Walter H Horl

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint [Goal blood pressure values from the nephrologic viewpoint]
    W H Horl
    Klinischen Abteilung für Nephrologie und Dialyse, Medizinischen Universitätsklinik III, Wien
    Wien Med Wochenschr 149:629-32. 1999
  2. ncbi request reprint Renal osteodystrophy: role of calcimimetics
    Walter H Horl
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Austria
    Am J Kidney Dis 41:S104-7. 2003
  3. ncbi request reprint Adjunctive therapy in anaemia management
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 17:56-9. 2002
  4. ncbi request reprint [Atherosclerosis and uremia: signifance of non-traditional risk factors]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universitatsklinik III, Wien, Osterreich
    Wien Klin Wochenschr 115:220-34. 2003
  5. ncbi request reprint Non-erythropoietin-based anaemia management in chronic kidney disease
    Walter H Horl
    Department of Medicine III, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 17:35-8. 2002
  6. ncbi request reprint Atherosclerosis and uremic retention solutes
    Walter H Horl
    Division of Nephrology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Kidney Int 66:1719-31. 2004
  7. ncbi request reprint Predialysis Survey on Anemia Management: patient referral
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wien, Austria
    Am J Kidney Dis 41:49-61. 2003
  8. ncbi request reprint Hemodialysis membranes: interleukins, biocompatibility, and middle molecules
    Walter H Horl
    Department of Medicine, Division of Nephrology, University of Vienna, Vienna, Austria
    J Am Soc Nephrol 13:S62-71. 2002
  9. ncbi request reprint The clinical consequences of secondary hyperparathyroidism: focus on clinical outcomes
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, University Hospital, Vienna, Austria
    Nephrol Dial Transplant 19:V2-8. 2004
  10. ncbi request reprint Risk factors for capillary C4d deposition in kidney allografts: evaluation of a large study cohort
    Matthias Lorenz
    Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Transplantation 78:447-52. 2004

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint [Goal blood pressure values from the nephrologic viewpoint]
    W H Horl
    Klinischen Abteilung für Nephrologie und Dialyse, Medizinischen Universitätsklinik III, Wien
    Wien Med Wochenschr 149:629-32. 1999
    ..In patients with primary renal disease or renal involvement in systemic diseases, ACE inhibitors or angiotensin II blockers with or without diuretics are preferably used...
  2. ncbi request reprint Renal osteodystrophy: role of calcimimetics
    Walter H Horl
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Austria
    Am J Kidney Dis 41:S104-7. 2003
    ..Coadministration of active vitamin D compounds may be necessary to overcome intestinal malabsorption of calcium and maintain normocalcemia in patients on long-term treatment with calcimimetics...
  3. ncbi request reprint Adjunctive therapy in anaemia management
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 17:56-9. 2002
    ..v. L-carnitine therapy results in an increase in haematocrit and a significant decrease in rHuEPO requirement in HD patients. As yet, there is no general recommendation for L-carnitine supplementation for ESRD patients with renal anaemia...
  4. ncbi request reprint [Atherosclerosis and uremia: signifance of non-traditional risk factors]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universitatsklinik III, Wien, Osterreich
    Wien Klin Wochenschr 115:220-34. 2003
    ....
  5. ncbi request reprint Non-erythropoietin-based anaemia management in chronic kidney disease
    Walter H Horl
    Department of Medicine III, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 17:35-8. 2002
    ..Correction of anaemia with rHuEPO may slow progression of CKD by reducing oxidative stress. These and other factors need to be considered for the optimal treatment of patients with anaemia of CKD...
  6. ncbi request reprint Atherosclerosis and uremic retention solutes
    Walter H Horl
    Division of Nephrology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Kidney Int 66:1719-31. 2004
  7. ncbi request reprint Predialysis Survey on Anemia Management: patient referral
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wien, Austria
    Am J Kidney Dis 41:49-61. 2003
    ..In this presentation, we focus on demographic data and patient referral practices of patients who enter kidney centers...
  8. ncbi request reprint Hemodialysis membranes: interleukins, biocompatibility, and middle molecules
    Walter H Horl
    Department of Medicine, Division of Nephrology, University of Vienna, Vienna, Austria
    J Am Soc Nephrol 13:S62-71. 2002
    ..Currently available membrane materials do not provide long-lasting, effective reduction of middle molecules in patients who require maintenance hemodialysis...
  9. ncbi request reprint The clinical consequences of secondary hyperparathyroidism: focus on clinical outcomes
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, University Hospital, Vienna, Austria
    Nephrol Dial Transplant 19:V2-8. 2004
    ..These treatments do not provide optimal treatment for many patients, and compounds that directly inhibit PTH secretion may prove a major step forward in the treatment of SHPT...
