N Leitinger

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Oxidized phospholipids as modulators of inflammation in atherosclerosis
    Norbert Leitinger
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
    Curr Opin Lipidol 14:421-30. 2003
  2. ncbi request reprint Cholesteryl ester oxidation products in atherosclerosis
    Norbert Leitinger
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Mol Aspects Med 24:239-50. 2003
  3. ncbi request reprint Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS
    Alexandra Kadl
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Vascul Pharmacol 38:219-27. 2002
  4. ncbi request reprint Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Nature 419:77-81. 2002
  5. ncbi request reprint Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Blood 99:199-206. 2002
  6. ncbi request reprint Oxidized phospholipids trigger atherogenic inflammation in murine arteries
    Alexander Furnkranz
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 25:633-8. 2005
  7. ncbi request reprint Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40
    Stefan Bluml
    Institute of Immunology, Medical University of Vienna, Medical University of Vienna, Vienna, Austria
    J Immunol 175:501-8. 2005
  8. ncbi request reprint Anti-inflammatory properties of lipid oxidation products
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    J Mol Med (Berl) 81:613-26. 2003
  9. ncbi request reprint Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:581-6. 2002
  10. ncbi request reprint Apoptotic cells as sources for biologically active oxidized phospholipids
    Alexandra Kadl
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
    Antioxid Redox Signal 6:311-20. 2004

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Oxidized phospholipids as modulators of inflammation in atherosclerosis
    Norbert Leitinger
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
    Curr Opin Lipidol 14:421-30. 2003
    ..This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions...
  2. ncbi request reprint Cholesteryl ester oxidation products in atherosclerosis
    Norbert Leitinger
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Mol Aspects Med 24:239-50. 2003
    ..Based on the current knowledge, cholesteryl ester oxidation leads to the formation of biologically active substances, which could actively contribute to the progression of atherosclerotic lesions and their resulting complications...
  3. ncbi request reprint Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS
    Alexandra Kadl
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Vascul Pharmacol 38:219-27. 2002
    ..In addition, we demonstrate that the quantitative real-time RT-PCR technology is a proper tool to investigate differential inflammatory gene induction in vivo...
  4. ncbi request reprint Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Nature 419:77-81. 2002
    ..Furthermore, identified chemical structures capable of inhibiting the effects of endotoxins such as LPS could be used for the development of new drugs for treatment of sepsis...
  5. ncbi request reprint Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Blood 99:199-206. 2002
    ..Thus, oxidized phospholipids may contribute to inflammation by activating pathways alternative to the classical NF-kappa B pathway...
  6. ncbi request reprint Oxidized phospholipids trigger atherogenic inflammation in murine arteries
    Alexander Furnkranz
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 25:633-8. 2005
    ..Therefore, the aim of this study was to investigate if structurally defined oxidized phospholipids induce expression of atherogenic chemokines and monocyte adhesion in intact murine arteries...
  7. ncbi request reprint Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40
    Stefan Bluml
    Institute of Immunology, Medical University of Vienna, Medical University of Vienna, Vienna, Austria
    J Immunol 175:501-8. 2005
    ..Thus, formation of ox-PLs during the course of an inflammatory response may represent a negative-feedback loop preventing excessive and sustained immune reactions through regulating DC maturation...
  8. ncbi request reprint Anti-inflammatory properties of lipid oxidation products
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    J Mol Med (Berl) 81:613-26. 2003
    ..We discuss confirmed and suggested mechanisms as well as the (patho)physiological significance of these findings...
  9. ncbi request reprint Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:581-6. 2002
    ..Thus, oxidized cholesteryl esters may play an important role as novel mediators in the initiation and progression of atherosclerosis...
  10. ncbi request reprint Apoptotic cells as sources for biologically active oxidized phospholipids
    Alexandra Kadl
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
    Antioxid Redox Signal 6:311-20. 2004
    ..In this review, we discuss the hypothesis that oxidized phospholipids generated in apoptotic cells (a) propagate chronic inflammation and (b) contribute to the resolution of acute inflammation...
