Bernhard K Keppler


Affiliation: University of Vienna
Country: Austria


  1. Legin A, Theiner S, Schintlmeister A, Reipert S, Heffeter P, Jakupec M, et al. Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney. Chem Sci. 2016;7:3052-3061 pubmed publisher
    ..Those in the tumor were subsequently identified as organelles of lysosomal origin, demonstrating the potential of the combinatorial approach for investigating therapeutically relevant drug concentrations on a submicrometer scale. ..
  2. Klose M, Theiner S, Kornauth C, Meier Menches S, Heffeter P, Berger W, et al. Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS. Metallomics. 2018;10:388-396 pubmed publisher
    ..Interestingly, osmium from 2 was largely located at the periphery and tissue edges, whereas ruthenium from 1 was observed to penetrate deeper into the organs and tumours. ..
  3. Tamasi G, Merlino A, Scaletti F, Heffeter P, Legin A, Jakupec M, et al. {Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo. Dalton Trans. 2017;46:3025-3040 pubmed publisher
    ..In contrast to CORM-3 and 2, a significantly reduced tumor growth was observed with 4 in the murine colon cancer CT-26 model in vivo. ..
  4. Pirkwieser P, López López J, Kandioller W, Keppler B, Moreno C, Jirsa F. Solvent Bar Micro-Extraction of Heavy Metals from Natural Water Samples Using 3-Hydroxy-2-Naphthoate-Based Ionic Liquids. Molecules. 2018;23: pubmed publisher
    ..The method presented here proves to be a useful tool for an efficient SBME of heavy metals from natural waters without the need to pretreat or modify the sample. ..
  5. Höfer D, Varbanov H, Legin A, Jakupec M, Roller A, Galanski M, et al. Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy. J Inorg Biochem. 2015;153:259-271 pubmed publisher
  6. Heffeter P, Pape V, Enyedy E, Keppler B, Szakas G, Kowol C. Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development. Antioxid Redox Signal. 2018;: pubmed publisher
    ..Consequently, in addition to the discussion of physicochemical properties (e.g. complex stability, redox activity), this review contains an overview on the diversity of cellular thiosemicarbazone targets and drug resistance mechanisms. ..
  7. Höfer D, Varbanov H, Hejl M, Jakupec M, Roller A, Galanski M, et al. Impact of the equatorial coordination sphere on the rate of reduction, lipophilicity and cytotoxic activity of platinum(IV) complexes. J Inorg Biochem. 2017;174:119-129 pubmed publisher
  8. Artner C, Holtkamp H, Kandioller W, Hartinger C, Meier Menches S, Keppler B. DNA or protein? Capillary zone electrophoresis-mass spectrometry rapidly elucidates metallodrug binding selectivity. Chem Commun (Camb). 2017;53:8002-8005 pubmed publisher
    ..Moreover, for the first time, oligonucleotide metallation was resolved at single-nucleotide resolution by MS. ..