T Jenuwein

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Translating the histone code
    T Jenuwein
    Research Institute of Molecular Pathology IMP at the Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 293:1074-80. 2001
  2. ncbi request reprint Molecular biology. An RNA-guided pathway for the epigenome
    Thomas Jenuwein
    Research Institute of Molecular Pathology IMP, Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 297:2215-8. 2002
  3. ncbi request reprint Re-SET-ting heterochromatin by histone methyltransferases
    T Jenuwein
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030, Vienna, Austria
    Trends Cell Biol 11:266-73. 2001
  4. ncbi request reprint Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    M Lachner
    Research Institute of Molecular Pathology, The Vienna Biocenter, Vienna, Austria
    Nature 410:116-20. 2001
  5. ncbi request reprint Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
    A H Peters
    Research Institute of Molecular Pathology IMP, Vienna Biocenter, Dr Bohrgasse 7, A 1030, Vienna, Austria
    Cell 107:323-37. 2001
  6. pmc Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression
    D O'Carroll
    Research Institute of Molecular Pathology at The Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    Mol Cell Biol 20:9423-33. 2000
  7. ncbi request reprint Regulation of chromatin structure by site-specific histone H3 methyltransferases
    S Rea
    Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
    Nature 406:593-9. 2000
  8. pmc Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression
    M Melcher
    Research Institute of Molecular Pathology, The Vienna Biocenter, A 1030 Vienna, Austria
    Mol Cell Biol 20:3728-41. 2000
  9. ncbi request reprint Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice
    S Czvitkovich
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Mech Dev 107:141-53. 2001
  10. pmc Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
    L Aagaard
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    EMBO J 18:1923-38. 1999

Detail Information

Publications72

  1. ncbi request reprint Translating the histone code
    T Jenuwein
    Research Institute of Molecular Pathology IMP at the Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 293:1074-80. 2001
    ....
  2. ncbi request reprint Molecular biology. An RNA-guided pathway for the epigenome
    Thomas Jenuwein
    Research Institute of Molecular Pathology IMP, Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 297:2215-8. 2002
  3. ncbi request reprint Re-SET-ting heterochromatin by histone methyltransferases
    T Jenuwein
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030, Vienna, Austria
    Trends Cell Biol 11:266-73. 2001
    ..g. centromeres) and for chromatin-dependent inheritance of gene expression patterns. This review discusses how understanding this methylation system should address some of the long-standing mysteries of heterochromatin...
  4. ncbi request reprint Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    M Lachner
    Research Institute of Molecular Pathology, The Vienna Biocenter, Vienna, Austria
    Nature 410:116-20. 2001
    ..Our data define a molecular mechanism through which the SUV39H-HP1 methylation system can contribute to the propagation of heterochromatic subdomains in native chromatin...
  5. ncbi request reprint Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
    A H Peters
    Research Institute of Molecular Pathology IMP, Vienna Biocenter, Dr Bohrgasse 7, A 1030, Vienna, Austria
    Cell 107:323-37. 2001
    ..These in vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development...
  6. pmc Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression
    D O'Carroll
    Research Institute of Molecular Pathology at The Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    Mol Cell Biol 20:9423-33. 2000
    ....
  7. ncbi request reprint Regulation of chromatin structure by site-specific histone H3 methyltransferases
    S Rea
    Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
    Nature 406:593-9. 2000
    ..Our data reveal a functional interdependence of site-specific H3 tail modifications and suggest a dynamic mechanism for the regulation of higher-order chromatin...
  8. pmc Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression
    M Melcher
    Research Institute of Molecular Pathology, The Vienna Biocenter, A 1030 Vienna, Austria
    Mol Cell Biol 20:3728-41. 2000
    ..Together, our data reveal a dominant role(s) for the SET domain of SUV39H1 in the distribution of prominent heterochromatic proteins and suggest a possible link between a chromosomal SU(VAR) protein and histone H3...
  9. ncbi request reprint Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice
    S Czvitkovich
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Mech Dev 107:141-53. 2001
    ....
  10. pmc Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
    L Aagaard
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    EMBO J 18:1923-38. 1999
    ..These data indicate the existence of a mammalian SU(VAR) complex and define Suv39h1/SUV39H1 as novel components of mammalian higher order chromatin...
