Michael Glotzer

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint The molecular requirements for cytokinesis
    Michael Glotzer
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 307:1735-9. 2005
  2. pmc Cleavage furrow positioning
    Michael Glotzer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Biol 164:347-51. 2004
  3. pmc An ECT2-centralspindlin complex regulates the localization and function of RhoA
    Ozlem Yüce
    Research Institute of Molecular Pathology, 1030, Vienna, Austria
    J Cell Biol 170:571-82. 2005
  4. ncbi request reprint Cell cycle regulation of central spindle assembly
    Masanori Mishima
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Nature 430:908-13. 2004
  5. ncbi request reprint Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle
    Mark Petronczki
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Dev Cell 12:713-25. 2007
  6. ncbi request reprint Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis
    Annika Guse
    Research Institute of Molecular Pathology, Vienna, Austria
    Curr Biol 15:778-86. 2005
  7. ncbi request reprint Centrosome separation and central spindle assembly act in redundant pathways that regulate microtubule density and trigger cleavage furrow formation
    Reinhard Dechant
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Dev Cell 4:333-44. 2003
  8. pmc CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1
    Alper Romano
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, Vienna A 1030, Austria
    J Cell Biol 161:229-36. 2003
  9. ncbi request reprint Cytokinesis: progress on all fronts
    Michael Glotzer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Opin Cell Biol 15:684-90. 2003
  10. ncbi request reprint Cytokinesis: regulated by destruction
    Michael Glotzer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:R344-6. 2002

