Roland Haubner

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi request reprint Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis?
    Roland Haubner
    Universitätsklinik für Nuklearmedizin, Medizinische Universitat Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:54-63. 2006
  2. ncbi request reprint Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
  3. ncbi request reprint [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, Munich, Germany
    Clin Cancer Res 13:6610-6. 2007
  4. pmc Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes
    Yared Tekabe
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    EJNMMI Res 1:3. 2011
  5. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
  6. ncbi request reprint Myocardial kinetics of reporter probe 124I-FIAU in isolated perfused rat hearts after in vivo adenoviral transfer of herpes simplex virus type 1 thymidine kinase reporter gene
    Marcus V Simoes
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    J Nucl Med 46:98-105. 2005
  7. ncbi request reprint Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography
    Bettina Wagner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    J Am Coll Cardiol 48:2107-15. 2006
  8. ncbi request reprint Non-invasive imaging of cardiac transgene expression with PET: comparison of the human sodium/iodide symporter gene and HSV1-tk as the reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munchen, Germany
    Eur J Nucl Med Mol Imaging 32:1108-14. 2005
  9. ncbi request reprint Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
  10. ncbi request reprint PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, 81675 Munich, Germany
    J Nucl Med 45:1917-23. 2004

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis?
    Roland Haubner
    Universitätsklinik für Nuklearmedizin, Medizinische Universitat Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:54-63. 2006
    ..One target structure involved in the angiogenic process is the integrin alphavbeta3, which mediates the migration of activated endothelial cells during vessel formation...
  2. ncbi request reprint Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
    ..We have developed [18F]Galacto-RGD, a highly alpha(v)beta3-selective tracer for positron emission tomography (PET). Here, we show, in man, that the intensity of [18F]Galacto-RGD uptake correlates with alpha(v)beta3 expression...
  3. ncbi request reprint [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, Munich, Germany
    Clin Cancer Res 13:6610-6. 2007
    ..Our aim was to study the feasibility of PET imaging with [(18)F]Galacto-RGD in patients with squamous cell carcinoma of the head and neck (SCCHN)...
  4. pmc Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes
    Yared Tekabe
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    EJNMMI Res 1:3. 2011
    ..abstract:..
  5. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
    ..We developed [(18)F]Galacto-RGD, a (18)F-labeled glycosylated alphavbeta3 antagonist, allowing monitoring of alphavbeta3 expression with positron emission tomography (PET)...
  6. ncbi request reprint Myocardial kinetics of reporter probe 124I-FIAU in isolated perfused rat hearts after in vivo adenoviral transfer of herpes simplex virus type 1 thymidine kinase reporter gene
    Marcus V Simoes
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    J Nucl Med 46:98-105. 2005
    ..Myocardial kinetics of (124)I-FIAU are still poorly understood. This study aimed at a further investigation under controlled conditions using an isolated heart perfusion model...
  7. ncbi request reprint Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography
    Bettina Wagner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    J Am Coll Cardiol 48:2107-15. 2006
    ..We sought to investigate the usefulness of integrated positron emission tomography (PET) and computed tomography (CT) for in vivo characterization of an angiogenesis-directed molecular intervention...
  8. ncbi request reprint Non-invasive imaging of cardiac transgene expression with PET: comparison of the human sodium/iodide symporter gene and HSV1-tk as the reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munchen, Germany
    Eur J Nucl Med Mol Imaging 32:1108-14. 2005
    ....
  9. ncbi request reprint Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    J Nucl Med 46:1333-41. 2005
    ..Our aim was to study the kinetics and biodistribution of (18)F-Galacto-RGD in cancer patients...
  10. ncbi request reprint PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene
    Masao Miyagawa
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, 81675 Munich, Germany
    J Nucl Med 45:1917-23. 2004
    ..The aim of this study was to compare these 2 combinations with regard to specificity, imaging contrast, and reporter probe kinetics using dynamic PET in small and large animals...
  11. doi request reprint 68Ga- and 111In-labelled DOTA-RGD peptides for imaging of alphavbeta3 integrin expression
    Clemens Decristoforo
    Department of Nuclear Medicine, Medizinische Universitat Innsbruck, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 35:1507-15. 2008
    ..Recently, we demonstrated using [(18)F]Galacto-RGD that monitoring of alphavbeta3 expression is feasible. Here, we introduce (68)Ga- and (111)In-labelled derivatives and compare them with [(18)F]Galacto-RGD...
