G Luef

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate
    G Luef
    Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Epilepsy Res 48:91-102. 2002
  2. ncbi Valproic acid modulates islet cell insulin secretion: a possible mechanism of weight gain in epilepsy patients
    Gerhard J Luef
    Departments of Neurology and Internal Medicine, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Epilepsy Res 55:53-8. 2003
  3. ncbi Valproate therapy and nonalcoholic fatty liver disease
    Gerhard J Luef
    Department of Neurology, Innsbruck University Hospital, Innsbruck, Austria
    Ann Neurol 55:729-32. 2004
  4. ncbi Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women
    Gerhard Luef
    Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, Austria
    J Neurol 249:835-41. 2002
  5. ncbi Oxcarbazepine in glossopharyngeal neuralgia: clinical response and effect on serum lipids
    Gerhard Luef
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, A 6020, Austria
    Neurology 63:2447-8. 2004
  6. ncbi Gyratory seizures revisited: a video-EEG study
    J Dobesberger
    Universitätskliniken für Neurologie, Innsbruck, Austria
    Neurology 64:1884-7. 2005
  7. ncbi Peri-ictal water drinking lateralizes seizure onset to the nondominant temporal lobe
    E Trinka
    Universitätskliniken für Neurologie, Innsbruck, Austria
    Neurology 60:873-6. 2003
  8. ncbi Idiopathic generalized epilepsies with pure grand mal: clinical data and genetics
    I Unterberger
    Universitätsklinik für Neurologie, Innsbruck Anichstrasse 35, A 6020, Innsbruck, Austria
    Epilepsy Res 44:19-25. 2001
  9. doi Effect of valproic acid treatment on body composition, leptin and the soluble leptin receptor in epileptic children
    M Rauchenzauner
    Department of Pediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Epilepsy Res 80:142-9. 2008
  10. doi Non-alcoholic fatty liver disease (NAFLD), insulin resistance and lipid profile in antiepileptic drug treatment
    G Luef
    Department of Neurology, Epilepsy Unit, Medical University Innsbruck, Innsbruck, Austria
    Epilepsy Res 86:42-7. 2009

Collaborators

Detail Information

Publications38

  1. ncbi Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate
    G Luef
    Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Epilepsy Res 48:91-102. 2002
    ..The pronounced increase in pp insulin levels during VPA treatment may indicate an effect of the fatty acid derivate VPA on pancreatic islet cells...
  2. ncbi Valproic acid modulates islet cell insulin secretion: a possible mechanism of weight gain in epilepsy patients
    Gerhard J Luef
    Departments of Neurology and Internal Medicine, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Epilepsy Res 55:53-8. 2003
    ..It can be speculated that an increase in pancreatic insulin secretion under chronic VPA treatment enhances appetite and energy storage and is related to the observed weight gain...
  3. ncbi Valproate therapy and nonalcoholic fatty liver disease
    Gerhard J Luef
    Department of Neurology, Innsbruck University Hospital, Innsbruck, Austria
    Ann Neurol 55:729-32. 2004
    ..We here demonstrate in abdominal ultrasound investigations that characteristics of fatty liver disease were present in 61% of valproate-treated patients as compared with 23% receiving carbamazepine therapy...
  4. ncbi Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women
    Gerhard Luef
    Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, Austria
    J Neurol 249:835-41. 2002
    ..With respect to the metabolic side-effects of VPA therapy our data indicate that VPA increases glucose stimulated pancreatic insulin secretion, which might be followed by an increase in body weight...
  5. ncbi Oxcarbazepine in glossopharyngeal neuralgia: clinical response and effect on serum lipids
    Gerhard Luef
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, A 6020, Austria
    Neurology 63:2447-8. 2004
  6. ncbi Gyratory seizures revisited: a video-EEG study
    J Dobesberger
    Universitätskliniken für Neurologie, Innsbruck, Austria
    Neurology 64:1884-7. 2005
    ..The mechanisms of generation are unknown and have been discussed controversially. The aim of this investigation was to further delineate seizure semiology and assess a possible lateralizing and localizing value of GSs...
