Cornelia Lass-Flörl

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. pmc Studies of in vitro activities of voriconazole and itraconazole against Aspergillus hyphae using viability staining
    C Lass-Florl
    Department of Hygiene and Social Medicine, University of Innsbruck, Innsbruck, Austria
    Antimicrob Agents Chemother 45:124-8. 2001
  2. ncbi request reprint Fungal colonization in neutropenic patients: a randomized study comparing itraconazole solution and amphotericin B solution
    C Lass-Florl
    Department of Hygiene and Social Medicine, University of Innsbruck, Fritz Pregl Strasse 3 III, 6020, Innsbruck, Austria
    Ann Hematol 82:565-9. 2003
  3. ncbi request reprint Diagnosing and monitoring of invasive aspergillosis during antifungal therapy by polymerase chain reaction: an experimental study in mice
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Diagn Microbiol Infect Dis 47:569-72. 2003
  4. ncbi request reprint [Epidemiology and prevention of pulmonary aspergillosis in patients with hematological malignancies]
    C Lass-Florl
    Medizinische Universitat Innsbruck, Innsbruck
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:379-83. 2004
  5. pmc Diagnosing invasive aspergillosis during antifungal therapy by PCR analysis of blood samples
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, Innsbruck, Austria
    J Clin Microbiol 42:4154-7. 2004
  6. pmc Disseminated infection with Prototheca zopfii after unrelated stem cell transplantation for leukemia
    Cornelia Lass-Flörl
    Division of Bacteriology, Department of Hygiene and Social Medicine, Medical University Innsbruck, Innsbruck, Austria
    J Clin Microbiol 42:4907-8. 2004
  7. ncbi request reprint Clinical evaluation of Aspergillus-PCR for detection of invasive aspergillosis in immunosuppressed patients
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, A 6020 Innsbruck, Austria
    Mycoses 48:12-7. 2005
  8. pmc In vitro activities of amphotericin B and voriconazole against aleurioconidia from Aspergillus terreus
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3 III, Innsbruck 6020, Austria
    Antimicrob Agents Chemother 49:2539-40. 2005
  9. ncbi request reprint Epidemiology and outcome of infections due to Aspergillus terreus: 10-year single centre experience
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Innsbruck, Austria
    Br J Haematol 131:201-7. 2005
  10. ncbi request reprint Effect of increasing inoculum sizes of Aspergillus hyphae on MICs and MFCs of antifungal agents by broth microdilution method
    Cornelia Lass-Flörl
    Institute of Hygiene and Social Medicine, Leopold Franzens University of Innsbruck, Fritz Pregl Strasse 3, 6020 Innsbruck, Austria
    Int J Antimicrob Agents 21:229-33. 2003

Detail Information

Publications80

  1. pmc Studies of in vitro activities of voriconazole and itraconazole against Aspergillus hyphae using viability staining
    C Lass-Florl
    Department of Hygiene and Social Medicine, University of Innsbruck, Innsbruck, Austria
    Antimicrob Agents Chemother 45:124-8. 2001
    ..In conclusion, our study demonstrates the importance of the type of inoculum used to test antifungals and the applicability of FUN-1 staining as a rapid and sensitive method for assaying the viability of hyphae...
  2. ncbi request reprint Fungal colonization in neutropenic patients: a randomized study comparing itraconazole solution and amphotericin B solution
    C Lass-Florl
    Department of Hygiene and Social Medicine, University of Innsbruck, Fritz Pregl Strasse 3 III, 6020, Innsbruck, Austria
    Ann Hematol 82:565-9. 2003
    ..Most patients remained infected with the colonized strains for the entire study period, irrespective of antifungal prophylaxis...
  3. ncbi request reprint Diagnosing and monitoring of invasive aspergillosis during antifungal therapy by polymerase chain reaction: an experimental study in mice
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Diagn Microbiol Infect Dis 47:569-72. 2003
    ..The results suggest that this PCR method has possible clinical value for improving the diagnosis of invasive Aspergillus infection. Monitoring of blood under antifungal therapy is not recommended...
