P Holzer

Summary

Affiliation: University of Graz
Country: Austria

Publications

  1. pmc Chemical nociception in the jejunum induced by capsaicin
    B Schmidt
    Abteilung für Gastroenterologie und Hepatologie, University of Vienna, Vienna, Austria
    Gut 53:1109-16. 2004
  2. ncbi request reprint Differential effects of clonidine, dopamine, dobutamine, and dopexamine on basal and acid-stimulated mucosal blood flow in the rat stomach
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Graz, Austria
    Crit Care Med 29:335-43. 2001
  3. ncbi request reprint Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Neuropharmacology 37:131-8. 1998
  4. ncbi request reprint Implications of tachykinins and calcitonin gene-related peptide in inflammatory bowel disease
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Digestion 59:269-83. 1998
  5. ncbi request reprint Gastrointestinal afferents as targets of novel drugs for the treatment of functional bowel disorders and visceral pain
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Eur J Pharmacol 429:177-93. 2001
  6. ncbi request reprint Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Inflamm Res 50:602-8. 2001
  7. ncbi request reprint Tachykinin receptors in the gut: physiological and pathological implications
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Curr Opin Pharmacol 1:583-90. 2001
  8. ncbi request reprint Neurogenic vasodilatation and plasma leakage in the skin
    P Holzer
    University of Graz, Department of Experimental and Clinical Pharmacology, Austria
    Gen Pharmacol 30:5-11. 1998
  9. ncbi request reprint Calcitonin gene-related peptide action on intestinal circular muscle
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Am J Physiol 256:G546-52. 1989
  10. ncbi request reprint Cooperation of NMDA and tachykinin NK(1) and NK(2) receptors in the medullary transmission of vagal afferent input from the acid-threatened rat stomach
    M Jocic
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010 Graz, Austria
    Pain 89:147-57. 2001