  11. ncbi request reprint Trilogies of histone lysine methylation as epigenetic landmarks of the eukaryotic genome
    M Lachner
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, A 1030 Vienna, Austria
    Cold Spring Harb Symp Quant Biol 69:209-18. 2004
  12. ncbi request reprint Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres
    L Aagaard
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    J Cell Sci 113:817-29. 2000
    ..This intriguing localisation and modification pattern would be consistent with a regulatory role(s) for SUV39H1 in participating in higher order chromatin organisation at mammalian centromeres...
  13. pmc The polycomb-group gene Ezh2 is required for early mouse development
    D O'Carroll
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Mol Cell Biol 21:4330-6. 2001
    ..Together, these data suggest an essential role for Ezh2 during early mouse development and genetically link Ezh2 with eed and YY1, the only other early-acting Pc-G genes...
  14. ncbi request reprint The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6
    G Laible
    Research Institute of Molecular Pathology IMP The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Mamm Genome 10:311-4. 1999
  15. pmc Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
    G Laible
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    EMBO J 16:3219-32. 1997
    ..Together, these data provide a functional link between Pc-G-dependent gene repression and inactive chromatin domains, and indicate that silencing mechanism(s) may be broadly conserved in eukaryotes...
  16. ncbi request reprint A crack in histone lysine methylation
    Stefan Kubicek
    Research Institute of Molecular Pathology, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Cell 119:903-6. 2004
    ..2004 [this issue of Cell])...
  17. pmc Histone modification patterns associated with the human X chromosome
    Arie B Brinkman
    Department of Molecular Biology, Nijmegen Centre for Molecular Life Sciences, NCMLS M850 3 79, Radboud University, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    EMBO Rep 7:628-34. 2006
    ....
  18. ncbi request reprint Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state
    Kelly M McGarvey
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 66:3541-9. 2006
    ..This finding has important implications for the translational goal of reactivating aberrantly silenced cancer genes as a therapeutic maneuver...
  19. ncbi request reprint Oncogene-induced senescence as an initial barrier in lymphoma development
    Melanie Braig
    Charité Universitätsmedizin Berlin Haematology Oncology, 13353 Berlin, Germany
    Nature 436:660-5. 2005
    ..These results identify H3K9me-mediated senescence as a novel Suv39h1-dependent tumour suppressor mechanism whose inactivation permits the formation of aggressive but apoptosis-competent lymphomas in response to oncogenic Ras...
  20. ncbi request reprint EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells
    Madoka Koyanagi
    Department of Immunology, University of Washington, Seattle, Washington 98195 7650, USA
    J Biol Chem 280:31470-7. 2005
    ....
  21. pmc Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis
    Kathrin Naumann
    Institute of Genetics, Biologicum, Martin Luther University Halle, Halle, Germany
    EMBO J 24:1418-29. 2005
    ..Gene silencing by SUVH2 depends on MET1 and DDM1, but not CMT3. In Arabidopsis, SUVH2 with its histone H3K9 and H4K20 methylation activity has a central role in heterochromatic gene silencing...
  22. ncbi request reprint Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    Mario F Fraga
    Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 37:391-400. 2005
    ..Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells...
  23. ncbi request reprint Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
    Susana Gonzalo
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre CNIO, Madrid E 28029, Spain
    Nat Cell Biol 7:420-8. 2005
    ..These observations indicate that the RB1 family is involved in maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin, linking tumour suppression and the epigenetic definition of chromatin...
  24. pmc The profile of repeat-associated histone lysine methylation states in the mouse epigenome
    Joost H A Martens
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Vienna, Austria
    EMBO J 24:800-12. 2005
    ..Our data define a profile of repressive histone lysine methylation states for the repetitive complement of four distinct mouse epigenomes and suggest tandem repeats and dsRNA as primary triggers for more stable chromatin imprints...
  25. pmc Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
    Dale K Shumaker
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 103:8703-8. 2006
    ..The epigenetic changes described most likely represent molecular mechanisms responsible for the rapid progression of premature aging in HGPS patients...
  26. pmc Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
    Barna D Fodor
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 20:1557-62. 2006
    ..These data reveal that certain members of the jmjC class of hydroxylases can work in a pathway that actively antagonizes a histone lysine trimethyl state...