  4. ncbi request reprint [Epidemiology and prevention of pulmonary aspergillosis in patients with hematological malignancies]
    C Lass-Florl
    Medizinische Universitat Innsbruck, Innsbruck
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:379-83. 2004
    ..This article addresses epidemiological aspects, exposure factors, and preventive aspects with special attention to construction work in hospitals...
  5. pmc Diagnosing invasive aspergillosis during antifungal therapy by PCR analysis of blood samples
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, Innsbruck, Austria
    J Clin Microbiol 42:4154-7. 2004
    ..Performance of Aspergillus PCR using tissue samples is recommended in addition to microscopic examination and culture technique for sensitive detection of fungal infection...
  6. pmc Disseminated infection with Prototheca zopfii after unrelated stem cell transplantation for leukemia
    Cornelia Lass-Flörl
    Division of Bacteriology, Department of Hygiene and Social Medicine, Medical University Innsbruck, Innsbruck, Austria
    J Clin Microbiol 42:4907-8. 2004
    ..zopfii following unrelated stem cell transplantation for leukemia. Breakthrough protothecosis occurred during long-term administration of voriconazole in the case of pulmonary aspergillosis...
  7. ncbi request reprint Clinical evaluation of Aspergillus-PCR for detection of invasive aspergillosis in immunosuppressed patients
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, A 6020 Innsbruck, Austria
    Mycoses 48:12-7. 2005
    ..The performance of Aspergillus PCR from tissue samples should be recommended in addition to microscopic examination and culture technique for sensitive detection of fungal infection...
  8. pmc In vitro activities of amphotericin B and voriconazole against aleurioconidia from Aspergillus terreus
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3 III, Innsbruck 6020, Austria
    Antimicrob Agents Chemother 49:2539-40. 2005
    ..For conidia and aleurioconidia, the MIC at which 90% of strains were inhibited was 2.5 microg/ml and 5 microg/ml with amphotericin B and 1 microg/ml and 2 microg/ml with voriconazole...
  9. ncbi request reprint Epidemiology and outcome of infections due to Aspergillus terreus: 10-year single centre experience
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Innsbruck, Austria
    Br J Haematol 131:201-7. 2005
    ..terreus causes systemic infections of endemic character in Tyrol, Austria. The onset of A. terreus infection depends not on the degree of immunosuppression but on environmental Aspergillus spp. exposure...
  10. ncbi request reprint Effect of increasing inoculum sizes of Aspergillus hyphae on MICs and MFCs of antifungal agents by broth microdilution method
    Cornelia Lass-Flörl
    Institute of Hygiene and Social Medicine, Leopold Franzens University of Innsbruck, Fritz Pregl Strasse 3, 6020 Innsbruck, Austria
    Int J Antimicrob Agents 21:229-33. 2003
    ..05). Thus azoles showed significant inoculum effects, while AMB showed comparatively minimum inoculum effects against Aspergillus spp...
  11. ncbi request reprint Antifungal activity against Candida species of the selective serotonin-reuptake inhibitor, sertraline
    C Lass-Florl
    Institutes of Hygiene and Social Medicine, University of Innsbruck, Austria
    Clin Infect Dis 33:E135-6. 2001
    ..During sertraline intervention, patients had no recurrent episodes of acute VVC. Antifungal activity was observed for sertraline against various isolates of Candida species...
  12. ncbi request reprint Antifungal properties of selective serotonin reuptake inhibitors against Aspergillus species in vitro
    C Lass-Florl
    Department of Hygiene and Social Medicine, University of Innsbruck, Innsbruck, Austria
    J Antimicrob Chemother 48:775-9. 2001
    ..fumigatus and A. flavus. In conclusion, our in vitro studies clearly demonstrate antifungal effects of SSRIs. Animal studies are needed to evaluate the potential role of these psychotropic drugs in the management of fungal infections...
  13. ncbi request reprint Antifungal properties of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, Austria
    Int J Med Microbiol 291:655-7. 2002
    ..68 to 117.5 mM and 29.37 to 235 mM during 24 and 48 h of incubation. Several serotonin receptor antagonists (5-HT2, 5-HT3) studied in vitro did not influence antifungal activity...
