F X Heinz

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi The machinery for flavivirus fusion with host cell membranes
    F X Heinz
    Institute of Virology, University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    Curr Opin Microbiol 4:450-5. 2001
  2. ncbi Spontaneous and engineered deletions in the 3' noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus
    C W Mandl
    Institute of Virology, University of Vienna, Austria
    J Virol 72:2132-40. 1998
  3. ncbi Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E
    S L Allison
    Institute of Virology, University of Vienna, Vienna, Austria
    J Virol 73:5605-12. 1999
  4. ncbi Recombinant and virion-derived soluble and particulate immunogens for vaccination against tick-borne encephalitis
    F X Heinz
    Institute of Virology, University of Vienna, Austria
    Vaccine 13:1636-42. 1995
  5. ncbi Proteolytic activation of tick-borne encephalitis virus by furin
    K Stadler
    Institute of Virology, University of Vienna, Austria
    J Virol 71:8475-81. 1997
  6. ncbi Attenuation of tick-borne encephalitis virus by structure-based site-specific mutagenesis of a putative flavivirus receptor binding site
    C W Mandl
    Institute of Virology, University of Vienna, A 1095 Vienna, Austria
    J Virol 74:9601-9. 2000
  7. ncbi Mutational evidence for an internal fusion peptide in flavivirus envelope protein E
    S L Allison
    Institute of Virology, University of Vienna, A 1095 Vienna, Austria
    J Virol 75:4268-75. 2001
  8. ncbi Structural requirements for low-pH-induced rearrangements in the envelope glycoprotein of tick-borne encephalitis virus
    K Stiasny
    Institute of Virology, University of Vienna, Austria
    J Virol 70:8142-7. 1996
  9. ncbi Role of metastability and acidic pH in membrane fusion by tick-borne encephalitis virus
    K Stiasny
    Institute of Virology, University of Vienna, A 1095 Vienna, Austria
    J Virol 75:7392-8. 2001
  10. ncbi In vitro-synthesized infectious RNA as an attenuated live vaccine in a flavivirus model
    C W Mandl
    Institute of Virology, University of Vienna, Austria
    Nat Med 4:1438-40. 1998

