Harald Greger

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides
    Brigitte Brem
    Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    J Agric Food Chem 50:6383-8. 2002
  2. doi request reprint Pandanus alkaloids in Stemonaceae: finding of a plausible biogenetic origin of Stemona alkaloids
    Harald Greger
    Comparative and Ecological Phytochemistry, Faculty Center of Botany, University of Vienna, Vienna, Austria
    J Nat Prod 72:1708-11. 2009
  3. doi request reprint The diversity of Stemona stilbenoids as a result of storage and fungal infection
    Harald Greger
    Chemodiversity Research Group, Faculty Center of Biodiversity, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    J Nat Prod 75:2261-8. 2012
  4. ncbi request reprint Amide-esters from Aglaia tenuicaulis--first representatives of a class of compounds structurally related to bisamides and flavaglines
    Harald Greger
    Comparative and Ecological Phytochemistry, Faculty Center of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    Phytochemistry 69:928-38. 2008
  5. ncbi request reprint Structural relationships, distribution and biological activities of stemona alkaloids
    Harald Greger
    Comparative and Ecological Phytochemistry Section, Institute of Botany, University of Vienna, Rennweg 14, 1030 Vienna, Austria
    Planta Med 72:99-113. 2006
  6. doi request reprint Anti-leishmanial activity of plant-derived acridones, flavaglines, and sulfur-containing amides
    Florian Astelbauer
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    Vector Borne Zoonotic Dis 11:793-8. 2011
  7. ncbi request reprint Pyrrolo- and pyridoazepine alkaloids as chemical markers in Stemona species
    Johann Schinnerl
    Comparative and Ecological Phytochemistry Section, Faculty Center of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    Phytochemistry 68:1417-27. 2007
  8. ncbi request reprint Insecticidal pyrido[1,2-a]azepine alkaloids and related derivatives from Stemona species
    Elisabeth Kaltenegger
    Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A 1030 Vienna, Austria
    Phytochemistry 63:803-16. 2003
  9. ncbi request reprint Dihydrophenanthrenes and other antifungal stilbenoids from Stemona cf. pierrei
    Katharina Kostecki
    Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A 1030, Wien, Austria
    Phytochemistry 65:99-106. 2004
  10. ncbi request reprint Antioxidant dehydrotocopherols as a new chemical character of Stemona species
    Brigitte Brem
    Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    Phytochemistry 65:2719-29. 2004

Collaborators

  • Christoph Seger
  • Thomas Efferth
  • Oumaporn Tasanor
  • Lothar Brecker
  • Paul Pui Hay But
  • Klaus Teichmann
  • Walther H Wernsdorfer
  • David Leitsch
  • Markus Bacher
  • Julia Walochnik
  • Hanspeter Kählig
  • P C Shaw
  • S Sturm
  • Brigitte Brem
  • Otmar Hofer
  • Thomas Pacher
  • Srunya Vajrodaya
  • Ren Wang Jiang
  • Florian Astelbauer
  • Adriane Raninger
  • Brigitte Lukaseder
  • Marie Eve Bordeleau
  • Silvia Pointinger
  • Nantiya Joycharat
  • Song Lin Li
  • Johann Schinnerl
  • Po Ming Hon
  • Hong Xi Xu
  • Kurt Mereiter
  • Michael Adams
  • Barbara Hausott
  • Beate Rinner
  • Katharina Kostecki
  • Elisabeth Kaltenegger
  • Andreas Obwaller
  • Michael Duchene
  • Eberhard Lorbeer
  • Michael Nagl
  • Wolfgang Robien
  • Tina Hehenberger
  • Gerda Lutz-Kutschera
  • Somnuk Promdang
  • John A Porco
  • Scott W Lowe
  • Francis Robert
  • Caroline M Pannell
  • Lisa Lindqvist
  • Jerry Pelletier
  • Samuel M H Chen
  • Ekarin Saifah
  • Baudouin Gerard
  • Hans Guido Wendel
  • Ling Cheng
  • Yan Zhou
  • Yan Tong Xu
  • Yiu Man Chan
  • Rudolf Bauer
  • Roswitha Pfragner
  • Markus Hartl
  • Brigitte Marian
  • Franz Hadacek
  • Doris Engelmeier
  • Peter Pürstner
  • Veronika Siegl
  • Hermann Kalchhauser
  • Srumya Vajrodaya