  14. ncbi request reprint In vitro studies on the activity of amphotericin B and lipid-based amphotericin B formulations against Aspergillus conidia and hyphae
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, Innsbruck University Hospital, Austria
    Mycoses 45:166-9. 2002
    ..This study demonstrates the importance of the type of inoculum used to test antifungal susceptibilities of Aspergillus spp. The significance of these results for in vivo outcome needs to be determined...
  15. ncbi request reprint Screening for Aspergillus spp. using polymerase chain reaction of whole blood samples from patients with haematological malignancies
    C Lass-Florl
    Department of Hygiene and Social Medicine, University of Innsbruck, Austria
    Br J Haematol 113:180-4. 2001
    ..Our results indicate the potential usefulness of PCR for screening for Aspergillus spp. in patients at risk, but without antifungal treatment...
  16. ncbi request reprint Antifungal properties of 5-hydroxytryptamine (serotonin) against Candida species in vitro
    Cornelia Lass-Flörl
    Institute of Hygiene and Social Medicine, University of Innsbruck, Austria
    J Med Microbiol 52:169-71. 2003
    ..In conclusion, these in vitro studies clearly demonstrate antifungal effects of 5 HT. Identifying the mode of action could be of great help in developing and researching new antifungal drugs...
  17. ncbi request reprint Interaction of sertraline with Candida species selectively attenuates fungal virulence in vitro
    Cornelia Lass-Flörl
    Department of Hygiene and Social Medicine, University of Innsbruck, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    FEMS Immunol Med Microbiol 35:11-5. 2003
    ..In conclusion, our findings suggest that the interaction between sertraline and Candida spp. may also diminish the virulence properties of this fungal pathogen in vivo...
  18. doi request reprint Infections caused by Candida krusei in five transplant and two surgical patients
    Hugo Bonatti
    Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Surg Infect (Larchmt) 10:265-71. 2009
    ..Candida krusei (Ck) may cause severe infections in immunocompromised hosts and is innately resistant to fluconazole...
  19. ncbi request reprint Antifungal activity of the local complement system in cerebral aspergillosis
    Gunter Rambach
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, and Ludwig Boltzmann Institute for AIDS Research, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Microbes Infect 7:1285-95. 2005
    ..These data indicate that low local complement synthesis and activation may represent a central reason for the insufficient antifungal defense in the brain and the high mortality rate of cerebral aspergillosis...
  20. pmc Activities of antifungal agents against yeasts and filamentous fungi: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz Pregl Str 3, Innsbruck 6020, Austria
    Antimicrob Agents Chemother 52:3637-41. 2008
    ..AMB, l-AMB, and POS were active against the majority of pathogens, including species that cause rare and difficult-to-treat infections...
  21. ncbi request reprint Importance of the terminal complement components for immune defence against Candida
    Till Triebel
    Institut für Hygiene and Sozialmedizin, University of Innsbruck, Innsbruck, Austria
    Int J Med Microbiol 292:527-36. 2003
    ....
  22. pmc Posaconazole enhances the activity of amphotericin B against Aspergillus hyphae in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Antimicrob Agents Chemother 51:791-3. 2007
    ..POS-AMB had more synergistic activity against hyphae (75% of isolates) than VRZ-AMB (37%) and significantly more synergistic activity against hyphae than against conidia (12%)...
  23. ncbi request reprint HIV-1 induces complement factor C3 synthesis in astrocytes and neurons by modulation of promoter activity
    Cornelia Bruder
    Institute of Hygiene and Social Medicine, University of Innsbruck and Ludwig Boltzmann Institute for AIDS Research, Fritz Pregl Str 3, A 6020, Innsbruck, Austria
    Mol Immunol 40:949-61. 2004
    ..Our experiments clearly define the mechanism for the induction of complement factors in the HIV-infected brain and reveal a decisive role of the regulator protein C/EBPdelta for the HIV-induced increase in C3 expression...
  24. doi request reprint First case of breakthrough pulmonary Aspergillus niveus infection in a patient after allogeneic hematopoietic stem cell transplantation
    Jutta Auberger
    Clinical Division of Hematology and Oncology, Department of Internal Medicine, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Diagn Microbiol Infect Dis 62:336-9. 2008
    ..This is the 1st report on a pulmonary breakthrough aspergillosis caused by A. niveus in a 21-year-old woman after allogeneic hematopoietic stem cell transplantation for Fanconi anemia...
