S Kapiotis

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi Morning hypercoagulability and hypofibrinolysis. Diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor complex
    S Kapiotis
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Circulation 96:19-21. 1997
  2. ncbi Plasma levels of activated factor VII decrease during the menstrual cycle
    S Kapiotis
    Department of Clinical Pharmacology TARGET, General Hospital Vienna, University of Vienna, Austria
    Thromb Haemost 80:588-91. 1998
  3. ncbi Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL
    S Kapiotis
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 17:2868-74. 1997
  4. ncbi Evidence against an effect of endothelin-1 on blood coagulation, fibrinolysis, and endothelial cell integrity in healthy men
    S Kapiotis
    Department of Clinical Pharmacology, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 17:2861-7. 1997
  5. ncbi Endotoxin-induced activation of the coagulation cascade in humans: effect of acetylsalicylic acid and acetaminophen
    T Pernerstorfer
    Department of Clinical Pharmacology, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 19:2517-23. 1999
  6. ncbi Genistein prevents the glucose autoxidation mediated atherogenic modification of low density lipoprotein
    M Exner
    Department of Laboratory Medicine, University of Vienna, Austria
    Free Radic Res 34:101-12. 2001
  7. ncbi Rapid, fluorescence-based assay for microtiter plates to test drug influences on neutrophil transmigration through endothelial cell monolayers
    R Hofbauer
    Department of Internal Medicine, University of Vienna, Austria
    Life Sci 65:2453-61. 1999
  8. ncbi Effect of intradermal tumor necrosis factor-alpha-induced inflammation on coagulation factors in dermal vessel endothelium. An in vivo study of human skin biopsies
    W Speiser
    Department of Clinical Pharmacology, and Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Thromb Haemost 85:362-7. 2001
  9. ncbi Pioglitazone does not affect vascular or inflammatory responses after endotoxemia in humans
    G Schaller
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Horm Metab Res 40:549-55. 2008
  10. ncbi Leukocyte migration: a new triple migration chamber assay allows investigation of various cell interactions simultaneously
    R Hofbauer
    Department of Anesthesiology and Intensive Care Medicine, University of Vienna, Austria
    Life Sci 63:1725-37. 1998

