Research Topics
Species | P A KyrleSummaryAffiliation: University of Vienna Country: Austria Publications
| Collaborators
|
Detail Information
Publications
High plasma levels of factor VIII and the risk of recurrent venous thromboembolismP A Kyrle
Department of Internal Medicine I, Vienna University Hospital, Austria
N Engl J Med 343:457-62. 2000..We evaluated the risk of a recurrence of thrombosis after an initial episode of spontaneous venous thromboembolism among patients with high plasma levels of factor VIII...- The risk of recurrent venous thromboembolism: the Austrian Study on Recurrent Venous ThromboembolismPaul Alexander Kyrle
Division of Hematology and Hemostasis, Ludwig Boltzmann Institute for Thrombosis Research, Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
Wien Klin Wochenschr 115:471-4. 2003.... - Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosisI Pabinger
Department of Internal Medicine I, Division of Haematology and Blood Coagulation, Medical University, Vienna, Austria
J Thromb Haemost 3:949-54. 2005..Objective: To evaluate the risk of recurrent pregnancy-associated thrombosis in women with previous VTE in a large retrospective cohort study... - The post-thrombotic syndrome: risk factors and impact on the course of thrombotic diseaseM Stain
Division of Hematology and Hemostasis, Department of Internal Medicine I, Vienna, Austria
J Thromb Haemost 3:2671-6. 2005..CONCLUSIONS: Proximal DVT, male gender, and high D-dimer levels are independently associated with the development of PTS in patients with a first DVT. Patients with PTS have an increased risk of recurrent venous thromboembolism... - The risk of recurrent venous thromboembolism among patients with high factor IX levelsA Weltermann
Department of Internal Medicine I, Division of Hematology and Hemostasis, Vienna University Hospital, Vienna, Austria
J Thromb Haemost 1:28-32. 2003..6 among patients with high FIX and high FVIII. High levels of FIX confer an increased risk of recurrent venous thromboembolism and enhance the risk of recurrence among patients with high FVIII... - Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V LeidenS Eichinger
Department of Internal Medicine I, University Vienna, Austria
Thromb Haemost 82:1232-6. 1999..Higher levels of D-Dimer in women with FVL than in women with wildtype factor V at baseline as well as during pregnancy indicate increased fibrinolytic system activation in carriers of the mutation... - Impact of the factor II: G20210A variant on the risk of venous thromboembolism in relatives from families with the factor V: R506Q mutationC Rintelen
University of Vienna Medical School, First Department of Medicine, Division of Hematology and Blood Coagulation, Vienna, Austria
Eur J Haematol 67:165-9. 2001..The aim of this study was to investigate the impact of the coinheritance of both mutations on the risk of VTE in relatives of symptomatic carriers of the factor V: R506Q mutation and the factor II: G20210A variant... 
6 versus 30 months anticoagulation for recurrent venous thrombosis in patients with high factor VIIIL Eischer
Department of Internal Medicine I, Medical University of Vienna, Austria
Ann Hematol 88:485-90. 2009..Our findings in a small number of patients indicate that prolonged anticoagulation seems to be effective but that the benefit is not maintained after discontinuation of anticoagulation...- Thrombin generation in haemophilia A patients with factor VIII inhibitors after infusion of recombinant factor VIIaS Eichinger
Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
Eur J Clin Invest 39:707-13. 2009..Development of factor VIII inhibitors is a serious complication in haemophilia A patients. Recombinant factor VIIa (rVIIa) is clinically effective, but its effects on haemostatic system need still to be fully elucidated... - Comparison between idiopathic deep vein thrombosis of the upper and lower extremity regarding risk factors and recurrenceD Lechner
Department of Medicine I, Medical University of Vienna, Vienna, Austria
J Thromb Haemost 6:1269-74. 2008..The pathogenesis and natural course of idiopathic upper extremity deep vein thrombosis (UEDVT) are unclear... - Prediction of recurrent venous thromboembolism by the activated partial thromboplastin timeG Hron
Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
J Thromb Haemost 4:752-6. 2006..39-0.87, P = 0.009) after adjustment for sex, age, factor V Leiden, and factor II G20210A. CONCLUSIONS: Measurement of APTT allows stratification of patients with VTE into high- and low-risk categories with regard to recurrence... - The risk of recurrent venous thromboembolismP A Kyrle