  12. ncbi request reprint PET-based human dosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 47:763-9. 2006
    ..18)F-Galacto-RGD is a new tracer for PET imaging of alpha v beta3, a receptor involved in a variety of pathologic processes including angiogenesis and metastasis. Our aim was to study the dosimetry of (18)F-galacto-RGD in humans...
  13. doi request reprint [⁶⁸Ga]NS₃-RGD and [⁶⁸Ga] Oxo-DO3A-RGD for imaging α(v)β₃ integrin expression: synthesis, evaluation, and comparison
    Peter A Knetsch
    Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Nucl Med Biol 40:65-72. 2013
    ....
  14. ncbi request reprint [18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates
    Roland Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, 81675 Munchen, Germany
    Bioconjug Chem 15:61-9. 2004
    ..2 GBq of [18F]flouride. Moreover, the fast excretion, the suitable metabolic stability and the low estimated radiation dose allow to evaluate this tracer in human studies...
  15. ncbi request reprint Imaging of delayed-type hypersensitivity reaction by PET and 18F-galacto-RGD
    Bernd J Pichler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Nucl Med 46:184-9. 2005
    ..We studied a hapten-induced delayed-type hypersensitivity reaction (DTHR) as a model for inflammatory processes, since DTHRs are involved in many human autoimmune disorders...
  16. doi request reprint Development of ⁶⁸Ga-labelled DTPA galactosyl human serum albumin for liver function imaging
    Roland Haubner
    Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 40:1245-55. 2013
    ..Here we present the synthesis and evaluation of [(68)Ga]GSA for the potential use with positron emission tomography (PET)...
  17. doi request reprint Radiolabelling of peptides for PET, SPECT and therapeutic applications using a fully automated disposable cassette system
    Milos Petrik
    Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Nucl Med Commun 32:887-95. 2011
    ....
  18. ncbi request reprint Coexpression of herpesviral thymidine kinase reporter gene and VEGF gene for noninvasive monitoring of therapeutic gene transfer: an in vitro evaluation
    Martina Anton
    Institut für Experimentelle Onkologie und Therapieforschung, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 45:1743-6. 2004
    ..We sought to evaluate the usefulness of an adenoviral vector expressing mutant herpesviral thymidine kinase reporter gene (HSV1-sr39tk) and vascular endothelial growth factor (VEGF) 121 in independent expression cassettes (Ad4tk)...
  19. doi request reprint [68Ga]NODAGA-RGD for imaging αvβ3 integrin expression
    Peter A Knetsch
    Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 38:1303-12. 2011
    ..Here we introduce a (68)Ga-labelled NOTA-conjugated RGD peptide ([(68)Ga]NODAGA-RGD) and compare its imaging properties with [(68)Ga]DOTA-RGD using small animal PET...
  20. doi request reprint PET radiopharmaceuticals in radiation treatment planning - synthesis and biological characteristics
    Roland Haubner
    Medizinische Universitat Innsbruck, Innsbruck, Austria
    Radiother Oncol 96:280-7. 2010
    ....
  21. ncbi request reprint Radiolabelled RGD peptides and peptidomimetics for tumour targeting
    Roland Haubner
    Clinical Department of Nuclear Medicine, Medical University Innsbruck, Austria, Anichstrasse 35, A 6020 Innsbruck, Austria
    Front Biosci (Landmark Ed) 14:872-86. 2009
    ..To improve targeting efficiency multimeric constructs were reported revealing improved targeting properties in preclinical models. These developments still have to be transferred into the clinical setting...
  22. ncbi request reprint [99mTc]HYNIC-RGD for imaging integrin alphavbeta3 expression
    Clemens Decristoforo
    Department of Nuclear Medicine, Medical University of Innsbruck, A 6020 Innsbruck, Austria
    Nucl Med Biol 33:945-52. 2006
    ..Tumor uptake studies showed specific targeting of alpha(v)beta(3)-receptor-positive tumors with tumor-to-organ ratios comparable to those of [(18)F]Galacto-RGD...
  23. pmc Influence of PEGylation and RGD loading on the targeting properties of radiolabeled liposomal nanoparticles
    Christine Rangger
    Department of Nuclear Medicine, Innsbruck Medical University, Austria
    Int J Nanomedicine 7:5889-900. 2012
    ..RGD peptides are known to bind to α(v)β(3) integrin receptors overexpressed during tumor-induced angiogenesis...