  25. doi request reprint Significant alterations in the epidemiology and treatment outcome of invasive fungal infections in patients with hematological malignancies
    Jutta Auberger
    Department of Internal Medicine, Division of Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Int J Hematol 88:508-15. 2008
    ..7, P = 0.018). A significant decrease in fungus-related deaths was observed despite a significant increase of IFI over time, probably due to improved diagnostic and therapeutic approaches...
  26. pmc Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Antimicrob Agents Chemother 52:2636-8. 2008
    ..The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed...
  27. ncbi request reprint The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, University Hospital Innsbruck, Innsbruck, Tirol, Austria
    Clin Infect Dis 45:e101-4. 2007
    ..The sensitivity and specificity of computerized tomography, Aspergillus polymerase chain reaction, and galactomannan enzyme immunoassay were 100% and 50%, 100% and 86%, and 88% and 94%, respectively...
  28. pmc Susceptibility testing of anidulafungin and voriconazole alone and in combination against conidia and hyphae of Aspergillus spp. under hypoxic conditions
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Antimicrob Agents Chemother 52:1873-5. 2008
    ..Anidulafungin exhibited excellent activity against conidia and hyphae of Aspergillus spp. The visual reading of the MIC for anidulafungin was optimal under hypoxic conditions...
  29. pmc New insight into amphotericin B resistance in Aspergillus terreus
    Gerhard Blum
    Department of Hygiene and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Antimicrob Agents Chemother 57:1583-8. 2013
    ..AMB might exert its antifungal activity by oxidative injury rather than by an increase in membrane permeation...
  30. doi request reprint Airborne fungus exposure prior to hospitalisation as risk factor for mould infections in immunocompromised patients
    Gerhard Blum
    Department of Hygiene and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Mycoses 55:237-43. 2012
    ..015) were significantly more frequently infected with fungi. Hospital-independent fungal sources highlight risk-factors for IMI in severe immunocompromised patients and the rate of community-acquired IMI does increase...
  31. doi request reprint Gliotoxin as putative virulence factor and immunotherapeutic target in a cell culture model of cerebral aspergillosis
    Cornelia Speth
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Mol Immunol 48:2122-9. 2011
    ..Thus, exploration of these substances may lead to novel approaches for adjunctive treatment of cerebral aspergillosis...
  32. pmc Potential basis for amphotericin B resistance in Aspergillus terreus
    Gerhard Blum
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Antimicrob Agents Chemother 52:1553-5. 2008
    ..terreus was significantly higher than that in A. fumigatus (P < 0.05). This higher-level production may contribute to AMB resistance in A. terreus since oxidative damage has been implicated in AMB action...
  33. ncbi request reprint HIV-1 and its transmembrane protein gp41 bind to different Candida species modulating adhesion
    Andreas Gruber
    Institute for Hygiene and Social Medicine, University of Innsbruck, and Ludwig Boltzmann Institute for AIDS Research, Innsbruck, Austria
    FEMS Immunol Med Microbiol 37:77-83. 2003
    ..albicans strain 10S was not inhibitable by an anti-YKT receptor antibody. In conclusion, HIV-1 interacts with different clinically important Candida spp., and may thereby affect the outcome of the respective fungal infection...
  34. pmc Interaction of platelets and anidulafungin against Aspergillus fumigatus
    Susanne Perkhofer
    University of Applied Sciences Tyrol, Innsbruck, Austria
    Antimicrob Agents Chemother 57:626-8. 2013
    ..Platelets decreased the expression of the fks gene, which plays an important role in cell wall synthesis. Our results suggest that human platelets plus anidulafungin might contribute to defense against A. fumigatus...
  35. doi request reprint Aspergillus fumigatus activates thrombocytes by secretion of soluble compounds
    Cornelia Speth
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    J Infect Dis 207:823-33. 2013
    ..These findings imply that measuring platelet activation in patients might be an interesting diagnostic parameter...
  36. pmc Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 39:1175-83. 2012
    ..fumigatus infection in rats. Here we report on the further evaluation of the most promising (68)Ga-siderophore candidates, triacetylfusarinine (TAFC) and ferrioxamine E (FOXE)...