Collaborators

Detail Information

Publications33

  1. ncbi Morning hypercoagulability and hypofibrinolysis. Diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor complex
    S Kapiotis
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Circulation 96:19-21. 1997
    ..In the present study, the diurnal variations in blood coagulation and fibrinolysis activity were investigated in 10 young, healthy control subjects by use of specific molecular activation markers...
  2. ncbi Plasma levels of activated factor VII decrease during the menstrual cycle
    S Kapiotis
    Department of Clinical Pharmacology TARGET, General Hospital Vienna, University of Vienna, Austria
    Thromb Haemost 80:588-91. 1998
    ..This may at least partially explain the marked gender differences found in FVIIa...
  3. ncbi Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL
    S Kapiotis
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 17:2868-74. 1997
    ..Our findings will support the suggested and documented beneficial action of a soy diet in preventing chronic vascular diseases and early atherogenic events...
  4. ncbi Evidence against an effect of endothelin-1 on blood coagulation, fibrinolysis, and endothelial cell integrity in healthy men
    S Kapiotis
    Department of Clinical Pharmacology, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 17:2861-7. 1997
    ..In contrast to previous reports from preclinical experiments, ET-1 does not appear to affect coagulation or fibrinolysis, nor does this peptide induce relevant endothelial cell perturbations in humans...
  5. ncbi Endotoxin-induced activation of the coagulation cascade in humans: effect of acetylsalicylic acid and acetaminophen
    T Pernerstorfer
    Department of Clinical Pharmacology, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 19:2517-23. 1999
    ....
  6. ncbi Genistein prevents the glucose autoxidation mediated atherogenic modification of low density lipoprotein
    M Exner
    Department of Laboratory Medicine, University of Vienna, Austria
    Free Radic Res 34:101-12. 2001
    ....
  7. ncbi Rapid, fluorescence-based assay for microtiter plates to test drug influences on neutrophil transmigration through endothelial cell monolayers
    R Hofbauer
    Department of Internal Medicine, University of Vienna, Austria
    Life Sci 65:2453-61. 1999
    ..Moreover, this assay can also be used for other cell-cell interactions...
  8. ncbi Effect of intradermal tumor necrosis factor-alpha-induced inflammation on coagulation factors in dermal vessel endothelium. An in vivo study of human skin biopsies
    W Speiser
    Department of Clinical Pharmacology, and Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Thromb Haemost 85:362-7. 2001
    ..This procoagulant shift in the haemostatic balance on the cell surface, caused by TNF-alpha-induced inflammation, is likely to contribute to thrombosis associated with tissue inflammation in humans...
  9. ncbi Pioglitazone does not affect vascular or inflammatory responses after endotoxemia in humans
    G Schaller
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Horm Metab Res 40:549-55. 2008
    ..The anti-inflammatory properties of short-term pioglitazone to endotoxins in healthy subjects are therefore limited...
  10. ncbi Leukocyte migration: a new triple migration chamber assay allows investigation of various cell interactions simultaneously
    R Hofbauer
    Department of Anesthesiology and Intensive Care Medicine, University of Vienna, Austria
    Life Sci 63:1725-37. 1998
    ..In conclusion, this assay allows to study cell migration into the subendothelial space and interactions between different vascular cells. Moreover, this assay can also be used for studies on other cell-cell interactions in man...
  11. ncbi Semicarbazide-sensitive amine oxidase catalyzes endothelial cell-mediated low density lipoprotein oxidation
    M Exner
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
    Cardiovasc Res 50:583-8. 2001
    ..CONCLUSION: DAO, beside generating angiopathic deamination products, has the potential to act as a pathophysiological catalyst of LDL atherogenic modification by vascular cells...
  12. ncbi Dexamethasone inhibits leukocyte migration through endothelial cells towards smooth muscle cells
    R Hofbauer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, and Dept of Anesthesiology and Intensive Care Medicine, University of Vienna, Austria
    Life Sci 64:671-9. 1999
    ..The inhibition seems to be due to a decrease in IL-1 release. Treatment of all cell types, PMNL, endothelial cells, as well as smooth muscle cell layers, simulating an in-vivo situation, seems to have an additive effect...
  13. ncbi Glucose and insulin exert additive ocular and renal vasodilator effects on healthy humans
    A Luksch
    Department of Clinical Pharmacology, University of Vienna, Austria
    Diabetologia 44:95-103. 2001
    ..To find out whether this observation is related to the increased regional perfusion in diabetes longitudinal studies on patients with Type I (insulin-dependent) diabetes mellitus are needed...
  14. ncbi Effects of sodium nitroprusside on hemodialysis-induced platelet activation
    B Jilma
    Department of Clinical Pharmacology TARGET, Vienna University Hospital School of Medicine, Austria
    Kidney Int 55:686-91. 1999
    ..As nitric oxide (NO) is a potent inhibitor of platelet activation, we were interested in whether HD-induced platelet activation could be blunted by a NO donor...
  15. ncbi Sufentanil inhibits migration of human leukocytes through human endothelial cell monolayers
    R Hofbauer
    Department of General Anesthesiology Intensive Care Medicine, University of Vienna, Austria
    Anesth Analg 87:1181-5. 1998
    ..Therefore, we used a migration assay including endothelial cell monolayers. Sufentanil showed a reducing effect on transendothelial leukocyte migration...
  16. ncbi Thiopental inhibits migration of human leukocytes through human endothelial cell monolayers in vitro
    R Hofbauer
    Department of Anesthesiology and Intensive Care Medicine, University of Vienna, Austria
    Intensive Care Med 24:973-6. 1998
    ..The aim of the current study was to investigate the influence of thiopental on the migration of leukocytes through endothelial cell monolayers (ECM)...
  17. ncbi Amoxycillin/clavulanic acid combinations increase transmigration of leucocytes through endothelial cell monolayers: endothelial cells play a key role
    R Hofbauer
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    J Antimicrob Chemother 44:465-9. 1999
    ..In conclusion, co-amoxiclav was identified as a potent drug to increase leucocyte transmigration through ECMs. ECMs were also critically involved. Co-amoxiclav also affects endothelial cells...
