C Gasche

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi A novel variant of lysosomal acid lipase in cholesteryl ester storage disease associated with mild phenotype and improvement on lovastatin
    C Gasche
    Department of Gastroenterology and Hepatology, University of Vienna, Austria
    J Hepatol 27:744-50. 1997
  2. ncbi Genotype-phenotype correlations: how many disorders constitute inflammatory bowel disease?
    Christoph Gasche
    Department of Medicine 4, Division of Gastroenterology and Hepatology, University of Vienna, Austria
    Eur J Gastroenterol Hepatol 15:599-606. 2003
  3. ncbi Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production
    Christoph Gasche
    Department of Medicine 4, Division of Gastroenterology and Hepatology, University of Vienna, Vienna, Austria
    J Immunol 170:5578-82. 2003
  4. pmc Identification of frame-shift intermediate mutant cells
    Christoph Gasche
    Department of Medicine and Cancer Center, University of California at San Diego, La Jolla, CA 92093 0688, USA
    Proc Natl Acad Sci U S A 100:1914-9. 2003
  5. ncbi Sequential treatment of anemia in ulcerative colitis with intravenous iron and erythropoietin
    C Gasche
    University of California, San Diego, La Jolla, Calif, USA
    Digestion 60:262-7. 1999
  6. doi The IL-10R1 S138G loss-of-function allele and ulcerative colitis
    P Grundtner
    Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria
    Genes Immun 10:84-92. 2009
  7. ncbi In vivo effects of recombinant human interleukin-10 on lymphocyte phenotypes and leukocyte activation markers in inflammatory bowel disease
    C Dejaco
    Department of Internal Medicine IV, University of Vienna, Austria
    J Investig Med 48:449-56. 2000
  8. ncbi IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease
    C Gasche
    Department of Gastroenterology and Hepatology, University of Vienna, Austria
    J Clin Immunol 20:362-70. 2000
  9. ncbi Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection
    H Hofer
    Department of Internal Medicine IV, Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria
    Genes Immun 6:242-7. 2005
  10. pmc An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation
    M Finsterbusch
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology and Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria
    Genes Immun 12:575-81. 2011

