Bernhard K Keppler

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint [Development, importance and perspectives. Tumor inhibiting metal compounds]
    Markus Galanski
    Universitat Wien, Institut für Anoganische Chemie Bioanorganische, Umwelt Radiochemie
    Pharm Unserer Zeit 35:118-23. 2006
  2. pmc Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
    Gerhard Mühlgassner
    University of Vienna, Institute of Inorganic Chemistry, Währinger Straße 42, A 1090 Vienna, Austria
    J Inorg Biochem 116:180-7. 2012
  3. pmc Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin
    Hristo Varbanov
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090 Vienna, Austria
    Eur J Med Chem 46:5456-64. 2011
  4. ncbi request reprint Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Anticancer Agents Med Chem 7:55-73. 2007
  5. ncbi request reprint Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis
    Andrei R Timerbaev
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Waehringer Str 42, A 1090 Vienna, Austria
    Anal Biochem 341:326-33. 2005
  6. ncbi request reprint Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches
    Markus Galanski
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Vienna, Austria
    Curr Med Chem 12:2075-94. 2005
  7. ncbi request reprint CE in anticancer metallodrug research--an update
    Christian G Hartinger
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    Electrophoresis 28:3436-46. 2007
  8. ncbi request reprint Capillary electrophoresis of metal-based drugs
    Andrei R Timerbaev
    Institute of Inorganic Chemistry, University of Vienna, A 1090 Vienna, Austria
    Anal Biochem 369:1-7. 2007
  9. ncbi request reprint Probing the stability of serum protein-ruthenium(III) drug adducts in the presence of extracellular reductants using CE
    Andrei R Timerbaev
    Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow, Russia
    Electrophoresis 28:2235-40. 2007
  10. ncbi request reprint From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
    Christian G Hartinger
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Inorg Biochem 100:891-904. 2006

Collaborators

  • Christian G Hartinger
  • Andrei R Timerbaev
  • Vladimir B Arion
  • Paul J Dyson
  • Haralabos Zorbas
  • Markus Galanski
  • Michael R Reithofer
  • Franz Jirsa
  • Thilo Hofmann
  • Ulrich Warnke
  • Hedwig Sutterluety
  • Ulrich Jaehde
  • C Kloft
  • Michael Groessl
  • Michael A Jakupec
  • Christian R Kowol
  • Erwin Reisner
  • Alexander Roller
  • Wolfgang F Schmid
  • Berta Cebrián-Losantos
  • Stefanie Zorbas-Seifried
  • Olga Semenova
  • Alexander V Rudnev
  • Gerhard Mühlgassner
  • Iryna N Stepanenko
  • Lidia S Foteeva
  • Roland O John
  • Rene Eichinger
  • Petra Heffeter
  • Svetlana S Aleksenko
  • Kristof Meelich
  • Nikolai Graf von Keyserlingk
  • Ladislav Habala
  • Anna Eichinger
  • Hristo Varbanov
  • Vesna M Djinovic
  • Regina Krachler
  • Seied M Valiahdi
  • Kasia Połeć-Pawlak
  • Alexei Y Shmykov
  • Antoine Dorcier
  • Artem A Krokhin
  • Isabella Berger
  • Jan K Abramski
  • Maciej Jarosz
  • Sergiu Shova
  • Walter Berger
  • Roland Berger
  • Zhuo Huang
  • Christian Kowol
  • Kasia Polec-Pawlak
  • Alexey A Nazarov
  • Anatoly Dobrov
  • Norbert Kandler
  • Vadim Yu Kukushkin
  • Alexander Egger
  • Afshin Yasemi
  • Susanne Kapitza
  • Petra Schluga
  • Christina Rappel
  • Armando J L Pombeiro
  • Dirk B Strickmann
  • Caroline Bartel
  • Anton A Legin
  • Robert Trondl
  • Irene Lichtscheidl
  • Shahram Ayromlou
  • Rudolf F Krachler
  • Frank von der Kammer
  • Altan Süphandag
  • Richard H Fish
  • Julia Ferenc
  • Vladimir N Filippov
  • Rosario Scopelliti
  • Nikolay V Kukushkin
  • Peter P Schmidt
  • Ion Chiorescu
  • Michael Micksche
  • Takeshi Hirokawa
  • Stefan Wild
  • Wilfried Körner
  • Anna Rufińska
  • Leonilla Elbling
  • Hedwig Sutterlüty
  • Alla Korynevska
  • Werner Ginzinger
  • Siegfried Knasmuller
  • Günter Trettenhahn
  • Maria Uhl
  • Brigitte Marian

Detail Information

Publications64

  1. ncbi request reprint [Development, importance and perspectives. Tumor inhibiting metal compounds]
    Markus Galanski
    Universitat Wien, Institut für Anoganische Chemie Bioanorganische, Umwelt Radiochemie
    Pharm Unserer Zeit 35:118-23. 2006
  2. pmc Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
    Gerhard Mühlgassner
    University of Vienna, Institute of Inorganic Chemistry, Währinger Straße 42, A 1090 Vienna, Austria
    J Inorg Biochem 116:180-7. 2012
    ..Induction of apoptosis is most pronounced for complex 1, accompanied by a low fraction of necrotic cells, as observed by annexin V-fluorescein isothiocyanate/propidium iodide staining and flow cytometric analysis...