  27. pmc Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination
    Roberta Benetti
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Madrid, Spain
    J Cell Biol 178:925-36. 2007
    ..These results demonstrate the importance of chromatin architecture in the maintenance of telomere length homeostasis and reveal a novel role for histone lysine methylation in controlling telomere recombination...
  28. pmc Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome
    Kakkad Regha
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Institute of Genetics, Max F Perutz Laboratories, Vienna Biocenter, Dr Bohr Gasse 9 4, A 1030 Vienna, Austria
    Mol Cell 27:353-66. 2007
    ..Thus, mammalian chromosome arms contain active chromatin interspersed with repressive chromatin resembling the type of heterochromatin previously considered a feature of centromeres, telomeres, and the inactive X chromosome...
  29. ncbi request reprint Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
    Raffaella Villa
    Centre de Regulacio Genomica, C Dr Aiguader 88, 08003 Barcelona, Spain
    Cancer Cell 11:513-25. 2007
    ..Our results demonstrate that the direct targeting of Polycomb group proteins by an oncogene plays a key role during carcinogenesis...
  30. ncbi request reprint DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2
    Kelly M McGarvey
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD 21231, USA
    Cancer Res 67:5097-102. 2007
    ..These results suggest that EZH2 can modulate transcription of basally expressed genes but not silent genes that are densely DNA methylated...
  31. ncbi request reprint Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3
    Thomas Rudolph
    Institute of Biology, Developmental Genetics, Martin Luther University Halle, D 06120 Halle, Germany
    Mol Cell 26:103-15. 2007
    ....
  32. ncbi request reprint Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
    Stefan Kubicek
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Mol Cell 25:473-81. 2007
    ..Our data identify a biologically active HMTase inhibitor that allows for the transient modulation of H3K9me2 marks in mammalian chromatin...
  33. pmc A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    Joyce E Ohm
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center
    Nat Genet 39:237-42. 2007
    ....
  34. pmc Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27
    Daniel Schubert
    Institute for Molecular Plant Sciences, School of Biology, University of Edinburgh, Edinburgh, UK
    EMBO J 25:4638-49. 2006
    ..We suggest that the spread of H3K27me3 contributes to the mitotic heritability of Pc-G silencing, and that the loss of silencing caused by transposon insertions at plant Pc-G targets reflects impaired spreading...
  35. ncbi request reprint The epigenetic magic of histone lysine methylation
    Thomas Jenuwein
    Research Institute of Molecular Pathology and The Vienna Biocenter, Austria
    FEBS J 273:3121-35. 2006
    ....
  36. pmc Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
    Stefan Schoeftner
    Research Institute of Molecular Pathology, Vienna, Austria
    EMBO J 25:3110-22. 2006
    ..Our data show that Xist recruits PRC1 components by both PRC2 dependent and independent modes and in the absence of PRC2 function is sufficient for the establishment of Polycomb-based memory systems in X inactivation...
  37. pmc Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila
    Anja Ebert
    Institute of Genetics, Biologicum, Martin Luther University Halle, D 06120 Halle, Germany
    Genes Dev 18:2973-83. 2004
    ....
  38. pmc Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes
    Jonathan Baxter
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    EMBO J 23:4462-72. 2004
    ....
  39. pmc Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3
    Anders M Lindroth
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
    EMBO J 23:4286-96. 2004
    ..Our results suggest a model in which H3K9 methylation by KYP, and H3K27 methylation by an unknown enzyme provide a combinatorial histone code for the recruitment of CMT3 to silent loci...
  40. ncbi request reprint Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
    Bernhard Lehnertz
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Curr Biol 13:1192-200. 2003
    ..H3-K9 methylation was recently shown to be a prerequisite for DNA methylation in Neurospora crassa and Arabidopsis thaliana. Currently, it is unknown whether a similar dependence exists in mammalian organisms...
  41. ncbi request reprint Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos
    Fatima Santos
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Curr Biol 13:1116-21. 2003
    ..These results suggest a mechanistic link between DNA and histone methylation in the mammalian embryo and reveal an association between epigenetic marks and developmental potential of cloned embryos...
  42. ncbi request reprint An epigenetic road map for histone lysine methylation
    Monika Lachner
    Research Institute of Molecular Pathology, The Vienna Biocenter, Dr Bohrgasse7, A 1030 Vienna, Austria
    J Cell Sci 116:2117-24. 2003
  43. ncbi request reprint Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes
    Jose Silva
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Dev Cell 4:481-95. 2003
    ..Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure...
