W W Fleischhacker

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Comparative efficacy of antipsychotics in the treatment of schizophrenia: a critical assessment
    Rajiv Tandon
    Office of Mental Health, Department of Children and Families, State of Florida, 1317 Winewood Boulevard, Tallahassee, FL 32399 0700, USA
    Schizophr Res 79:145-55. 2005
  2. ncbi The first-episode of schizophrenia: a challenge for treatment
    W W Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur Psychiatry 17:371s-375s. 2002
  3. ncbi Treatment of schizophrenia patients: comparing new-generation antipsychotics to each other
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    Curr Opin Psychiatry 19:128-34. 2006
  4. ncbi [Pharmacotherapy for schizophrenia]
    W W Fleischhacker
    Abteilung für Biologische Psychiatrie, Medizinische Universitat Innsbruck, Anichstrasse 35, 6020 Innsbruck, Osterreich
    Nervenarzt 77:S77-97; S98. 2006
  5. ncbi Treatment of schizophrenia with long-acting injectable risperidone: a 12-month open-label trial of the first long-acting second-generation antipsychotic
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck, Austria
    J Clin Psychiatry 64:1250-7. 2003
  6. ncbi Factors influencing compliance in schizophrenia patients
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    J Clin Psychiatry 64:10-3. 2003
  7. ncbi The European First Episode Schizophrenia Trial (EUFEST): rationale and design of the trial
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Schizophr Res 78:147-56. 2005
  8. ncbi Perceived functioning, well-being and psychiatric symptoms in patients with stable schizophrenia treated with long-acting risperidone for 1 year
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Br J Psychiatry 187:131-6. 2005
  9. ncbi [Extrapyramidal side-effects: avoidance, diagnosis and treatment]
    W Wolfgang Fleischhacker
    Abteilung für Biologische Psychiatrie Universitätsklinik für Psychiatrie Innsbruck, Medizinische Universitat Innsbruck
    Psychiatr Prax 32:S25-30. 2005
  10. ncbi [Problems in evaluating new antipsychotic drugs]
    W W Fleischhacker
    Abteilung für Biologische Psychiatrie, Universitätsklinik für Psychiatrie, Innsbruck
    Wien Med Wochenschr 148:266-72. 1998

Detail Information

Publications101 found, 100 shown here

  1. ncbi Comparative efficacy of antipsychotics in the treatment of schizophrenia: a critical assessment
    Rajiv Tandon
    Office of Mental Health, Department of Children and Families, State of Florida, 1317 Winewood Boulevard, Tallahassee, FL 32399 0700, USA
    Schizophr Res 79:145-55. 2005
    ..Dosing appears to be a critical variable in optimizing efficacy...
  2. ncbi The first-episode of schizophrenia: a challenge for treatment
    W W Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur Psychiatry 17:371s-375s. 2002
    ..The main challenge in this phase of the illness is therefore to convince patients that maintenance treatment is necessary in order to assure the best possible outcome...
  3. ncbi Treatment of schizophrenia patients: comparing new-generation antipsychotics to each other
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    Curr Opin Psychiatry 19:128-34. 2006
    ....
  4. ncbi [Pharmacotherapy for schizophrenia]
    W W Fleischhacker
    Abteilung für Biologische Psychiatrie, Medizinische Universitat Innsbruck, Anichstrasse 35, 6020 Innsbruck, Osterreich
    Nervenarzt 77:S77-97; S98. 2006
    ..This review is meant to serve as a guide for clinicians involved in managing schizophrenia, whether in a psychiatric hospital setting or as family physicians in private practice...
  5. ncbi Treatment of schizophrenia with long-acting injectable risperidone: a 12-month open-label trial of the first long-acting second-generation antipsychotic
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck, Austria
    J Clin Psychiatry 64:1250-7. 2003
    ..The long-term safety and efficacy of long-acting injectable risperidone, the first long-acting second-generation antipsychotic, were evaluated in stable patients with schizophrenia...
  6. ncbi Factors influencing compliance in schizophrenia patients
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    J Clin Psychiatry 64:10-3. 2003
    ....
  7. ncbi The European First Episode Schizophrenia Trial (EUFEST): rationale and design of the trial
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Schizophr Res 78:147-56. 2005
    ..These and other facts have stimulated discussions regarding the effectiveness of the new generation of antipsychotics...