  10. ncbi request reprint Risk factors for capillary C4d deposition in kidney allografts: evaluation of a large study cohort
    Matthias Lorenz
    Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Transplantation 78:447-52. 2004
    ..The impact of pre- and posttransplant variables including particular immunosuppressive regimens on the frequency of C4d deposition has not yet been systematically investigated in a large multivariate analysis...
  11. ncbi request reprint Alemtuzumab (Campath-1H) induction therapy and dendritic cells: Impact on peripheral dendritic cell repertoire in renal allograft recipients
    Bernhard M Kirsch
    Department of Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    Transpl Immunol 16:254-7. 2006
    ..Further studies are warranted to further elucidate the functional significance of these finding in the setting of allogeneic organ transplantation...
  12. doi request reprint Calcineurin inhibitor-based immunosuppressive therapy, donor age, and long-term outcome after kidney transplantation
    Georg Heinze
    Section of Clinical Biometrics, Core Unit for Medical Statistics and Informatics, Medical University Vienna, Vienna, Austria
    Transplantation 87:1821-9. 2009
    ..It is unclear whether the choice of maintenance immunosuppression modulates the negative effect of advanced donor age on outcome after renal transplantation...
  13. doi request reprint Glucose control is associated with patient survival in diabetic patients after renal transplantation
    Franz Wiesbauer
    Department of Cardiology, Medical University of Vienna, Vienna, Austria
    Transplantation 89:612-9. 2010
    ..However, in diabetic renal-allograft recipients, the effect of different treatment strategies on outcomes is undetermined...
  14. ncbi request reprint Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 80:1105-11. 2005
    ....
  15. ncbi request reprint Intravenous iron increases labile serum iron but does not impair forearm blood flow reactivity in dialysis patients
    Georg Schaller
    Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria
    Kidney Int 68:2814-22. 2005
    ..We therefore examined the effect of a single high dose of intravenous iron on endothelial function and biochemical markers of iron homeostasis...
  16. ncbi request reprint Efficacy of a low-dose intravenous iron sucrose regimen in peritoneal dialysis patients
    Elisabeth Dittrich
    Department of Medicine III, University of Vienna, Austria
    Perit Dial Int 22:60-6. 2002
    ..Therefore, we investigated the effectiveness of a low-dose i.v. iron regimen in peritoneal dialysis (PD) patients...
  17. doi request reprint Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients
    Gregor Bartel
    Department of Medicine III, Medical University Vienna, Vienna, Austria
    Transpl Int 26:121-30. 2013
    ..C4d]DSA detected 6 months post-transplantation were not related to clinical outcomes. Our data suggest that pretransplant SAB-based detection of complement-fixing DSA may be a valuable tool for risk stratification...
  18. ncbi request reprint Long-term patient and graft survival in the eurotransplant senior program: a single-center experience
    Veronika Fabrizii
    Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Austria
    Transplantation 80:582-9. 2005
    ..The Eurotransplant Senior Program (ESP) was launched in 1999, targeted to increase the supply of donor kidneys to the elderly. This program requires local allocation of kidneys from cadaveric donors >>65 years to recipients >>65 years...
  19. ncbi request reprint A case of severe C4d-positive kidney allograft dysfunction in the absence of histomorphologic features of rejection
    Antje Habicht
    Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 114:945-8. 2002
    ..This case reinforces the high diagnostic value of C4d staining. In severe graft dysfunction humoral immune mechanisms should be considered, even when histopathologic features of humoral rejection are completely absent...
  20. ncbi request reprint Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation
    Maximilian Zeyda
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 52:2730-9. 2005
    ..In this study, we evaluated the impact of the active leflunomide metabolite teriflunomide on T cell integrin activation, evolution of the IS, and antigen-specific formation of stable T cell/APC conjugates...
  21. pmc A randomized, placebo-controlled, double-blind, prospective trial to evaluate the effect of vildagliptin in new-onset diabetes mellitus after kidney transplantation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Austria
    Trials 11:91. 2010
    ..This study will evaluate the safety and efficacy of vildagliptin monotherapy in renal transplant recipients with recently diagnosed NODAT...
  22. ncbi request reprint Rescue therapy with tacrolimus and mycophenolate mofetil does not prevent deterioration of graft function in C4d-positive chronic allograft nephropathy
    Christoph Schwarz
    Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Wien Klin Wochenschr 118:397-404. 2006
    ..For chronic humoral rejection, the efficacy of rescue therapy with tacrolimus and mycophenolate mofetil has been suggested...
