Andrey V Kozlov

Summary

Affiliation: University of Veterinary Medicine
Country: Austria

Publications

  1. ncbi request reprint Different effects of endotoxic shock on the respiratory function of liver and heart mitochondria in rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Am J Physiol Gastrointest Liver Physiol 290:G543-9. 2006
  2. ncbi request reprint Release and hemodynamic influence of nitro-glycerine-derived nitric oxide in endotoxemic rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstr 13, A 1200 Vienna, Austria
    Vascul Pharmacol 43:411-4. 2005
  3. ncbi request reprint Skeletal muscles, heart, and lung are the main sources of oxygen radicals in old rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Biochim Biophys Acta 1740:382-9. 2005
  4. ncbi request reprint Epr analysis reveals three tissues responding to endotoxin by increased formation of reactive oxygen and nitrogen species
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Free Radic Biol Med 34:1555-62. 2003
  5. pmc Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver
    Andrey V Kozlov
    Department of Pharmacology and Toxicology Institute for Applied Botany, University of Veterinary Medicine, Vienna, Austria
    Br J Pharmacol 139:989-97. 2003
  6. pmc Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA, Vienna, Austria
    Mol Med 16:254-61. 2010
  7. ncbi request reprint Opposite effects of endotoxin on mitochondrial and endoplasmic reticulum functions
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Donaueschingen Street 13, A 1200 Vienna, Austria
    Biochem Biophys Res Commun 352:91-6. 2007
  8. doi request reprint Peritoneal inflammation in pigs is associated with early mitochondrial dysfunction in liver and kidney
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, 1200, Vienna, Austria
    Inflammation 33:295-305. 2010
  9. doi request reprint Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer
    Katrin Friedbichler
    Ludwig Boltzmann Institute for Cancer Research LBI CR, Vienna, Austria
    Hepatology 55:941-52. 2012
  10. doi request reprint Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate
    Peter Dungel
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA, Donaueschingenstr 23, A 1200 Vienna, Austria
    Arch Biochem Biophys 471:109-15. 2008