  24. ncbi request reprint 124I-Anti-CD52 Dosimetry Before Radioimmunotherapy as Part of Conditioning for Stem Cell Transplantation in Acute Leukemia
    Daniel Putzer
    From the Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria and Division of Hematology and Oncology, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Clin Nucl Med 37:390-2. 2012
    ..Marrow ablation and donor cell engraftment was achieved with conditioning and immunosuppression. Leukemia control was transient. The patient succumbed 2 months after transplantation...
  25. ncbi request reprint Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells
    Martina Anton
    Institute of Experimental Oncology, Technische Universitat Munchen, Germany
    J Gene Med 6:119-26. 2004
    ..Its expression is almost exclusively restricted to the sympathetic nervous system. In this study we evaluated whether the NET can be used as a reporter gene for non-invasive imaging of genetically modified cells with radiolabeled probes...
  26. doi request reprint Intratumoral spatial distribution of hypoxia and angiogenesis assessed by 18F-FAZA and 125I-Gluco-RGD autoradiography
    Maria Picchio
    Nuclear Medicine Department, IBFM CNR, Scientific Institute H San Raffaele, Milan, Italy
    J Nucl Med 49:597-605. 2008
    ..The hypoxia-inducible factor-1 alpha (HIF-1 alpha) activates angiogenesis in response to cellular hypoxia, suggesting a spatial correlation between angiogenesis and tissue hypoxia...
  27. ncbi request reprint Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice
    Manfred Kneilling
    Eberhard Karls University, Tubingen, Germany
    Arthritis Rheum 56:1806-16. 2007
    ....
  28. ncbi request reprint In vitro and in vivo evaluation of a novel 99mTc(CO)3-pyrazolyl conjugate of cyclo-(Arg-Gly-Asp-d-Tyr-Lys)
    Susana Alves
    Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri Columbia School of Medicine, Columbia, Missouri 65211, USA
    Bioconjug Chem 18:530-7. 2007
    ..50 +/- 0.29 and 0.71 +/- 0.08% ID/g in alphavbeta3 integrin positive (M21) and negative (M21L) tumors at 1 h postinjection (p.i.), respectively...
  29. ncbi request reprint Radiolabeled tracers for imaging of tumor angiogenesis and evaluation of anti-angiogenic therapies
    Roland Haubner
    Department of Nuclear Medicine, Technische Universitat, Munich, Germany
    Curr Pharm Des 10:1439-55. 2004
    ..Further studies have to demonstrate that this approach can be translated to clinical settings allowing visualisation of alpha v beta 3-positive tumours and alpha v beta 3 expression during tumour-induced angiogenesis in patients...
  30. ncbi request reprint Molecular (functional) imaging for radiotherapy applications: an RTOG symposium
    J D Chapman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 55:294-301. 2003
  31. pmc Radionuclide imaging: a molecular key to the atherosclerotic plaque
    Harald F Langer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Am Coll Cardiol 52:1-12. 2008
    ..This review gives an update on the relevant noninvasive plaque imaging approaches using nuclear imaging techniques to detect atherosclerotic vascular lesions...
  32. doi request reprint TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis
    Nele Müller-Hermelink
    Department of Dermatology, Eberhard Karls University, Liebermeisterstrasse 25, 72076 Tubingen, Germany
    Cancer Cell 13:507-18. 2008
    ..Thus, tumor-specific T cells can directly survey multistage carcinogenesis through cytokine signaling...
  33. ncbi request reprint A fully automated synthesis for the preparation of 68Ga-labelled peptides
    Clemens Decristoforo
    Clinical Department of Nuclear Medicine, Medical University Innsbruck, Austria
    Nucl Med Commun 28:870-5. 2007
    ..So far, the synthesis of Ga-peptide radiopharmaceuticals is mainly based on semi-automated systems. Here we describe a fully automated approach for the synthesis of Ga-labelled peptides...
  34. ncbi request reprint Non-invasive imaging of glycoprotein VI binding to injured arterial lesions
    Meinrad Gawaz
    Medizinische Klink III, Universitatsklinikum Tubingen, Germany
    Thromb Haemost 93:910-3. 2005
    ..Because GPVI is the critical collagen receptor that mediates platelet adhesion to vascular lesions, soluble radiolabeled GPVI may be an agent for non-invasive imaging of thrombogenic thus, vulnerable atherosclerotic plaques...