Detail Information

Publications25

  1. ncbi request reprint Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides
    Brigitte Brem
    Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    J Agric Food Chem 50:6383-8. 2002
    ..Tuberostemonine was the dominating alkaloid in the roots of S. tuberosa, showing outstanding repellency but no toxic effects...
  2. doi request reprint Pandanus alkaloids in Stemonaceae: finding of a plausible biogenetic origin of Stemona alkaloids
    Harald Greger
    Comparative and Ecological Phytochemistry, Faculty Center of Botany, University of Vienna, Vienna, Austria
    J Nat Prod 72:1708-11. 2009
    ....
  3. doi request reprint The diversity of Stemona stilbenoids as a result of storage and fungal infection
    Harald Greger
    Chemodiversity Research Group, Faculty Center of Biodiversity, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    J Nat Prod 75:2261-8. 2012
    ..Potential neuroprotective activities have been reported for three dihydrostilbene glucosides against 6-hydroxydopamine-induced neurotoxicity in human neuroblastoma SH-SY5Y cells...
  4. ncbi request reprint Amide-esters from Aglaia tenuicaulis--first representatives of a class of compounds structurally related to bisamides and flavaglines
    Harald Greger
    Comparative and Ecological Phytochemistry, Faculty Center of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    Phytochemistry 69:928-38. 2008
    ..Structural and biosynthetic connections between amide-esters, bisamides and flavaglines are discussed and the chemotaxonomic significance of accumulating specific derivatives within the genus Aglaia is highlighted...
  5. ncbi request reprint Structural relationships, distribution and biological activities of stemona alkaloids
    Harald Greger
    Comparative and Ecological Phytochemistry Section, Institute of Botany, University of Vienna, Rennweg 14, 1030 Vienna, Austria
    Planta Med 72:99-113. 2006
    ..Studies on structure-activity relationship with seven related compounds revealed that the saturated tricyclic pyrrolobenzazepine nucleus of tuberostemonines is the prerequisite for antitussive activity...
  6. doi request reprint Anti-leishmanial activity of plant-derived acridones, flavaglines, and sulfur-containing amides
    Florian Astelbauer
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    Vector Borne Zoonotic Dis 11:793-8. 2011
    ..None of the compounds showed hemolytic activity...
  7. ncbi request reprint Pyrrolo- and pyridoazepine alkaloids as chemical markers in Stemona species
    Johann Schinnerl
    Comparative and Ecological Phytochemistry Section, Faculty Center of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    Phytochemistry 68:1417-27. 2007
    ..A new stereoisomer of tuberostemonine was isolated and identified by spectroscopic methods...
  8. ncbi request reprint Insecticidal pyrido[1,2-a]azepine alkaloids and related derivatives from Stemona species
    Elisabeth Kaltenegger
    Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A 1030 Vienna, Austria
    Phytochemistry 63:803-16. 2003
    ..Based on the various insecticidal activities of 13 derivatives structure-activity relationships became apparent...
  9. ncbi request reprint Dihydrophenanthrenes and other antifungal stilbenoids from Stemona cf. pierrei
    Katharina Kostecki
    Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A 1030, Wien, Austria
    Phytochemistry 65:99-106. 2004
    ..Because of weak inhibition and chemical instability of stemanthrenes, no EC(50) and EC(90) values could be calculated...
  10. ncbi request reprint Antioxidant dehydrotocopherols as a new chemical character of Stemona species
    Brigitte Brem
    Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    Phytochemistry 65:2719-29. 2004
    ....
  11. doi request reprint Alcoholysis of naturally occurring imides: misleading interpretation of antifungal activities
    Thomas Pacher
    Comparative and Ecological Phytochemistry, Faculty Center of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    J Nat Prod 73:1389-93. 2010
    ....
  12. doi request reprint Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia
    Markus Bacher
    Institute of Organic Chemistry, University of Vienna, A 1090 Wien, Austria
    Magn Reson Chem 48:83-8. 2010
    ..Structure elucidation and signal assignment were achieved by the extensive use of 1D and 2D NMR experiments (selective 1D NOE, COSY, NOESY, HSQC, HMBC)...
  13. doi request reprint Silvaglins and related 2,3-secodammarane derivatives - unusual types of triterpenes from Aglaia silvestris
    Silvia Pointinger
    Comparative and Ecological Phytochemistry, Faculty Center of Botany, University of Vienna, Rennweg 14, A 1030 Wien, Austria
    Phytochemistry 69:2696-703. 2008
    ..The structural diversity and distribution of triterpenoids within the genus Aglaia is highlighted with respect to chemotaxonomic implications...
  14. doi request reprint Prenylated flavanones and flavanonols as chemical markers in Glycosmis species (Rutaceae)
    Brigitte Lukaseder
    Comparative and Ecological Phytochemistry, Faculty Center of Botany, University of Vienna, A 1030 Wien, Austria