Collaborators

Detail Information

Publications48

  1. pmc Chemical nociception in the jejunum induced by capsaicin
    B Schmidt
    Abteilung für Gastroenterologie und Hepatologie, University of Vienna, Vienna, Austria
    Gut 53:1109-16. 2004
    ..Our aims were to evaluate motor activity during capsaicin induced nociception and to compare qualities of jejunal nociception induced by capsaicin and mechanical distension...
  2. ncbi request reprint Differential effects of clonidine, dopamine, dobutamine, and dopexamine on basal and acid-stimulated mucosal blood flow in the rat stomach
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Graz, Austria
    Crit Care Med 29:335-43. 2001
    ..To analyze the effects of clonidine, dopamine, dobutamine, and dopexamine on gastric mucosal blood flow (GMBF) at baseline and after stimulation by acid back diffusion through a disrupted gastric mucosal barrier...
  3. ncbi request reprint Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Neuropharmacology 37:131-8. 1998
    ..NK2 receptors help maintaining peristalsis once cholinergic neuroneuronal transmission via nicotinic receptors has been blocked, whereas NK3 receptors play little role in the neural pathways of peristalsis...
  4. ncbi request reprint Implications of tachykinins and calcitonin gene-related peptide in inflammatory bowel disease
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Digestion 59:269-83. 1998
    ..In a therapeutic perspective it seems conceivable that tachykinin and CGRP receptors antagonists can be employed as spasmolytic, antidiarrhoeal, anti-inflammatory and antinociceptive drugs...
  5. ncbi request reprint Gastrointestinal afferents as targets of novel drugs for the treatment of functional bowel disorders and visceral pain
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Eur J Pharmacol 429:177-93. 2001
    ..The utility of sensory neuron-targeting drugs in functional bowel disorders will critically depend on the compounds' selectivity of action for afferent versus enteric or central neurons...
  6. ncbi request reprint Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Inflamm Res 50:602-8. 2001
    ....
  7. ncbi request reprint Tachykinin receptors in the gut: physiological and pathological implications
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Curr Opin Pharmacol 1:583-90. 2001
    ..It would therefore appear that tachykinin receptors, which in the digestive system are expressed in a cell-specific manner, represent attractive targets for novel therapeutics in gastroenterology...
  8. ncbi request reprint Neurogenic vasodilatation and plasma leakage in the skin
    P Holzer
    University of Graz, Department of Experimental and Clinical Pharmacology, Austria
    Gen Pharmacol 30:5-11. 1998
    ..Impaired nerve function represents a deficit in skin homeostasis while neuronal overactivity is a factor in allergic and hyperreactive disorders of the skin...
  9. ncbi request reprint Calcitonin gene-related peptide action on intestinal circular muscle
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Am J Physiol 256:G546-52. 1989
    ....
  10. ncbi request reprint Cooperation of NMDA and tachykinin NK(1) and NK(2) receptors in the medullary transmission of vagal afferent input from the acid-threatened rat stomach
    M Jocic
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010 Graz, Austria
    Pain 89:147-57. 2001
    ..These opposing interactions in the AP and NTS and the increase in NMDA receptor function in the NTS after a gastric acid insult are likely to have a bearing on the neuropharmacology of dyspepsia...
  11. ncbi request reprint Ascending enteric reflex contraction: roles of acetylcholine and tachykinins in relation to distension and propagation of excitation
    P Holzer
    University of Graz, Department of Experimental and Clinical Pharmacology, Austria
    J Pharmacol Exp Ther 264:391-6. 1993
    ....
  12. pmc Nitric oxide-dependent and -independent hyperaemia due to calcitonin gene-related peptide in the rat stomach
    P Holzer
    University of Graz, Department of Experimental and Clinical Pharmacology, Austria
    Br J Pharmacol 110:404-10. 1993
    ..5, whereas D-NAME was without effect.6. These data show that CGRP is a potent dilator of mucosal and extramural resistance vessels in the rat stomach. Its dilator action involves both NO-dependent and NO-independent mechanisms...
  13. ncbi request reprint Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain
    T Michl
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010, Graz, Austria
    Pain 92:19-27. 2001
    ....
  14. pmc Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperaemia due to acid back-diffusion
    I T Lippe
    University of Graz, Department of Experimental and Clinical Pharmacology, Austria
    Br J Pharmacol 105:708-14. 1992
    ..6. These findings indicate that endothelium-derived NO plays an important mediator role in the gastric mucosal vasodilatation caused by back-diffusion whilst vasodilator prostanoids such as prostacyclin are not involved...
  15. ncbi request reprint Gastric mucosal hyperemia due to acid backdiffusion depends on splanchnic nerve activity
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Am J Physiol 262:G505-9. 1992
    ..The efferent pathway involves ganglionic transmission through nicotinic acetylcholine receptors but is independent of noradrenergic neurons...
  16. doi request reprint Evidence from knockout mice for distinct implications of neuropeptide-Y Y2 and Y4 receptors in the circadian control of locomotion, exploration, water and food intake
    M E Edelsbrunner
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuropeptides 43:491-7. 2009
    ..These phenotypic traits can be sensitively and continuously recorded by the LabMaster system...
