Research Topics
| N LeitingerSummaryAffiliation: University of Vienna Country: Austria Publications
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Detail Information
Publications
Cholesteryl ester oxidation products in atherosclerosisNorbert Leitinger
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Mol Aspects Med 24:239-50. 2003..Based on the current knowledge, cholesteryl ester oxidation leads to the formation of biologically active substances, which could actively contribute to the progression of atherosclerotic lesions and their resulting complications...- Oxidized phospholipids as modulators of inflammation in atherosclerosisNorbert Leitinger
Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
Curr Opin Lipidol 14:421-30. 2003..This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions... - Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPSAlexandra Kadl
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Vascul Pharmacol 38:219-27. 2002..In addition, we demonstrate that the quantitative real-time RT-PCR technology is a proper tool to investigate differential inflammatory gene induction in vivo... - Protective role of phospholipid oxidation products in endotoxin-induced tissue damageValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Nature 419:77-81. 2002..Furthermore, identified chemical structures capable of inhibiting the effects of endotoxins such as LPS could be used for the development of new drugs for treatment of sepsis... - Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFATValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Blood 99:199-206. 2002..Thus, oxidized phospholipids may contribute to inflammation by activating pathways alternative to the classical NF-kappa B pathway... - Oxidized phospholipids trigger atherogenic inflammation in murine arteriesAlexander Furnkranz
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Arterioscler Thromb Vasc Biol 25:633-8. 2005.... - Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40Stefan Bluml
Institute of Immunology, Medical University of Vienna, Medical University of Vienna, Vienna, Austria
J Immunol 175:501-8. 2005..Thus, formation of ox-PLs during the course of an inflammatory response may represent a negative-feedback loop preventing excessive and sustained immune reactions through regulating DC maturation... - Anti-inflammatory properties of lipid oxidation productsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
J Mol Med (Berl) 81:613-26. 2003..We discuss confirmed and suggested mechanisms as well as the (patho)physiological significance of these findings... - Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathwayJoakim Huber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
Arterioscler Thromb Vasc Biol 22:581-6. 2002..Thus, oxidized cholesteryl esters may play an important role as novel mediators in the initiation and progression of atherosclerosis... - Apoptotic cells as sources for biologically active oxidized phospholipidsAlexandra Kadl
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
Antioxid Redox Signal 6:311-20. 2004..In this review, we discuss the hypothesis that oxidized phospholipids generated in apoptotic cells (a) propagate chronic inflammation and (b) contribute to the resolution of acute inflammation... 
Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipidsElena von Schlieffen
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
Arterioscler Thromb Vasc Biol 29:356-62. 2009..Molecular mechanisms of their effects are largely unknown. Here we present novel information on the mechanisms whereby OxPLs modulate activation of TLR4 by lipopolysaccharide (LPS)...- Regulation of inflammatory responses by oxidized phospholipids: structure-function relationshipsA Furnkranz
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Curr Pharm Des 10:915-21. 2004.... - Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding proteinGerhard Kronke
Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
J Biol Chem 278:51006-14. 2003..Induction of HO-1 expression by lipid oxidation products via CREB may represent a feedback mechanism to limit inflammation and associated tissue damage... - The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathwaysJoakim Huber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, A-1090 Vienna, Austria
Antioxid Redox Signal 5:163-9. 2003..Thus, formation of 8-iso-PGE(2) may play an important role in chronic inflammatory diseases such as atherosclerosis by increasing adhesion and extravasation of monocytes... - Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid compositionT M Stulnig
Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
J Biol Chem 276:37335-40. 2001..In conclusion, these data provide strong evidence that displacement of acylated proteins from rafts in PUFA-treated T cells is predominantly due to altered raft lipid composition... - Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acidsJ Huber
Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria
Int J Obes (Lond) 31:1004-13. 2007..As polyunsaturated fatty acids (PUFA) appear to inhibit diabetes development, we investigated PUFA effects on markers of matrix remodeling in white adipose tissue... - Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactionsJoakim Huber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Arterioscler Thromb Vasc Biol 22:101-7. 2002..In addition to oxidized lipoproteins, oxidized MVs and apoptotic blebs may play an important role in chronic inflammatory diseases, such as atherosclerosis... - Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesionsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Circ Res 99:900-8. 2006..Our data suggest that accumulation of OxPLs may contribute to increased growth of blood capillaries in advanced lesions, thus leading to progression and destabilization of atherosclerotic plaques... - Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenaseJoakim Huber
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
J Lipid Res 47:1054-62. 2006..Further analysis of signaling pathways induced by oxidized phospholipids that lead to specific monocyte adhesion should ultimately lead to the development of novel therapeutic approaches against chronic inflammatory diseases... 
Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injuryStephanie Nonas
Division of Pulmonary and Critical Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Respir Crit Care Med 173:1130-8. 2006..CONCLUSIONS: These studies demonstrate in vivo and in vitro protective effects of oxidized phospholipids on LPS-induced lung dysfunction...- Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteinsKonstantin G Birukov
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Microvasc Res 67:18-28. 2004.... - Regulation of platelet adhesion by oxidized lipoproteins and oxidized phospholipidsJadwiga Hartwich
Department of Clinical Biochemistry, , Poland
Platelets 13:141-51. 2002..The effect of okadaic acid on CD36 and CD41 argue for the participation of phosphorylation-dependent reorganization of cellular trafficking and microtubule organization by ox-PAPC... - Oxidized phospholipids as triggers of inflammation in atherosclerosisNorbert Leitinger
Department of Pharmacology and Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Mol Nutr Food Res 49:1063-71. 2005..Better understanding of how OxPL contribute to vascular inflammation should lead to new strategies in the treatment of chronic inflammatory disorders... - Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemiaAlexandra Kadl
Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, Virginia, USA
Shock 28:582-8. 2007..These data show that single-dose administration of bilirubin attenuates tissue injury induced by endotoxin, and that bilirubin, in addition to its antioxidant effects, also exerts potent anti-inflammatory activity... - Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosisChristian A Gleissner
Department of Biomedical Engineering, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Hypertension 50:276-83. 2007 - Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitroNataliya A Pidkovka
University of Virginia, Cardiovascular Research Center, Department of Molecular Physiology and Biophysics, 415 Lane Road, Charlottesville, VA 22908, USA
Circ Res 101:792-801. 2007..These results may have important novel implications for the mechanisms by which oxPLs contribute to the pathogenesis of atherosclerosis... - Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivoStephanie Nonas
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Crit Care 12:R27. 2008.... - Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and RacKonstantin G Birukov
Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circ Res 95:892-901. 2004..Thus, oxidative modification of phospholipids during inflammation leads to the formation of novel regulators that may be critically involved in restoration of vascular barrier function... - Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixtureGabriella Leonarduzzi
Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
Aging Cell 7:375-82. 2008..These experimental findings point to cholesterol oxidation as an essential reaction for this sterol to exert cellular stress and tissue damage in age-related diseases in which inflammation represents a main driving force... - Modification of LDL with oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) results in a novel form of minimally modified LDL that modulates gene expression in macrophagesMathijs Groeneweg
Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Biochim Biophys Acta 1781:336-43. 2008 - Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cellsFlorian Gruber
Deparment of Dermatology, Medical University of Vienna, Vienna 1090, Austria
J Biol Chem 282:16934-41. 2007.... - Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptorsGerhard Kronke
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, P O Box 801394, Charlottesville, VA, USA
Arterioscler Thromb Vasc Biol 27:1276-82. 2007..Here we investigate if the vasculoprotective and anti-inflammatory enzyme heme oxygenase-1 (HO-1) is regulated by PPAR ligands in vascular cells... - Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivoSylvia Knapp
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 178:993-1001. 2007..These data suggest that oxidized phospholipids such as produced during inflammatory reactions may contribute to mortality during Gram-negative sepsis in vivo via impairment of the phagocytic properties of professional phagocytes... - The dietary soy flavonoid genistein abrogates tissue factor induction in endothelial cells induced by the atherogenic oxidized phospholipid oxPAPCGregor Holzer
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
Thromb Res 120:71-9. 2007.... - Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communicationBrant E Isakson
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Arterioscler Thromb Vasc Biol 26:2216-21. 2006..Lipoprotein-derived phospholipid oxidation products (OxPAPC) play a critical role in atherosclerosis, and we hypothesized that they may act as trigger molecules causing the changes in connexin expression... - A rancid culprit in vascular inflammation acts on the prostaglandin receptor EP2Norbert Leitinger
Circ Res 98:587-9. 2006 - The role of endothelial cells in the resolution of acute inflammationAlexandra Kadl
Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Antioxid Redox Signal 7:1744-54. 2005..This review will summarize recent advances in the field of endothelial biology, which point to an active participation of the endothelial barrier in the resolving process... - Glucose regulates monocyte adhesion through endothelial production of interleukin-8Suseela Srinivasan
Division of Cardiology, University of California Los Angeles, Los Angeles, Calif, USA
Circ Res 92:371-7. 2003..These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs... - Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cellsGabriella Leonarduzzi
Department of Clinical and Biological Sciences, University of Turin, S Luigi Hospital, 10043 Orbassano Turin, Italy
Free Radic Biol Med 39:1152-61. 2005..The results indicate that cholesterol may contribute to the progression of atherosclerotic lesions by strongly up-regulating crucial proinflammatory factors like MCP-1, but only after having been oxidized to oxysterols...