J A Knoblich

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Asymmetric cell division during animal development
    J A Knoblich
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Mol Cell Biol 2:11-20. 2001
  2. ncbi request reprint Mechanisms of asymmetric cell division during animal development
    J A Knoblich
    Research Institute of Molecular Pathology, Vienna, Austria
    Curr Opin Cell Biol 9:833-41. 1997
  3. ncbi request reprint Epithelial polarity: the ins and outs of the fly epidermis
    J A Knoblich
    Research Institute of Molecular Pathology I M P, Vienna, Austria
    Curr Biol 10:R791-4. 2000
  4. ncbi request reprint Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system
    M Schaefer
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Cell 107:183-94. 2001
  5. ncbi request reprint Protein localization during asymmetric cell division
    M Schaefer
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, Vienna, 1030, Austria
    Exp Cell Res 271:66-74. 2001
  6. ncbi request reprint A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila
    M Schaefer
    Research Institute of Molecular Pathology IMP, Vienna, A 1030, Austria
    Curr Biol 10:353-62. 2000
  7. ncbi request reprint DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
    M Petronczki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Cell Biol 3:43-9. 2001
  8. ncbi request reprint Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division
    S Bulgheresi
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 114:3655-62. 2001
  9. ncbi request reprint Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts
    M Schober
    Research Institute of Molecular Pathology, Vienna, Austria
    Nature 402:548-51. 1999
  10. ncbi request reprint Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila
    J R Huynh
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, CB21QR, Cambridge, United Kingdom
    Curr Biol 11:901-6. 2001

Collaborators

  • Y M Chan
  • M Schaefer
  • W Chia
  • M Petronczki
  • S Bulgheresi
  • J R Huynh
  • L Y Jan
  • Y N Jan
  • M Schober
  • H W Jacobs
  • C P Shen
  • C F Lehner
  • R Kraut
  • E Frise
  • E Kleiner
  • D St Johnston
  • M S Rhyu
  • K Sauer
  • M M Jiang
  • S Younger-Shepherd
  • H Richardson

Detail Information

Publications21

  1. ncbi request reprint Asymmetric cell division during animal development
    J A Knoblich
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Mol Cell Biol 2:11-20. 2001
    ..The discovery of asymmetrically segregating proteins in vertebrates indicates that the results obtained in invertebrate model organisms might also apply to mammalian stem cells...
  2. ncbi request reprint Mechanisms of asymmetric cell division during animal development
    J A Knoblich
    Research Institute of Molecular Pathology, Vienna, Austria
    Curr Opin Cell Biol 9:833-41. 1997
    ..The identification of Numb homologs in other species has suggested that this machinery might be conserved from Drosophila to vertebrates...
  3. ncbi request reprint Epithelial polarity: the ins and outs of the fly epidermis
    J A Knoblich
    Research Institute of Molecular Pathology I M P, Vienna, Austria
    Curr Biol 10:R791-4. 2000
    ..Recent experiments have shed light on how apical-basal polarity is generated during cellularization in Drosophila, when around 6000 epithelial cells are created synchronously from a syncytium...
  4. ncbi request reprint Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system
    M Schaefer
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Cell 107:183-94. 2001
    ..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types...
  5. ncbi request reprint Protein localization during asymmetric cell division
    M Schaefer
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, Vienna, 1030, Austria
    Exp Cell Res 271:66-74. 2001
  6. ncbi request reprint A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila
    M Schaefer
    Research Institute of Molecular Pathology IMP, Vienna, A 1030, Austria
    Curr Biol 10:353-62. 2000
    ..How apically localised Inscuteable directs asymmetric cell divisions is unclear...
  7. ncbi request reprint DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
    M Petronczki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Cell Biol 3:43-9. 2001
    ....
  8. ncbi request reprint Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division
    S Bulgheresi
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 114:3655-62. 2001
    ....
  9. ncbi request reprint Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts
    M Schober
    Research Institute of Molecular Pathology, Vienna, Austria
    Nature 402:548-51. 1999
    ..Our results suggest that direct binding to Bazooka mediates the asymmetric localization of Inscuteable and connects the asymmetric division of neuroblasts to the axis of epithelial apical-basal polarity...
  10. ncbi request reprint Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila
    J R Huynh
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, CB21QR, Cambridge, United Kingdom
    Curr Biol 11:901-6. 2001
    ..elegans and Drosophila, the relationships between them are different, as the localization of PAR-1 does not require Bazooka or PAR-6 in Drosophila, as it does in the worm...
  11. ncbi request reprint Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization
    J A Knoblich
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0725, USA
    Curr Biol 9:155-8. 1999
    ....
  12. pmc Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B
    H W Jacobs
    Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
    Genes Dev 12:3741-51. 1998
    ..However, both are required for female fertility and Cyclin B also for male fertility...
  13. ncbi request reprint Spindle orientation and asymmetric cell fate
    M S Rhyu
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Cell 82:523-6. 1995
  14. pmc Synergistic action of Drosophila cyclins A and B during the G2-M transition
    J A Knoblich
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Germany
    EMBO J 12:65-74. 1993
    ..However, mitotic spindles are clearly abnormal and progression through mitosis is delayed in these cyclin B deficient embryos...
  15. ncbi request reprint Role of inscuteable in orienting asymmetric cell divisions in Drosophila
    R Kraut
    Institute of Molecular and Cell Biology, National University of Singapore
    Nature 383:50-5. 1996
    ..The Inscuteable protein localizes to the apical cell cortex before mitosis, suggesting that Inscuteable functions in establishing polarity for asymmetric cell division...
  16. pmc The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
    E Frise
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Proc Natl Acad Sci U S A 93:11925-32. 1996
    ..Our results suggest that Numb determines daughter cell fates in the external sense organ lineage by inhibiting Notch signaling...
  17. pmc The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization
    J A Knoblich
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Proc Natl Acad Sci U S A 94:13005-10. 1997
    ....
  18. ncbi request reprint Asymmetric segregation of the Drosophila numb protein during mitosis: facts and speculations
    J A Knoblich
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Cold Spring Harb Symp Quant Biol 62:71-7. 1997
  19. pmc Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila
    C P Shen
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0725 USA
    Genes Dev 12:1837-46. 1998
    ..Our results suggest that Miranda directs the basal cortical localization of multiple molecules, including Staufen and prospero RNA, in mitotic neuroblasts in an actin-dependent manner...
  20. ncbi request reprint Asymmetric segregation of Numb and Prospero during cell division
    J A Knoblich
    Howard Hughes Medical Institute, University of California at San Francisco 94143 0724, USA
    Nature 377:624-7. 1995
    ..We propose that there is an organizer of asymmetric cell division which provides positional information for both the orientation of the mitotic spindle and asymmetric localization of Numb and Prospero...
  21. ncbi request reprint Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis
    K Sauer
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Germany
    Genes Dev 9:1327-39. 1995
    ..Observations in cyclin A mutants implicate G2 cyclins in this regulation. Our results suggest molecular explanations for the different rules governing S phase during mitotic and endoreduplication cycles...