  23. doi request reprint A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    J Immunol 185:3919-31. 2010
    ....
  24. doi request reprint Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transpl Int 23:777-85. 2010
    ..Larger studies are warranted to further examine the relationship between clinical parameters and the molecular response to mTOR-inhibition in TSC patients after renal transplantation...
  25. pmc Mortality in renal transplant recipients given erythropoietins to increase haemoglobin concentration: cohort study
    Georg Heinze
    Core Unit of Medical Statistics and Informatics, Medical University of Vienna, 1090 Vienna, Austria
    BMJ 339:b4018. 2009
    ..To determine the optimal range of increase in haemoglobin concentration with treatment with erythropoietins that is safe and is not associated with mortality...
  26. ncbi request reprint Effects of 12 months of recombinant growth hormone therapy on parameters of bone metabolism and bone mineral density in patients on chronic hemodialysis
    Harald Kotzmann
    Division of Endocrinology and Metabolism, Department of Medicine III, Ludwig Boltzmann Institute for Experimental Endocrinology, University of Vienna, Vienna, Austria
    J Nephrol 17:87-94. 2004
    ....
  27. ncbi request reprint The effect of ACE inhibitor and angiotensin II blocker therapy on early posttransplant kidney graft function
    Matthias Lorenz
    Department of Internal Medicine III, Division of Nephrology and Dialysis, University Hospital Vienna, Vienna, Austria
    Am J Kidney Dis 43:1065-70. 2004
    ..It is unknown whether continuation of angiotensin-converting enzyme (ACE) inhibitor or angiotensin II (ATII) blocker therapy after kidney transplantation has an influence on early kidney graft function...
  28. doi request reprint Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells
    Thomas Weichhart
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Blood 117:4273-83. 2011
    ....
  29. ncbi request reprint Vitamin C plasma level and response to erythropoietin in patients on maintenance haemodialysis
    Robert Deicher
    Universitätsklinik für Innere Medizin III, Klinische Abteilung für Nephrologie und Dialyse, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Nephrol Dial Transplant 19:2319-24. 2004
    ..This study was performed to analyse the relation between vitamin C plasma concentration and response to rHuEpo...
  30. ncbi request reprint Riboflavin is a determinant of total homocysteine plasma concentrations in end-stage renal disease patients
    Sonja Skoupy
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
    J Am Soc Nephrol 13:1331-7. 2002
    ..This finding may have implications for tHcy lowering therapy in individuals with end-stage renal disease...
  31. doi request reprint Clinical evaluation of two novel biointact PTH(1-84) assays in hemodialysis patients
    Manfred Hecking
    Medical University of Vienna, Department of Medicine III, Division of Nephrology and Dialysis, Austria
    Clin Biochem 45:1645-51. 2012
    ..Here, we aimed at assessing the technical and clinical performance of two novel automated biointact PTH(1-84) assays, from Roche Diagnostics (Ro) and DiaSorin (DS), in hemodialysis patients...
  32. pmc Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial
    Manfred Hecking
    Department of Internal Medicine III, Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna 1090, Austria
    Trials 13:79. 2012
    ....
  33. pmc Early basal insulin therapy decreases new-onset diabetes after renal transplantation
    Manfred Hecking
    Department of Nephrology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 23:739-49. 2012
    ..In conclusion, this study suggests regimens that include basal insulin significantly reduce the odds for NODAT after renal transplantation, presumably via insulin-mediated protection of β cells...
  34. ncbi request reprint Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3
    Marcus D Saemann
    Institute of Immunology, University of Vienna, Vienna, Austria
    Am J Transplant 3:1341-9. 2003
    ..This property of JAK3 inhibitors therefore represents a further level of interference, which together with the well-established suppression of cgamma signaling could be responsible for their clinical efficacy...
  35. ncbi request reprint Potential risk for infection and atherosclerosis due to iron therapy
    Gürkan Sengoelge
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    J Ren Nutr 15:105-10. 2005
    ..Potential long-term complications of intravenous iron therapy in end-stage renal disease patients include atherosclerosis and infection, particularly in patients with iron overload...
  36. pmc p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin
    Karl Katholnig
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria
    J Immunol 190:1519-27. 2013
    ..Our data link p38α to mTOR signaling in myeloid immune cells that is decisive for tuning the immune response in dependence on the environmental milieu...
  37. doi request reprint Modified solid-phase alloantibody detection for improved crossmatch prediction
    Markus Wahrmann
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Hum Immunol 74:32-40. 2013
    ..Overall, B-cell-CDXM prediction was less precise, but could be enhanced by adjusting CDCXM thresholds to higher levels. Our data suggest particular efficiency of solid-phase complement detection as a tool for virtual crossmatching...
