A Jozkowicz

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi Ligands of peroxisome proliferator-activated receptor-gamma increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages
    A Jozkowicz
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 47:1147-57. 2000
  2. ncbi Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF
    A Jozkowicz
    Department of Vascular Surgery, University of Vienna, AKH, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Cardiovasc Res 51:773-83. 2001
  3. ncbi Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner
    A Jozkowicz
    Department of Vascular Surgery, AKH, University of Vienna, Austria
    Prostaglandins Other Lipid Mediat 66:165-77. 2001
  4. ncbi Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1
    Alicja Jozkowicz
    Department of Vascular Surgery, AKH, University of Vienna, Austria
    Antioxid Redox Signal 4:577-85. 2002
  5. ncbi Nitric oxide mediates the mitogenic effects of insulin and vascular endothelial growth factor but not of leptin in endothelial cells
    A Jozkowicz
    Department of Clinical Biochemistry, Jagiellonian University School of Medicine, Krakow, Poland
    Acta Biochim Pol 46:703-15. 1999
  6. ncbi Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells
    J Dulak
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Arterioscler Thromb Vasc Biol 20:659-66. 2000
  7. ncbi Gene transfer of vascular endothelial growth factor and endothelial nitric oxide synthase--implications for gene therapy in cardiovascular diseases
    J Dulak
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Pol J Pharmacol 51:233-41. 1999
  8. ncbi Positive effect of treatment with synthetic steroid hormone tibolon on intimal hyperplasia and restenosis after experimental endothelial injury of rabbit carotid artery
    J Nanobashvili
    Department of Vascular Surgery, University of Vienna, Austria
    Eur Surg Res 36:74-82. 2004
  9. ncbi Expression of beta-galactosidase gene and endothelial nitric oxide synthase gene in rat vascular smooth muscle cells after in vitro lipotransfection
    A Jozkowicz
    Department of Clinical Biochemistry, Collegium Medicum of Jagiellonian University, Kopernika 15A, 31 501, Krakow, Poland
    Clin Chim Acta 288:1-19. 1999
  10. ncbi Delivery of high dose VEGF plasmid using fibrin carrier does not influence its angiogenic potency
    A Jozkowicz
    Department of Vascular Surgery, University of Vienna, Vienna, Austria
    Int J Artif Organs 26:161-9. 2003

Collaborators

  • H Nohl
  • J Dulak
  • M Prager
  • R Blumer
  • G Weigel
  • A Szuba
  • B Winter
  • M A Papiez
  • Bo Chen
  • C Kieda
  • G Rimbach
  • M B Grant
  • W Dichtl
  • Agnieszka Loboda
  • Agnieszka Jazwa
  • Halina Was
  • Witold N Nowak
  • H Taha
  • Mir Farzin Mashreghi
  • Anupam Agarwal
  • Anna Grochot-Przeczek
  • Laia Jofre-Monseny
  • Jaroslaw Cisowski
  • Jessy Deshane
  • Anna Grochot
  • Philip Funovics
  • Grietje Molema
  • A Loboda
  • Daniela Jurek
  • J Nanobashvili
  • Andrzej Szczeklik
  • Karolina Bukowska-Strakov√°
  • Katarzyna Kusinska
  • Piotr Mika
  • Roman Nowobilski
  • Rafal Nizankowski
  • A Marek
  • A Balcerczyk
  • K Skrzypek
  • H Was
  • M Kozakowska
  • B Lackowska
  • A Grochot-Przeczek
  • S Mustafa
  • J Kotlinowski
  • Katja Kotsch
  • Hans Dieter Volk
  • Andrzej J Rutkowski
  • Roman Klemz
  • Roland Buelow
  • Bernhard Gerstmayer
  • Isabela Schmitt Knosalla
  • Uwe Janssen
  • Thomas D Hock
  • Nathalie Hill-Kapturczak
  • Anne Marie Minihane
  • Sifeng Chen
  • Radoslaw Lach
  • Anika E Wagner
  • Christine Boesch-Saadatmandi
  • Patricia Huebbe
  • Gene P Siegal
  • Sergio Li Calzi
  • Sergio Caballero
  • Katarzyna Mleczko
  • Christine Brostjan
  • Stanislaw Szala
  • Ryszard Smolarczyk
  • Anneliese Nigisch
  • Magdalena Szelag
  • Magdalena Stopa
  • Jerzy Dorosz
  • Jean J Leger
  • Karolina Bojkowska
  • Dominika Rudnicka
  • Patrycja Sroczynska
  • Bozena Lackowska
  • Slawomir Golda
  • Justyna Drukala
  • Jozsef Balla
  • Anna Ratajska
  • Catherine Chevalier
  • Tomasz Cichon
  • Anna Zagorska
  • Anna Fila
  • Rolf Schulte-Hermann
  • Natalia Udilova
  • Brigitte Marian
  • B Wegiel
  • A Jazwa

