Georg Heinze

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi A comparative investigation of methods for logistic regression with separated or nearly separated data
    Georg Heinze
    Section of Clinical Biometrics, Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, A 1090 Vienna, Austria
    Stat Med 25:4216-26. 2006
  2. ncbi A solution to the problem of monotone likelihood in Cox regression
    G Heinze
    Department of Medical Computer Sciences, Vienna University, Austria
    Biometrics 57:114-9. 2001
  3. ncbi SAS and SPLUS programs to perform Cox regression without convergence problems
    Georg Heinze
    Department of Medical Computer Sciences, University of Vienna, A 1090 Vienna, Spitalgasse 23, Austria
    Comput Methods Programs Biomed 67:217-23. 2002
  4. ncbi Exact log-rank tests for unequal follow-up
    Georg Heinze
    Department of Medical Computer Sciences, Section of Clinical Biometrics, University of Vienna Medical School, Spitalgasse 23, A 1090 Vienna, Austria
    Biometrics 59:1151-7. 2003
  5. ncbi Fixing the nonconvergence bug in logistic regression with SPLUS and SAS
    Georg Heinze
    Department of Medical Computer Sciences, University of Vienna, Spitalgasse 23, A 1090 Vienna, Austria
    Comput Methods Programs Biomed 71:181-7. 2003
  6. ncbi Comparing the importance of prognostic factors in Cox and logistic regression using SAS
    Georg Heinze
    Department of Medical Computer Sciences, University of Vienna, A 1090 Vienna, Spitalgasse 23, Austria
    Comput Methods Programs Biomed 71:155-63. 2003
  7. ncbi Two multidrug-resistance (ABCB1) gene polymorphisms as prognostic parameters in women with ovarian cancer
    Christoph Grimm
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Anticancer Res 30:3487-91. 2010
  8. ncbi Avoiding infinite estimates of time-dependent effects in small-sample survival studies
    Georg Heinze
    Section of Clinical Biometrics, Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, Vienna A 1090, Austria
    Stat Med 27:6455-69. 2008
  9. ncbi Bias-reduced and separation-proof conditional logistic regression with small or sparse data sets
    Georg Heinze
    Section of Clinical Biometrics, Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, Vienna A 1090, Austria
    Stat Med 29:770-7. 2010
  10. ncbi Methods from the theory of random heterogeneous media for quantifying myocardial morphology in normal and dilated hearts
    Rudolf Karch
    Department of Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, A 1090, Vienna, Austria
    Ann Biomed Eng 38:308-18. 2010

Collaborators

Detail Information

Publications53

  1. ncbi A comparative investigation of methods for logistic regression with separated or nearly separated data
    Georg Heinze
    Section of Clinical Biometrics, Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, A 1090 Vienna, Austria
    Stat Med 25:4216-26. 2006
    ..General advantages of the penalized likelihood approach are discussed...
  2. ncbi A solution to the problem of monotone likelihood in Cox regression
    G Heinze
    Department of Medical Computer Sciences, Vienna University, Austria
    Biometrics 57:114-9. 2001
    ..The advantage of the procedure over previous options of analysis is finally exemplified in the analysis of a breast cancer study...
  3. ncbi SAS and SPLUS programs to perform Cox regression without convergence problems
    Georg Heinze
    Department of Medical Computer Sciences, University of Vienna, A 1090 Vienna, Spitalgasse 23, Austria
    Comput Methods Programs Biomed 67:217-23. 2002
    ..Heinze, M. Schemper, A solution to the problem of monotone likelihood in Cox regression, Biometrics 57 (2001)...
  4. ncbi Exact log-rank tests for unequal follow-up
    Georg Heinze
    Department of Medical Computer Sciences, Section of Clinical Biometrics, University of Vienna Medical School, Spitalgasse 23, A 1090 Vienna, Austria
    Biometrics 59:1151-7. 2003
    ..The advantage of this test over other options of analysis is finally exemplified in the analysis of a breast cancer study...
  5. ncbi Fixing the nonconvergence bug in logistic regression with SPLUS and SAS
    Georg Heinze
    Department of Medical Computer Sciences, University of Vienna, Spitalgasse 23, A 1090 Vienna, Austria
    Comput Methods Programs Biomed 71:181-7. 2003
    ..Our programs are also capable of performing interval estimation based on profile penalized log likelihood (PPL) and of plotting the PPL function as was suggested by Heinze and Schemper (Stat. Med. 21 (2002) pp. 2409-3419)...
