P A Kyrle

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint High plasma levels of factor VIII and the risk of recurrent venous thromboembolism
    P A Kyrle
    Department of Internal Medicine I, Vienna University Hospital, Austria
    N Engl J Med 343:457-62. 2000
  2. ncbi request reprint The risk of recurrent venous thromboembolism: the Austrian Study on Recurrent Venous Thromboembolism
    Paul Alexander Kyrle
    Division of Hematology and Hemostasis, Ludwig Boltzmann Institute for Thrombosis Research, Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
    Wien Klin Wochenschr 115:471-4. 2003
  3. ncbi request reprint Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis
    I Pabinger
    Department of Internal Medicine I, Division of Haematology and Blood Coagulation, Medical University, Vienna, Austria
    J Thromb Haemost 3:949-54. 2005
  4. ncbi request reprint The post-thrombotic syndrome: risk factors and impact on the course of thrombotic disease
    M Stain
    Division of Hematology and Hemostasis, Department of Internal Medicine I, Vienna, Austria
    J Thromb Haemost 3:2671-6. 2005
  5. ncbi request reprint The risk of recurrent venous thromboembolism among patients with high factor IX levels
    A Weltermann
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Vienna University Hospital, Vienna, Austria
    J Thromb Haemost 1:28-32. 2003
  6. ncbi request reprint Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden
    S Eichinger
    Department of Internal Medicine I, University Vienna, Austria
    Thromb Haemost 82:1232-6. 1999
  7. ncbi request reprint Impact of the factor II: G20210A variant on the risk of venous thromboembolism in relatives from families with the factor V: R506Q mutation
    C Rintelen
    University of Vienna Medical School, First Department of Medicine, Division of Hematology and Blood Coagulation, Vienna, Austria
    Eur J Haematol 67:165-9. 2001
  8. doi request reprint 6 versus 30 months anticoagulation for recurrent venous thrombosis in patients with high factor VIII
    L Eischer
    Department of Internal Medicine I, Medical University of Vienna, Austria
    Ann Hematol 88:485-90. 2009
  9. doi request reprint Thrombin generation in haemophilia A patients with factor VIII inhibitors after infusion of recombinant factor VIIa
    S Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Eur J Clin Invest 39:707-13. 2009
  10. doi request reprint Comparison between idiopathic deep vein thrombosis of the upper and lower extremity regarding risk factors and recurrence
    D Lechner
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 6:1269-74. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint High plasma levels of factor VIII and the risk of recurrent venous thromboembolism
    P A Kyrle
    Department of Internal Medicine I, Vienna University Hospital, Austria
    N Engl J Med 343:457-62. 2000
    ..We evaluated the risk of a recurrence of thrombosis after an initial episode of spontaneous venous thromboembolism among patients with high plasma levels of factor VIII...
  2. ncbi request reprint The risk of recurrent venous thromboembolism: the Austrian Study on Recurrent Venous Thromboembolism
    Paul Alexander Kyrle
    Division of Hematology and Hemostasis, Ludwig Boltzmann Institute for Thrombosis Research, Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
    Wien Klin Wochenschr 115:471-4. 2003
    ....
  3. ncbi request reprint Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis
    I Pabinger
    Department of Internal Medicine I, Division of Haematology and Blood Coagulation, Medical University, Vienna, Austria
    J Thromb Haemost 3:949-54. 2005
    ..Objective: To evaluate the risk of recurrent pregnancy-associated thrombosis in women with previous VTE in a large retrospective cohort study...
  4. ncbi request reprint The post-thrombotic syndrome: risk factors and impact on the course of thrombotic disease
    M Stain
    Division of Hematology and Hemostasis, Department of Internal Medicine I, Vienna, Austria
    J Thromb Haemost 3:2671-6. 2005
    ..The post-thrombotic syndrome (PTS) is a frequent complication of deep vein thrombosis (DVT). Patients with recurrent ipsilateral DVT have an increased risk of PTS; other risk factors are unknown...
  5. ncbi request reprint The risk of recurrent venous thromboembolism among patients with high factor IX levels
    A Weltermann
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Vienna University Hospital, Vienna, Austria
    J Thromb Haemost 1:28-32. 2003
    ..6 among patients with high FIX and high FVIII. High levels of FIX confer an increased risk of recurrent venous thromboembolism and enhance the risk of recurrence among patients with high FVIII...
  6. ncbi request reprint Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden
    S Eichinger
    Department of Internal Medicine I, University Vienna, Austria
    Thromb Haemost 82:1232-6. 1999
    ..Higher levels of D-Dimer in women with FVL than in women with wildtype factor V at baseline as well as during pregnancy indicate increased fibrinolytic system activation in carriers of the mutation...
  7. ncbi request reprint Impact of the factor II: G20210A variant on the risk of venous thromboembolism in relatives from families with the factor V: R506Q mutation
    C Rintelen
    University of Vienna Medical School, First Department of Medicine, Division of Hematology and Blood Coagulation, Vienna, Austria
    Eur J Haematol 67:165-9. 2001
    ..The aim of this study was to investigate the impact of the coinheritance of both mutations on the risk of VTE in relatives of symptomatic carriers of the factor V: R506Q mutation and the factor II: G20210A variant...
  8. doi request reprint 6 versus 30 months anticoagulation for recurrent venous thrombosis in patients with high factor VIII
    L Eischer
    Department of Internal Medicine I, Medical University of Vienna, Austria
    Ann Hematol 88:485-90. 2009
    ..Our findings in a small number of patients indicate that prolonged anticoagulation seems to be effective but that the benefit is not maintained after discontinuation of anticoagulation...