  8. ncbi Perceived functioning, well-being and psychiatric symptoms in patients with stable schizophrenia treated with long-acting risperidone for 1 year
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Br J Psychiatry 187:131-6. 2005
    ..The extent to which antipsychotics improve patients' well-being is uncertain...
  9. ncbi [Extrapyramidal side-effects: avoidance, diagnosis and treatment]
    W Wolfgang Fleischhacker
    Abteilung für Biologische Psychiatrie Universitätsklinik für Psychiatrie Innsbruck, Medizinische Universitat Innsbruck
    Psychiatr Prax 32:S25-30. 2005
    ..Nevertheless, there are some conflicting results on this topic. This article discusses some of these results and sheds light on methodological problems in the evaluation of side-effects of antipsychotic treatment...
  10. ncbi [Problems in evaluating new antipsychotic drugs]
    W W Fleischhacker
    Abteilung für Biologische Psychiatrie, Universitätsklinik für Psychiatrie, Innsbruck
    Wien Med Wochenschr 148:266-72. 1998
    ..Clinical psychiatrists also face the challenge to modify some of the traditional treatment approaches. These prerequisites will allow the embedding of novel antipsychotics into modern integrative treatment concepts of schizophrenia...
  11. ncbi Feasibility of placebo-controlled clinical trials of antipsychotic compounds in Europe
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck, Austria
    Psychopharmacology (Berl) 162:82-4. 2002
    ..Most recent phase II and phase III PCTs of antipsychotics in schizophrenia have been conducted outside Europe. This development needs to be better understood...
  12. ncbi Drug treatment of schizophrenia in the 1990s. Achievements and future possibilities in optimising outcomes
    W W Fleischhacker
    Innsbruck University Clinics, Department of Biological Psychiatry, Austria
    Drugs 53:915-29. 1997
    ..Long term maintenance therapy is crucial and continuous monitoring for the development of adverse effects essential...
  13. ncbi Placebo or active control trials of antipsychotic drugs?
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Austria
    Arch Gen Psychiatry 60:458-64. 2003
    ..Sample size requirements for various equivalence margins in noninferiority trials are provided. Scientific and ethical arguments should lead to a more frequent use of the active-control noninferiority trial design...
  14. ncbi Subjective response and attitudes toward antipsychotic drug therapy during the initial treatment period: a prospective follow-up study in patients with schizophrenia
    A Hofer
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    Acta Psychiatr Scand 116:354-61. 2007
    ....
  15. ncbi Sexual disturbances during clozapine and haloperidol treatment for schizophrenia
    M Hummer
    Department of Biological Psychiatry, Innsbruck University Clinics, Austria
    Am J Psychiatry 156:631-3. 1999
    ..The aim of this study was to evaluate the frequency and course of sexual disturbances associated with clozapine and haloperidol and their potential influence on compliance with medication regimens in patients with schizophrenia...
  16. ncbi Clozapine: a comparison with other novel antipsychotics
    W W Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Austria
    J Clin Psychiatry 60:30-4. 1999
    ....
  17. ncbi Quality of life measurement in oncology--a matter of the assessment instrument?
    B Holzner
    Department of Biological Psychiatry, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur J Cancer 37:2349-56. 2001
    ..The results of the QoL investigations should not be interpreted independently of the instrument used and an interpretation of results must be based on the contents of items of the respective questionnaires...
  18. doi Symptomatic remission and neurocognitive functioning in patients with schizophrenia
    A Hofer
    Medical University Innsbruck, Department of Psychiatry and Psychotherapy, Biological Psychiatry Division, Innsbruck, Austria
    Psychol Med 41:2131-9. 2011
    ....
  19. doi Effects of six second generation antipsychotics on body weight and metabolism - risk assessment and results from a prospective study
    A Tschoner
    Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria
    Pharmacopsychiatry 42:29-34. 2009
    ..Due to the association of second generation antipsychotics (SGAs) with weight gain and alterations of glucose and lipid homeostasis, we aimed to group six commonly prescribed SGAs into classes of differing risks...