  38. ncbi request reprint Protocol biopsies after kidney transplantation
    Georg A Böhmig
    Division of Nephrology and Dialysis, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Transpl Int 18:131-9. 2005
    ..In this review, potential benefits and risks associated with kidney allograft biopsy in stable renal transplant recipients are discussed...
  39. ncbi request reprint Effect of radio contrast media on residual renal function in peritoneal dialysis patients--a prospective study
    Elisabeth Dittrich
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Nephrol Dial Transplant 21:1334-9. 2006
    ..Systemic administration of radio contrast media (CM) may increase the risk of acute renal failure in patients with impaired renal function not on dialysis. There are few data on the influence of CM administration in dialysis patients...
  40. doi request reprint Cinacalcet increases calcium excretion in hypercalcemic hyperparathyroidism after kidney transplantation
    Kyra A Borchhardt
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Transplantation 86:919-24. 2008
    ..The mechanism of action is not fully understood. We hypothesized that cinacalcet increases renal elimination of calcium, thereby improving hypercalcemia in kidney transplant recipients...
  41. doi request reprint The uraemic retention solute para-hydroxy-hippuric acid attenuates apoptosis of polymorphonuclear leukocytes from healthy subjects but not from haemodialysis patients
    Gerald Cohen
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Austria
    Nephrol Dial Transplant 23:2512-9. 2008
    ....
  42. ncbi request reprint Antithymocyte globulin impairs T-cell/antigen-presenting cell interaction: disruption of immunological synapse and conjugate formation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 84:117-21. 2007
    ..In conclusion, ATG impairs T-cell/APC conjugate formation, a mechanism that may help to understand the functional inactivation of peripheral blood T-cells that have escaped cellular depletion after ATG treatment...
  43. ncbi request reprint Donor heme oxygenase-1 genotype is associated with renal allograft function
    Markus Exner
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
    Transplantation 77:538-42. 2004
    ..In the present study we investigated the impact of the promoter polymorphism of kidney allograft donors on clinical outcomes after transplantation...
  44. ncbi request reprint Endothelial progenitor cells in kidney transplant recipients
    Sabine Steiner
    Division of Angiology, Department of Medicine II, Medical University Vienna, Vienna, Austria
    Transplantation 81:599-606. 2006
    ..Lower concentrations of endothelial progenitor cells (EPCs) may be associated with increased cardiovascular risk. EPC counts and their correlates have not yet been studied in kidney transplant recipients (KTR)...
  45. ncbi request reprint Immunoadsorption and plasma exchange in pregnancy
    Elisabeth Dittrich
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Kidney Blood Press Res 25:232-9. 2002
    ..Immunoadsorption is established for removal of pathogenic proteins lipoproteins or autoantibodies, but this procedure has only rarely been used in pregnancy...
  46. ncbi request reprint TGF-beta1 impairs homocysteine metabolism in human renal cells: possible implications for transplantation
    Gürkan Sengoelge
    Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Transpl Int 16:843-8. 2003
    ..We demonstrated that the release of Hcy from huRPTECs is enhanced by TGF-beta1, but that TGF-beta1 plasma levels in renal graft recipients show no independent relationship with hyperhomocysteinemia...
  47. ncbi request reprint Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy
    Elisabeth Dittrich
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, 1090 Vienna, Austria
    Transpl Int 17:215-20. 2004
    ..We conclude that in the case of rapamycin-associated post-transplantation glomerulonephritis an attempt should be made to replace rapamycin by a calcineurin inhibitor...
  48. ncbi request reprint A need for an individualized approach to end-stage renal disease patients
    Walter H Horl
    Universitätsklinik für Innere Medizin III, Wien, Austria
    Nephrol Dial Transplant 17:17-21. 2002
    ..As early intervention has an impact on patient outcome and the progression of risk factors, this approach may also be appropriate for patients who are not yet receiving RRT...
  49. ncbi request reprint Anaemia as a risk factor for the progression of chronic kidney disease
    Robert Deicher
    Department of Medicine III, Division of Nephrology and Dialysis, University Hospital of Vienna, Austria
    Curr Opin Nephrol Hypertens 12:139-43. 2003
    ..This review addresses the question of why and how anaemia could possibly enhance the progression of chronic kidney disease, and summarizes relevant clinical trials...
  50. ncbi request reprint Prospective multicenter study of HX575 (biosimilar epoetin-α) in patients with chronic kidney disease applying a target hemoglobin of 10--12 g/dl
    Walter H Horl
    Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Clin Nephrol 78:24-32. 2012
    ..3 g/dl following the conversion from a broad spectrum of pre-study ESA treatments with stable overall mean i.v. HX575 doses. The proportion of patients within the Hb target range increased from 57.5% at baseline to 66.8% at study end...