Collaborators

Detail Information

Publications34

  1. ncbi A novel variant of lysosomal acid lipase in cholesteryl ester storage disease associated with mild phenotype and improvement on lovastatin
    C Gasche
    Department of Gastroenterology and Hepatology, University of Vienna, Austria
    J Hepatol 27:744-50. 1997
    ..5% (p<0.05) and 41.7+/-5.1% to 33.4+/-4.4% (p<0.01). We conclude that in two siblings with a novel LAL variant and mild phenotype of CESD, lovastatin decreased both serum lipid concentrations and hepatocellular lysosomal content...
  2. ncbi Genotype-phenotype correlations: how many disorders constitute inflammatory bowel disease?
    Christoph Gasche
    Department of Medicine 4, Division of Gastroenterology and Hepatology, University of Vienna, Austria
    Eur J Gastroenterol Hepatol 15:599-606. 2003
    ..Certainly, inflammatory bowel diseases consist of more than two genotypes and phenotypes. At this stage, predictions on the number of disease causing genes, mutations or environmental factors are impossible...
  3. ncbi Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production
    Christoph Gasche
    Department of Medicine 4, Division of Gastroenterology and Hepatology, University of Vienna, Vienna, Austria
    J Immunol 170:5578-82. 2003
    ..In addition, these IL-10R1 variants had no influence on the IL-10R1 expression density. Structural analysis of the S138G variant revealed that the substitution of S138G may interfere with binding of IL-10 to IL-10R1...
  4. pmc Identification of frame-shift intermediate mutant cells
    Christoph Gasche
    Department of Medicine and Cancer Center, University of California at San Diego, La Jolla, CA 92093 0688, USA
    Proc Natl Acad Sci U S A 100:1914-9. 2003
    ..87 x 10(-3)) and HCT116+chr3 (4.13 x 10(-3)), indicating that the generation of intermediate mutants is not affected by mismatch-repair proficiency...
  5. ncbi Sequential treatment of anemia in ulcerative colitis with intravenous iron and erythropoietin
    C Gasche
    University of California, San Diego, La Jolla, Calif, USA
    Digestion 60:262-7. 1999
    ..The aim of this study was to test the sequential treatment of anemia in ulcerative colitis with intravenous iron in the first phase and erythropoietin in the second...
  6. doi The IL-10R1 S138G loss-of-function allele and ulcerative colitis
    P Grundtner
    Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria
    Genes Immun 10:84-92. 2009
    ..9 versus 15.5%; P=0.8). In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10-induced STAT1 and STAT3 activation but does not protect from UC susceptibility...
  7. ncbi In vivo effects of recombinant human interleukin-10 on lymphocyte phenotypes and leukocyte activation markers in inflammatory bowel disease
    C Dejaco
    Department of Internal Medicine IV, University of Vienna, Austria
    J Investig Med 48:449-56. 2000
    ..The present study investigates the in vivo immunomodulatory properties of rHuIL-10 in inflammatory bowel disease (IBD)...
  8. ncbi IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease
    C Gasche
    Department of Gastroenterology and Hepatology, University of Vienna, Austria
    J Clin Immunol 20:362-70. 2000
    ..Our data suggest that LPMC derived from inflamed colonic mucosa have a reduced ability to produce and to respond to rhIL-10. A disease-specific alteration in the IL-10 pathway, however, was not found...
  9. ncbi Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection
    H Hofer
    Department of Internal Medicine IV, Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria
    Genes Immun 6:242-7. 2005
    ..Our work implies that IL-10R1 SNP4 is a recessively inherited risk factor for hepatic cirrhosis in HCV genotype-1 infection...
  10. pmc An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation
    M Finsterbusch
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology and Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria
    Genes Immun 12:575-81. 2011
    ..Our results indicate that IL10R1-G330R does not alter surface expression but duration of STAT phosphorylation, indicating that the position of G330 is important in stabilizing the STAT signal...
  11. ncbi Oxidative stress increases frameshift mutations in human colorectal cancer cells
    C Gasche
    Department of Medicine and Cancer Center, University of California at San Diego, La Jolla, California 92093-0688, USA
    Cancer Res 61:7444-8. 2001
    ..These data indicate that oxidative stress is a potential mutagen leading to accumulation of frameshift mutations and may contribute to MSI in the setting of chronic inflammation...
  12. ncbi Extracorporeal photochemotherapy in patients with steroid-dependent Crohn's disease: a prospective pilot study
    W Reinisch
    Department of Internal Medicine IV, Division of Gastroenterology and Hepatology, University of Vienna, Austria
    Aliment Pharmacol Ther 15:1313-22. 2001
    ..Extracorporeal photochemotherapy has been proven effective in selected T-cell mediated diseases...
  13. ncbi Systematic review: managing anaemia in Crohn's disease
    S Kulnigg
    Department of Medicine, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria
    Aliment Pharmacol Ther 24:1507-23. 2006
    ..Anaemia is a serious complication of Crohn's disease that triggers hospitalization and, if not interfered with, may lead to death...
  14. pmc Genotypes and phenotypes in Crohn's disease: do they help in clinical management?
    C Gasche
    Medical University Vienna, Department of Medicine 4, Division of Gastroenterology and Hepatology, Austria
    Gut 54:162-7. 2005
  15. doi A randomized head-to-head study of small-bowel imaging comparing MiroCam and EndoCapsule
    W Dolak
    Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria
    Endoscopy 44:1012-20. 2012
    ....
  16. pmc Iron, anaemia, and inflammatory bowel diseases
    C Gasche
    Department of Medicine 4, Division of Gastroenterology and Hepatology, Medical University Vienna, Austria
    Gut 53:1190-7. 2004
    ..It is our experience that virtually all patients with IBD associated anaemia can be successfully treated with a combination of iron sucrose and erythropoietin, which then may positively affect the misled immune response in IBD...