  20. ncbi Outcomes in schizophrenia outpatients treated with amisulpride or olanzapine
    A Hofer
    Department of Biological Psychiatry, Innsbruck Medical University, Austria
    Pharmacopsychiatry 40:1-8. 2007
    ..We compared stable patients with schizophrenia who were treated with either amisulpride or olanzapine in terms of symptomatic outcome, neurocognitive functioning, functionality, and subjective outcome...
  21. doi Neutropenia induced by second generation antipsychotics: a prospective investigation
    M A Rettenbacher
    Medical University Innsbruck, Department of Psychiatry, Innsbruck, Austria
    Pharmacopsychiatry 43:41-4. 2010
    ..We prospectively investigated schizophrenia patients treated with second generation antipsychotics with respect to alterations of white blood cell counts...
  22. ncbi Association of olanzapine-induced weight gain with an increase in body fat
    U Eder
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    Am J Psychiatry 158:1719-22. 2001
    ..The goal of this study was to explore the pathophysiology of weight gain during treatment with olanzapine for schizophrenia...
  23. ncbi Brain activation pattern during a verbal fluency test in healthy male and female volunteers: a functional magnetic resonance imaging study
    E M Weiss
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    Neurosci Lett 352:191-4. 2003
    ..Our data argue against genuine between-sex differences in cerebral activation patterns during lexical verbal fluency activities when confounding factors like performance differences are excluded...
  24. ncbi Selection bias in clinical trials with antipsychotics
    A Hofer
    Department of Biological Psychiatry, University Clinics Innsbruck, Austria
    J Clin Psychopharmacol 20:699-702. 2000
    ..A history of noncompliance with previous treatment and the refusal of consent were the most common reasons for not including theoretically eligible patients in a clinical trial...
  25. ncbi Metabolic side effects of antipsychotic medication
    A Tschoner
    Clinical Division of General Internal Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria
    Int J Clin Pract 61:1356-70. 2007
    ..However, further trials are required to support a specific therapeutical approach as well as studies to investigate the underlying mechanisms for future drug development...
  26. ncbi The clinical implications of weight gain in schizophrenia
    I Kurzthaler
    Department of Biological Psychiatry, Innsbruck University Clinics, Austria
    J Clin Psychiatry 62:32-7. 2001
    ..Physicians must be aware of the problem of weight gain associated with schizophrenia and choose antipsychotic medication carefully, especially in patients at high risk for weight gain...
  27. ncbi Cognitive impairment in schizophrenia: clinical ratings are not a suitable alternative to neuropsychological testing
    Alex Hofer
    Medical University Innsbruck, Department of Biological Psychiatry, Anichstrasse 35, A 6020 Innsbruck, Austria
    Schizophr Res 92:126-31. 2007
    ..These data clearly show that clinical assessment of cognitive deficits by the PANSS is not a viable alternative to neuropsychological testing to obtain information about cognitive functioning in schizophrenia...
  28. doi A double-blind, randomized comparative study of aripiprazole and olanzapine in patients with schizophrenia
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University of Innsbruck, Austria
    Biol Psychiatry 65:510-7. 2009
    ..Few studies have directly compared the efficacy and tolerability of atypical agents...
  29. doi Low bone mineral density and impaired bone metabolism in young alcoholic patients without liver cirrhosis: a cross-sectional study
    Peter Malik
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, Innsbruck, Austria
    Alcohol Clin Exp Res 33:375-81. 2009
    ..Ethanol's direct effect on bone-modeling cells as well as alcoholism-related "life-style factors" such as malnutrition, lack of exercise, hormonal changes, and liver cirrhosis are discussed as potential causative factors...
  30. ncbi Quality of life in breast cancer patients--not enough attention for long-term survivors?
    B Holzner
    Department of Biological Psychiatry, Innsbruck University Hospital, Austria
    Psychosomatics 42:117-23. 2001
    ..The findings imply that besides recovering from the acute consequences of cancer therapy, long-term survivors of breast cancer (> 5 years after initial treatment) still may have a special need for psycho-oncological support...
  31. ncbi Risk factors for the development of neuroleptic induced akathisia
    C H Miller
    Department of Biological Psychiatry, Innsbruck University Clinics, Austria
    Eur Neuropsychopharmacol 7:51-5. 1997
    ..75% of all NIA cases occurred within the first three days of antipsychotic treatment. When attempting to determine risk factors for the development of NIA, we found a significant influence of dose increase in the first days of treatment...