  7. ncbi Peri-ictal water drinking lateralizes seizure onset to the nondominant temporal lobe
    E Trinka
    Universitätskliniken für Neurologie, Innsbruck, Austria
    Neurology 60:873-6. 2003
    ..All patients had an excellent outcome after epilepsy surgery. Peri-ictal water drinking may represent a lateralizing sign indicating seizure onset in the nondominant temporal lobe...
  8. ncbi Idiopathic generalized epilepsies with pure grand mal: clinical data and genetics
    I Unterberger
    Universitätsklinik für Neurologie, Innsbruck Anichstrasse 35, A 6020, Innsbruck, Austria
    Epilepsy Res 44:19-25. 2001
    ..To analyze the clinical features and family history of patients with idiopathic generalized epilepsy (IGE), with pure grand mal (GM), divided into epilepsies with GM occurring exclusively on awakening (GMA) and random GM (RGM)...
  9. doi Effect of valproic acid treatment on body composition, leptin and the soluble leptin receptor in epileptic children
    M Rauchenzauner
    Department of Pediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Epilepsy Res 80:142-9. 2008
    ..The aim of the study was to determine the influence of valproic acid (VPA) treatment on leptin, the soluble leptin receptor (sOB-R), the sOB-R/leptin ratio, body composition and insulin resistance in epileptic children...
  10. doi Non-alcoholic fatty liver disease (NAFLD), insulin resistance and lipid profile in antiepileptic drug treatment
    G Luef
    Department of Neurology, Epilepsy Unit, Medical University Innsbruck, Innsbruck, Austria
    Epilepsy Res 86:42-7. 2009
    ....
  11. ncbi Unilateral polymicrogyria with ipsilateral cerebral hemiatrophy: a distinct syndrome?
    G Kuchukhidze
    Department of Neurology, Medical University of Innsbruck, Austria
    Epileptic Disord 9:71-6. 2007
    ..The aim of our study was to delineate further, clinical and neuroimaging features of this malformation of cortical development and to explore its possible etiological background...
  12. doi Idiopathic generalised epilepsy of late onset: a separate nosological entity?
    J Reichsoellner
    Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
    J Neurol Neurosurg Psychiatry 81:1218-22. 2010
    ..Seizure onset in idiopathic generalised epilepsies (IGE) is considered to be rare after the second decade of life. The authors aimed to explore age of seizure onset in patients with IGE and compare 'classical' onset to late onset cases...
  13. ncbi Asymmetric termination of secondarily generalized tonic-clonic seizures in temporal lobe epilepsy
    E Trinka
    Universitätskliniken für Neurologie, Innsbruck, Austria
    Neurology 59:1254-6. 2002
    ..The clonic phase of sGTCS did not end synchronously in 65.7% of all patients and in 59.4% of all seizures. In 79.3% to 80% this was ipsilateral to the hemisphere of seizure onset, and there was excellent interobserver agreement...
  14. ncbi Prefrontal disturbances as the sole manifestation of simple partial nonconvulsive status epilepticus
    Gerhard Bauer
    Universitätsklinik für Neurologie Medizinischen Universität Innsbruck, Innsbruck, Austria
    Epilepsy Behav 8:331-5. 2006
    ..This unique case is classified as simple partial nonconvulsive status epilepticus with prefrontal disturbances as the sole manifestation...
  15. doi Oxcarbazepine treatment in male epilepsy patients improves pre-existing sexual dysfunction
    G Luef
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Acta Neurol Scand 119:94-9. 2009
    ..To collect data on sexual dysfunction in a larger population of male patients with epilepsy treated with oxcarbazepine in a naturalistic setting...
  16. ncbi Multimodal P3 under different attentional states in mesial temporal lobe epilepsy
    E Trinka
    Universitätsklinik für Neurologie, Innsbruck, Austria
    Eur J Neurol 8:261-6. 2001
    ..Several studies demonstrate that the P3 component of the event-related potentials (ERP) is generated by mesial temporal structures. The P3 is considered as endogenous information processing component independent from modality...