  37. ncbi request reprint In vitro determination of phagocytosis and intracellular killing of Aspergillus species by mononuclear phagocytes
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz Pregl Strasse 3, 6020, Innsbruck, Austria
    Mycopathologia 163:303-7. 2007
    ..whereas phagocytosis was similar for all isolates tested in vitro. No differences were observed within environmental and clinical isolates...
  38. pmc Utility of PCR in diagnosis of invasive fungal infections: real-life data from a multicenter study
    Cornelia Lass-Flörl
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    J Clin Microbiol 51:863-8. 2013
    ..1%, 97.0%, 80%, and 91.7%, respectively, for microscopy-negative fungal infections. This study defines a possible helpful role of broad-range PCR for diagnosis of microscopy-negative fungal infections in conjunction with other tests...
  39. doi request reprint Secretion of a fungal protease represents a complement evasion mechanism in cerebral aspergillosis
    Gunter Rambach
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Mol Immunol 47:1438-49. 2010
    ..Glutamine or arginine are of special interest for this purpose since they represent endogenous substances in the CNS and might be included in a future supportive therapy to reduce the high lethality of cerebral aspergillosis...
  40. doi request reprint Virulence and thrombocyte affectation of two Aspergillus terreus isolates differing in amphotericin B susceptibility
    Cornelia Speth
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Fritz Pregl Straße 3, 6020, Innsbruck, Austria
    Med Microbiol Immunol 202:379-89. 2013
    ..Furthermore, ATS secreted more soluble factors that triggered platelet stimulation than ATR. Thus, it might be suggested that the capacity of a fungal isolate to modulate thrombocyte parameters contributes to its virulence in vivo. ..
  41. ncbi request reprint Standard dosing regimen of liposomal amphotericin B is as effective as a high-loading dose for patients with invasive aspergillosis: AmBiLoad trial
    Cornelia Lass-Flörl
    Innsbruck Medical University, Department of Hygiene, Microbiology and Social Medicine, Section of Hygiene and Medical Microbiology, Fritz Pregl Str 3 III, 6020 Innsbruck, Austria
    Expert Rev Anti Infect Ther 5:929-32. 2007
    ..This article analyzes the study, discusses the rationale and the results and concludes that this study supports the routine application of L-AMB...
  42. ncbi request reprint Absent reduction by HIV protease inhibitors of Candida albicans adhesion to endothelial cells
    Barbara Falkensammer
    Department for Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck and Ludwig Boltzmann Institute for AIDS Research, Innsbruck, Austria
    Mycoses 50:172-7. 2007
    ..albicans to human cells by HIV protease inhibitors is not a general feature, but strongly cell type-dependent, and clearly not observed for endothelial cells in vitro, which are a main target of systemic candidiasis in vivo...
  43. ncbi request reprint The role of complement in invasive fungal infections
    Cornelia Speth
    Institute of Hygiene and Social Medicine, University of Innsbruck, Innsbruck, Austria
    Mycoses 47:93-103. 2004
    ....
  44. pmc Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Austria
    Int J Antimicrob Agents 29:424-9. 2007
    ..05). 5-HT treatment for 4h resulted in a lag of re-growth (post-antifungal effect). In conclusion, our findings suggest that 5-HT affects hyphal growth and diminishes fungal cell membrane integrity...
  45. doi request reprint In vitro susceptibility testing in fungi: a global perspective on a variety of methods
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Mycoses 53:1-11. 2010
    ..Early recognition of infections caused by pathogens that are resistant to one or more antifungals is highly warranted to optimise treatment and patient outcome...
  46. pmc Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons
    Cornelia Speth
    Institute of Hygiene and Social Medicine, University of Innsbruck Ludwig Boltzmann Institute for AIDS Research, Innsbruck, Austria
    J Virol 76:3179-88. 2002
    ..This strengthens the hypothesis that HIV-induced complement synthesis represents an important mechanism for the pathogenesis of AIDS in the brain...