Detail Information

Publications20

  1. ncbi The machinery for flavivirus fusion with host cell membranes
    F X Heinz
    Institute of Virology, University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    Curr Opin Microbiol 4:450-5. 2001
    ..New structural data have shown that the alphaviruses, another group of icosahedral enveloped viruses, also have class II fusion proteins, suggesting a common origin...
  2. ncbi Spontaneous and engineered deletions in the 3' noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus
    C W Mandl
    Institute of Virology, University of Vienna, Austria
    J Virol 72:2132-40. 1998
    ..Thus, 3'-NCR deletions represent a useful technique for achieving stable attenuation of flaviviruses that can be included in the rational design of novel flavivirus live vaccines...
  3. ncbi Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E
    S L Allison
    Institute of Virology, University of Vienna, Vienna, Austria
    J Virol 73:5605-12. 1999
    ..This functional mapping will aid in the understanding of the molecular mechanisms of membrane fusion and virus assembly...
  4. ncbi Recombinant and virion-derived soluble and particulate immunogens for vaccination against tick-borne encephalitis
    F X Heinz
    Institute of Virology, University of Vienna, Austria
    Vaccine 13:1636-42. 1995
    ....
  5. ncbi Proteolytic activation of tick-borne encephalitis virus by furin
    K Stadler
    Institute of Virology, University of Vienna, Austria
    J Virol 71:8475-81. 1997
    ..In vivo, prM cleavage was blocked by a furin inhibitor, and infection of the furin-deficient cell line LoVo yielded only immature virions, suggesting that furin is essential for cleavage activation of flaviviruses...
  6. ncbi Attenuation of tick-borne encephalitis virus by structure-based site-specific mutagenesis of a putative flavivirus receptor binding site
    C W Mandl
    Institute of Virology, University of Vienna, A 1095 Vienna, Austria
    J Virol 74:9601-9. 2000
    ..The information obtained in this study is relevant for the development of specific attenuated flavivirus strains that may serve as future live vaccines...
  7. ncbi Mutational evidence for an internal fusion peptide in flavivirus envelope protein E
    S L Allison
    Institute of Virology, University of Vienna, A 1095 Vienna, Austria
    J Virol 75:4268-75. 2001
    ..These data support the hypothesis that the cd loop may be directly involved in interactions with target membranes during fusion...
  8. ncbi Structural requirements for low-pH-induced rearrangements in the envelope glycoprotein of tick-borne encephalitis virus
    K Stiasny
    Institute of Virology, University of Vienna, Austria
    J Virol 70:8142-7. 1996
    ..This region contains potential amphipathic alpha-helical and conserved structural elements whose interactions may contribute to the rearrangements which initiate the fusion process...
  9. ncbi Role of metastability and acidic pH in membrane fusion by tick-borne encephalitis virus
    K Stiasny
    Institute of Virology, University of Vienna, A 1095 Vienna, Austria
    J Virol 75:7392-8. 2001
    ....
  10. ncbi In vitro-synthesized infectious RNA as an attenuated live vaccine in a flavivirus model
    C W Mandl
    Institute of Virology, University of Vienna, Austria
    Nat Med 4:1438-40. 1998
    ....
  11. ncbi Adaptation of tick-borne encephalitis virus to BHK-21 cells results in the formation of multiple heparan sulfate binding sites in the envelope protein and attenuation in vivo
    C W Mandl
    Institute of Virology, University of Vienna, Vienna, Austria
    J Virol 75:5627-37. 2001
    ..Recognition of this principle may be of practical value for designing attenuated flavivirus strains in the future...
  12. ncbi Complete genomic sequence of Powassan virus: evaluation of genetic elements in tick-borne versus mosquito-borne flaviviruses
    C W Mandl
    Institute of Virology, Vienna, Austria
    Virology 194:173-84. 1993
    ..The comparisons among tick-borne flaviviruses revealed conserved sequence elements that might represent important determinants of the tick-borne flavivirus phenotype...
  13. ncbi Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form
    S L Allison
    Institute of Virology, University of Vienna, Austria
    J Virol 69:5816-20. 1995
    ....
  14. ncbi Application of a dot blot hybridization assay for the diagnosis of CMV infection or reactivation
    E Stockl
    Institute of Virology, University of Vienna, Austria
    Zentralbl Bakteriol Mikrobiol Hyg A 270:288-94. 1988
    ..In several patients, however, hybridization showed positive signals although there was no sign for a productive CMV infection...
  15. ncbi Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH
    S L Allison
    Institute of Virology, University of Vienna, Austria
    J Virol 69:695-700. 1995
    ..This is consistent with a protective role of protein prM for protein E during intracellular transport of immature virions through acidic compartments of the trans-Golgi network...
  16. ncbi Possible influence of the mutant CCR5 Allele on vertical transmission of HIV-1
    C W Mandl
    Institute of Virology, University of Vienna, Austria
    J Med Virol 55:51-5. 1998
    ..These results suggest that CCR5/delta 32ccr5 heterozygous children are less susceptible to vertical transmission of HIV-1. The data also support the hypothesis that delta 32ccr5 homozygous individuals are resistant to HIV-1 infection...
  17. ncbi Flaviviruses and their antigenic structure
    F X Heinz
    Department of Virology, Medical University of Vienna, Kinderspitalgasse 15, A 1095 Vienna, Austria
    J Clin Virol 55:289-95. 2012
    ....
  18. ncbi Comparison of virtual phenotype and HIV-SEQ program (Stanford) interpretation for predicting drug resistance of HIV strains
    E Puchhammer-Stöckl
    Institute of Virology, University of Vienna, Vienna, Austria
    HIV Med 3:200-6. 2002
    ..In the present study, the comparability of two of these programs was investigated...
  19. ncbi The flavivirus 3'-noncoding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus
    G Wallner
    Institute of Virology, University of Vienna, Austria
    Virology 213:169-78. 1995
    ....
  20. ncbi Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses
    C W Mandl
    Institute of Virology, University of Vienna, Austria
    Virology 173:291-301. 1989
    ..Other characteristics, such as the potential N-glycosylation sites of protein NS1 and a potential proteolytic cleavage site within protein NS4B, are conserved within the mosquito-borne group, but differ in the TBE virus sequence...