  6. ncbi Comparing the importance of prognostic factors in Cox and logistic regression using SAS
    Georg Heinze
    Department of Medical Computer Sciences, University of Vienna, A 1090 Vienna, Spitalgasse 23, Austria
    Comput Methods Programs Biomed 71:155-63. 2003
    ..The programs further allow to base the computation of PEV on models with shrinked or bias-corrected parameter estimates. The SAS macros are freely available at www.akh-wien.ac.at/imc/biometrie/relimp..
  7. ncbi Two multidrug-resistance (ABCB1) gene polymorphisms as prognostic parameters in women with ovarian cancer
    Christoph Grimm
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Anticancer Res 30:3487-91. 2010
    ..Treatment response to paclitaxel has been shown to correlate with ABCB1 gene polymorphisms. Data regarding the prognostic value of ABCB1 gene polymorphisms in ovarian cancer patients is conflicting...
  8. ncbi Avoiding infinite estimates of time-dependent effects in small-sample survival studies
    Georg Heinze
    Section of Clinical Biometrics, Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, Vienna A 1090, Austria
    Stat Med 27:6455-69. 2008
    ..An SAS macro and an R package for FC Cox regression with time-varying covariates and time-dependent effects are available at: http://www.muw.ac.at/msi/biometrie/programs...
  9. ncbi Bias-reduced and separation-proof conditional logistic regression with small or sparse data sets
    Georg Heinze
    Section of Clinical Biometrics, Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, Vienna A 1090, Austria
    Stat Med 29:770-7. 2010
    ..A SAS program implementing CFL is available at: http://www.muw.ac.at/msi/biometrie/programs...
  10. ncbi Methods from the theory of random heterogeneous media for quantifying myocardial morphology in normal and dilated hearts
    Rudolf Karch
    Department of Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, A 1090, Vienna, Austria
    Ann Biomed Eng 38:308-18. 2010
    ....
  11. ncbi C-reactive protein serum levels are closely associated with lymph node status, but not with prognosis in patients with vulvar cancer
    Lucia Six
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 137:217-21. 2008
    ..To evaluate whether C-reactive protein (CRP) serum levels can be used as prognostic parameter in patients with vulvar cancer...
  12. ncbi Association of C-reactive protein (CRP) gene polymorphisms, serum CRP levels and cervical cancer prognosis
    Stephan Polterauer
    Department of General Gynecology and Gynecologic Oncology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Anticancer Res 31:2259-64. 2011
    ..The purpose of this study was to evaluate the association between four polymorphisms of the CRP gene, CRP serum levels, clinicopathological parameters of cervical cancer and survival in patients with cervical cancer...
  13. ncbi The estimation of average hazard ratios by weighted Cox regression
    Michael Schemper
    Section of Clinical Biometrics, Department for Medical Statistics and Informatics, Medical University of Vienna, Spitalgasse 23, A 1090 Vienna, Austria
    Stat Med 28:2473-89. 2009
    ..A Monte Carlo study confirms the satisfactory performance. Advantages of the approach are exemplified by comparing standard and weighted analyses of an international lung cancer study. SAS and R programs facilitate application...
  14. ncbi Calcineurin inhibitor-based immunosuppressive therapy, donor age, and long-term outcome after kidney transplantation
    Georg Heinze
    Section of Clinical Biometrics, Core Unit for Medical Statistics and Informatics, Medical University Vienna, Vienna, Austria
    Transplantation 87:1821-9. 2009
    ..It is unclear whether the choice of maintenance immunosuppression modulates the negative effect of advanced donor age on outcome after renal transplantation...
  15. ncbi A solution to the problem of separation in logistic regression
    Georg Heinze
    Section of Clinical Biometrics, Department of Medical Computer Sciences, University of Vienna, Spitalgasse 23, A 1090 Vienna, Austria
    Stat Med 21:2409-19. 2002
    ..The clear advantage of the procedure over previous options of analysis is impressively demonstrated by the statistical analysis of two cancer studies...