  47. ncbi request reprint Alternaria alternata soft tissue infection in a forearm transplant recipient
    Hugo Bonatti
    Department of General and Transplant Surgery, Medical University, Innsbruck, Austria
    Surg Infect (Larchmt) 8:539-44. 2007
    ..Composite tissue allograft recipients require intensive immunosuppression and are therefore at risk of infections. Filamentous fungal infections are among the complications most difficult to manage in organ transplant recipients...
  48. pmc Human platelets attenuate Aspergillus species via granule-dependent mechanisms
    Susanne Perkhofer
    Department of Hygiene, Innsbruck Medical University, Austria
    J Infect Dis 198:1243-6. 2008
    ..05). A lack of antifungal effects was observed with the microfilament inhibitor cytochalasin D. Platelets attenuate the virulence of Aspergillus species in vitro on the basis of granule-dependent effects...
  49. doi request reprint Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes
    Wilfried Posch
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    J Allergy Clin Immunol 130:1368-74.e2. 2012
    ..Antigen opsonization can modulate the capture of antigen, its presentation, and the priming of specific CD8(+) T-cell responses...
  50. doi request reprint Rapid detection of bloodstream pathogens by real-time PCR in patients with sepsis
    Katharina Grif
    Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schopfstrasse 41, 6020, Innsbruck, Austria
    Wien Klin Wochenschr 124:266-70. 2012
    ..Thus we recommend the SeptiFast assay as a valuable tool for rapid diagnosis of bloodstream infections in addition to, but not as replacement for, the blood culture test...
  51. doi request reprint Caspofungin: when and how? The microbiologist's view
    Astrid Mayr
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Mycoses 55:27-35. 2012
    ..Caspofungin represents a significant advance in the care of patients with serious fungal infections...
  52. doi request reprint Triazole antifungal agents in invasive fungal infections: a comparative review
    Cornelia Lass-Flörl
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Drugs 71:2405-19. 2011
    ....
  53. doi request reprint Platelets enhance activity of antimycotic substances against non-Aspergillus fumigatus Aspergillus species in vitro
    Susanne Perkhofer
    Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria
    Med Mycol 49:157-66. 2011
    ....
  54. pmc In vitro activities of various antifungal drugs against Aspergillus terreus: Global assessment using the methodology of the European committee on antimicrobial susceptibility testing
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Austria
    Antimicrob Agents Chemother 53:794-5. 2009
    ..Posaconazole and anidulafungin had the lowest and amphotericin B the highest MICs. No differences in susceptibility patterns were observed between environmental and clinical isolates...
  55. ncbi request reprint New insights into invasive aspergillosis--from the pathogen to the disease
    Ulrike Binder
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Tirol, Austria
    Curr Pharm Des 19:3679-88. 2013
    ..This review focuses on properties of A. fumigatus in terms of putative virulence factors and interactions of the pathogen with a main focus on the innate immune system...
  56. ncbi request reprint Up-date on diagnostic strategies of invasive aspergillosis
    Michaela Lackner
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University MUI, Innsbruck, Austria
    Curr Pharm Des 19:3595-614. 2013
    ..g., Platelia Aspergillus®, Fungitell®, in situ hybridization, immunohistochemisty) and their purposes as screening tools and/or diagnostic tools. This review gives a future outlook on how to best diagnose Aspergillus infections...
  57. pmc Molecular typing of Aspergillus terreus isolates collected in Houston, Texas, and Innsbruck, Austria: evidence of great genetic diversity
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    J Clin Microbiol 45:2686-90. 2007
    ..No strain similarity in either institution was detected, indicating great genetic diversity of A. terreus...
  58. ncbi request reprint [Serological tests for diagnosing fungal infections]
    Cornelia Lass-Flörl
    Department für Hygiene, Mikrobiologie und Sozalmedizin, Medizinische Universitat Innsbruck, Innsbruck, Osterreich
    Wien Med Wochenschr 157:526-9. 2007
    ..Detection of macromolecular microbial antigens generally requires a relatively large microbial burden, which may limit assay sensitivity...
  59. pmc Human protothecosis
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz Pregl Str 3 III, 6020 Innsbruck, Tyrol, Austria
    Clin Microbiol Rev 20:230-42. 2007
    ..Among them, amphotericin B displays the best activity against Prototheca spp. Diagnosis is largely made upon detection of characteristic structures observed on histopathologic examination of tissue...