Detail Information

Publications31

  1. ncbi Ligands of peroxisome proliferator-activated receptor-gamma increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages
    A Jozkowicz
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 47:1147-57. 2000
    ..We conclude that the activation of PPARgamma upregulates the generation of VEGF and may be involved in the regulation of angiogenesis...
  2. ncbi Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF
    A Jozkowicz
    Department of Vascular Surgery, University of Vienna, AKH, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Cardiovasc Res 51:773-83. 2001
    ..Vascular endothelial growth factor (VEGF) induces the release of nitric oxide (NO) from endothelial cells. There is also limited data suggesting that NO may enhance VEGF generation...
  3. ncbi Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner
    A Jozkowicz
    Department of Vascular Surgery, AKH, University of Vienna, Austria
    Prostaglandins Other Lipid Mediat 66:165-77. 2001
    ..We conclude, that 15d-PGJ2 is a potent inducer of IL-8 production and can be a mediator of inflammatory response, but this effect is independent of PPARgamma activation...
  4. ncbi Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1
    Alicja Jozkowicz
    Department of Vascular Surgery, AKH, University of Vienna, Austria
    Antioxid Redox Signal 4:577-85. 2002
    ..Thus, we postulate that the up-regulation of VEGF expression in response to 15d-PGJ(2 )in HMEC-1 is mediated by the activation of HO-1...
  5. ncbi Nitric oxide mediates the mitogenic effects of insulin and vascular endothelial growth factor but not of leptin in endothelial cells
    A Jozkowicz
    Department of Clinical Biochemistry, Jagiellonian University School of Medicine, Krakow, Poland
    Acta Biochim Pol 46:703-15. 1999
    ....
  6. ncbi Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells
    J Dulak
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Arterioscler Thromb Vasc Biol 20:659-66. 2000
    ..The results indicate that endogenous NO enhances VEGF synthesis. The positive interaction between endogenous NO and VEGF may have implications for endothelial regeneration after balloon angioplasty and for angiogenesis...
  7. ncbi Gene transfer of vascular endothelial growth factor and endothelial nitric oxide synthase--implications for gene therapy in cardiovascular diseases
    J Dulak
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Pol J Pharmacol 51:233-41. 1999
    ..Additionally, we evidenced that NO can enhance the endogenous generation of VEGF. A new protective mechanism of NO has been thus revealed...
  8. ncbi Positive effect of treatment with synthetic steroid hormone tibolon on intimal hyperplasia and restenosis after experimental endothelial injury of rabbit carotid artery
    J Nanobashvili
    Department of Vascular Surgery, University of Vienna, Austria
    Eur Surg Res 36:74-82. 2004
    ....
  9. ncbi Expression of beta-galactosidase gene and endothelial nitric oxide synthase gene in rat vascular smooth muscle cells after in vitro lipotransfection
    A Jozkowicz
    Department of Clinical Biochemistry, Collegium Medicum of Jagiellonian University, Kopernika 15A, 31 501, Krakow, Poland
    Clin Chim Acta 288:1-19. 1999
    ....
  10. ncbi Delivery of high dose VEGF plasmid using fibrin carrier does not influence its angiogenic potency
    A Jozkowicz
    Department of Vascular Surgery, University of Vienna, Vienna, Austria
    Int J Artif Organs 26:161-9. 2003
    ..In conclusion, injection of pSG5-VEGF165 into ischemic adductor muscle leads to synthesis of human VEGF and increases the number of capillaries. Fibrin carrier does not influence its angiogenic potential...
  11. pmc Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells
    A Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Cell Mol Biol (Noisy-le-grand) 51:347-55. 2005
    ..Our data show that although both CoCl2 and CoPPIX induce HO-1, the influence of CoCl2 on VEGF does not involve HO-1 and is HIF-1-dependent, while the effect of CoPPIX does not involve HIF-1 but relies on HO-1...
  12. ncbi Modulation of inflammatory response by pentoxifylline is independent of heme oxygenase-1 pathway
    H Taha
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    J Physiol Pharmacol 60:3-12. 2009
    ..It was reported that some effects of pentoxifylline (PTX) are mediated by heme oxygenase-1 (HO-1) induction. We investigated the role of HO-1 in anti-inflammatory activity of PTX...
  13. doi Exercise training in intermittent claudication: effects on antioxidant genes, inflammatory mediators and proangiogenic progenitor cells
    Witold N Nowak
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Thromb Haemost 108:824-31. 2012
    ....
  14. doi The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats
    M A Papiez
    Department of Cytobiology and Histochemistry, Jagiellonian University, Medyczna 9 Street, 30 688 Krakow, Poland
    Food Chem Toxicol 46:3053-8. 2008
    ..The results of our study prove that changes in the antioxidant state, caused by quercetin, do not lead to DNA damage or exert any pro-apoptotic activity in vivo...
  15. pmc Angiogenic transcriptome of human microvascular endothelial cells: Effect of hypoxia, modulation by atorvastatin