  16. ncbi Microbial invasion of the amniotic cavity at birth is associated with adverse short-term outcome of preterm infants
    Angelika Berger
    Department of Pediatrics, Division of Neonatology, University Hospital Vienna, Austria
    J Perinat Med 31:115-21. 2003
    ..To determine the frequency and clinical significance of microbial invasion of the amniotic cavity at the time of delivery in preterm infants...
  17. ncbi Amniotic cavity cultures, blood cultures, and surface swabs in preterm infants--useful tools for the management of early-onset sepsis?
    Angelika Berger
    Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria
    J Perinat Med 32:446-52. 2004
    ..To evaluate the potential benefit of amniotic fluid and amniotic/placental membrane cultures for the management of early-onset sepsis in preterm infants...
  18. ncbi Uveal and capsular biocompatibility of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses
    Claudette Abela-Formanek
    Department of Ophthalmology, Medical School, University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    J Cataract Refract Surg 28:50-61. 2002
    ..To evaluate the long-term response of 6 types of 3-piece intraocular lenses (IOLs) by assessing the cellular reaction on the anterior IOL surface, the behavior of posterior and anterior capsule fibrosis, and flare...
  19. ncbi Effects of pretreatment with clopidogrel on platelet and coagulation activation in patients undergoing elective coronary stenting
    Ansgar Weltermann
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Vienna University Hospital, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Thromb Res 112:19-24. 2003
    ....
  20. ncbi Pathogenesis of bone loss in heart transplant candidates and recipients
    Katharina Kerschan-Schindl
    Department of Physical Medicine and Rehabilitation, University of Vienna, Vienna, Austria
    J Heart Lung Transplant 22:843-50. 2003
    ..Heart transplantation (HTX) is associated with decreased bone mineral density and changes in bone metabolism. We conducted this study to evaluate the pathophysiology of bone metabolism in HTX candidates and recipients...
  21. ncbi Combined thrombophilic polymorphisms in women with idiopathic recurrent miscarriage
    Maria Hohlagschwandtner
    Department of Obstetrics and Gynecology, University of Vienna School of Medicine, Vienna, Austria
    Fertil Steril 79:1141-8. 2003
    ....
  22. ncbi Nonsustained effect of short-term bisphosphonate therapy on bone turnover three years after renal transplantation
    Christoph Schwarz
    Department of Internal Medicine, Division of Nephrology, University of Vienna, Vienna, Austria
    Kidney Int 65:304-9. 2004
    ..CONCLUSION: The early bone-sparing effect of short-term ZOL therapy confers no sustained benefit versus placebo at three year post-transplantation...
  23. ncbi Statistical analysis principles for Omics data
    Daniela Dunkler
    Section of Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria
    Methods Mol Biol 719:113-31. 2011
    ..All calculations can be done using the freely available statistical software R. Accompanying, commented code is available at: http://www.meduniwien.ac.at/msi/biometrie/MIMB...
  24. ncbi Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer
    Dan Tong
    Department of Obstetrics and Gynaecology, Clinical Institute of Pathology, Section of Clinical Biometrics, Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Austria
    Clin Cancer Res 12:2442-8. 2006
    ..Because tumor cell proliferation is tightly associated with tumor progression, and consequently, with survival of cancer patients, we wanted to examine the prognostic value of KLF5 gene expression for patients with breast cancer...
  25. ncbi Gene selection in microarray survival studies under possibly non-proportional hazards
    Daniela Dunkler
    Section of Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, 1090 Vienna, Austria
    Bioinformatics 26:784-90. 2010
    ..Here we consider its generalization to continuous data c' and investigate the suitability of c' for gene selection...
  26. ncbi Vascular endothelial growth factor gene polymorphisms in ovarian cancer
    Stephan Polterauer
    Department of Obstetrics and Gynecology, Medical University of Vienna, A 1090 Vienna, Wahringer Gurtel 18 20, Austria
    Gynecol Oncol 105:385-9. 2007
    ..No data have been reported in ovarian cancer...
  27. ncbi Antibiotic prophylaxis before surgery vs after cord clamping in elective cesarean delivery: a double-blind, prospective, randomized, placebo-controlled trial
    Armin Witt
    Division of Feto Maternal Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Arch Surg 146:1404-9. 2011
    ..Also, the optimal timing of prophylactic antibiotic administration is unclear...