  51. ncbi request reprint Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation
    Maximilian Zeyda
    Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Leukoc Biol 81:319-27. 2007
    ..Furthermore, these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation...
  52. doi request reprint Prognosis in patients with congestive heart failure and subacute renal failure treated with hemodialysis
    Gregor Lindner
    Department of Medicine III, Division of Nephrology, Vienna, Austria
    Wien Klin Wochenschr 121:391-7. 2009
    ..Little, however, is known about prognostic indices and outcome in patients with CHF who (sub-)acutely progress to dialysis dependency...
  53. doi request reprint The TSC-mTOR signaling pathway regulates the innate inflammatory response
    Thomas Weichhart
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Immunity 29:565-77. 2008
    ..These data identify the TSC2-mTOR pathway as a key regulator of innate immune homeostasis with broad clinical implications for infectious and autoimmune diseases, vaccination, cancer, and transplantation...
  54. ncbi request reprint Iron overload in kidney transplants: prospective analysis of biochemical and genetic markers
    Matthias Lorenz
    Division of Nephrology and Dialysis, Department of Medicine III, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, Austria
    Kidney Int 67:691-7. 2005
    ..The prevalence of iron overload and the influence of mutations in the HFE and TRF2 gene on biochemical markers of iron overload among renal transplant patients is unknown...
  55. ncbi request reprint Asymmetrical dimethylarginine plasma concentrations are related to basal nitric oxide release but not endothelium-dependent vasodilation of resistance arteries in peritoneal dialysis patients
    Friedrich Mittermayer
    Medical University Vienna, Department of Clinical Pharmacology, Division of Nephrology and Dialysis, AKH Wien, Wahringer Gurtel 18 20, Vienna, A 1090 Austria
    J Am Soc Nephrol 16:1832-8. 2005
    ..Impaired endothelium-dependent vasodilation found in chronic renal failure is not explained by elevated circulating NO synthase inhibitors in renal failure...
  56. ncbi request reprint Clinical aspects of iron use in the anemia of kidney disease
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Währinger Gürtel 18 20 A 1090 Vienna, Austria
    J Am Soc Nephrol 18:382-93. 2007
  57. ncbi request reprint Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells
    Marcus D Saemann
    Institute of Immunology, University of Vienna, Austria
    J Leukoc Biol 71:238-46. 2002
    ....
  58. ncbi request reprint Dose-dependent effect of parenteral iron therapy on bleomycin-detectable iron in immune apheresis patients
    Gürkan Sengoelge
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Vienna, Austria
    Kidney Int 66:295-302. 2004
    ..This makes erythropoietin and iron substitution necessary in most patients. However, intravenous iron therapy may result in an increase of potentially toxic nontransferrin-bound iron...
  59. ncbi request reprint Determinants of the complement-fixing ability of recipient presensitization against HLA antigens
    Gregor Bartel
    Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 83:727-33. 2007
    ..The aim of this study was to evaluate variables that determine the complement-fixing capability of human leukocyte antigen (HLA) sensitization...
  60. ncbi request reprint Analysis of liver function in renal transplant recipients undergoing C2-monitoring for cyclosporine
    Manfred Hecking
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Transpl Int 21:223-33. 2008
    ..Collectively, our data emphasize the need for increased awareness toward individual predispositions for CsA-sensitivity...
  61. ncbi request reprint No associations between prolactin concentrations and response to erythropoiesis-stimulating agents in hemodialysis patients
    Markus Riegersperger
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Vienna, Austria
    Am J Nephrol 27:390-6. 2007
    ..The effect of serum prolactin levels on the response to erythropoiesis-stimulating agents (ESA) in patients on chronic hemodialysis is unknown...
  62. doi request reprint Sodium setpoint and sodium gradient: influence on plasma sodium change and weight gain
    Manfred Hecking
    Department of Medicine III, Medical University of Vienna, Austria
    Am J Nephrol 33:39-48. 2011
    ..We determined the relationship between setpoint, gradient and pre- to postdialysis PNa change (delta PNa), and studied associations with dialysis-related variables...
  63. ncbi request reprint High-dose parenteral iron sucrose depresses neutrophil intracellular killing capacity
    Robert Deicher
    Universitätsklinik für Innere Medizin III, Klinische Abteilung für Nephrologie und Dialyse, Allgemeines Krankenhaus der Stadt Wien, Vienna, Austria
    Kidney Int 64:728-36. 2003
    ..However, concern exists about possible detrimental effects of parenteral iron on cellular host defense and iron-mediated increments of oxidative stress...
