Frank Madeo


Affiliation: University of Graz
Country: Austria


  1. request reprint
    Madeo F, Eisenberg T, Buttner S, Ruckenstuhl C, Kroemer G. Spermidine: a novel autophagy inducer and longevity elixir. Autophagy. 2010;6:160-2 pubmed
    ..We hypothesize that increased autophagic turnover of cytoplasmic organelles or long-lived proteins is involved in most if not all life span-prolonging therapies...
  2. Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018;359: pubmed publisher
    ..Because spermidine is already present in daily human nutrition, clinical trials aiming at increasing the uptake of this polyamine appear feasible. ..
  3. Carmona Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019;10:651 pubmed publisher
    ..In summary, we have identified and mechanistically characterised the conserved longevity-promoting effects of a natural anti-ageing drug. ..
  4. Madeo F, Carmona Gutierrez D, Hofer S, Kroemer G. Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential. Cell Metab. 2019;29:592-610 pubmed publisher
    ..We anticipate that CRMs will become part of the pharmacological armamentarium against aging and age-related cardiovascular, neurodegenerative, and malignant diseases. ..
  5. Wirth M, BENSON G, Schwarz C, Köbe T, Grittner U, Schmitz D, et al. The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex. 2018;109:181-188 pubmed publisher
    ..Registered in with the Identifier NCT02755246. ..
  6. Braun R, Sommer C, Leibiger C, Gentier R, Dumit V, Paduch K, et al. Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin. Cell Rep. 2015;10:1557-1571 pubmed publisher
    ..The fact that AD-induced cellular dysfunctions can be avoided by UPS activity at mitochondria has potentially far-reaching pathophysiological implications. ..
  7. Pietrocola F, Galluzzi L, Bravo San Pedro J, Madeo F, Kroemer G. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015;21:805-21 pubmed publisher
    ..Thus, acetyl-CoA determines the balance between cellular catabolism and anabolism by simultaneously operating as a metabolic intermediate and as a second messenger. ..
  8. Tripolt N, Stekovic S, Aberer F, Url J, Pferschy P, Schröder S, et al. Intermittent Fasting (Alternate Day Fasting) in Healthy, Non-obese Adults: Protocol for a Cohort Trial with an Embedded Randomized Controlled Pilot Trial. Adv Ther. 2018;35:1265-1283 pubmed publisher
    ..NCT02673515; registered 24 November 2015. Current protocol date/version: 7 February 2017/version 1.8. ..
  9. Madeo F, Eisenberg T, Kroemer G. Autophagy for the avoidance of neurodegeneration. Genes Dev. 2009;23:2253-9 pubmed publisher
    ..These findings suggest the existence of a homeostatic-if not hormetic-balance between distinct cellular defense mechanisms. ..

More Information


  1. Mariño G, Pietrocola F, Eisenberg T, Kong Y, Malik S, Andryushkova A, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014;53:710-25 pubmed publisher
    ..Altogether, our results indicate that cytosolic AcCoA functions as a central metabolic regulator of autophagy, thus delineating AcCoA-centered pharmacological strategies that allow for the therapeutic manipulation of autophagy. ..
  2. Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Kuttner V, Bhukel A, et al. Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab. 2014;19:431-44 pubmed publisher
    ..Since AcCoA integrates various nutrition pathways, our findings may explain diet-dependent lifespan and autophagy regulation. ..
  3. De Cabo R, Carmona Gutierrez D, Bernier M, Hall M, Madeo F. The search for antiaging interventions: from elixirs to fasting regimens. Cell. 2014;157:1515-26 pubmed publisher
    ..Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms. ..
  4. Libiseller G, Dvorzak M, Kleb U, Gander E, Eisenberg T, Madeo F, et al. IPO: a tool for automated optimization of XCMS parameters. BMC Bioinformatics. 2015;16:118 pubmed publisher
    ..The source code is implemented in R, tested on Linux and Windows and it is freely available for download at . The training sets and test sets can be downloaded from . ..
  5. Kainz K, Tadic J, Zimmermann A, Pendl T, Carmona Gutierrez D, Ruckenstuhl C, et al. Methods to Assess Autophagy and Chronological Aging in Yeast. Methods Enzymol. 2017;588:367-394 pubmed publisher
    ..In sum, we have recapped established protocols used to evaluate a link between lifespan extension and autophagy in yeast. ..
  6. Rockenfeller P, Smolnig M, Diessl J, Bashir M, Schmiedhofer V, Knittelfelder O, et al. Diacylglycerol triggers Rim101 pathway-dependent necrosis in yeast: a model for lipotoxicity. Cell Death Differ. 2018;25:765-781 pubmed publisher
    ..high-fat diet in Drosophila and palmitic acid administration in cultured human endothelial cells, we present evidence that the core mechanism underlying this calpain-dependent lipotoxic cell death pathway is phylogenetically conserved. ..