  28. ncbi The salvage potential of coronary sinus interventions: meta-analysis and pathophysiologic consequences
    Bonni Syeda
    Department of Cardiology, Internal Medicine II, University of Vienna, Vienna, Austria
    J Thorac Cardiovasc Surg 127:1703-12. 2004
    ..Intermittent coronary sinus occlusion in combination with retroperfusion exhibits no significant profit in salvaging the ischemic myocardium in comparison with that provided by intermittent coronary sinus occlusion alone...
  29. ncbi Flow monitoring: performance characteristics of ultrasound dilution versus color Doppler ultrasound compared with fistulography
    Christoph Schwarz
    Department of Internal Medicine, Division of Nephrology, University of Vienna, Vienna, Austria
    Am J Kidney Dis 42:539-45. 2003
    ..Conclusion: Our data suggest that blood flow monitoring of AV hemodialysis access by ultrasound provides a reasonable prediction of access stenosis and restenosis...
  30. ncbi Heterogeneous perfusion is a consequence of uniform shear stress in optimized arterial tree models
    Wolfgang Schreiner
    Department of Medical Computer Sciences, University of Vienna, Department of Medical Computer Sciences Spitalgasse 23, A 1090 Vienna, Austria
    J Theor Biol 220:285-301. 2003
    ..While the present paper refers only to optimized models, we assume that this dual relation between the heterogeneities in flow and shear stress may represent a more general principle of vascular systems...
  31. ncbi Intrathecal temperature is closely reflected by the aortic, but not by the rectal, temperature in a rabbit model of spinal cord ischemia
    Erich Knolle
    Department of Anesthesiology and General Intensive Care B, University of Vienna, Austria
    Anesth Analg 97:244-6, table of contents. 2003
    ..The intrathecal temperature is significantly better reflected by the temperature from the thermistor of the catheter than by the rectal temperature...
  32. ncbi The short- and long-term benefit in chronic low back pain through adjuvant electrical versus manual auricular acupuncture
    Sabine M Sator-Katzenschlager
    Department of Anesthesiology and Intensive Care Medicine B, Outpatient Pain Center, University of Vienna, Vienna, Austria
    Anesth Analg 98:1359-64, table of contents. 2004
    ....
  33. ncbi Electrical stimulation of auricular acupuncture points is more effective than conventional manual auricular acupuncture in chronic cervical pain: a pilot study
    Sabine M Sator-Katzenschlager
    Department of Anesthesiology and Intensive Care B, University of Vienna, Vienna, Austria
    Anesth Analg 97:1469-73. 2003
    ....
  34. ncbi Polymorphisms associated with thrombophilia and vascular homeostasis and the timing of menarche and menopause in 728 white women
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, University of Freiburg School of Medicine, Freiburg, Germany
    Menopause 12:325-30. 2005
    ..We attempted to assess the association of SNPs and the timing of menarche and natural and surgical menopause in an ethnically homogenous cohort of Middle European white women...
  35. ncbi Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
    Cancer 101:264-9. 2004
    ..In these candidate genes, no critical combination of single-nucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to date...
  36. ncbi A permutation test for inference in logistic regression with small- and moderate-sized data sets
    Georg Heinze
    Stat Med 25:719. 2006
  37. ncbi Identification of patients with low-risk for aneuploidy: comparative discriminatory models using linear and machine-learning classifiers in prostate cancer
    Girish Venkataraman
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Prostate 67:1524-36. 2007
    ..Prostate needle biopsy (PNB) ploidy status has proven utility to predict adverse outcomes after prostatectomy. We sought to develop models to predict ploidy status using clinicopathologic variables...
  38. ncbi Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Breast Cancer Res Treat 98:151-5. 2006
    ..No significant associations were ascertained with respect to the intron 4 Nos3 polymorphism. In our series, presence of the mutant exon7 Nos3 polymorphism was associated with an increased risk for breast cancer in Caucasian women...
  39. ncbi Interleukin-1 and interleukin-6 gene polymorphisms and the risk of breast cancer in caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Austria
    Clin Cancer Res 11:5718-21. 2005
    ..Interleukin (IL)-1 and IL-6 are crucially involved in breast carcinogenesis. Whether polymorphisms of the genes encoding IL-1 (IL1) and IL-6 (IL6) also influence breast cancer risk is unknown...