  17. pmc Disturbance of peristalsis in the guinea-pig isolated small intestine by indomethacin, but not cyclo-oxygenase isoform-selective inhibitors
    A Shahbazian
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010 Graz, Austria
    Br J Pharmacol 132:1299-309. 2001
    ....
  18. ncbi request reprint Surveillance of the gastrointestinal mucosa by sensory neurons
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    J Physiol Pharmacol 52:505-21. 2001
    ..This concept identifies a number of receptors and ion channels that are selectively expressed by primary afferent neurons as important molecular targets at which to aim novel therapies for functional bowel disorders...
  19. ncbi request reprint Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis
    P Holzer
    University Department of Pharmacology, Graz, Austria
    Naunyn Schmiedebergs Arch Pharmacol 349:194-201. 1994
    ..abstract truncated at 250 words)..
  20. ncbi request reprint Ascending enteric reflex: multiple neurotransmitter systems and interactions
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Am J Physiol 256:G540-5. 1989
    ..These findings demonstrate that the AER is mediated by multiple neural pathways with different transmitters and that adaptive interactions between these pathways take place after blockade of one of its neurotransmitters systems...
  21. ncbi request reprint Mucosal acid challenge activates nitrergic neurons in myenteric plexus of rat stomach
    R Schicho
    Department of Experimental and Clinical Pharmacology, University of Graz, A 8010 Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 281:G1316-21. 2001
    ..It is concluded that gastric acid challenge concentration-dependently stimulates a subpopulation of nitrergic, but not cholinergic, myenteric plexus neurons, which may play a role in muscle relaxation, vasodilatation, and/or secretion...
  22. doi request reprint Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice
    E Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Genes Brain Behav 7:532-42. 2008
    ..Unlike Y2 receptor knockout, Y4 receptor knockout does not impair object memory. We propose that Y4 receptors play an important role in the regulation of behavioral homeostasis...
  23. ncbi request reprint Experimental gastritis in mice enhances anxiety in a gender-related manner
    E Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuroscience 150:522-36. 2007
    ..Gastric inflammation thus has a distinct gender-dependent influence on emotional-affective behavior and its neuroendocrine control...
  24. ncbi request reprint Facilitation of gastric compliance and cardiovascular reaction by repeated isobaric distension of the rat stomach
    M Romer
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Neurogastroenterol Motil 17:399-409. 2005
    ..These findings show that isobaric gastric distension elicits both MAP and gastric compliance responses whose characteristics, mechanisms and sensitization properties differ profoundly...
  25. ncbi request reprint Endogenous neuropeptide Y depresses the afferent signaling of gastric acid challenge to the mouse brainstem via neuropeptide Y type Y2 and Y4 receptors
    T Wultsch
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuroscience 136:1097-107. 2005
    ..Endogenous neuropeptide Y acting via Y2 and Y4 receptors depresses the afferent input to the nucleus tractus solitarii by a presumably central site of action...
  26. ncbi request reprint Effect of angiotensin II and telmisartan, an angiotensin1 receptor antagonist, on rat gastric mucosal blood flow
    A Heinemann
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Aliment Pharmacol Ther 13:347-55. 1999
    ..Angiotensin II (ATII) has been suggested to contribute to shock-induced dysfunction of the gastric circulation...
  27. ncbi request reprint Role of tachykinin receptors in the central processing of afferent input from the acid-threatened rat stomach
    T Michl
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010, Graz, Austria
    Regul Pept 102:119-26. 2001
    ..These data show that the transmission of input from the acid-threatened stomach in distinct brain nuclei involves tachykinins acting at NK1 and NK3 receptors, but not NK2 receptors...
  28. doi request reprint Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice
    E Painsipp
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    J Psychopharmacol 24:1541-9. 2010
    ..These findings attest to a role of Y1 receptor signalling in the control of stress coping and/or adaptation...
  29. ncbi request reprint Increase in gastric acid-induced afferent input to the brainstem in mice with gastritis
    P Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Universitatsplatz 4, A 8010 Graz, Austria
    Neuroscience 145:1108-19. 2007
    ....
  30. ncbi request reprint Vagal afferent input from the acid-challenged rat stomach to the brainstem: enhancement by interleukin-1beta
    P Holzer
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuroscience 129:439-45. 2004
    ..This effect seems to arise from a peripheral action on vagal afferents and may be of relevance to gastric chemonociception...
  31. ncbi request reprint The gut as a neurological organ
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Wien Klin Wochenschr 113:647-60. 2001
    ..The ENS and extrinsic afferents are hence prime targets for the therapeutic management of gut diseases and for the relief of the pain and discomfort associated with these disorders...
  32. pmc Stimulant action of pituitary adenylate cyclase-activating peptide on normal and drug-compromised peristalsis in the guinea-pig intestine
    A Heinemann
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Br J Pharmacol 127:763-71. 1999
    ..The action of PACAP seems to involve multiple signalling mechanisms including stimulation of adenylate cyclase...