Department of Internal Medicine I, Division of Hematology and Hemostasis, Ludwig Boltzmann Institute for Thrombosis Research, Vienna University Hospital, Vienna, Austria
Vasa 31:163-6. 2002..In these patients short-term secondary thromboprophylaxis (6 to 12 weeks) is justified whereas patients with a first episode of spontaneous VTE should be treated with oral anticoagulants for a longer period of time (3 to 6 months)... - Duration of anticoagulation after initial idiopathic venous thrombosis--the swinging pendulum: risk assessment to predict recurrenceS Eichinger
Department of Medicine I, Medical University of Vienna, Vienna, Austria
J Thromb Haemost 7:291-5. 2009..Reproducible and simple scoring systems may improve stratification of patients according to their recurrence risk and optimize duration of anticoagulant therapy... - Efficacy and safety of splenectomy in adult chronic immune thrombocytopeniaC Zoghlami-Rintelen
Division of Hematology and Hemostaseology, Department of Internal Medicine I, University Hospital of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Ann Hematol 82:290-4. 2003..Patients aged >45 years had a similar success rate as compared with younger patients. Three patients had infections (one pneumonia and two fever of unknown origin) requiring hospitalization, but none had overwhelming septicemia... - Prevention of deep vein thrombosis in orthopedic surgerySabine Eichinger
Dept of Internal Medicine I, Div of Hematology and Hemostasis, Medical University of Vienna, Austria
Eur J Med Res 9:112-8. 2004..g., an increased bleeding risk) and high costs the role of these new drugs in the prophylaxis of VTE in patients undergoing major orthopedic surgery of the lower extremities remains to be established... - Mechanisms underlying acquired von Willebrand syndrome associated with an IgM paraproteinM Mayerhofer
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
Eur J Clin Invest 39:833-6. 2009..The patient required surgery and was successfully managed by chemotherapy consisting of rituximab and fludarabin as well as plasma exchange... - Pregnancy-associated risk for venous thromboembolism and pregnancy outcome in women homozygous for factor V LeidenI Pabinger
I Department of Internal Medicine, Division of Hematology Blood Coagulation, University Hospital, Vienna, Austria
Hematol J 1:37-41. 2000.... - Chemotherapy-induced thrombin generation via procoagulant endothelial microparticles is independent of tissue factor activityD Lechner
Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
J Thromb Haemost 5:2445-52. 2007..Cisplatin-based chemotherapy predisposes cancer patients to thromboembolic events... - Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolismSabine Eichinger
Division of Hematology and Hemostasis, Department of Internal Medicine I, University of Vienna, Vienna, Austria
Arch Intern Med 164:92-6. 2004..3-12.3; P =.03). CONCLUSION: Patients with a first symptomatic PE not only have a higher risk of recurrent VTE than those with DVT without symptoms of PE, but are also at high risk of symptomatic PE at recurrence... - Unilateral chronic thromboembolic pulmonary disease associated with combined inherited thrombophiliaKlaus Laczika
Intensive Care Unit, the Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
Chest 121:286-9. 2002..This case is unique because unilateral CTEPH is extremely uncommon, and it illustrates the severe clinical sequelae of the cosegregation of inherited thrombophilic defects... - Family history for venous thromboembolism and the risk for recurrenceGregor Hron
Department of Internal Medicine I, Division of Angiology, Medical University of Vienna, Vienna, Austria
Am J Med 119:50-3. 2006..The relevance of a family history for venous thromboembolism with regard to the likelihood for recurrence is unknown... - The optimal duration of secondary thromboprophylaxis in patients with venous thromboembolism. The importance of thrombophilia screeningPaul Alexander Kyrle
Division of Hematology and Hemostasis, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
Wien Med Wochenschr 155:17-21. 2005..The clinical relevance of new treatment strategies such as extended low-intensity warfarin or administration of the direct thrombin inhibitor (xi-)melagatran is at present unclear... - The course of severe autoimmune thrombocytopenia in patients not undergoing splenectomyThomas Sailer
Department of Internal Medicine I, Division Haematology and Haemostaseology, Medical University of Vienna, 1090 Vienna, , Austria
Haematologica 91:1041-5. 2006..INTERPRETATION AND CONCLUSIONS: These data indicate that splenectomy may be delayed for up to 3 years, in particular in those patients whose AITP has had an insidious onset...