  3. pmc Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin
    Hristo Varbanov
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090 Vienna, Austria
    Eur J Med Chem 46:5456-64. 2011
    ..Remarkably the most active (and also most lipophilic) compounds, having 4-propyloxy-4-oxobutanoato and 4-(2-propyloxy)-4-oxobutanoato axial ligands, showed IC(50) values down to the low nanomolar range...
  4. ncbi request reprint Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Anticancer Agents Med Chem 7:55-73. 2007
    ....
  5. ncbi request reprint Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis
    Andrei R Timerbaev
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Waehringer Str 42, A 1090 Vienna, Austria
    Anal Biochem 341:326-33. 2005
    ....
  6. ncbi request reprint Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches
    Markus Galanski
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Vienna, Austria
    Curr Med Chem 12:2075-94. 2005
    ..It focuses also on innovative synthetic strategies leading to novel classes of platinum complexes. A small part of the review is dedicated to new analytical approaches which have been supplied to or emerged in this field of research...
  7. ncbi request reprint CE in anticancer metallodrug research--an update
    Christian G Hartinger
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    Electrophoresis 28:3436-46. 2007
    ....
  8. ncbi request reprint Capillary electrophoresis of metal-based drugs
    Andrei R Timerbaev
    Institute of Inorganic Chemistry, University of Vienna, A 1090 Vienna, Austria
    Anal Biochem 369:1-7. 2007
  9. ncbi request reprint Probing the stability of serum protein-ruthenium(III) drug adducts in the presence of extracellular reductants using CE
    Andrei R Timerbaev
    Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow, Russia
    Electrophoresis 28:2235-40. 2007
    ..This work appears the first to present the application of CE to the stability studies of the protein-bound metallodrugs...
  10. ncbi request reprint From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
    Christian G Hartinger
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Inorg Biochem 100:891-904. 2006
    ..In this review, the preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated...
  11. ncbi request reprint Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance
    Andrei R Timerbaev
    Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow, Russia
    J Sep Sci 30:399-406. 2007
    ....
  12. doi request reprint Novel bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) complexes with exceptionally high cytotoxicity
    Michael R Reithofer
    University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Inorg Biochem 102:2072-7. 2008
    ..Structure-activity relationships showed that the cytotoxicity increased with increasing lipophilicity of the alcoholate moiety yielding IC50 values in the low micromolar or even low nanomolar range...
  13. ncbi request reprint Carbohydrate-metal complexes and their potential as anticancer agents
    Christian G Hartinger
    University of Vienna, Institute of Inorganic Chemistry, Waehringer Str 42, A 1090 Vienna, Austria
    Curr Med Chem 15:2574-91. 2008
    ..Herein, metal complexes with carbohydrate ligands are reviewed and the role of the carbohydrate carriers on the antineoplastic activity of these compounds, both in vitro and in vivo, is described...
  14. doi request reprint KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients
    Christian G Hartinger
    University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, A 1090 Vienna
    Chem Biodivers 5:2140-55. 2008
    ..The results of the early clinical development of KP1019 are summarized in which five out of six evaluated patients experienced disease stabilization with no severe side effects...