  44. ncbi request reprint Maintenance of stable heterochromatin domains by dynamic HP1 binding
    Thierry Cheutin
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 299:721-5. 2003
    ..These data argue against HP1 repression of transcription by formation of static, higher order oligomeric networks but support a dynamic competition model, and they demonstrate that heterochromatin is accessible to regulatory factors...
  45. pmc Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins
    Richard G A B Sewalt
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    Mol Cell Biol 22:5539-53. 2002
    ..Our findings suggest a role for the SUV39H1 HMTase and histone H3-K9 methylation in the targeting of human HPC/HPH PcG proteins to modified chromatin structures...
  46. ncbi request reprint The many faces of histone lysine methylation
    Monika Lachner
    Research Institute of Molecular Pathology, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Curr Opin Cell Biol 14:286-98. 2002
    ..Together, the available data strongly establish histone lysine methylation as a central modification for the epigenetic organisation of eukaryotic genomes...
  47. pmc Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing
    Gunnar Schotta
    Institute of Genetics, Biologicum, Martin Luther University Halle, Weinbergweg 10, D 06120 Halle, Germany
    EMBO J 21:1121-31. 2002
    ..Finally, the human SUV39H1 gene is able to partially rescue Su(var)3-9 silencing defects. Together, these data indicate a central role for the SU(VAR)3-9 HMTase in heterochromatin-induced gene silencing in Drosophila...
  48. ncbi request reprint Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation
    Jacqueline E Mermoud
    X Inactivation Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    Curr Biol 12:247-51. 2002
    ..Here we show that H3-K9 methylation is a very early event in the process of X inactivation, which closely parallels the onset of Xist RNA accumulation...
  49. ncbi request reprint Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
    Antoine H F M Peters
    Research Institute of Molecular Pathology, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Nat Genet 30:77-80. 2002
    ..These observations suggest the existence of an Suv39h-HP1-independent pathway regulating H3-Lys9 methylation of facultative heterochromatin...
  50. ncbi request reprint Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
    Sylvia Erhardt
    Wellcome Trust Cancer Research UK Institute, University of Cambridge, Cambridge CB2 1QR, UK
    Development 130:4235-48. 2003
    ..Thus, Ezh2 has significant and diverse roles during early development, as well as during the establishment of the first differentiated cells, the trophectoderm, and of the pluripotent epiblast cells...
  51. pmc Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte
    Siqin Bao
    The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge
    EMBO Rep 6:748-54. 2005
    ..All the epigenetic marks on the X are apparently erased in the epiblast, suggesting that the oocyte and epiblast may have distinct properties for stepwise programming of the genome...
  52. ncbi request reprint Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3
    Andrei Kuzmichev
    Robert Wood Johnson Medical School, Howard Hughes Medical Institute and Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Mol Cell 14:183-93. 2004
    ..Our data provide evidence for a novel mechanism regulating the substrate specificity of a chromatin-modifying enzyme through disparate translational products of a regulatory subunit...
  53. ncbi request reprint Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana
    James P Jackson
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Chromosoma 112:308-15. 2004
    ..Our results suggest that multiple Su(var)3-9 family members are active in Arabidopsis and that dimethylation of histone H3 lysine 9 is the critical mark for gene silencing and DNA methylation...
  54. ncbi request reprint The indexing potential of histone lysine methylation
    Gunnar Schotta
    Research Institute of Molecular Pathology, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Novartis Found Symp 259:22-37; discussion 37-47, 163-9. 2004
    ..di- vs. trimethylation) and selective combinations of individually methylated lysine positions can indeed index chromatin regions, resulting in epigenetic landmarks for the partitioning of eukaryotic chromatin...
  55. ncbi request reprint Generation and characterization of methyl-lysine histone antibodies
    Laura Perez-Burgos
    Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
    Methods Enzymol 376:234-54. 2004
  56. ncbi request reprint Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
    Marta García-Cao
    Molecular Oncology Program, Spanish National Cancer Centre CNIO, E 28029 Madrid, Spain
    Nat Genet 36:94-9. 2004
    ..Taken together, the results indicate epigenetic regulation of telomere length in mammals by Suv39h1 and Suv39h2...