  33. ncbi request reprint Endotoxin pretreatment modifies peristalsis and attenuates the antipropulsive action of adrenoceptor agonists in the guinea-pig small intestine
    S Fruhwald
    Department of Anaesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria
    Neurogastroenterol Motil 16:213-22. 2004
    ..We conclude that systemic endotoxin pretreatment of guinea-pigs modifies baseline peristalsis by an action on the gut and inhibits the antipropulsive action of adrenoceptor agonists through changes in adrenoceptor activity...
  34. ncbi request reprint Acid challenge delays gastric pressure adaptation, blocks gastric emptying and stimulates gastric fluid secretion in the rat
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Graz, Austria
    Neurogastroenterol Motil 15:45-55. 2003
    ..It is proposed that the gastropyloric motor changes induced by luminal acid challenge have a bearing on the motor disturbances underlying functional dyspepsia...
  35. ncbi request reprint Gastric enteric neurones that respond to luminal injury
    R Schicho
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Neurogastroenterol Motil 16:129-32. 2004
    ....
  36. ncbi request reprint Capsaicin-sensitive extrinsic afferents are involved in acid-induced activation of distinct myenteric neurons in the rat stomach
    R Schicho
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Neurogastroenterol Motil 15:33-44. 2003
    ..Activation of these neurons is partly mediated by capsaicin-sensitive afferents and involves ganglionic transmission via nicotinic receptors...
  37. ncbi request reprint Sensory neurone responses to mucosal noxae in the upper gut: relevance to mucosal integrity and gastrointestinal pain
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Graz, Austria
    Neurogastroenterol Motil 14:459-75. 2002
    ..Such sensory neurone-specific molecules, which include vanilloid (capsaicin) receptors, may represent important targets for novel drugs to treat abdominal pain...
  38. ncbi request reprint Afferent signalling of gastric acid challenge
    P Holzer
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    J Physiol Pharmacol 54:43-53. 2003
    ..Taken together, these observations are of relevance to the understanding and treatment of gastric hyperalgesia and dyspeptic pain...
  39. ncbi request reprint New approaches to the treatment of opioid-induced constipation
    P Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Eur Rev Med Pharmacol Sci 12:119-27. 2008
    ..In addition, there is preliminary evidence that these peripherally restricted opioid receptor antagonists may act as prokinetic drugs in their own right...
  40. pmc Role of bradykinin in the hyperaemia following acid challenge of the rat gastric mucosa
    G Petho
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Br J Pharmacol 113:1036-42. 1994
    ..It appears as if this kinin is formed during severe acid challenge of the rat gastric mucosa and participates in the hyperaemic reaction to gastric acid back diffusion...
  41. ncbi request reprint Sufentanil potentiates the inhibitory effect of epinephrine on intestinal motility
    S Fruhwald
    Department of Anesthesiology and Intensive Care Medicine, University of Graz, Auenbruggerplatz 29, 8036 Graz, Austria
    Intensive Care Med 28:74-80. 2002
    ..The aim of our study was to evaluate the effect of the combination of different catecholamines and sufentanil on peristalsis of the isolated guinea pig small bowel in vitro...
  42. pmc The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor
    P Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, Graz, Austria
    Br J Pharmacol 155:1145-62. 2008
    ....
  43. ncbi request reprint Role of extrinsic afferent neurons in gastrointestinal motility
    L Bartho
    Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary
    Eur Rev Med Pharmacol Sci 12:21-31. 2008
    ..The afferent function of capsaicin-sensitive nerves plays a role in sympathetic reflexes, such as the inhibition of GI motility after laparotomy or by peritoneal irritation...
  44. ncbi request reprint New vistas on gastrointestinal motility: from physiology to therapy an international symposium in Rome
    D Curro
    Eur Rev Med Pharmacol Sci 12:1-2. 2008
  45. ncbi request reprint Experimental pancreatitis disturbs gastrointestinal and colonic motility in mice: effect of the prokinetic agent tegaserod
    T C Seerden
    Division of Gastroenterology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Neurogastroenterol Motil 19:856-64. 2007
    ..Tegaserod improves ANP-induced motility disturbances in vivo and in vitro, suggesting a therapeutic benefit of prokinetic 5HT4 receptor agonists in the treatment of pancreatitis-induced ileus...
  46. ncbi request reprint [Thio- and oxybarbiturates inhibit peristalsis in the Guinea-pig ileum in vitro]
    M K Herbert
    Klinik für Anaesthesiologie der Universität Würzburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:721-6. 2002
    ..Thus this study examines whether the thio- and oxybarbiturates thiopentone and pentobarbitone exert an inhibitory effect on intestinal peristalsis...
  47. pmc Tachykinin NK1 and NK2 receptor antagonists and atropine-resistant ascending excitatory reflex to the circular muscle of the guinea-pig ileum
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:161-8. 1994
    ....
  48. ncbi request reprint Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons
    Zs Lazar
    Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Szigeti ut 12, H 7643 Pecs, Hungary
    Neuropeptides 37:220-32. 2003
    ..CRF acts by specifically stimulating excitatory (but not inhibitory) neurons of the myenteric plexus. Neither endogenous ET-1 nor CRF seems to play a role in the excitatory or inhibitory effects of capsaicin...