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Different effects of endotoxic shock on the respiratory function of liver and heart mitochondria in rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Am J Physiol Gastrointest Liver Physiol 290:G543-9. 2006
    ....
  2. ncbi request reprint Release and hemodynamic influence of nitro-glycerine-derived nitric oxide in endotoxemic rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstr 13, A 1200 Vienna, Austria
    Vascul Pharmacol 43:411-4. 2005
    ....
  3. ncbi request reprint Skeletal muscles, heart, and lung are the main sources of oxygen radicals in old rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Biochim Biophys Acta 1740:382-9. 2005
    ..This study identifies heart, lung, and skeletal muscle as the tissues with increased RONS formation as a function of age...
  4. ncbi request reprint Epr analysis reveals three tissues responding to endotoxin by increased formation of reactive oxygen and nitrogen species
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Free Radic Biol Med 34:1555-62. 2003
    ..In summary, low-temperature EPR combined with CP-H infusion allowed detection of local RONS formation in tissues. Increased formation of RONS in response to endotoxin challenge is organ specific...
  5. pmc Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver
    Andrey V Kozlov
    Department of Pharmacology and Toxicology Institute for Applied Botany, University of Veterinary Medicine, Vienna, Austria
    Br J Pharmacol 139:989-97. 2003
    ....
  6. pmc Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA, Vienna, Austria
    Mol Med 16:254-61. 2010
    ..Thus, E2 appears to be a novel hormonal adjunct that prolongs permissive hypotension during lengthy transportation of the injured patient between the injury site and the hospital in both civilian and military injuries...
  7. ncbi request reprint Opposite effects of endotoxin on mitochondrial and endoplasmic reticulum functions
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Donaueschingen Street 13, A 1200 Vienna, Austria
    Biochem Biophys Res Commun 352:91-6. 2007
    ..We hypothesize that upregulation of this enzyme protects mitochondria against mitochondrial ROS, but does not protect other cellular compartments such as endoplasmic reticulum and plasma membrane causing necrosis...
  8. doi request reprint Peritoneal inflammation in pigs is associated with early mitochondrial dysfunction in liver and kidney
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, 1200, Vienna, Austria
    Inflammation 33:295-305. 2010
    ..We did not find proof that mitochondrial dysfunction was due to increased levels of either nitric oxide (NO) or products of HO, but it was accompanied by increased levels of oxidative stress markers...
  9. doi request reprint Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer
    Katrin Friedbichler
    Ludwig Boltzmann Institute for Cancer Research LBI CR, Vienna, Austria
    Hepatology 55:941-52. 2012
    ..Thus, HCC was never observed in STAT5(Δhep) mice...
  10. doi request reprint Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate
    Peter Dungel
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA, Donaueschingenstr 23, A 1200 Vienna, Austria
    Arch Biochem Biophys 471:109-15. 2008
    ..The inhibition of mitochondrial respiration by GTN is not sensitive to visible light, suggesting an inhibition mechanism other that NO mediation...
  11. doi request reprint Neither nitrite nor nitric oxide mediate toxic effects of nitroglycerin on mitochondria
    Peter Dungel
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Workers Compensation Board Research Center, A 1200 Vienna, Austria
    J Biochem Mol Toxicol 25:297-302. 2011
    ..In summary, our data suggest that although NG induces vasodilatation via NO release, it causes mitochondrial dysfunction via an NO-independent pathway...
  12. doi request reprint Transient increase of free iron in rat livers following hemorrhagic-traumatic shock and reperfusion is independent of heme oxygenase 1 upregulation
    Astrid Postl
    Department of Biomedical Sciences, University of Veterinary Medicine, Veterinaerplatz 1, Vienna, Austria
    Shock 36:501-9. 2011
    ..Thus, upregulation of HO activity by hemin does not increase Fe2+ levels following HTS and reperfusion...
  13. doi request reprint Endotoxin causes functional endoplasmic reticulum failure, possibly mediated by mitochondria
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Donaueschingenstr 13, 1200 Vienna, Austria
    Biochim Biophys Acta 1792:521-30. 2009
    ..We suggest that functional ER failure may be a reason for organ dysfunction upon excessive inflammatory response mediated by endotoxin...
  14. doi request reprint Antimycin A and lipopolysaccharide cause the leakage of superoxide radicals from rat liver mitochondria
    Christina Piskernik
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA, Vienna, Austria
    Biochim Biophys Acta 1782:280-5. 2008
    ....
  15. ncbi request reprint Mechanisms of vasodilatation induced by nitrite instillation in intestinal lumen: possible role of hemoglobin
    Andrey V Kozlov
    L Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingen strasse 13, A 1200 Vienna, Austria
    Antioxid Redox Signal 7:515-21. 2005
    ..The exact mechanism underlying vasodilatation observed when the concentration of NO-bound Hb was > 10 microM is, however, not clear yet and requires further studies...
  16. doi request reprint Rons formation under restrictive reperfusion does not affect organ dysfunction early after hemorrhage and trauma
    Clara Zifko
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUVA Research Center, Vienna, Austria
    Shock 34:384-9. 2010
    ..Moreover, scavenging of RONS does not affect the early organ dysfunction manifested at the end of a phase of restrictive reperfusion...
  17. doi request reprint Reperfusion does not induce oxidative stress but sustained endoplasmic reticulum stress in livers of rats subjected to traumatic-hemorrhagic shock
    Johanna Catharina Duvigneau
