increase in more cardiac specific proteins, such as troponins or CKMB...
  11. ncbi Progress in myocardial damage detection: new biochemical markers for clinicians
    J Mair
    Institut für Medizinische Chemie and Biochemie, University of Innsbruck, Austria
    Crit Rev Clin Lab Sci 34:1-66. 1997
    ....
  12. ncbi Clinical and experimental results on cardiac troponin expression in Duchenne muscular dystrophy
    A Hammerer-Lercher
    Department of Medical Chemistry and Biochemistry, Division of Clinical Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Clin Chem 47:451-8. 2001
    ....
  13. ncbi Head-to-head comparison of N-terminal pro-brain natriuretic peptide, brain natriuretic peptide and N-terminal pro-atrial natriuretic peptide in diagnosing left ventricular dysfunction
    A Hammerer-Lercher
    Department of Medical Chemistry and Biochemistry, Division of Clinical Biochemistry, University of Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Clin Chim Acta 310:193-7. 2001
    ..However, NT-proBNP showed no significant differences to BNP and it is therefore a new promising alternative marker for the detection of left ventricular dysfunction...
  14. ncbi Myocardial damage after minimally invasive coronary artery bypass grafting on the beating heart
    J Bonatti
    Department of Anesthesiology and General Intensive Care, University of Innsbruck, Austria
    Ann Thorac Surg 66:1093-6. 1998
    ..For minimally invasive direct coronary artery bypass grafting, few data are available concerning myocardial marker protein release...
  15. ncbi Early assessment of exercise induced skeletal muscle injury using plasma fatty acid binding protein
    S Sorichter
    Department of Medical Chemistry and Biochemistry, University of Innsbruck Medical School, Austria
    Br J Sports Med 32:121-4. 1998
    ..To test whether fatty acid binding protein (FABP) is a useful plasma marker for the early detection of exercise induced skeletal muscle injury in healthy subjects...
  16. ncbi Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis
    P Erlacher
    Department of Medical Chemistry and Biochemistry, Division of Clinical Biochemistry, University of Innsbruck, Innsbruck, Austria
    Clin Chim Acta 306:27-33. 2001
    ..However, the prognostic values of cardiac troponins and other muscle damage markers in PM/DM patients remain to be compared in prospective outcome trials...
  17. ncbi Limited utilities of N-terminal pro B-type natriuretic peptide and other newer risk markers compared with traditional risk factors for prediction of significant angiographic lesions in stable coronary artery disease
    A Peer
    Universitaetsklinik für Innere Medizin III Kardiologie, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria
    Heart 95:297-303. 2009
    ....
  18. ncbi Hypoxia induces heat shock protein expression in human coronary artery bypass grafts
    A Hammerer-Lercher
    Department of Med Chemistry and Biochemistry, Division of Clinical Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A 6020, Innsbruck, Austria
    Cardiovasc Res 50:115-24. 2001
    ..Heat shock and hypoxia markedly increase the expression of several HSPs in various tissues, i.e. heart. In our in vitro study, we investigated whether HSPs are inducible in human vessels which are used as coronary artery bypass grafts...
  19. ncbi Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1
    B Metzler
    Division of Cardiology, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    Cardiovasc Res 49:399-407. 2001
    ..We studied the effects of temporary myocardial ischemia and reperfusion on myocyte injury and ventricular remodelling in wildtype and intercellular adhesion molecule-1- (ICAM-1) deficient mice...
  20. ncbi Utility of N-terminal pro-B-type natriuretic peptide to differentiate cardiac diseases from noncardiac diseases in young pediatric patients
    Angelika Hammerer-Lercher
    Division of Clinical Biochemistry, Innsbruck Biocenter, Department of Pediatrics, Clinical Division of Cardiology, Innsbruck Medical University, Austria
    Clin Chem 52:1415-9. 2006
    ....
  21. ncbi Direct comparison of relaxation and cGMP production in human coronary by-pass grafts in response to stimulation with natriuretic peptides and a nitric oxide donor
    Angelika Hammerer-Lercher
    Division of Clinical Biochemistry, Innsbruck Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Clin Sci (Lond) 111:225-31. 2006
    ..In contrast with sin-1, ANP and BNP were not effective vasorelaxants of the SV. Net relaxation in response to natriuretic peptides correlated with cGMP net concentrations in the IMA...