  15. doi request reprint Synthesis, structure, spectroscopic properties, and antiproliferative activity in vitro of novel osmium(III) complexes with azole heterocycles
    Iryna N Stepanenko
    University of Vienna, Institute of Inorganic Chemistry, Wahringerstr 42, A 1090 Vienna, Austria
    Inorg Chem 47:7338-47. 2008
    ....
  16. ncbi request reprint Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    J Med Chem 46:4946-51. 2003
    ..Within the series of complexes under investigation, potency decreases depending on the coordinated amine ligand in the following order: trans-R,R-chxn > trans-S,S-chxn > NH(3) > or = cis-R,S-chxn > en...
  17. ncbi request reprint Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Waehringerstr 42, A 1090 Vienna, Austria
    Eur J Med Chem 39:707-14. 2004
    ....
  18. ncbi request reprint Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes
    Vladimir B Arion
    Institute of Inorganic Chemistry of the University of Vienna, Wahringerstrasse 42, A 1090 Vienna, Austria
    Inorg Chem 42:6024-31. 2003
    ..Time-dependent response of all three lines to 1 and 2 and a structure-activity relationship, i.e., higher activity of the trans-isomer 2 than that of cis-species 1, have been observed...
  19. doi request reprint Relevance of peat-draining rivers for the riverine input of dissolved iron into the ocean
    Regina Krachler
    Institute of Inorganic Chemistry, University of Vienna, Wahringerstrasse 42, 1090 Vienna, Austria
    Sci Total Environ 408:2402-8. 2010
    ..We propose highly electrostatic and sterical stabilized iron-organic matter complexes in the size range of <2kDa to be responsible for iron transport across the estuarine mixing zone...
  20. ncbi request reprint Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone
    Vladimir B Arion
    Institute of Inorganic Chemistry of the University of Vienna, Waehringerstr 42, A 1090 Vienna, Austria
    J Inorg Biochem 91:298-305. 2002
    ..In vitro cytotoxic activity exceeds that of all other tested gallium(III) complexes and is slightly higher than that of HL...
  21. ncbi request reprint Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin
    Andrei R Timerbaev
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 25:1988-95. 2004
    ..Also apparent was a two-step mechanism of the binding reaction. Results demonstrated the suitability of CE-ICP-MS as a rapid assay for high-throughput studying of drug/HSA interactions...
  22. doi request reprint Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(II) and platinum(III) dinuclear complexes
    Vesna M Djinovic
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090, Vienna, Austria
    Dalton Trans 39:3633-43. 2010
    ..The Pt-Pt distances in the platinum(iii) dimers are 2.5982(4) in 5 and 2.5569(3) A in 6...
  23. doi request reprint Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex
    Christian R Kowol
    University of Vienna, Institute of Inorganic Chemistry, Wahringerstr 42, A 1090, Vienna, Austria
    Dalton Trans 39:704-6. 2010
    ....
  24. ncbi request reprint Novel di- and tetracarboxylatoplatinum(IV) complexes. Synthesis, characterization, cytotoxic activity, and DNA platination
    Michael R Reithofer
    Institute of Inorganic Chemistry, University of Vienna, Austria
    J Med Chem 50:6692-9. 2007
    ..DNA platination studies of selected complexes revealed a high DNA platination capacity in parallel to a high cytotoxic potential and vice versa...
  25. ncbi request reprint A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin?
    Isabella Berger
    Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str 42, 1090 Vienna, Austria
    ChemMedChem 2:505-14. 2007
    ..2. Cytotoxicity of the chloro complex is one to two orders of magnitude lower than that of oxaliplatin, but still comparable to that of carboplatin in two of the four cell lines...
  26. ncbi request reprint Gallium and other main group metal compounds as antitumor agents
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, A 1090 Vienna, Austria
    Met Ions Biol Syst 42:425-62. 2004
    ..Although this development is currently focusing on arsenic trioxide, it should be suited to stimulate investigations into the therapeutic potential of other arsenic compounds as well...
  27. ncbi request reprint Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiprolif
    Michael Groessl
    Institute of Inorganic Chemistry, University of Vienna, A 1090 Vienna, Austria
    J Med Chem 50:2185-93. 2007
    ..The redox potentials (between 0.25 and 0.35 V) were found to be biologically accessible for activation of the complexes in the tumor, and the indazole-containing compound shows the highest antiproliferative activity in vitro...