  60. doi request reprint Microbial challenge tests on nonradioactive TiO2-based 68Ge/68Ga generator columns
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Nucl Med Commun 33:819-23. 2012
    ..Nonradioactive generator columns were loaded with various microorganisms and tested to determine whether the microorganisms were proliferating or surviving in eluates of the columns...
  61. ncbi request reprint Bacterial contamination of solutions for parenteral administration for single- and multiple-dose vials after multiple use in the hospital
    Elisabeth Nogler-Semenitz
    Hospital Pharmacy, University Hospital Innsbruck, Innsbruck, Austria
    Wien Med Wochenschr 157:398-401. 2007
    ..A proportion of 4% of vials was not sterile. A training programme for health care workers in aseptic techniques and for validation of the preparation of solutions for parenteral use should be installed...
  62. ncbi request reprint The changing face of epidemiology of invasive fungal disease in Europe
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Mycoses 52:197-205. 2009
    ..Choice between agents should be based on a variety of factors, including spectrum of activity, adverse events, drug interactions, route of administration, clinical efficacy of individual agents and local epidemiology...
  63. ncbi request reprint Complement synthesis and activation in the brain of SIV-infected monkeys
    Cornelia Speth
    Institute of Hygiene and Social Medicine, Innsbruck Medical University and Ludwig Bolthmann Institute for AIDS Research, Fritz Pregl Str 3, Innsbruck A 6020, Austria
    J Neuroimmunol 151:45-54. 2004
    ..The membrane deposition thus might suggest complement-induced lysis of bystander neurons as a potential mechanism for cell damage during viral infection of the brain...
  64. pmc In vitro activity of Isavuconazole against Aspergillus species and zygomycetes according to the methodology of the European Committee on Antimicrobial Susceptibility Testing
    Susanne Perkhofer
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Antimicrob Agents Chemother 53:1645-7. 2009
    ..ISAV exhibited good antifungal activity against the tested isolates with the exception of Aspergillus niger and Mucorales. The in vitro activity of ISAV was comparable to that of voriconazole aside from Mucorales...
  65. doi request reprint Complement induction and complement evasion in patients with cerebral aspergillosis
    Gunter Rambach
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Microbes Infect 10:1567-76. 2008
    ..Complement indeed seems to represent an important selection pressure and evokes the development of fungal evasion mechanisms. Counteractions for these evasion processes might represent interesting therapeutic approaches...
  66. doi request reprint Complement and fungal pathogens: an update
    Cornelia Speth
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Mycoses 51:477-96. 2008
    ..However, we also mention the 'Yin-Yang' nature of the complement system in fungal infections, as growing evidence assigns to complement a contributory part in the pathogenesis of fungus-induced allergic manifestations...
  67. ncbi request reprint Tolerability of N-chlorotaurine in chronic rhinosinusitis applied via yamik catheter
    Andreas Neher
    Department of Otorhinolaryngology, Innsbruck Medical University, Anichstr 35, Innsbruck, Austria
    Auris Nasus Larynx 32:359-64. 2005
    ..N-Chlorotaurine (NCT), a mild endogenous oxidant with broad-spectrum antimicrobial activity, has been tested for the first time in CRS...
  68. doi request reprint Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro
    Barbara Falkensammer
    Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
    Mycoses 51:505-14. 2008
    ..Interestingly, these drugs are neither fungistatic nor fungicidal at the concentrations applied. Laccaridione B may represent a promising novel type of antimycotic drug--targeting virulence factors without killing the yeast...
  69. doi request reprint In vitro susceptibility-testing in Aspergillus species
    Cornelia Lass-Flörl
    Department of Hygiene and Clinical Microbiology, University of Innsbruck, Innsbruck, Austria
    Mycoses 51:437-46. 2008
    ..EUCAST-AFST-ASPERGILLUS) defining breakpoints. This paper reviews the available methods for antifungal susceptibility-testing in Aspergillus spp. as well as the scant data regarding the clinical implications of in vitro testing...