  22. ncbi Thermal preconditioning protects the human internal mammary artery from hypoxia/re-oxygenation-induced damage
    Angelika Hammerer-Lercher
    Division of Clinical Biochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Clin Exp Pharmacol Physiol 33:584-90. 2006
    ..6. Mild heat preconditioning before hypoxia/re-oxygenation injury is a stimulus for Hsp72 protein expression and a reduction in apoptosis in the human IMA...
  23. ncbi B-type natriuretic peptide (BNP) is more sensitive to rapid hemodynamic changes in acute heart failure than N-terminal proBNP
    Johannes Mair
    Department of Internal Medicine, Clinical Division of Cardiology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Clin Chim Acta 379:163-6. 2007
    ....
  24. ncbi [Biomarkers in cardiology--state of the art 2007]
    Johannes Mair
    Klinische Abteilung für Kardiologie, Universitatsklinik fur Innere Medizin, Medizinische Universitat Innsbruck, Innsbruck, Austria
    Wien Med Wochenschr 157:48-56. 2007
    ..This review summarizes the state of the art of cardiac biomarkers suitable for routine use...
  25. ncbi Head-to-head comparison of B-type natriuretic peptide (BNP) and NT-proBNP in daily clinical practice
    Johannes Mair
    Int J Cardiol 124:244-6. 2008
    ..In conclusion, despite a close correlation and a satisfactory agreement between both markers in classification, frequent discrepancies in individual patients demonstrate that both markers are clinically not completely equivalent...
  26. ncbi National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine practice guidelines: Analytical issues for biomarkers of heart failure
    Fred S Apple
    Hennepin County Medical Center, Minneapolis, Minn, USA
    Circulation 116:e95-8. 2007
  27. ncbi National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biomarkers of heart failure
    Fred S Apple
    Hennepin County Medical Center, Minneapolis, MN, USA
    Clin Biochem 41:222-6. 2008
  28. ncbi N-terminal pro A-type natriuretic peptide but not N-terminal pro C-type natriuretic peptide concentrations are related to cardiac diseases in infants
    Angelika Hammerer-Lercher
    Clin Chim Acta 391:118-9. 2008
  29. ncbi Cross-reactivity of BNP, NT-proBNP, and proBNP in commercial BNP and NT-proBNP assays: preliminary observations from the IFCC Committee for Standardization of Markers of Cardiac Damage
    Kristin N Luckenbill
    Clin Chem 54:619-21. 2008
  30. ncbi B-type natriuretic peptide and N-terminal pro brain natriuretic peptide are related to systolic and diastolic left ventricular function assessed by radionuclide ventriculography
    Gerda Falkensammer
    Int J Cardiol 105:340-1. 2005
  31. ncbi Influence of antithrombin on ischemia/reperfusion injury in the isolated blood-free perfused rat heart
    Josef Margreiter
    Department of Anesthesia and Intensive Care Medicine, The Leopold Franzens University of Innsbruck, Austria
    Thromb Res 108:249-55. 2002
    ..Since the perfusion of the hearts was without blood, the used model essentially describes effects of antithrombin on endothelial cells...
  32. ncbi N-terminal pro-B-type natriuretic peptide concentrations are markedly higher in the umbilical cord blood of newborns than in their mothers
    Angelika Hammerer-Lercher
    Biocenter, Division of Clinical Biochemistry, Innsbruck Medical University, Austria
    Clin Chem 51:913-5. 2005
  33. ncbi B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide are comparably useful for disease monitoring in heart failure
    Angelika Hammerer-Lercher
    Int J Cardiol 106:415-7. 2006
  34. ncbi Role of cardiac natriuretic peptide testing in heart failure
    Johannes Mair
    Clin Chem 48:977-8. 2002
  35. ncbi Analytical and clinical evaluation of the Bayer ADVIA Centaur automated B-type natriuretic peptide assay in patients with heart failure: a multisite study
    Alan H B Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, 80 Seymour St, Hartford, CT 06102, USA
    Clin Chem 50:867-73. 2004
    ..B-Type natriuretic peptide (BNP) is released from the left ventricle of the heart into the circulation in response to ventricular stretching and volume overload. Increased BNP concentrations are associated with heart failure (HF)...