  17. ncbi Chronic epilepsy with complex partial seizures is not always medically intractable--a long-term observational study
    E Trinka
    Universitätsklinik für Neurologie Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Acta Neurol Scand 103:219-25. 2001
    ..To study the prognosis of patients with complex partial seizures (CPS) with or without simple partial (SPS) and secondarily generalized tonic-clonic seizures (GTCS) and to analyze the factors related to the degree of medical responsiveness...
  18. ncbi Increase in postprandial serum insulin levels in epileptic patients with valproic acid therapy
    Gerhard Luef
    Department of Neurology, University Hospital Innsbruck, Innsbruck, Austria
    Metabolism 51:1274-8. 2002
    ..Therefore, it might be suspected that VPA therapy is associated with increased glucose stimulated pancreatic secretion and thus a higher body weight in the VPA group...
  19. doi Chronic antiepileptic monotherapy, bone metabolism, and body composition in non-institutionalized children
    Markus Rauchenzauner
    Department of Paediatrics IV, Division of Neuropaediatrics, Medical University Innsbruck, Innsbruck, Austria
    Dev Med Child Neurol 52:283-8. 2010
    ..The aim of this study was to determine the influence of chronic monotherapy with antiepileptic drugs (AEDs) on vitamin D levels, bone metabolism, and body composition...
  20. ncbi Childhood febrile convulsions--which factors determine the subsequent epilepsy syndrome? A retrospective study
    Eugen Trinka
    Universitätsklinik für Neurologie, Innsbruck, Anichstrasse 35, Austria
    Epilepsy Res 50:283-92. 2002
    ..2% to TLE and in 100% to GE. A broad spectrum of epilepsy syndromes follow FC. We found a strong association of prolonged and focal FC with later development of TLE. Short generalized FC were associated with GE...
  21. ncbi Computerized tremor analysis of valproate-induced tremor: a comparative study of controlled-release versus conventional valproate
    Martina Rinnerthaler
    Department of Neurology, Innsbruck Medical University, Austria
    Epilepsia 46:320-3. 2005
    ..conventional VPA). The aim of this study was quantitatively to assess tremor in epilepsy patients receiving VPA and to compare the effects of two VPA formulations (CR-VPA vs. VPA) on tremor severity...
  22. ncbi Non convulsive status epilepticus after replacement of valproate with lamotrigine
    Eugen Trinka
    Universitätsklinik für Neurologie, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 249:1417-22. 2002
    ..The aim of this study was to describe clinical features and EEG findings in patients with non convulsive status epilepticus (NCSE) after replacement of VPA with LTG...
  23. doi Effects of levetiracetam and valproic acid monotherapy on sex-steroid hormones in prepubertal children--results from a pilot study
    Markus Rauchenzauner
    Department of Paediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Innsbruck, Austria
    Epilepsy Res 88:264-8. 2010
    ..All other reproductive endocrine hormones were similar among groups. In conclusion, LEV does not seem to induce changes in reproductive endocrine functions as well as clinically relevant endocrine side effects in prepubertal children...
  24. ncbi Genital automatisms: a video-EEG study in patients with medically refractory seizures
    Judith Dobesberger
    Universitätskliniken für Neurologie, Innsbruck, Austria
    Epilepsia 45:777-80. 2004
    ..They are defined as repeated fondling, grabbing, or scratching of the genitals. The anatomic correlates of GAs have been discussed controversially. The aim of this investigation was to assess the localizing and lateralizing value of GAs...
  25. doi The ketogenic diet in children with Glut1 deficiency syndrome and epilepsy
    Markus Rauchenzauner
    Department of Pediatrics IV, Division of Neuropediatrics, University Hospital Innsbruck, Innsbruck, Austria
    J Pediatr 153:716-8. 2008
    ..Although serum lipids and apolipoproteins reflect a proatherogenic lipoprotein profile, adipocytokine constellation is not indicative of enhanced cardiovascular risk...
  26. doi Female issues in epilepsy: a critical review
    Gerhard Luef
    Department of Neurology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Epilepsy Behav 15:78-82. 2009
    ..Contraception and pregnancy issues for women with epilepsy have received the appropriate attention...