  40. ncbi Amnionitis with Ureaplasma urealyticum or other microbes leads to increased morbidity and prolonged hospitalization in very low birth weight infants
    Lieselotte Kirchner
    Department of Neonatology and Intensive Care, University Hospital of Pediatrics, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 134:44-50. 2007
    ..To investigate the influence of culture proven intrauterine infection on preterm morbidity and to test the effect of antimicrobial treatment...
  41. ncbi Vascular endothelial growth factor gene polymorphisms are associated with prognosis in ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology and Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Austria
    Clin Cancer Res 13:898-901. 2007
    ..Gene polymorphisms within the gene encoding VEGF were shown to be independently associated with an adverse outcome in various malignancies. No data are available for ovarian cancer...
  42. ncbi Premedication with montelukast reduces local reactions of allergen immunotherapy
    Stefan Wöhrl
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 144:137-42. 2007
    ..We were interested whether pretreatment with the leukotriene antagonist montelukast would be better suited for preventing those reactions than pretreatment with the antihistamine desloratadine...
  43. ncbi A model for predicting age at menopause in white women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Fertil Steril 85:451-4. 2006
    ..To develop a model to predict the age at natural menopause and the risk for premenopausal hysterectomy...
  44. ncbi Natural course of intraocular pressure after cataract surgery with sodium chondroitin sulfate 4%-sodium hyaluronate 3% (Viscoat)
    Georg Rainer
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Ophthalmology 112:1714-8. 2005
    ..To investigate the natural course of intraocular pressure (IOP) and its peak after small-incision cataract surgery with chondroitin sulfate 4%-sodium hyaluronate 3% (Viscoat, Alcon Laboratories, Inc., Fort Worth, TX)...
  45. ncbi Influence on fetal blood pH when adding amniotic fluid: an in vitro model
    Alexander Lösch
    Department of Obstetrics and Gynaecology, St Pölten Hospital, Austria
    BJOG 110:453-6. 2003
    ..To assess the effect of contamination with amniotic fluid in different quantities on fetal capillary blood pH...
  46. ncbi Angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor antagonist therapy is associated with prolonged patient and graft survival after renal transplantation
    Georg Heinze
    Core Unit of Medical Statistics and Informatics, Department of Nephrology, Medical University of Vienna, Austria
    J Am Soc Nephrol 17:889-99. 2006
    ..More frequent use of these medications may reduce the high incidence of death and renal allograft failure in these patients...
  47. ncbi "Oldest old" patients in intensive care: prognosis and therapeutic activity
    Sophie Brunner-Ziegler
    Department of Internal Medicine II, Intensive Care Unit, Krankenanstalt Rudolfstiftung, Vienna, Austria
    Wien Klin Wochenschr 119:14-9. 2007
    ....
  48. ncbi Overweight, obesity, and the risk of recurrent venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Arch Intern Med 168:1678-83. 2008
    ..Excess body weight is a risk factor for a first venous thromboembolism. The impact of excess body weight on risk of recurrent venous thrombosis is uncertain...
  49. ncbi Statin use is associated with prolonged survival of renal transplant recipients
    Franz Wiesbauer
    Department of Cardiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Am Soc Nephrol 19:2211-8. 2008
    ..Although these results are encouraging, a definitive causal relationship can be determined only from randomized clinical trials...
  50. ncbi Lack of impact of ABO blood group or corresponding isoantibodies on the immune response after rabies vaccination
    Christoph Buchta
    University Clinic for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 117:412-6. 2005
    ..Rabies vaccination schemes for immunized donors cannot be optimized on the basis of blood groups or isoantibody titers...
  51. ncbi Does size matter?
    Georg Heinze
    Nephrol Dial Transplant 22:2725-6. 2007
  52. ncbi The -463G/A polymorphism in myeloperoxidase gene and cervical cancer
    Alexander Mustea
    Department of Gynaecology and Obstetrics, Charite, Campus Virchow Klinikum, Medical University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Anticancer Res 27:1531-5. 2007
    ..Our study was performed in order to evaluate the association between the -463G polymorphism and the prevalence of cervical cancer...
  53. ncbi Expression of the human MTA1 gene in breast cell lines and in breast cancer tissues
    Dan Tong
    Division of Gynaecology, Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria
    Oncol Res 16:465-70. 2007
    ..It also correlated positively with expression of noninvasive factors and reverse correlated with invasive factors in both cell lines and tumor tissues...