  28. ncbi request reprint The first ruthenium-based paullones: syntheses, X-ray diffraction structures, and spectroscopic and antiproliferative properties in vitro
    Wolfgang F Schmid
    Institute of Inorganic Chemistry, Wahringerstr 42, A 1090 Vienna, Austria
    Inorg Chem 46:3645-56. 2007
    ..The novel complexes show an intercalative mode of interaction with DNA, which may render them attractive alternatives to metal compounds with a coordinative mode of interaction...
  29. ncbi request reprint Osmium NAMI-A analogues: synthesis, structural and spectroscopic characterization, and antiproliferative properties
    Berta Cebrián-Losantos
    Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Wahringerstrasse 42, A 1090 Vienna, Austria
    Inorg Chem 46:5023-33. 2007
    ..Structure-activity relationships and the potential of the prepared complexes for further development are discussed...
  30. doi request reprint Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-
    Berta Cebrián-Losantos
    Institute of Inorganic Chemistry, University of Vienna, Wahringerstr 42, A 1090 Vienna, Austria
    Inorg Chem 47:6513-23. 2008
    ..The lability of the aqua ligand in 2 suggests that this complex is a potential active species responsible for the high antitumor activity of trans-[Ru(III)Cl4(Hind)2](-)...
  31. doi request reprint Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: a novel approach for the analysis of anticancer metallodrugs in human serum and plasma
    Michael Groessl
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 29:2224-32. 2008
    ..KP1019 was found to bind to a high degree to HSA both in serum, plasma and the patient samples. Only minor fractions of ruthenium were found attached to other proteins...
  32. doi request reprint Toward high-throughput monitoring of metallodrug-protein interaction using capillary electrophoresis in chemically modified capillaries
    Alexei Y Shmykov
    Institute of Analytical Instrumentation, Russian Academy of Sciences, 190103 St Petersburg, Russia
    Anal Biochem 379:216-8. 2008
    ....
  33. doi request reprint Application of capillary electrophoresis-inductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins
    Kasia Połeć-Pawlak
    Warsaw University of Technology, Noakowskiego 3, 00 664 Warsaw, Poland
    J Chromatogr A 1192:323-6. 2008
    ..The results of this brief study showed that changing from organic to inorganic counter-ion at the stage of formulation could commonly be recommended for improving ruthenium-based drug solubility and bioavailability...
  34. ncbi request reprint Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones
    Christian R Kowol
    Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str 42, A 1090 Vienna, Austria
    J Inorg Biochem 101:1946-57. 2007
    ....
  35. doi request reprint CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP
    Michael Groessl
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Street 42, A 1090 Vienna, Austria
    J Inorg Biochem 102:1060-5. 2008
    ..RAPTA-C was found to hydrolyze fastest and showed the highest reactivity toward the DNA model compound, whereas KP418 was the most stable compound in both these respects...
  36. ncbi request reprint Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds
    Antoine Dorcier
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Inorg Biochem 102:1066-76. 2008
    ..The X-ray structures of the precursor complexes, [(eta5-C10H15)RhCl(pta-Me)2]Cl2, [(eta6-C10H14)OsCl(pta)2]Cl, and [(eta6-C6H6)OsCl2(CH3CN)], are also reported...
  37. ncbi request reprint Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy
    Wolfgang F Schmid
    Institute of Inorganic Chemistry, University of Vienna, Wahringerstr 42, A 1090 Vienna, Austria
    J Med Chem 50:6343-55. 2007
    ..3)H-Thymidine incorporation assays revealed the compounds to lower the rate of DNA synthesis, and flow cytometric analyses showed cell cycle arrest mainly in G 0/ G 1 phase...
  38. ncbi request reprint Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase
    Christian R Kowol
    Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 50:1254-65. 2007
    ..The capacity of ligand 1 and its Ga(III) and Fe(III) complexes to destroy the tyrosyl radical of the presumed target ribonucleotide reductase is reported...