  9. doi request reprint Thrombin generation in haemophilia A patients with factor VIII inhibitors after infusion of recombinant factor VIIa
    S Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Eur J Clin Invest 39:707-13. 2009
    ..Development of factor VIII inhibitors is a serious complication in haemophilia A patients. Recombinant factor VIIa (rVIIa) is clinically effective, but its effects on haemostatic system need still to be fully elucidated...
  10. doi request reprint Comparison between idiopathic deep vein thrombosis of the upper and lower extremity regarding risk factors and recurrence
    D Lechner
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 6:1269-74. 2008
    ..The pathogenesis and natural course of idiopathic upper extremity deep vein thrombosis (UEDVT) are unclear...
  11. ncbi request reprint Prediction of recurrent venous thromboembolism by the activated partial thromboplastin time
    G Hron
    Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 4:752-6. 2006
    ..Venous thromboembolism (VTE) is a multi-factorial disease. Extensive thrombophilia screening is costly and often inconclusive. Simple laboratory methods are required to predict the risk of recurrence...
  12. ncbi request reprint The risk of recurrent venous thromboembolism
    P A Kyrle
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Ludwig Boltzmann Institute for Thrombosis Research, Vienna University Hospital, Vienna, Austria
    Vasa 31:163-6. 2002
    ..In these patients short-term secondary thromboprophylaxis (6 to 12 weeks) is justified whereas patients with a first episode of spontaneous VTE should be treated with oral anticoagulants for a longer period of time (3 to 6 months)...
  13. doi request reprint Duration of anticoagulation after initial idiopathic venous thrombosis--the swinging pendulum: risk assessment to predict recurrence
    S Eichinger
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 7:291-5. 2009
    ..Reproducible and simple scoring systems may improve stratification of patients according to their recurrence risk and optimize duration of anticoagulant therapy...
  14. ncbi request reprint Efficacy and safety of splenectomy in adult chronic immune thrombocytopenia
    C Zoghlami-Rintelen
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, University Hospital of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Ann Hematol 82:290-4. 2003
    ..Patients aged >45 years had a similar success rate as compared with younger patients. Three patients had infections (one pneumonia and two fever of unknown origin) requiring hospitalization, but none had overwhelming septicemia...
  15. ncbi request reprint Prevention of deep vein thrombosis in orthopedic surgery
    Sabine Eichinger
    Dept of Internal Medicine I, Div of Hematology and Hemostasis, Medical University of Vienna, Austria
    Eur J Med Res 9:112-8. 2004
    ..g., an increased bleeding risk) and high costs the role of these new drugs in the prophylaxis of VTE in patients undergoing major orthopedic surgery of the lower extremities remains to be established...
  16. doi request reprint Mechanisms underlying acquired von Willebrand syndrome associated with an IgM paraprotein
    M Mayerhofer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 39:833-6. 2009
    ..The patient required surgery and was successfully managed by chemotherapy consisting of rituximab and fludarabin as well as plasma exchange...
  17. ncbi request reprint Pregnancy-associated risk for venous thromboembolism and pregnancy outcome in women homozygous for factor V Leiden
    I Pabinger
    I Department of Internal Medicine, Division of Hematology Blood Coagulation, University Hospital, Vienna, Austria
    Hematol J 1:37-41. 2000
    ....
  18. ncbi request reprint Chemotherapy-induced thrombin generation via procoagulant endothelial microparticles is independent of tissue factor activity
    D Lechner
    Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    J Thromb Haemost 5:2445-52. 2007
    ..Cisplatin-based chemotherapy predisposes cancer patients to thromboembolic events...
  19. ncbi request reprint Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolism
    Sabine Eichinger
    Division of Hematology and Hemostasis, Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Arch Intern Med 164:92-6. 2004
    ..We therefore investigated the risk of recurrence among patients with spontaneous symptomatic PE and among those with deep vein thrombosis (DVT) without symptoms of PE...
  20. ncbi request reprint Unilateral chronic thromboembolic pulmonary disease associated with combined inherited thrombophilia
    Klaus Laczika
    Intensive Care Unit, the Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
    Chest 121:286-9. 2002
    ..This case is unique because unilateral CTEPH is extremely uncommon, and it illustrates the severe clinical sequelae of the cosegregation of inherited thrombophilic defects...
  21. ncbi request reprint Family history for venous thromboembolism and the risk for recurrence
    Gregor Hron
    Department of Internal Medicine I, Division of Angiology, Medical University of Vienna, Vienna, Austria
    Am J Med 119:50-3. 2006
    ..The relevance of a family history for venous thromboembolism with regard to the likelihood for recurrence is unknown...
  22. ncbi request reprint The optimal duration of secondary thromboprophylaxis in patients with venous thromboembolism. The importance of thrombophilia screening
    Paul Alexander Kyrle
    Division of Hematology and Hemostasis, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Wien Med Wochenschr 155:17-21. 2005
    ..The clinical relevance of new treatment strategies such as extended low-intensity warfarin or administration of the direct thrombin inhibitor (xi-)melagatran is at present unclear...
  23. ncbi request reprint The course of severe autoimmune thrombocytopenia in patients not undergoing splenectomy
    Thomas Sailer
    Department of Internal Medicine I, Division Haematology and Haemostaseology, Medical University of Vienna, 1090 Vienna, Währingergürtel 18 20, Austria
    Haematologica 91:1041-5. 2006
    ..There is no consensus on the indications and optimal timing of splenectomy, since it is unknown up to which time from onset of symptoms a remission can be expected without splenectomy...