  36. ncbi B-type natriuretic peptide as a marker of allograft rejection after heart transplantation
    Angelika Hammerer-Lercher
    Department of Medical Chemistry and Biochemistry, Division of Clinical Biochemistry, Innsbruck Medical University, Innsbruck, Austria
    J Heart Lung Transplant 24:1444. 2005
    ..BNP monitoring seems to be a useful addition in the individual follow-up of heart transplant recipients to rule out significant rejection...
  37. ncbi Evaluation of imprecision for cardiac troponin assays at low-range concentrations
    Mauro Panteghini
    Laboratorio Analisi Chimico Cliniche 1, Azienda Ospedaliera Spedali Civili, 25125 Brescia, Italy
    Clin Chem 50:327-32. 2004
    ..Pools of human sera containing cardiac troponin concentrations around the MI decision limit were assessed to identify the lowest concentration associated with a 10% CV...
  38. ncbi Possible placental exchange of neopterin as indicated by significant correlations in matched maternal neonatal blood samples at delivery
    Angelika Hammerer-Lercher
    Clin Chim Acta 365:350-1. 2006
  39. ncbi Plasma cardiac troponin T closely correlates with infarct size in a mouse model of acute myocardial infarction
    Bernhard Metzler
    Division of Cardiology, Department of Internal Medicine, University Hospital of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    Clin Chim Acta 325:87-90. 2002
    ..84, p < 0.001). CONCLUSIONS: This study for the first time demonstrates a close correlation of cTnT release with pathological infarct size in a suitable experimental model with a sufficient sample size...
  40. ncbi Analysis of circulating forms of proBNP and NT-proBNP in patients with severe heart failure
    Angelika Hammerer-Lercher
    Division of Clinical Biochemistry, Innsbruck Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Clin Chem 54:858-65. 2008
    ....
  41. ncbi National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes
    Fred S Apple
    Clin Chem 53:547-51. 2007
  42. ncbi Standardization of immunoassays for measurement of myoglobin in serum. Phase I: evaluation of candidate secondary reference materials
    Mauro Panteghini
    Laboratorio Analisi Chimico Cliniche 1, Azienda Ospedaliera Spedali Civili, 25125 Brescia, Italy
    Clin Chim Acta 341:65-72. 2004
    ..Its concentrations in serum can be measured by immunoassays and are used as an early indicator of myocardial necrosis. Since variability among commercial myoglobin assays exists, standardization of myoglobin assays is needed...
  43. ncbi 3-week hiking holidays at moderate altitude do not impair cardiac function in individuals with metabolic syndrome
    Johannes Mair
    Int J Cardiol 123:186-8. 2008
    ..The blood pressure at rest significantly decreased from baseline to follow-up...
  44. ncbi Chronic heart failure is associated with vascular remodeling of the brachial artery
    Gerhard Poelzl
    Division of Cardiology, Department of Medicine, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Heart Fail 7:43-8. 2005
    ..We therefore investigated the hypothesis that vascular remodeling is associated with functional changes in peripheral conduit arteries and with systemic overexpression of ET-1 in patients suffering from CHF...
  45. ncbi Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Clinical Laboratories, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 51:810-24. 2005
    ....
  46. ncbi Short-term improvement in submaximal exercise capacity by optimized therapy with ACE inhibitors and beta blockers in heart failure patients is associated with restoration of peripheral endothelial function
    Gerhard Poelzl
    Clinical Division of Cardiology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Int J Cardiol 108:48-54. 2006
    ....
  47. ncbi Transient impairment of flow-mediated vasodilation in patients with metabolic syndrome at moderate altitude (1,700 m)
    Matthias Frick
    Division of Cardiology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria, Europe
    Int J Cardiol 109:82-7. 2006
    ..The discrepancy to improvement of other cardiovascular and metabolic parameters requires further investigation...
  48. ncbi Natriuretic peptides correlate between newborn twins but not between twins and their mothers
    Angelika Hammerer-Lercher
    Clin Chim Acta 377:279-80. 2007