  27. doi Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy
    Sabine Pittschieler
    Department of Neurology, Medical University Innsbruck, Anichstrasse 35, Innsbruck, Austria
    J Neurol 255:1926-31. 2008
    ..Antiepileptic drugs (AEDs) like phenytoin (PHE), carbamazepine (CBZ), barbiturates and valproic acid (VPA) interfere with folic acid absorption and metabolism, which in turn can be the cause of adverse pregnancy outcome...
  28. doi Mode of vagus nerve stimulation differentially affects sleep related breathing in patients with epilepsy
    Viola Gschliesser
    Medical University Innsbruck, Department of Neurology, Anichstrasse 35, A 6020 Innsbruck, Austria
    Seizure 18:339-42. 2009
    ..We describe the influence of vagus nerve stimulation (VNS) with standard mode and rapid cycling mode on sleep related breathing in two patients with epilepsy...
  29. doi Epilepsy and hormones: a critical review
    Gerhard Luef
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Epilepsy Behav 15:73-7. 2009
    ....
  30. doi N-terminal pro-brain natriuretic peptide (NT-proBNP) release in children with vagus nerve stimulation. A prospective case series
    Markus Rauchenzauner
    Dept of Paediatrics, Medical University, Innsbruck, Austria
    J Neurol 255:980-5. 2008
    ..Especially in patients with pre-existing cardiovascular dysfunction,measurement of NT-proBNP concentrations may help to identify patients with high baseline concentrations and possibly at greater risk for cardiac side effects...
  31. ncbi Psychiatric comorbidity in juvenile myoclonic epilepsy
    Eugen Trinka
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Epilepsia 47:2086-91. 2006
    ..To assess the prevalence of psychiatric disturbances among patients with juvenile myoclonic epilepsy (JME)...
  32. ncbi Brain-type natriuretic peptide secretion following febrile and afebrile seizures - a new marker in childhood epilepsy?
    Markus Rauchenzauner
    Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria
    Epilepsia 48:101-6. 2007
    ..The aim of this study was to assess whether epileptic seizures or FC are related to increased secretion of the N-terminal fragment of BNP (NT-proBNP)...
  33. ncbi Long-term prognosis for childhood and juvenile absence epilepsy
    Eugen Trinka
    Universitätsklinik für Neurologie, Medizinische Universitat Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 251:1235-41. 2004
    ..To analyse prognostic factors for long term seizure remission in patients with childhood (CAE) and juvenile absence epilepsy (JAE)...
  34. ncbi Adiponectin and visfatin concentrations in children treated with valproic acid
    Markus Rauchenzauner
    Department of Paediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Austria
    Epilepsia 49:353-7. 2008
    ..Therefore, adiponectin and leptin but not visfatin may be considered as potential regulators of glucose and fat metabolism during VPA-therapy...
  35. ncbi Gender issues in epilepsy--the science of why it is special
    Erik Taubøll
    Seizure 17:99-100. 2008
  36. ncbi Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation
    Torbjorn Tomson
    Deparatment of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Epilepsia 48:1111-6. 2007
    ..To study pharmacokinetics of levetiracetam (LEV) during pregnancy, delivery, lactation, and in the neonatal period...
  37. ncbi Topiramate kinetics during delivery, lactation, and in the neonate: preliminary observations
    Inger Ohman
    Departments of Internal Medicine, Division of Clinical Pharmacology and Clinical Neuroscience, Karolinska Hospital, and Department of Neuroscience and Locomotion, Linkoping University, Stockholm and Linköping, Sweden
    Epilepsia 43:1157-60. 2002
    ..To study the pharmacokinetics of topiramate (TPM) during delivery, lactation, and in the neonate...
  38. doi Effects of pregnancy and contraception on lamotrigine disposition: new insights through analysis of lamotrigine metabolites
    Inger Ohman
    Department of Medicine, Solna, Clinical Pharmacology Unit, Karolinska Institutet, Stockholm, Sweden
    Seizure 17:199-202. 2008
    ..To investigate possible underlying mechanisms for alterations in lamotrigine (LTG) kinetics by gestation and use of contraceptives...