  32. doi Factors influencing the choice of new generation antipsychotic medication in the treatment of patients with schizophrenia
    Monika Edlinger
    University Clinic of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University Innsbruck, Innsbruck, Austria
    Schizophr Res 113:246-51. 2009
    ..This prospective, naturalistic study investigated the factors influencing physicians' choice of antipsychotic drug therapy in the treatment of patients with schizophrenia...
  33. ncbi A qualitative assessment of the neurological safety of antipsychotic drugs; an analysis of a risperidone database
    W W Fleischhacker
    Dept of Biological Psychiatry, Innsbruck University Clinics, Austria
    Pharmacopsychiatry 34:104-10. 2001
    ..To provide more definitive answers, EPS assessments in future studies should be refined to more accurately predict the type of EPS expected with a given agent in clinical practice...
  34. ncbi Time after bone marrow transplantation as an important variable for quality of life: results of a cross-sectional investigation using two different instruments for quality-of-life assessment
    M Kopp
    Department of Psychiatry, University Hospital Innsbruck, Austria
    Ann Hematol 77:27-32. 1998
    ..Patients should be informed about potential deficits in physical and emotional well-being within the first year after BMT. This could enhance insight and compliance in the critical period early after BMT...
  35. ncbi Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment
    J Marksteiner
    Department of Psychiatry, University of Innsbruck, A 6020, Innsbruck, Austria
    Neuroscience 104:325-33. 2001
    ..From these results we suggest that phencyclidine may induce synaptic alterations in specific brain areas and may contribute to a better understanding of synaptic dysfunction which may also occur in schizophrenia...
  36. ncbi EORTC QLQ-C30 and FACT-BMT for the measurement of quality of life in bone marrow transplant recipients: a comparison
    M Kopp
    Department of General Psychiatry, Innsbruck University Hospital, Austria
    Eur J Haematol 65:97-103. 2000
    ..We therefore conclude that neither of the two instruments can be replaced by the other in the assessment of QOL of BMT patients and that a direct comparison of results obtained with the two instruments is likely to be misleading...
  37. ncbi Intravenous versus oral administration of amitriptyline in patients with major depression
    E A Deisenhammer
    Department of General Psychiatry, University of Innsbruck, Austria
    J Clin Psychopharmacol 20:417-22. 2000
    ..The results of this study do not clearly favor one of the tested options. The main differences found in this study seem to be dose-related rather than differentiating between oral and intravenous routes of administration...
  38. ncbi Patient outcomes in schizophrenia I: correlates with sociodemographic variables, psychopathology, and side effects
    Alex Hofer
    Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur Psychiatry 20:386-94. 2005
    ..The present cross-sectional study examined the relationships of psychopathology, side effects, and sociodemographic factors with treatment outcomes in terms of patients' quality of life (QOL), functioning, and needs for care...
  39. ncbi Alcohol and benzodiazepines in falls: an epidemiological view
    Ilsemarie Kurzthaler
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Drug Alcohol Depend 79:225-30. 2005
    ..5%; females=2.4%). In addition, this study shows that alcohol plays a more important role in patients up to 70 years in fall-related accidents when compared to accidents of other causes...
  40. ncbi Various bilateral olfactory deficits in male patients with schizophrenia
    Claudia I Rupp
    Department of General Psychiatry, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Schizophr Bull 31:155-65. 2005
    ..Olfactory dysfunctions were found across both nostrils. Results suggest specific dysfunctions in olfactory processing in schizophrenia patients, including early stages of the odor identification process...
  41. ncbi QTc variability in schizophrenia patients treated with antipsychotics and healthy controls
    Maria A Rettenbacher
    Department of Biological Psychiatry, Innsbruck University Hospital, A 6020 Innsbruck, Austria
    J Clin Psychopharmacol 25:206-10. 2005
    ....
  42. ncbi The effect of nabilone on neuropsychological functions related to driving ability: an extended case series
    Ilsemarie Kurzthaler
    Department of Biological Psychiatry, Innsbruck University Clinics, Austria
    Hum Psychopharmacol 20:291-3. 2005
    ..No indication was found of a deterioration of any of the five investigated neuropsychological functions during the 4-week treatment period with nabilone...