Collaborators

Detail Information

Publications27

  1. ncbi request reprint The molecular requirements for cytokinesis
    Michael Glotzer
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 307:1735-9. 2005
    ..Cytokinesis involves additional proteins, but they, or their requirement in cytokinesis, are not conserved among animal cells...
  2. pmc Cleavage furrow positioning
    Michael Glotzer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Biol 164:347-51. 2004
    ..Although the mechanism of cleavage furrow positioning is not understood at a molecular level, recent results suggest that it might be mediated by local relief from the inhibitory effects of microtubules...
  3. pmc An ECT2-centralspindlin complex regulates the localization and function of RhoA
    Ozlem Yüce
    Research Institute of Molecular Pathology, 1030, Vienna, Austria
    J Cell Biol 170:571-82. 2005
    ..Thus, central spindle localization of ECT2 assists division plane positioning and the CYK-4 subunit of centralspindlin acts upstream of RhoA to promote furrow assembly...
  4. ncbi request reprint Cell cycle regulation of central spindle assembly
    Masanori Mishima
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Nature 430:908-13. 2004
    ..Thus, phosphoregulation of the motor domain of MKLP1 kinesin ensures that central spindle assembly occurs at the appropriate time in the cell cycle and maintains genomic stability...
  5. ncbi request reprint Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle
    Mark Petronczki
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Dev Cell 12:713-25. 2007
    ..We propose that late mitotic Plk1 activity promotes recruitment of Ect2 to the central spindle, triggering the initiation of cytokinesis and contributing to cleavage plane specification in human cells...
  6. ncbi request reprint Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis
    Annika Guse
    Research Institute of Molecular Pathology, Vienna, Austria
    Curr Biol 15:778-86. 2005
    ..Inhibition of aurora B in late anaphase causes cytokinesis defects without disrupting the central spindle. These data indicate a conserved role for aurora-B-mediated phosphorylation of ZEN-4/MKLP1 in the completion of cytokinesis...
  7. ncbi request reprint Centrosome separation and central spindle assembly act in redundant pathways that regulate microtubule density and trigger cleavage furrow formation
    Reinhard Dechant
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Dev Cell 4:333-44. 2003
    ..These data suggest that reduced microtubule density triggers cleavage furrow initiation and demonstrate that redundant mechanisms direct efficient formation of the cleavage furrow...
  8. pmc CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1
    Alper Romano
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, Vienna A 1030, Austria
    J Cell Biol 161:229-36. 2003
    ..ICP-1 dramatically stimulates AIR-2 kinase activity. This activity is not stimulated by CSC-1/BIR-1, suggesting that these two subunits function as targeting subunits for AIR-2 kinase...
  9. ncbi request reprint Cytokinesis: progress on all fronts
    Michael Glotzer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Opin Cell Biol 15:684-90. 2003
    ..New results have provided some initial clues as to how furrow positioning is achieved. Particularly notable is the discovery that a protein activated by RhoA, formin, has actin nucleation activity...
  10. ncbi request reprint Cytokinesis: regulated by destruction
    Michael Glotzer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:R344-6. 2002
    ..Important transitions in the cell cycle are regulated by ubiquitin-dependent degradation of specific proteins. Recent data indicate that cytokinesis is also regulated by proteolysis...
  11. ncbi request reprint Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners
    Alexander Schleiffer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mol Cell 11:571-5. 2003
    ..Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure. Since these are the only domains conserved among kleisins, we suggest that ring formation with SMC proteins may define this family...
  12. ncbi request reprint Cytokinesis: a logical GAP
    Masanori Mishima
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 13:R589-91. 2003
    ..Aurora B kinase is known to regulate localization of centralspindlin and may regulate the activity of the RhoGAP component of centralspindlin...
  13. ncbi request reprint A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo
    Susanne Kaitna
    Research Institute for Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:2293-302. 2002
    ..These data indicate that the deubiquitination of certain substrates by CYK-3 is crucial for cellular osmoregulation. Defects in osmoregulation appear to indirectly affect actin-dependent processes...
  14. ncbi request reprint The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis
    Susanne Kaitna
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:798-812. 2002
    ..The mechanisms responsible for orienting kinetochores in mitosis and for causing asynchronous loss of cohesion during meiosis are not well understood...
  15. ncbi request reprint GTP binding induces filament assembly of a recombinant septin
    Manuel Mendoza
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 12:1858-63. 2002
    ..If the properties of Xl Sept2 filaments reflect those of native septin complexes, these results imply that the growth or stability of septin filaments, or both, is regulated by the state of bound nucleotide...
  16. ncbi request reprint Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity
    Masanori Mishima
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Dev Cell 2:41-54. 2002
    ..Biochemical studies indicate that this complex, named centralspindlin, is a heterotetramer. Centralspindlin, but not its individual components, strongly promotes microtubule bundling in vitro...
  17. ncbi request reprint Comparative analysis of cytokinesis in budding yeast, fission yeast and animal cells
    Mohan K Balasubramanian
    Temasek Life Sciences Laboratory, The National University of Singapore, Singapore
    Curr Biol 14:R806-18. 2004
    ..To evaluate the overall evolutionary conservation of cytokinesis, it will be necessary to include representatives of these divergent branches. Nevertheless, the three species discussed here provide substantial mechanistic diversity...
  18. doi request reprint Control of cortical contractility during cytokinesis
    Michael Werner
    Department of Molecular Genetics and Cell Biology, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA
    Biochem Soc Trans 36:371-7. 2008
    ..We review our current understanding of the molecular mechanisms of furrow formation, with particular emphasis on the central spindle-independent pathway...
  19. ncbi request reprint Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis
    Alisa J Piekny
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Curr Biol 18:30-6. 2008
    ....
  20. pmc Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex
    Visnja Pavicic-Kaltenbrunner
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Mol Biol Cell 18:4992-5003. 2007
    ..This unexpected plasticity explains the lack of primary sequence conservation of the regions critical for this essential protein-protein interaction...
  21. pmc Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis
    Michael Werner
    Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Curr Biol 17:1286-97. 2007
    ..In both C. elegans embryos and human cells, the central spindle regulates division-plane positioning in parallel with a second pathway that involves astral microtubules...
  22. pmc The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo
    Ulrike Gruneberg
    Department of Cell Biology, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    J Cell Biol 158:901-14. 2002
    ..These findings identify the CDC14 phosphatase as an important regulator of central spindle formation and cytokinesis in a metazoan organism...
  23. ncbi request reprint Structural analysis of the ZEN-4/CeMKLP1 motor domain and its interaction with microtubules
    Dilem Hizlan
    European Molecular Biology Laboratory, Structural Biology and Biocomputing Programme, Heidelberg, Germany
    J Struct Biol 153:73-84. 2006
    ..Furthermore, we investigated the location, structure, and function of a highly conserved extension of approximately 50 residues unique to the Kinesin-6 subfamily, located in the motor core loop6/beta4 region...
  24. ncbi request reprint Cytokinesis: welcome to the Rho zone
    Alisa Piekny
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Trends Cell Biol 15:651-8. 2005
    ..Advances in detecting the active pool of RhoA have allowed insights into the mechanisms and the molecules that promote the accumulation of active RhoA at the correct time and place in the cell...
  25. pmc Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis
    Glenn C Simon
    Department of Cellular and Developmental Biology, School of Medicine, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    EMBO J 27:1791-803. 2008
    ..Thus, we propose that centralspindlin complex not only regulates acto-myosin ring contraction but also endocytic vesicle transport to the cleavage furrow and it does so through sequential interactions with ECT2 and FIP3...
  26. doi request reprint Developmental regulation of central spindle assembly and cytokinesis during vertebrate embryogenesis
    Esther K Kieserman
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Curr Biol 18:116-23. 2008
    ..These data suggest that PRC1 is a dose-dependent regulator of the central spindle in vertebrate embryos and demonstrate unexpected plasticity to fundamental mechanisms of cell division...
  27. pmc Mammalian septins nomenclature
    Ian G Macara
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Biol Cell 13:4111-3. 2002
    ..The human and mouse septin genes will be named SEPT1-SEPT10 and Sept1-Sept10, respectively. Splice variants will be designated by an underscore followed by a lowercase "v" and a number, e.g., SEPT4_v1...