R Likar

..To compare the efficacy and tolerability of transdermal buprenorphine in elderly patients and 2 younger populations, all requiring analgesic treatment for moderate-to-severe chronic pain...

..Growing evidence from clinical practice, in which much lower doses of buprenorphine are used, suggests that this conversion ratio may be too high...

..Long-term data are essential to determining the performance of an analgesic in the management of chronic pain...

..Since the patients presented in a pain-free state at the time of surgery, apparently no activation of the peripheral opioid receptors occurs. Thus, a peripheral effect of opioids could not be demonstrated in this model...

..Current practices for patient selection and management, screening, drug selection, dosing and implantation for intrathecal drug delivery systems are discussed...

..Although age-related differences in pharmacologic responsiveness are to be expected, the pharmacodynamic and pharmacokinetic (PK) properties of tramadol have not been systematically compared between patients of various ages...

..The primary recommendation contained in the prescribing information was that transdermal patches be worn for a 3-day period before application of a new patch...

..The aim of these case studies was to address the issue of opioid rotation or switching, raising the important issue of conversion ratios between different compounds and routes of administration...

..In each case, sufficient pain relief was obtained and no problems were encountered in switching from prior analgesic therapy with larger doses of other opioids...

..In this randomized double-blind study differences in the peripheral and central effects of opiates for pain treatment in the iliac crest region after augmentation of the severely resorbed maxilla were examined...

..Thus, consistent with experimental studies, the requirement of an inflammatory process for the occurrence of peripheral opioid effects is also found in the clinical setting...

..The secondary goal was to assess the time until rescue analgesia was needed, propofol requirements and the incidence of vomiting and time of discharge from the postanaesthesia recovery unit (PARU)...

..Furthermore there was a significant difference in the pain scores using the "Hamburg Pain Adjective List" in favour of the verum group. TENS applied postoperatively is a effective, simple modality with few side-effects...

..CONCLUSION: Lornoxicam administered preemptively appears to improve the quality of postoperative analgesia and lead to reduced consumption of opioid analgesics postoperatively in patients undergoing gynecological operations...

..A secondary goal was to determine the correlation of weight, height, head circumference, and age to the size and depth of these veins...

..a. morphine analgesia is not shifted by enhanced inflammation and END expression within synovial tissue. Thus, the presence of END within inflamed synovial tissue does not seem to interfere with i.a. morphine analgesia...

..Our contribution concludes with a detailed discussion and comparison of the literature...

..Buprenorphine is a potent opioid analgesic that is available in sublingual and parenteral formulations. A new formulation, buprenorphine transdermal delivery system (TDS), has been developed...

..In the case of haemodynamic instability, ultrasound should be used to exclude pericardial effusion...

..To determine objective and subjective indications of quality of life in hospitalized geriatric patients...

..This case report reviews the epidemiology, pathophysiology, prognostic markers and the therapeutic approaches of severe hypothermia...

..The study included a 3-week stimulation period and 2-week observation period after the end of stimulation...

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..The objective of this post-marketing surveillance study was to collect effectiveness and safety data on the labelled use of buprenorphine transdermal patches (Transtec*) under routine clinical conditions...

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..The pathophysiology of this syndrome appears to involve a disturbance of mitochondrial metabolism induced by propofol. Our report involves a case of propofol infusion syndrome in a patient having undergone cardiac surgery...

..Consideration will also be given to the anesthetic management of very low birth-weight infants with anesthetic key issues such as avoiding hyperoxia, keeping hemodynamic parameters as stable as possible and preventing hypothermia...

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..Furthermore the impact of these two doses of midazolam on sedation at induction of anesthesia was compared...

..Brachial plexus blockade and active vasodilatation in tiny neonates after severe local ischemia are discussed...

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..Therefore, histamine release seen at large concentrations of potent micro agonists is caused by an unspecific effect rather than an activation of opioid receptors...

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..The histological examination of kidneys revealed no differences among the various groups. These data indicate a role of the kidney in the induction of peripheral edema during permanent morphine administration...

..This is mostly seen in the combination of sufentanil/midazolam. In addition, an increase in the amplitude of the sensory-evoked potential suggests a postinhibitory excitatory state within the nociceptive system...

..This opens the way to new therapeutic options in the future through the development of systemic peripherally selective opioids without CNS adverse effects...