  11. doi request reprint Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids
    Elena von Schlieffen
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 29:356-62. 2009
    ..Molecular mechanisms of their effects are largely unknown. Here we present novel information on the mechanisms whereby OxPLs modulate activation of TLR4 by lipopolysaccharide (LPS)...
  12. ncbi request reprint Regulation of inflammatory responses by oxidized phospholipids: structure-function relationships
    A Furnkranz
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Curr Pharm Des 10:915-21. 2004
    ....
  13. ncbi request reprint Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein
    Gerhard Kronke
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
    J Biol Chem 278:51006-14. 2003
    ..Induction of HO-1 expression by lipid oxidation products via CREB may represent a feedback mechanism to limit inflammation and associated tissue damage...
  14. ncbi request reprint The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
    Antioxid Redox Signal 5:163-9. 2003
    ..Thus, formation of 8-iso-PGE(2) may play an important role in chronic inflammatory diseases such as atherosclerosis by increasing adhesion and extravasation of monocytes...
  15. ncbi request reprint Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition
    T M Stulnig
    Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
    J Biol Chem 276:37335-40. 2001
    ..In conclusion, these data provide strong evidence that displacement of acylated proteins from rafts in PUFA-treated T cells is predominantly due to altered raft lipid composition...
  16. ncbi request reprint Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids
    J Huber
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
    Int J Obes (Lond) 31:1004-13. 2007
    ..As polyunsaturated fatty acids (PUFA) appear to inhibit diabetes development, we investigated PUFA effects on markers of matrix remodeling in white adipose tissue...
  17. ncbi request reprint Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:101-7. 2002
    ..In addition to oxidized lipoproteins, oxidized MVs and apoptotic blebs may play an important role in chronic inflammatory diseases, such as atherosclerosis...
  18. ncbi request reprint Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Circ Res 99:900-8. 2006
    ..Our data suggest that accumulation of OxPLs may contribute to increased growth of blood capillaries in advanced lesions, thus leading to progression and destabilization of atherosclerotic plaques...
  19. ncbi request reprint Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
    J Lipid Res 47:1054-62. 2006
    ..Further analysis of signaling pathways induced by oxidized phospholipids that lead to specific monocyte adhesion should ultimately lead to the development of novel therapeutic approaches against chronic inflammatory diseases...
  20. pmc Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury
    Stephanie Nonas
    Division of Pulmonary and Critical Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Respir Crit Care Med 173:1130-8. 2006
    ....
  21. ncbi request reprint Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Microvasc Res 67:18-28. 2004
    ....
  22. ncbi request reprint Regulation of platelet adhesion by oxidized lipoproteins and oxidized phospholipids
    Jadwiga Hartwich
    Department of Clinical Biochemistry, Jagiellonian University Collegium Medicum Kraków, Poland
    Platelets 13:141-51. 2002
    ..The effect of okadaic acid on CD36 and CD41 argue for the participation of phosphorylation-dependent reorganization of cellular trafficking and microtubule organization by ox-PAPC...
  23. ncbi request reprint Oxidized phospholipids as triggers of inflammation in atherosclerosis
    Norbert Leitinger
    Department of Pharmacology and Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Mol Nutr Food Res 49:1063-71. 2005
    ..Better understanding of how OxPL contribute to vascular inflammation should lead to new strategies in the treatment of chronic inflammatory disorders...
  24. ncbi request reprint Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia
    Alexandra Kadl
    Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, Virginia, USA
    Shock 28:582-8. 2007
    ..These data show that single-dose administration of bilirubin attenuates tissue injury induced by endotoxin, and that bilirubin, in addition to its antioxidant effects, also exerts potent anti-inflammatory activity...