  18. ncbi Effect of anticoagulation on blood membrane interactions during hemodialysis
    R Hofbauer
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Kidney Int 56:1578-83. 1999
    ....
  19. ncbi Kinetics of circulating selectin levels during bone marrow aplasia
    B Jilma
    TARGET Department of Clinical Pharmacology, University of Vienna, Wien, Austria
    Eur J Haematol 61:36-41. 1998
    ..In summary, while our study cannot provide any evidence for endothelial cells as a source of cP-selectin, we have found for the first time evidence for the existence of ligands for soluble cE-selectin and cL-selectin in humans...
  20. ncbi Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux
    M Wolzt
    Department of Clinical Pharmacology, Medical University of Vienna, Allgemeines Krankenhaus Wien, A 1090 Vienna, Austria
    Thromb Haemost 105:1080-90. 2011
    ..Overall, edoxaban treatments were well tolerated. In conclusion, single oral doses of edoxaban 30, 60, or 120 mg caused rapid and sustained inhibition of coagulation up to 24 hours in the shed blood model...
  21. ncbi The green tea extract epigallocatechin gallate is able to reduce neutrophil transmigration through monolayers of endothelial cells
    R Hofbauer
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Wien Klin Wochenschr 111:278-82. 1999
    ..The treatment of both cell types showed an additive effect. Endothelial cells seem to be more affected than neutrophils. Further clinical investigations are necessary to understand the potential clinical consequences...
  22. ncbi Ketamine significantly reduces the migration of leukocytes through endothelial cell monolayers
    R Hofbauer
    Department of General Anesthesiology and Intensive Care, Clinical Institute of Medical and Chemical Laboratory Diagnostics, School of Medicine, The University of Vienna, Austria
    Crit Care Med 26:1545-9. 1998
    ..To study the role of neutrophils in host defense, using human endothelial cells in migration studies in the presence of ketamine (0.3, 3, and 30 microg/mL)...
  23. ncbi The release of the adipocytokine visfatin is regulated by glucose and insulin
    D G Haider
    Department of Clinical Pharmacology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Diabetologia 49:1909-14. 2006
    ..Since insulin-mimetic actions of visfatin may be part of the feedback regulation of glucose homeostasis, we hypothesised that visfatin concentrations are influenced by glucose or insulin blood levels in humans...
  24. ncbi C-reactive protein is expressed and secreted by peripheral blood mononuclear cells
    D G Haider
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Clin Exp Immunol 146:533-9. 2006
    ..Constitutive CRP expression and release in PBMC is enhanced by inflammatory stimuli in vivo and in vitro. LPS might induce CRP generation via activation of TLR-4, NF-kappaB and PKC...
  25. ncbi Ibuprofen inhibits leukocyte migration through endothelial cell monolayers
    R Hofbauer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    Life Sci 62:1775-81. 1998
    ..The inhibition of the leukocyte migration may contribute to the anti-inflammatory actions of the drug...
  26. ncbi Characterization of (123)I-vascular endothelial growth factor-binding sites expressed on human tumour cells: possible implication for tumour scintigraphy
    S Li
    Department of Nuclear Medicine, University of Vienna, AKH, Ebene 3L, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Int J Cancer 91:789-96. 2001
    ..In comparison with (123)I-VEGF(121), (123)I-VEGF(165) bound to a higher number of different tumour cell types with a higher capacity. Thus, (123)I-VEGF(165) may be a potentially useful tracer for in vivo imaging of solid tumours...
  27. ncbi Angiotensin inhibition stimulates PPARgamma and the release of visfatin
    A Storka
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Eur J Clin Invest 38:820-6. 2008
    ..Some antidiabetic properties of ARB and ACE-I might by exerted by activation of peroxisome proliferator-activated receptor gamma (PPARgamma). However, it is not clear whether this action is drug specific...
  28. ncbi Meloxicam effect on leukocyte migration under shear stress: a new perfused triple chamber (Hofbauer chamber) assay simulating an in vitro vascular wall
    R Hofbauer
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria
    J Investig Med 47:57-65. 1999
    ..The aim of the current study was to create a new three-dimensional assay investigating migration during simulated perfusion. The assay was used for investigating the effect of meloxicam on leukocyte migration under shear stress...
  29. ncbi The immune system and the effects of non-volatile anesthetics on neutrophil transmigration through endothelial cell monolayers
    R Hofbauer
    Department of Medical and Chemical Laboratory Diagnostics, Medical Intensive Care Unit, University of Vienna, Vienna, Austria
    Curr Pharm Des 5:1015-27. 1999
    ..It emphasizes in which way different non-volatile anesthetic drugs may affect the non-specific branch of the immune system, i.e. the leukocyte transmigration through endothelial cell monolayers...
  30. ncbi Oral contraceptives that contain ethinyl estradiol (0.035 mg) and cyproterone acetate (2 mg) inhibit leukocyte transmigration through endothelial cell monolayers
    R Hofbauer
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Wilhelminenspital, Austria
    Fertil Steril 72:652-6. 1999
    ..To investigate the influence of ethinyl estradiol and cyproterone acetate in oral contraceptives on leukocyte migration through endothelial cell monolayers...
  31. ncbi Marked increase in vascular endothelial growth factor concentrations during Escherichia coli endotoxin-induced acute inflammation in humans
    F Mittermayer
    Department of Clinical Pharmacology, University of Vienna, Vienna, Austria
    Eur J Clin Invest 33:758-61. 2003
    ..05). CONCLUSIONS: Inflammation-induced activation of leukcytes rather than platelets plays a role in the marked increase in VEGF, which cannot be abrogated by antithrombotic therapy...
  32. ncbi Homocysteine promotes the LDL oxidase activity of ceruloplasmin
    M Exner
    Department of Laboratory Medicine, University of Vienna, Vienna, Austria
    FEBS Lett 531:402-6. 2002
    ..Spectroscopic and oxidation inhibition studies using the Cu(+)-reagent bathocuproine revealed that HCY induced Cu(+)-CP formation, thus promoting its LDL oxidase activity...
  33. ncbi IgG subclass reactivity to human cardiac myosin in cardiomyopathy patients is indicative of a Th1-like autoimmune disease
    P Skyllouriotis
    General and Experimental Pathology, Vienna General Hospital, University of Vienna, Medical School, Vienna, Austria
    Clin Exp Immunol 115:236-47. 1999
    ....