  39. ncbi request reprint Characterization of interactions between human serum albumin and tumor-inhibiting amino alcohol platinum(II) complexes using capillary electrophoresis
    Svetlana S Aleksenko
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Str 42, A 1090, Vienna, Austria
    J Chromatogr A 1155:218-21. 2007
    ..4 x 10(4)M(-1). Such binding behavior was attributed to a distinctive structural feature of bis(amino alcohol)platinum(II) complexes, that is, existence of an equilibrium between ring-opened and ring-closed forms in solution...
  40. ncbi request reprint Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 48:2831-7. 2005
    ..Differences in the cellular uptake (probably resulting from different lipophilicity) contribute to this correlation but cannot solely account for it...
  41. ncbi request reprint Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel-Dreyer method
    Alexander V Rudnev
    Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 117975 Moscow, Russia
    J Sep Sci 28:121-7. 2005
    ..From a comparison with the binding parameters measured previously for cisplatin by other methods, conclusions were drawn about the validity of CE as a simple and convenient method for assaying protein-drug reactions with slow kinetics...
  42. ncbi request reprint Analysis of anticancer platinum(II)-complexes by microemulsion electrokinetic chromatography: separation of diastereomers and estimation of octanol-water partition coefficients
    Christina Rappel
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 26:878-84. 2005
    ....
  43. ncbi request reprint Reactions of potent antitumor complex trans-[Ru(III)Cl4(indazole)2]- with a DNA-relevant nucleobase and thioethers: insight into biological action
    Alexander Egger
    Institute of Inorganic Chemistry of the University of Vienna, Wahringerstrasse 42, A 1090 Vienna, Austria
    Inorg Chem 44:122-32. 2005
    ..9 +/- 0.1 s(-)(1), which obeys the first-order rate law, while k(2) is concentration dependent (0.2 +/- 0.1 M(1)(-)(n)().s(-)(1) with n > 1 for 4 mM solutions of 4 and 5), indicating higher-order reactions mechanism...
  44. ncbi request reprint Gallium in cancer treatment
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    Curr Top Med Chem 4:1575-83. 2004
    ....
  45. ncbi request reprint Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: indications of guanosine 5'-monophosphate O6-N7 chelation
    Ulrich Warnke
    Institute of Pharmacy, Department of Clinical Pharmacy, Freie Universitat Berlin, Germany
    Chembiochem 5:1543-9. 2004
    ..Additionally, offline MS experiments with 2'-deoxyguanosine (dG) and stabilization of the controversially discussed O(6)-N7 chelate by oxidation with hydrogen peroxide support the assumption of the existence of O(6)-N7 chelation...
  46. ncbi request reprint Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole
    Erwin Reisner
    Centro de Quimica Estrutural, Complexo I, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    Inorg Chem 43:7083-93. 2004
    ....
  47. ncbi request reprint The effect of cytoprotective agents in platinum anticancer therapy
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    Met Ions Biol Syst 42:179-208. 2004
  48. ncbi request reprint Tumor-inhibiting platinum(II) complexes with aminoalcohol ligands: comparison of the mode of action by capillary electrophoresis and electrospray ionization-mass spectrometry
    Christian G Hartinger
    Department of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 24:2038-44. 2003
    ..Also addressed was the interpretation of binding behavior as based on the structural features of the intact complexes, namely differing inclination to intramolecular chelation...
  49. ncbi request reprint Capillary electrophoresis in anti-cancer metallodrug research: advances and future challenges
    Christian G Hartinger
    Department of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 24:2023-37. 2003
    ....
  50. ncbi request reprint Cisplatin damage: are DNA repair proteins saviors or traitors to the cell?
    Haralabos Zorbas
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Chembiochem 6:1157-66. 2005
  51. ncbi request reprint The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells
    Susanne Kapitza
    Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
    Cancer Lett 226:115-21. 2005
    ..Both effects were inhibited by NAC which reduced the population with depolarized mitochondrial membranes to 24.1+/-1.2% and prevented PARP-cleavage indicating a central role oxidative stress in KP1019-induced apoptosis...
  52. ncbi request reprint Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives
    Ladislav Habala
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Waehringerstr 42, A 1090 Vienna, Austria
    Eur J Med Chem 40:1149-55. 2005
    ..With respect to the antiproliferative properties, the 4-methyl-, cis-4,5-dimethyl-, and especially the 4,4-dimethyl-trans-cyclohexane-1,2-diamine(oxalato)platinum(II) complexes are the most promising candidates to be further evaluated...