    Department of Biomedical Sciences, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria
    Shock 33:289-98. 2010
    ..Although ER stress was not associated with depressed hepatocyte function, it may act as an early trigger of protracted cell death, thereby contributing to delayed organ failure after THS...
  18. doi request reprint Tocopheryl quinones and mitochondria
    Lars Gille
    Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
    Mol Nutr Food Res 54:601-15. 2010
    ..It is shown that the understanding of how tocopheryl quinones and tocopherols interfere with mitochondrial functions on the molecular level is still incomplete and that a better comprehension requires further research activities...
  19. ncbi request reprint A novel endotoxin-induced pathway: upregulation of heme oxygenase 1, accumulation of free iron, and free iron-mediated mitochondrial dysfunction
    J Catharina Duvigneau
    Department of Natural Sciences, Veterinary University Vienna, Vienna, Austria
    Lab Invest 88:70-7. 2008
    ..Our data suggest that free iron released by HO-1 causes mitochondrial dysfunction in pathological situations accompanied by endotoxic shock...
  20. doi request reprint Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats
    Sylvia Nürnberger
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Allgemeine Unfallversicherungsanstalt Research Center, Vienna, Austria
    Am J Physiol Gastrointest Liver Physiol 303:G1373-83. 2012
    ..The pathway activating ER stress in response to SIR is not known yet...
  21. pmc Blue laser light increases perfusion of a skin flap via release of nitric oxide from hemoglobin
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria
    Mol Med 13:22-9. 2007
    ..This study demonstrates that blue laser irradiation improves local tissue perfusion in a controlled manner stimulating NO release from NO-Hb complexes...
  22. ncbi request reprint Nitric oxide synthase inhibitors affect nitric oxide synthesis in normoxic but not in ischemic organs during intestinal ischemia and early reperfusion
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, University of Veterinary Medicine, Vienna, Austria
    J Lab Clin Med 140:303-11. 2002
    ..The protective effect of L-arginine supplementation during I/R(i) is probably related to increasing intravascular NO formation...
  23. ncbi request reprint The existence and significance of a mitochondrial nitrite reductase
    Hans Nohl
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine of Vienna, Vienna, Austria
    Redox Rep 10:281-6. 2005
    ..In this paper, we describe the identity and the function of mitochondrial nitrite reductase and the consequences of NO-recycling in the metabolic compartment of mitochondria...
  24. pmc Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, A 1200 Vienna, Austria
    Ann Intensive Care 1:41. 2011
    ..Collectively the data discussed in this review suggest that appropriate diagnosis and specific treatment of mitochondrial dysfunction in ICU patients may significantly improve the clinical outcome...
  25. ncbi request reprint The biomolecule ubiquinone exerts a variety of biological functions
    Hans Nohl
    Fundamental Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biofactors 18:23-31. 2003
    ..Furthermore, we have addressed the antioxidant role of ubiquinone and found that the efficiency of this activity is widely dependent on the type of biomembrane where ubiquinone exerts its chain-breaking activity...
  26. ncbi request reprint Caroverine, a multifunctional drug with antioxidant functions
    Hans Nohl
    Department of Pharmacology and Toxicology Institute for Applied Botany, Veterinary University of Vienna, Vienna, Austria
    Biofactors 19:79-85. 2003
    ..The strong antioxidant activity of Caroverine is therefore based both on the partial prevention of the formation and the highly active scavenging of hydroxyl radicals...
  27. pmc Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice
    Kristina M Mueller
    Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria
    Hepatology 54:1398-409. 2011
    ..Moreover, activation of the c-Jun N-terminal kinase 1 (JNK1) and STAT3 was prominent...
  28. ncbi request reprint Combination of iron overload plus ethanol and ischemia alone give rise to the same endogenous free iron pool
    Odile Sergent
    Laboratoire de Biologie Cellulaire et Vegetale, UPRES 3891, UFR des Sciences Pharmaceutiques et Biologiques, University of Rennes 1, 2 AVE du Pr Léon Bernard, CS, 34317 35043, Rennes Cedex, France
    Biometals 18:567-75. 2005
    ....
  29. ncbi request reprint The antioxidant activity of caroverine
    Natalia Udilova
    Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 65:59-65. 2003
    ..OH radicals occurs at an extremely high rate constant (k=1.9 x 10(10)M(-1)s(-1)). The strong antioxidant activity of caroverine is therefore based both on the partial prevention and highly active scavenging of hydroxyl radicals...
  30. ncbi request reprint Proteome analysis of rat liver mitochondria reveals a possible compensatory response to endotoxic shock
    Ingrid Miller
    Institute of Medical Chemistry, Department of Natural Sciences, University of Veterinary Medicine Vienna, Austria
    FEBS Lett 580:1257-62. 2006
    ..Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage...
  31. ncbi request reprint Mitochondria produce reactive nitrogen species via an arginine-independent pathway
    Zsombor Lacza
    Department of Physiology Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Free Radic Res 40:369-78. 2006
    ..We conclude that mitochondria from brain, heart and liver are capable of significant RNS production via the respiratory chain rather than through an arginine-dependent mtNOS...
  32. ncbi request reprint Mitochondrial superoxide radical formation is controlled by electron bifurcation to the high and low potential pathways
    Katrin Staniek
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Free Radic Res 36:381-7. 2002
    ..The regulator, which controls leakage of electrons to oxygen, appears to be the electron-branching activity of the cytochrome bc1 complex...