  70. ncbi request reprint Prevention of transfusion of platelet components contaminated with low levels of bacteria: a comparison of bacteria culture and pathogen inactivation methods
    Walter Nussbaumer
    Department of Transfusion Medicine and the Institute for Hygiene and Social Medicine, University of Innsbruck, University Hospital Innsbruck, Innsbruck, Austria
    Transfusion 47:1125-33. 2007
    ..This study compared the efficacy of bacterial detection with inactivation for reducing the risk associated with transfusion of platelet (PLT) components contaminated with low levels of bacteria...
  71. doi request reprint In vitro susceptibility testing in Aspergillus species: an update
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Clinical Microbiology, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Future Microbiol 5:789-99. 2010
    ..This article reviews the available methods for antifungal susceptibility testing in Aspergillus spp. as well as the scant data regarding the clinical implications of in vitro testing...
  72. pmc Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature
    A Mayr
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Austria
    Eur J Med Res 16:153-7. 2011
    ..Reports on well documented in vitro and in vivo resistance to echinocandins are rare for Aspergillus species and resistance may be under-diagnosed as susceptibility testing is less frequently performed due to technical reasons...
  73. doi request reprint Invasive fungal infections in pediatric patients: a review focusing on antifungal therapy
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Expert Rev Anti Infect Ther 8:127-35. 2010
    ..The present article reviews these aspects for invasive aspergillosis and invasive candidiasis, the two most common life-threatening fungal infections...
  74. pmc Inhibition of human immunodeficiency virus replication by cell membrane-crossing oligomers
    Wilfried Posch
    Innsbruck Medical University, Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck, Austria
    Mol Med 18:111-22. 2012
    ..Finally, the CMCOs did not exert any cytotoxicity and did not inhibit proliferation of the cells. In vitro, our CMCOs are promising candidates as biologically active anti-HIV reagents for future in vivo applications...
  75. doi request reprint Anidulafungin and voriconazole in invasive fungal disease: pharmacological data and their use in combination
    Susanne Perkhofer
    Innsbruck Medical University, Department of Hygiene, Microbiology and Social Medicine, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Expert Opin Investig Drugs 18:1393-404. 2009
    ..In this review, the in vitro and in vivo activity of anidulafungin and voriconazole, both new antimycotic substances with a different mode of action, are analyzed...
  76. doi request reprint Susceptibility of Candida species and various moulds to antimycotic drugs: use of epidemiological cutoff values according to EUCAST and CLSI in an 8-year survey
    Gunter Rambach
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Med Mycol 49:856-63. 2011
    ..EUCAST and CLSI should continue their efforts to harmonize their methods of antimicrobial susceptibility testing (AST) and to define additional and shareable epidemiological cutoff values and clinical breakpoints...
  77. pmc 68Ga-siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Nucl Med 51:639-45. 2010
    ..fumigatus virulence. We aimed to evaluate the potential of siderophores radiolabeled with (68)Ga, a positron emitter with complexing properties comparable to those of Fe(III), as a radiopharmaceutical for imaging IPA...
  78. ncbi request reprint Biopsy procedures for molecular tissue diagnosis of invasive fungal infections
    Cornelia Mrazek
    Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Fritz Pregl Straße 3 III, 6020, Innsbruck, Austria
    Curr Infect Dis Rep 13:504-9. 2011
    ..Combining culture, microscopy, serology, and PCR in lung tissues and/or bronchial samples will increase the diagnostic yield by 99%. Here, we give an overview of biopsy procedures for molecular tissue diagnosis of IFI...
  79. ncbi request reprint Silver segregation and bacterial growth of intraventricular catheters impregnated with silver nanoparticles in cerebrospinal fluid drainages
    Klaus Galiano
    Department of Neurosurgery, Innsbruck Medical University, 6020 Innsbruck, Austria
    Neurol Res 30:285-7. 2008
    ..Silver released from these new catheters should have an anti-microbacterial effect. This study examines the silver ion release and a potential effect of bacterial growth in an in vitro experiment...
  80. ncbi request reprint In Vitro Susceptibility Testing in Fungi: What is its Role in Clinical Practice?
    Susanne Perkhofer
    Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020, Innsbruck, Austria
    Curr Infect Dis Rep 12:401-8. 2010
    ..This paper reviews the available methods for antifungal susceptibility testing of yeasts and filamentous fungi and the data regarding the clinical implications of in vitro testing...