  57. ncbi request reprint Partitioning and plasticity of repressive histone methylation states in mammalian chromatin
    Antoine H F M Peters
    Research Institute of Molecular Pathology, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Mol Cell 12:1577-89. 2003
    ..Our data underscore the selective presence of distinct histone lysine methylation states in partitioning chromosomal subdomains but also reveal a surprising plasticity in propagating methylation patterns in eukaryotic chromatin...
  58. pmc A chromosomal memory triggered by Xist regulates histone methylation in X inactivation
    Alexander Kohlmaier
    Research Institute of Molecular Pathology, Vienna, Austria
    PLoS Biol 2:E171. 2004
    ....
  59. pmc A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
    Gunnar Schotta
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 18:1251-62. 2004
    ..Together, our data indicate a function for H4-K20 trimethylation in gene silencing and further suggest H3-K9 and H4-K20 trimethylation as important components of a repressive pathway that can index pericentric heterochromatin...
  60. ncbi request reprint p53 is regulated by the lysine demethylase LSD1
    Jing Huang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 449:105-8. 2007
    ..Lysine methylation therefore provides similar regulatory complexity for non-histone proteins and for histones...
  61. ncbi request reprint Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component
    Christèle Maison
    Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Genet 30:329-34. 2002
    ..In addition, we identify an RNA- and histone modification-dependent structure that brings methylated H3-K9 tails together in a specific configuration required for the accumulation of HP1 proteins in these domains...
  62. pmc A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
    Gunnar Schotta
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 22:2048-61. 2008
    ..Thus, conversion to an H4K20me1 state results in compromised chromatin that is insufficient to protect genome integrity and to process a DNA-rearranging differentiation program in the mouse...
  63. pmc Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
    Chryssa Kanellopoulou
    The Dana Farber Cancer Institute, Department of Cancer Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:489-501. 2005
    ..Our data suggest that Dicer participates in multiple, fundamental biological processes in a mammalian organism, ranging from stem cell differentiation to the maintenance of centromeric heterochromatin structure and centromeric silencing...
  64. pmc Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
    Gerda Lagger
    Institute of Medical Biochemistry, Division of Molecular Biology, University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    EMBO J 21:2672-81. 2002
    ..Our study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors...
  65. ncbi request reprint Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
    Melanie Wissmann
    Universitäts Frauenklinik und Zentrum für Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
    Nat Cell Biol 9:347-53. 2007
    ..Thus, our data suggest that specific gene regulation requires the assembly and coordinate action of demethylases with distinct substrate specificities...
  66. ncbi request reprint Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes
    Yuki Takada
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Yokohama, Japan
    Development 134:579-90. 2007
    ..Therefore, for the first time, we are able to indicate a functional involvement of Prc1 during the meiotic prophase of male germ cells and a regulatory role of Scmh1 for Prc1, which involves sex chromosomes...
  67. ncbi request reprint Repression of p53 activity by Smyd2-mediated methylation
    Jing Huang
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nature 444:629-32. 2006
    ..Thus, similar to histones, p53 is subject to both activating and repressing lysine methylation. Our results also predict that Smyd2 may function as a putative oncogene by methylating p53 and repressing its tumour suppressive function...
  68. pmc Formation of facultative heterochromatin in the absence of HP1
    Nick Gilbert
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    EMBO J 22:5540-50. 2003
    ..To our knowledge, this is the first report of cell types that lack HP1s and that have gross changes in the levels of histone modifications...
  69. ncbi request reprint The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA
    Sean P Bradley
    Immunology and Virology Program, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:1179-88. 2006
    ..Taken together, our results suggest that Suv39h1 activity inhibits the activity of a sequence-specific DNA-binding protein that represses switch recombination to IgA...
  70. ncbi request reprint The polycomb group protein EZH2 is required for mammalian circadian clock function
    Jean Pierre Etchegaray
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, 01605, USA
    J Biol Chem 281:21209-15. 2006
    ..These results indicate that EZH2 is important for the maintenance of circadian rhythms and extend the activity of the polycomb group proteins to the core clockwork mechanism of mammals...
  71. ncbi request reprint Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8
    Yu ichi Fujimura
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Development 133:2371-81. 2006
    ..The present study indicates distinct roles for class 2 PcG complexes in transcriptionally repressed and active domains of Hoxb8 gene...