  17. ncbi Significant association of strictures and internal fistula formation in Crohn's disease
    G Oberhuber
    Department of Clinical Pathology, University of Vienna, Medical School, Austria
    Virchows Arch 437:293-7. 2000
    ..From these findings we conclude that that mechanical factors may contribute to fistula formation. This is further supported by the fact that fistulae appear to traverse the muscular layer along piercing vessels...
  18. ncbi Azathioprine treatment and male fertility in inflammatory bowel disease
    C Dejaco
    Division of Gastroenterology and Hepatology, Department of Internal Medicine IV, Institute of Tumor Biology, Vienna, Austria
    Gastroenterology 121:1048-53. 2001
    ..During the study period, 6 patients fathered 7 healthy children. CONCLUSIONS: Our data show that AZA does not reduce semen quality and thereby male fertility in IBD...
  19. ncbi Review article: the chemoprevention of colorectal carcinoma
    C Gasche
    Department of Internal Medicine IV, Division of Gastroenterology and Hepatology, Vienna, Austria
    Aliment Pharmacol Ther 20:31-5. 2004
    ..New molecular evidence points to a direct DNA stabilizing effect of mesalazine, resulting in a significant reduction of spontaneous microsatellite mutations...
  20. pmc Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma
    H Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Austria
    Gut 50:191-5. 2002
    ..Interleukin 10 (IL-10) exerts anti-inflammatory actions by counteracting many biological effects of interferon gamma (IFN-gamma)...
  21. pmc Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells
    C Campregher
    AKH Wien, Division of Gastroenterology and Hepatology, Wahringer Gurtel 18, A 1090 Vienna, Austria
    Gut 57:780-7. 2008
    ....
  22. ncbi Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophrenia
    Alexandra Schosser
    Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Vienna, Austria
    Am J Med Genet B Neuropsychiatr Genet 144:347-50. 2007
    ..032). No such difference was seen for S138G. Our results suggest that homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of disease phenotype in susceptible individuals...
  23. ncbi NOD2 and colorectal cancer: guilt by non-association
    Christoph Gasche
    Cancer Res 64:5525; author reply 5525-6. 2004
  24. ncbi Tourette's syndrome is not associated with interleukin-10 receptor 1 variants on chromosome 11q23.3
    Jochen Kindler
    Department of Biological Psychiatry, University Hospital of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Psychiatry Res 157:235-9. 2008
    ..DNA of 77 patients with a DSM-IV (Diagnostic and Statistical Manual IV) diagnosis of TS and 250 healthy controls was genotyped. IL-10R1 was not associated with TS...
  25. ncbi Mesalazine improves replication fidelity in cultured colorectal cells
    Christoph Gasche
    Department of Medicine 4, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria
    Cancer Res 65:3993-7. 2005
    ..This finding suggests that mesalazine improves replication fidelity, an effect that may be active in reducing mutations independent of its anti-inflammatory properties...
  26. ncbi Standard therapy of Crohn's disease
    Wolfgang Miehsler
    University of Vienna, Division of Gastroenterology and Hepatology, Vienna, Austria
    Dig Dis 21:146-56. 2003
    ..As the understanding of genetic mutations, their gene function and phenotypic expression grows, we anticipate that future treatment can be tailored to certain genotypes or phenotypes of Crohn's disease...
  27. doi A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT) randomized controlled trial
    Stefanie Kulnigg
    Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Am J Gastroenterol 103:1182-92. 2008
    ....
  28. doi Evolution of Crohn's disease-associated Nod2 mutations
    Christoph Gasche
    Department of Medicine 3, Medical University of Vienna, Vienna, Austria
    Immunogenetics 60:115-20. 2008
    ..As mutations in exons 4e, 8, and 12 were only found in association with SNP5, this variant may have allowed selection pressure to arise...
  29. ncbi Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases
    Christoph Gasche
    Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria
    Inflamm Bowel Dis 13:1545-53. 2007
    ..It therefore needs appropriate attention and specific care...
  30. ncbi Ingested matter affects intestinal lesions in Crohn's disease
    Gregor Bartel
    Department of Medicine 3, Division of Gastroenterology and Hepatology, Medical University of Vienna, Wahringer Gurtel 18, Vienna, Austria
    Inflamm Bowel Dis 14:374-82. 2008
    ..Because such factors could be part of ingested matter, we intended to improve intestinal Crohn's lesions by exclusion thereof...
  31. ncbi A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells
    Ajay Goel
    Department of Medicine and Comprehensive Cancer Center, University of California San Diego, San Diego, California, USA
    Clin Cancer Res 9:383-90. 2003
    ..We hypothesized that aspirin treatment might alter expression of DNA mismatch repair (MMR) proteins, representing another potential non-COX mechanism for its action...
  32. pmc 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint
    M Gloria Luciani
    Medical University of Vienna, Department of Internal Medicine IV, Division of Gastroenterology and Hepatology, Wahringer Gurtel 18, A 1090 Vienna, Austria
    Gastroenterology 132:221-35. 2007
    ..In this study, we hypothesized that 5-ASA restrains cell cycle progression by activating checkpoint pathways in colorectal cell lines, which would prevent tumor development and improve genomic stability...
  33. ncbi [Anemia in chronic inflammatory intestinal disease: an often underestimated problem]
    C Dejaco
    Universitatsklinik fur Innere Medizin IV, Wien, Germany
    Dtsch Med Wochenschr 127:805-8. 2002
  34. ncbi Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update
    David T Rubin
    University of Chicago Medical Center, Chicago, IL 60637, USA
    Inflamm Bowel Dis 14:265-74. 2008
    ..This article provides a comprehensive overview of the issues discussed and should act as a guide to shaping the design of future studies in this area...