  25. ncbi request reprint Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis
    Christian A Gleissner
    Department of Biomedical Engineering, Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 50:276-83. 2007
  26. ncbi request reprint Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro
    Nataliya A Pidkovka
    University of Virginia, Cardiovascular Research Center, Department of Molecular Physiology and Biophysics, 415 Lane Road, Charlottesville, VA 22908, USA
    Circ Res 101:792-801. 2007
    ..These results may have important novel implications for the mechanisms by which oxPLs contribute to the pathogenesis of atherosclerosis...
  27. pmc Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
    Stephanie Nonas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Crit Care 12:R27. 2008
    ....
  28. ncbi request reprint Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 95:892-901. 2004
    ..Thus, oxidative modification of phospholipids during inflammation leads to the formation of novel regulators that may be critically involved in restoration of vascular barrier function...
  29. doi request reprint Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture
    Gabriella Leonarduzzi
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    Aging Cell 7:375-82. 2008
    ..These experimental findings point to cholesterol oxidation as an essential reaction for this sterol to exert cellular stress and tissue damage in age-related diseases in which inflammation represents a main driving force...
  30. doi request reprint Modification of LDL with oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) results in a novel form of minimally modified LDL that modulates gene expression in macrophages
    Mathijs Groeneweg
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Biochim Biophys Acta 1781:336-43. 2008
  31. ncbi request reprint Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells
    Florian Gruber
    Deparment of Dermatology, Medical University of Vienna, Vienna 1090, Austria
    J Biol Chem 282:16934-41. 2007
    ....
  32. ncbi request reprint Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors
    Gerhard Kronke
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, P O Box 801394, Charlottesville, VA, USA
    Arterioscler Thromb Vasc Biol 27:1276-82. 2007
    ..Here we investigate if the vasculoprotective and anti-inflammatory enzyme heme oxygenase-1 (HO-1) is regulated by PPAR ligands in vascular cells...
  33. ncbi request reprint Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo
    Sylvia Knapp
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 178:993-1001. 2007
    ..These data suggest that oxidized phospholipids such as produced during inflammatory reactions may contribute to mortality during Gram-negative sepsis in vivo via impairment of the phagocytic properties of professional phagocytes...
  34. ncbi request reprint The dietary soy flavonoid genistein abrogates tissue factor induction in endothelial cells induced by the atherogenic oxidized phospholipid oxPAPC
    Gregor Holzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Thromb Res 120:71-9. 2007
    ....
  35. ncbi request reprint Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication
    Brant E Isakson
    Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 26:2216-21. 2006
    ..Lipoprotein-derived phospholipid oxidation products (OxPAPC) play a critical role in atherosclerosis, and we hypothesized that they may act as trigger molecules causing the changes in connexin expression...
  36. ncbi request reprint A rancid culprit in vascular inflammation acts on the prostaglandin receptor EP2
    Norbert Leitinger
    Circ Res 98:587-9. 2006
  37. ncbi request reprint The role of endothelial cells in the resolution of acute inflammation
    Alexandra Kadl
    Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Antioxid Redox Signal 7:1744-54. 2005
    ..This review will summarize recent advances in the field of endothelial biology, which point to an active participation of the endothelial barrier in the resolving process...
  38. ncbi request reprint Glucose regulates monocyte adhesion through endothelial production of interleukin-8
    Suseela Srinivasan
    Division of Cardiology, University of California Los Angeles, Los Angeles, Calif, USA
    Circ Res 92:371-7. 2003
    ..These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs...
  39. ncbi request reprint Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells
    Gabriella Leonarduzzi
    Department of Clinical and Biological Sciences, University of Turin, S Luigi Hospital, 10043 Orbassano Turin, Italy
    Free Radic Biol Med 39:1152-61. 2005
    ..The results indicate that cholesterol may contribute to the progression of atherosclerotic lesions by strongly up-regulating crucial proinflammatory factors like MCP-1, but only after having been oxidized to oxysterols...