  53. ncbi request reprint DNA interactions of pH-sensitive, antitumor bis(aminoalcohol)dichloroplatinum(II) complexes
    Stefanie Zorbas-Seifried
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Biochemistry 45:14817-25. 2006
    ..0. The results of this study may stimulate and contribute to further improvement of these novel, specific cytotoxic drugs that are anticipated to exert their full power in the tumor while being reasonably inactive in normal tissue...
  54. ncbi request reprint Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands
    Stefanie Zorbas-Seifried
    Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Pharmacol 71:357-65. 2007
    ..Implications of our findings for the minimal structural requirements (e.g., planarity around the nitrogen donor atom and/or ramified aliphatic moiety attached to the latter) of active trans-configured platinum complexes are discussed...
  55. ncbi request reprint Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins
    Alexander V Rudnev
    Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin St 19, 119991 Moscow, Russia
    J Inorg Biochem 100:1819-26. 2006
    ..A tendency of being faster converted into the protein-bound form found for KP1089 (due possibly to non-covalent binding) seems complementary to its greater in vitro antiproliferative activity...
  56. ncbi request reprint Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology
    Andrei R Timerbaev
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, A 1090 Vienna, Austria
    Chem Rev 106:2224-48. 2006
  57. ncbi request reprint The first metal-based paullone derivative with high antiproliferative activity in vitro
    Anatoly Dobrov
    Institute of Inorganic Chemistry, University of Vienna, Waehringerstrasse 42, A 1090 Vienna, Austria
    Inorg Chem 45:1945-50. 2006
    ..The gallium complex was found to be 1.5-18-fold more cytotoxic than HL, with an average IC50 value of 2.0 microM...
  58. ncbi request reprint Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins
    Kasia Polec-Pawlak
    Department of Analytical Chemistry, Warsaw University of Technology, Warsaw, Poland
    Electrophoresis 27:1128-35. 2006
    ..e. a ten-fold excess of albumin over transferrin. The fact that KP1019 binds to albumin stronger than to transferrin was manifested by finding almost all ruthenium (98-99%) in the albumin fraction...
  59. ncbi request reprint Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24)
    Petra Heffeter
    Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria
    Biochem Pharmacol 71:426-40. 2006
    ..Together, these data suggest further development of KP772 as a new anticancer metal-drug...
  60. ncbi request reprint Determination of cisplatin and its hydrolytic metabolite in human serum by capillary electrophoresis techniques
    Zhuo Huang
    Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, 1 4 1 Kagamiyama, Higashi Hiroshima 739 8527, Japan
    J Chromatogr A 1106:75-9. 2006
    ..Changes in the speciation of cisplatin occurring after intravenous administration can also be monitored using these simple and convenient CE techniques...
  61. ncbi request reprint Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands: biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry
    Petra Schluga
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Waehringer Str 42, A 1090 Vienna, Austria
    Analyst 130:1383-9. 2005
    ..This apparently takes place due to the shifting of the equilibrium towards the ring-opened species, induced by adduct formation between SDS and the platinum complex that was confirmed by electrospray ionization mass spectrometry...
  62. ncbi request reprint Tuning of redox properties for the design of ruthenium anticancer drugs: part 2. Syntheses, crystal structures, and electrochemistry of potentially antitumor [Ru III/II Cl6-n(Azole)n]z(n = 3, 4, 6) complexes
    Erwin Reisner
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Wahringerstrasse 42, A 1090 Vienna, Austria
    Inorg Chem 44:6704-16. 2005
    ..In addition, the pH-dependent electrochemical behavior of trans-[RuCl2(1,2,4-triazole)4]Cl is discussed...
  63. ncbi request reprint Application of capillary electrophoresis-mass spectrometry for the investigation of the binding behavior of oxaliplatin to 5'-GMP in the presence of the sulfur-containing amino acid L-methionine
    Dirk B Strickmann
    Institute of Inorganic Chemistry, University of Vienna, Austria
    Electrophoresis 23:74-80. 2002
    ....
  64. ncbi request reprint Capillary electrophoresis of platinum-group elements. Analytical, speciation and biochemical studies
    Andrei R Timerbaev
    Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow
    J Chromatogr A 945:25-44. 2002
    ....