  64. ncbi request reprint Low total vitamin C plasma level is a risk factor for cardiovascular morbidity and mortality in hemodialysis patients
    Robert Deicher
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    J Am Soc Nephrol 16:1811-8. 2005
    ..Future studies should address the potential protective effect of an adequate vitamin C supplementation...
  65. doi request reprint The uraemic toxin phenylacetic acid contributes to inflammation by priming polymorphonuclear leucocytes
    Gerald Cohen
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Austria
    Nephrol Dial Transplant 28:421-9. 2013
    ..One uraemic toxin is phenylacetic acid (PAA). We therefore investigated whether PAA contributes to the deranged immune response in uraemia by modulating PMNL activities...
  66. doi request reprint Lisinopril pharmacokinetics and erythropoietin requirement in haemodialysis patients
    Wolfgang Winnicki
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 42:1087-93. 2012
    ..However, it is unknown whether or not plasma levels or area under the curve (AUC) of ACE-I are associated with responsiveness to ESA therapy...
  67. pmc Serum amyloid A in uremic HDL promotes inflammation
    Thomas Weichhart
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    J Am Soc Nephrol 23:934-47. 2012
    ..These data suggest a potential link between the high levels of inflammation and cardiovascular mortality in uremia...
  68. doi request reprint [Contrast induced nephropathy]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universitatsklinik III, Medizinische Universität Wien, Austria
    Wien Klin Wochenschr 121:15-32. 2009
    ....
  69. ncbi request reprint Pre-transplant predictors of cerebrovascular events after kidney transplantation
    Susanne Aull-Watschinger
    Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    Nephrol Dial Transplant 23:1429-35. 2008
    ..We evaluated cerebrovascular events (CVE) after kidney transplantation (KTx) and sought to identify pre-transplant predictors of transient ischaemic attacks (TIA) and strokes post-transplantation...
  70. doi request reprint The versatility of HDL: a crucial anti-inflammatory regulator
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Wahringer Gurtel, Vienna, Austria
    Eur J Clin Invest 40:1131-43. 2010
    ..However, the current evidence that raising HDL per se will reduce atherosclerosis and thereby cardiovascular events still remains controversial...
  71. ncbi request reprint Ferrous sulfate does not affect mycophenolic acid pharmacokinetics in kidney transplant patients
    Matthias Lorenz
    Department of Medicine III, Division of Nephrology and Dialysis, and Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    Am J Kidney Dis 43:1098-103. 2004
    ..Oral administration of ferrous-sulfate was reported to decrease intestinal absorption of mycophenolate mofetil (MMF) in healthy Japanese individuals by 90%...
  72. ncbi request reprint Optimal treatment of renal anaemia (OPTA): improving the efficacy and efficiency of renal anaemia therapy in haemodialysis patients receiving intravenous epoetin
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Nephrol Dial Transplant 20:iii25-32. 2005
    ..The Optimal Treatment of Renal Anaemia (OPTA) initiative aims to help both physicians and nurses improve renal anaemia management by "translating" the standards set in published guidelines into practical clinical advice...
  73. pmc The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
    Bernhard M Kirsch
    Department of Internal Medicine III Clinical Division of Nephrology, Medical University of Vienna, Vienna, Austria
    Arthritis Res Ther 7:R694-703. 2005
    ..These data indicate that interference with several aspects of DC function could significantly contribute to the beneficial effects of leflunomide in inflammatory diseases, including RA...
  74. pmc Kidney biopsy in patients with glomerulonephritis: is the earlier the better?
    Dominik G Haider
    Department of Nephrology and Dialysis, University Hospital Vienna, Medical University of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    BMC Nephrol 13:34. 2012
    ..We have therefore analyzed whether histological diagnosis of glomerulonephritis (GN) at an early stage of chronic kidney disease (CKD) is associated with different outcome compared to diagnosis at a more advanced stage...
  75. doi request reprint No association of angiotensin-converting enzyme inhibitor or angiotensin 2 receptor blocker intake with acute kidney injury in patients undergoing kidney biopsy
    Alexander Friedl
    Department of Internal Medicine, Hartmann Hospital, Vienna, Austria
    Kidney Blood Press Res 35:558-60. 2012
    ..However, for patients undergoing kidney biopsy, no data is available...