  43. ncbi Patient outcomes in schizophrenia II: the impact of cognition
    Alex Hofer
    Department of Biological Psychiatry, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur Psychiatry 20:395-402. 2005
    ..Associations have been found between the severity of cognitive deficits and social dysfunction, impairments in independent living, occupational limitations, and disturbances in quality of life (QOL)...
  44. ncbi Correlates of subjective and functional outcomes in outpatient clinic attendees with schizophrenia and schizoaffective disorder
    Alex Hofer
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur Arch Psychiatry Clin Neurosci 256:246-55. 2006
    ..Our observations suggest that subjective and functional outcomes in highly compliant patients are mainly predicted by psychopathological symptoms and unchangeable sociodemographic variables...
  45. ncbi Alcohol and/or benzodiazepine use: different accidents--different impacts?
    Ilsemarie Kurzthaler
    Department of Biological Psychiatry, Medical University Innsbruck, Austria
    Hum Psychopharmacol 20:583-9. 2005
    ..This study adds evidence to the existing literature about the co-occurance of alcohol and/or benzodiazepine consumption and accident-related injuries...
  46. ncbi Dropout rates in placebo-controlled and active-control clinical trials of antipsychotic drugs: a meta-analysis
    Georg Kemmler
    Department of General Psychiatry, Innsbruck University Clinics, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Gen Psychiatry 62:1305-12. 2005
    ..Dropout rates in randomized clinical trials of antipsychotic drugs have consistently been reported to be high, and the use of a placebo-controlled design is hypothesized to be one of the reasons for this...
  47. ncbi Language lateralization in unmedicated patients during an acute episode of schizophrenia: a functional MRI study
    Elisabeth M Weiss
    Department of General Psychiatry, Anichstrasse 35, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Psychiatry Res 146:185-90. 2006
    ..These results suggest that decreased language lateralization is also evident in unmedicated patients experiencing an acute episode of schizophrenia...
  48. doi Attitudes of patients with schizophrenia and depression towards psychiatric research
    Monika Edlinger
    Medical University Innsbruck, Department of Psychiatry and Psychotherapy, University Clinic of Biological Psychiatry, Anichstrasse 35, A 6020 Innsbruck, Austria
    Psychiatry Res 177:172-6. 2010
    ..Our findings confirm and extend those of other groups. This should encourage psychiatrists at least in academic settings where most of this research has been done to approach patients to take part in clinical research...
  49. ncbi Neural substrates for episodic encoding and recognition of unfamiliar faces
    Alex Hofer
    Medical University Innsbruck, Department of Biological Psychiatry, Anichstrasse 35, A 6020 Innsbruck, Austria
    Brain Cogn 63:174-81. 2007
    ..These results support the view that the successful episodic retrieval of newly learned faces is based on a dorsal visual stream mechanism...
  50. ncbi Brain activation patterns during a selective attention test--a functional MRI study in healthy volunteers and unmedicated patients during an acute episode of schizophrenia
    Elisabeth M Weiss
    Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Psychiatry Res 154:31-40. 2007
    ..Treatment with second generation antipsychotics may improve executive performance in patients with schizophrenia and facilitate a normalization of functional hypofrontality after symptomatic improvement...
  51. ncbi Gender differences in regional cerebral activity during the perception of emotion: a functional MRI study
    Alex Hofer
    Medical University Innsbruck, Department of Biological Psychiatry, Anichstrasse 35, A 6020 Innsbruck, Austria
    Neuroimage 32:854-62. 2006
    ..Our findings suggest gender-related neural responses to emotional stimuli and could contribute to the understanding of mechanisms underlying gender-related vulnerability of the prevalence and severity of neuropsychiatric disorders...
  52. ncbi Association between antipsychotic-induced elevation of liver enzymes and weight gain: a prospective study
    Maria A Rettenbacher
    Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria
    J Clin Psychopharmacol 26:500-3. 2006
    ..We conclude that antipsychotic-induced elevation of liver enzymes is mostly transient and could be associated with weight gain...
  53. ncbi Early changes of plasma lipids during treatment with atypical antipsychotics
    Maria A Rettenbacher
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    Int Clin Psychopharmacol 21:369-72. 2006
    ..These results are important with regard to the increased risk for cardiovascular complications in patients with schizophrenia...