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Vascul Pharmacol 44:206-14. 2006
    ..The influence of atorvastatin on angiogenic gene expression is complex, and final pro- or anti-angiogenic outcome of statin therapy remains to be established for numerous angiogenesis-related diseases...
  16. pmc Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells
    Philip Funovics
    Medical Faculty, University of Vienna, Austria
    Prostaglandins Other Lipid Mediat 79:230-44. 2006
    ..This suggests that inhibition of this transcription factor by 15d-PGJ(2) contributes to decrease in angiogenic response...
  17. pmc Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes
    Agnieszka Jazwa
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Free Radic Biol Med 40:1250-63. 2006
    ..Recently the involvement of HO-1 in angiogenesis has been shown; however, the role of heme and HO-1 in wound healing angiogenesis has not been yet investigated...
  18. doi Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 10:1767-812. 2008
    ....
  19. ncbi Dietary lipid hydroperoxides induce expression of vascular endothelial growth factor (VEGF) in human colorectal tumor cells
    Daniela Jurek
    Institute of Cancer Research, Medical University Vienna, Vienna, Austria
    FASEB J 19:97-9. 2005
    ..Therefore, our results for the first time implicate dietary lipid hydroperoxide as a key risk factor in colon carcinogenesis...
  20. ncbi Inhibition of dendritic cell maturation and function is independent of heme oxygenase 1 but requires the activation of STAT3
    Mir Farzin Mashreghi
    Institute of Medical Immunology and Berlin Brandenburg Center of Regenerative Therapies, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 180:7919-30. 2008
    ....
  21. doi Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis
    Jozef Dulak
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
    Circulation 117:231-41. 2008
    ..This review will provide an overview of the role of heme oxygenase-1 and carbon monoxide in angiogenesis...
  22. pmc Heme oxygenase-1 in tumors: is it a false friend?
    Alicja Jozkowicz
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 9:2099-117. 2007
    ..Accordingly, inhibition of HO-1 can be suggested as a potential therapeutic approach sensitizing tumors to radiation, chemotherapy, or photodynamic therapy...
  23. pmc Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression
    Laia Jofre-Monseny
    Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Hermann Rodewald Strasse 6, 24098 Kiel, Germany
    Biochem Biophys Res Commun 357:319-24. 2007
    ..Current data indicate that apoE4 macrophages have an altered inflammatory response, which may contribute to the higher CVD risk observed in apoE4 carriers...
  24. pmc Comment on "A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells"
    Jozef Dulak
    J Immunol 178:4707; author reply 4707-8. 2007
  25. pmc Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism
    Jessy Deshane
    Department of Medicine, Nephrology Research and Training Center and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 204:605-18. 2007
    ..These findings demonstrate a mechanistic role for HO-1 in SDF-1-mediated angiogenesis and provide new avenues for therapeutic approaches in vascular repair...
  26. pmc New vectors and strategies for cardiovascular gene therapy
    Agnieszka Jazwa
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Curr Gene Ther 7:7-23. 2007
    ....
  27. pmc Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice
    Halina Was
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Am J Pathol 169:2181-98. 2006
    ....
  28. pmc Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells
    Agnieszka Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Atherosclerosis 187:26-30. 2006
    ..Therefore, we suggest that the protective effect of statins at their pharmacological concentrations is not mediated by enhancement of HO-1 activity, but may involve eNOS...
  29. pmc Atorvastatin affects several angiogenic mediators in human endothelial cells
    Jozef Dulak
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Endothelium 12:233-41. 2005
    ..In conclusion, the present findings points to other angiogenesis-related effects of atorvastatin, which may be of relevance to the beneficial influence of statins in cardiovascular system...
  30. pmc New strategies for cardiovascular gene therapy: regulatable pre-emptive expression of pro-angiogenic and antioxidant genes
    Jozef Dulak
    Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Cell Biochem Biophys 44:31-42. 2006
    ..Here, we demonstrated some indications of these drawbacks. Therefore, the final acceptance of these promising strategies for clinical trials requires careful validation in animal experiments...
  31. pmc Effects of local gene transfer of VEGF on neointima formation after balloon injury in hypercholesterolemic rabbits
    Jozef Dulak
    Clinical Division of Cardiology, Innsbruck Medical University, Austria
    Vasc Med 10:285-91. 2005
    ..05). Local transfer of the VEGF gene does not inhibit neointima formation in hypercholesterolemic rabbits. Our results suggest that VEGF gene therapy applied locally in atherosclerotic arteries may not be beneficial...