  76. doi request reprint Pure red cell aplasia induced by erythropoiesis-stimulating agents
    Carol Pollock
    Department of Medicine, Royal North Shore Hospital, University of Sydney, Department of Medicine, Pacific Highway, Street Leonards, NSW, 2065, Australia
    Clin J Am Soc Nephrol 3:193-9. 2008
    ..Continued study of epoetin-induced pure red cell aplasia is needed to help nephrologists prevent or manage future cases and will have implications for the use of other protein-based therapeutic agents...
  77. ncbi request reprint Peri-operative immunoadsorption in sensitized renal transplant recipients
    Martin Haas
    Division of Nephrology and Dialysis, Department of Internal Medicine III, University of Vienna, Austria
    Nephrol Dial Transplant 17:1503-8. 2002
    ..In these patients, prophylactic peri-operative antibody depletion by immunoadsorption (IA) could prevent humoral graft injury and thus, in combination with anti-cellular rejection therapy, improve graft survival...
  78. ncbi request reprint Impairment of transendothelial leukocyte migration by iron complexes
    Gürkan Sengoelge
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Vienna, Austria
    J Am Soc Nephrol 14:2639-44. 2003
    ..001), and of the preincubation of PMN with iron (P < 0.000001) on PMN diapedesis. It is concluded that iron sucrose and iron gluconate cause a significant inhibition of transendothelial migration of PMN...
  79. ncbi request reprint [Anemia and its treatment in peritoneal dialysis patients]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universitatsklinik III, Medizinische Universität Wien, Wien, Austria
    Wien Klin Wochenschr 117:69-72. 2005
    ..Factors that may negatively influence anemia in PD patients are inflammation, infection, antihypertensive therapy with ACE inhibitors or angiotensin II blockers and neutralizing antibodies against rhuEPO or darbepoetin-alpha...
  80. ncbi request reprint Natriuretic peptides in acute and chronic kidney disease and during renal replacement therapy
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Austria
    J Investig Med 53:366-70. 2005
    ..Since proANP31-67 peptide does not cause hypotension, this vessel dilator may protect the kidney during acute renal failure by intrarenal vasodilation and stimulation of endogenous prostaglandin E2 synthesis...
  81. ncbi request reprint Influence of mycophenolic acid and tacrolimus on homocysteine metabolism
    Mihaela C Ignatescu
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Wien, Austria
    Kidney Int 61:1894-8. 2002
    ..The effect of mycophenolate mofetil (MMF) on homocysteine (Hcy) metabolism is unknown...
  82. pmc Statin use is associated with prolonged survival of renal transplant recipients
    Franz Wiesbauer
    Department of Cardiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Am Soc Nephrol 19:2211-8. 2008
    ..Although these results are encouraging, a definitive causal relationship can be determined only from randomized clinical trials...
  83. doi request reprint Inorganic phosphate and FGF-23 predict outcome in stable systolic heart failure
    Max Plischke
    Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 42:649-56. 2012
    ..This study was carried out to assess whether circulating levels of inorganic phosphate and FGF-23, a new central hormone in mineral bone metabolism, predict outcome in systolic heart failure...
  84. pmc Iron therapy for renal anemia: how much needed, how much harmful?
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Pediatr Nephrol 22:480-9. 2007
    ..The integration of ESA and intravenous iron therapy into anemia management allowed attainment of target hemoglobin values in the majority of pediatric and adult CKD and ESRD patients...
  85. ncbi request reprint [Treatment of renal anemia with darbepoetin alfa: results of an Austrian multicenter study]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wien
    Wien Klin Wochenschr 114:967-71. 2002
    ..These data confirm that unit dosing with darbepoetin alfa at increased dosing intervals and reduced dose effectively and safely maintains Hb levels in haemodialysis patients...
  86. ncbi request reprint One-year growth hormone therapy improves granulocyte function without major effects on nutritional and anthropometric parameters in malnourished hemodialysis patients
    Harald Kotzmann
    Division of Endocrinology and Metabolism, Department of Medicine III, University of Vienna, Austria
    Nephron Clin Pract 93:C75-82. 2003
    ..In short-term trials anabolic effects of rhGH therapy have been demonstrated in patients on chronic hemodialysis...
  87. ncbi request reprint Effect of dialysis on serum/plasma levels of free immunoglobulin light chains in end-stage renal disease patients
    Gerald Cohen
    Division of Nephrology, Department of Medicine, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 17:879-83. 2002
    ..Free immunoglobulin light chains (FLCs) have previously been shown to be uraemic toxins. In this work we investigated the effect of haemodialysis and haemodiafiltration on the level of FLCs in serum/plasma of uraemic patients...