    Phytochemistry 70:1030-7. 2009
    ..Six compounds were described for the first time and two were only known so far as synthetic products. The chemotaxonomic significance of flavanoid accumulation within the genus Glycosmis is highlighted...
  15. ncbi request reprint Development of a pharmacodynamic screening model with Entamoeba histolytica
    Oumaporn Tasanor
    Institute for Specific Prophylaxis und Tropical Medicine, Center for Physiology und Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:88-95. 2007
    ..1325, followed by leaf extract from Stemona tuberosa with an IC(99) of 638 ng/ml and a slope S of 1.5648. All seven extracts showed full activity at concentrations <4000 ng/ml and qualified for further investigation...
  16. ncbi request reprint Flavaglines: a group of efficient growth inhibitors block cell cycle progression and induce apoptosis in colorectal cancer cells
    Barbara Hausott
    Institute of Cancer Research, University of Vienna, Vienna, Austria
    Int J Cancer 109:933-40. 2004
    ..Strong activation of p38 was observed after 2 hr of exposure, indicating that apoptosis may be induced via a p38-mediated stress pathway...
  17. ncbi request reprint Alkaloids and chemical diversity of Stemona tuberosa
    Ren Wang Jiang
    Institute of Chinese Medicine, Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    J Nat Prod 69:749-54. 2006
    ..tuberosa from 13 localities, and four types of chemical variation featured by the major components 3, neotuberostemonine (4), croomine (5), and stemoninine (6), respectively, were observed...
  18. doi request reprint Nonaqueous capillary electrophoresis-electrospray ionization-ion trap-mass spectrometry analysis of pyrrolo- and pyrido[1,2-a]azepine alkaloids in Stemona
    Sonja Sturm
    Institute of Pharmacy Pharmacognosy, Center of Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
    Electrophoresis 29:2079-87. 2008
    ..5 microg/mL, LOQs <25.0 microg/mL, for all analytes, recovery rates >98.9%) in several Stemona sp. extracts...
  19. ncbi request reprint Activity of novel plant extracts against medullary thyroid carcinoma cells
    Beate Rinner
    Department of Pathophysiology, Medical University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Anticancer Res 24:495-500. 2004
    ..Medullary thyroid carcinoma (MTC) is a rare calcitonin-producing tumor, derived from the parafollicular C-cells of the thyroid. MTC is known to be relatively insensitive to conventional chemotherapy...
  20. ncbi request reprint Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species
    Michael Adams
    Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, A 8010 Graz, Austria
    J Nat Prod 68:83-5. 2005
    ..7 to >50 microM. The alkaloids tuberostemonine (18) and neotuberostemonine (19) were inactive at a concentration of 50 microM...
  21. ncbi request reprint Two pyrrolo[1,2-a]azepine type alkaloids from Stemona collinsae Craib: structure elucidations, relationship to asparagamine A, and a new biogenetic concept of their formation
    Christoph Seger
    Institute of Organic Chemistry, University of Vienna, Wahringerstrasse 38, A 1090 Vienna
    Chem Biodivers 1:265-79. 2004
    ..In the context of the current investigations, a novel concept on the biosynthesis of Stemona alkaloids has been worked out and is presented here...
  22. ncbi request reprint Development of a pharmacodynamic screening model with Crithidia fasciculata
    Oumaporn Tasanor
    Institute of Specific Prophylaxis and Tropical Medicine, Centre for Physiology and Pathophysiology, Medical University of Vienna, Austria
    Wien Klin Wochenschr 118:42-9. 2006
    ..Encouraging results were obtained with extracts from Aglaia odorata leaves, A. elaeagnoidea stem bark and A. edulis leaves, with EC(90) values of 1213 ng/ml, 1606 ng/ml, and 1462 ng/ml, respectively...
  23. ncbi request reprint Quality evaluation of Radix Stemonae through simultaneous quantification of bioactive alkaloids by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors
    Song Lin Li
    Institute of Chinese Medicine, Department of Biology and Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, People s Republic of China
    Biomed Chromatogr 21:1088-94. 2007
    ..This simple, rapid, low-cost and reliable method is suitable for the routine quality control of herbal medicines containing bioactive components with different structure types such as Radix Stemonae...
  24. pmc Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
    Marie Eve Bordeleau
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 118:2651-60. 2008
    ..These results establish that targeting translation initiation can restore drug sensitivity in vivo and provide an approach to modulating chemosensitivity...
  25. ncbi request reprint Flavaglines and triterpenoids from the leaves of Aglaia forbesii
    Nantiya Joycharat
    Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 69:206-11. 2008
    ..Their structures were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. Compounds 3, 4, 5, and 6 were tested for antituberculosis and antiviral activity...