  88. doi request reprint HSP27 and HSP70 serum and urine levels in patients suffering from chronic kidney disease
    Diana Lebherz-Eichinger
    Department of Anesthesiology, General Intensive Care and Pain Medicine, Medical University of Vienna, Vienna, Austria
    Clin Chim Acta 413:282-6. 2012
    ..The aim of this study was to determine HSP27 and HSP70 concentrations in sera and urine of patients suffering from CKD...
  89. doi request reprint Gross proteinuria and subacute renal failure after coronary angiography - a case report of cholesterol crystal embolization
    Peter Biesenbach
    Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:251-4. 2010
    ..Identification of high-risk patients is of utmost importance as efficient therapeutic strategies do not exist...
  90. ncbi request reprint Resistin inhibits essential functions of polymorphonuclear leukocytes
    Gerald Cohen
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    J Immunol 181:3761-8. 2008
    ....
  91. ncbi request reprint Parathyroid hormone secretion during citrate anticoagulated hemodialysis in acutely ill maintenance hemodialysis patients
    Robert Apsner
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Vienna, Austria
    Anesth Analg 99:1199-204, table of contents. 2004
    ..5526 versus 0.3962, respectively). We conclude that the behavior of iPTH can be influenced in a predictive manner by adjusting the calcium-substitution rate during treatment...
  92. ncbi request reprint Janus kinase-3 (JAK3) inhibition: a novel immunosuppressive option for allogeneic transplantation
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Transpl Int 17:481-9. 2004
    ..The potential clinical application of JAK3 inhibitors in organ transplantations is discussed in the light of a recent series of successful kidney transplantations in non-human primates immunosuppressed solely with a novel JAK3 inhibitor...
  93. ncbi request reprint Reversibility of 'secondary hypercalcitoninemia' after kidney transplantation
    Kyra A Borchhardt
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Austria
    Am J Transplant 5:1757-63. 2005
    ..After transplantation, CT correlated with serum creatinine. Therefore, the increase of CT concentration in patients with impaired kidney function presumably reflects 'secondary hypercalcitoninemia' due to C-cell hyperactivity...
  94. pmc Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    J Clin Invest 115:468-75. 2005
    ..These data show that THP is a regulatory factor of innate and adaptive immunity and therefore could have significant impact on host immunity in the urinary tract...
  95. ncbi request reprint Patient and graft survival in older kidney transplant recipients: does age matter?
    Veronika Fabrizii
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 15:1052-60. 2004
    ..68 to 1.53). After thorough control for confounding, 5-yr graft survival was not materially different by age group. Discrimination against older candidates for kidney transplantation on age-related grounds alone is not warranted...
  96. doi request reprint Natriuretic peptides in chronic kidney disease and during renal replacement therapy: an update
    Neda Khalifeh
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    J Investig Med 57:33-9. 2009
    ..Serial estimations of natriuretic peptides will help in the identification of potential complications in CKD patients with or without renal replacement therapies and probably improve outcome of these patients...
  97. ncbi request reprint Capillary C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft injury
    Georg A Böhmig
    Department of Internal Medicine III, Institute of Nephrology and Dialysis, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 13:1091-9. 2002
    ..In conclusion, these data demonstrate that positive C4d staining, which is an independent predictor of kidney graft dysfunction, represents a reliable specific marker for antibody-dependent graft injury...
  98. ncbi request reprint Urinary tract infections after renal transplantation
    Sabine Schmaldienst
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
    Curr Opin Urol 12:125-30. 2002
    ..The prevention of urinary tract infections, or the early diagnosis and accurate treatment of urinary tract infections is important in renal transplant recipients...
  99. ncbi request reprint Anemia and iron deficiencies among long-term renal transplant recipients
    Matthias Lorenz
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
    J Am Soc Nephrol 13:794-7. 2002
    ..Therefore, assessment of the HRBC proportion is superior to decreased ferritin and decreased TSAT measurements for the diagnosis of iron deficiencies among renal transplant recipients...
  100. ncbi request reprint Antioxidant treatment of therapy-resistant idiopathic membranous nephropathy with probucol: a pilot study
    Martin Haas
    Division of Nephrology and Dialysis, University of Vienna, Austria
    Wien Klin Wochenschr 114:143-7. 2002
    ..Since the pathophysiology might be similar to idiopathic membranous nephropathy in humans, we performed a prospective multicenter trial to investigate the efficacy of the lipid peroxidation scavenger, probucol...
  101. ncbi request reprint Hepatorenal syndrome
    Ludwig Kramer
    Department of Medicine IV, Division of Nephrology, University of Vienna Medical School, Austria
    Semin Nephrol 22:290-301. 2002
    ..The definite role of these promising developments, however, is still uncertain, emphasizing the need for large prospective multicentric investigations...