  54. ncbi Olfactory functioning in patients with alcohol dependence: impairments in odor judgements
    Claudia I Rupp
    Medical University Innsbruck, Department of Psychiatry, Anichstrasse 35, 6020 Innsbruck, Austria
    Alcohol Alcohol 39:514-9. 2004
    ..However, olfactory functioning with regard to the immediate, perception driven odor associations is unknown. Therefore, this study assessed olfactory judgements in nonamnesic and nondemented patients with alcohol dependence...
  55. ncbi Clock drawing, clock reading, clock setting, and judgment of clock faces in elderly people with dementia and depression
    Thomas Bodner
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    J Am Geriatr Soc 52:1146-50. 2004
    ..To assess patient performance on different clock tasks...
  56. ncbi Attitudes of patients with schizophrenia toward placebo-controlled clinical trials
    Martina Hummer
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    J Clin Psychiatry 64:277-81. 2003
    ..Although much is known about the opinions of professionals concerning this issue, so far nothing is known about the opinions of patients who are most affected by the realization of placebo-controlled clinical trials...
  57. ncbi An FMRI study of episodic encoding and recognition of words in patients with schizophrenia in remission
    Alex Hofer
    Department of Biological Psychiatry and Radiology, Innsbruck University Clinics, Anichstrasse 35, A 6020 Innsbruck, Austria
    Am J Psychiatry 160:911-8. 2003
    ..Verbal memory deficits are among the most severe cognitive deficits observed in patients with schizophrenia. This study examined patterns of brain activity during episodic encoding and recognition of words in patients with schizophrenia...
  58. ncbi Normative data for functional assessment of cancer therapy--general scale and its use for the interpretation of quality of life scores in cancer survivors
    Bernhard Holzner
    Department of Biological Psychiatry, Innsbruck University Hospital, Innsbruck, Austria
    Acta Oncol 43:153-60. 2004
    ..Furthermore, unless patient data are compared with normative values, phenomena such as adaptation and response shift might be missed or misinterpreted...
  59. ncbi Schizophrenia: attitudes of patients and professional carers towards the illness and antipsychotic medication
    Maria A Rettenbacher
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    Pharmacopsychiatry 37:103-9. 2004
    ....
  60. ncbi Olanzapine induces insulin resistance: results from a prospective study
    Christoph F Ebenbichler
    Department of Medicine, University of Innsbruck, Innsbruck, Austria
    J Clin Psychiatry 64:1436-9. 2003
    ..The aim of this study was to compare glucose metabolism in patients with schizophrenia receiving olanzapine with that in control subjects...
  61. ncbi Brain activation patterns during a selective attention test-a functional MRI study in healthy volunteers and patients with schizophrenia
    Elisabeth M Weiss
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, A 6020 Innsbruck, Austria
    Psychiatry Res 123:1-15. 2003
    ....
  62. ncbi No evidence for an association between serum cholesterol and the course of depression and suicidality
    Eberhard A Deisenhammer
    Department of General Psychiatry, Innsbruck University Hospital, Anichstrasse 35, A 6020, Innsbruck, Austria
    Psychiatry Res 121:253-61. 2004
    ..Cholesterol levels do not appear to be an appropriate biological marker for suicidality during the first 4 weeks of treatment in patients with a major depressive episode...
  63. ncbi Alcohol and/or benzodiazepine use in injured road users
    Ilsemarie Kurzthaler
    Innsbruck University Clinics, Department of Biological Psychiatry, Innsbruck, Austria
    Hum Psychopharmacol 18:361-7. 2003
    ..Concerning alcohol or benzodiazepine use, females showed lower frequencies of both alcohol and benzodiazepine positive blood samples. The frequency of alcohol use was higher in patients <or= 60 years of age...
  64. ncbi Reduced olfactory sensitivity, discrimination, and identification in patients with alcohol dependence
    Claudia I Rupp
    University Clinics of Innsbruck, Department of General Psychiatry, Anichstrasse 35, 6020 Innsbruck, Austria
    Alcohol Clin Exp Res 27:432-9. 2003
    ..Various olfactory deficits have been reported in the alcohol-induced amnestic syndrome (Korsakoff's syndrome). Less is known about olfactory functioning in nonamnesic and nondemented alcoholic patients...
  65. ncbi Fatigue in ovarian carcinoma patients: a neglected issue?
    Bernhard Holzner
    Department of Biological Psychiatry, Innsbruck University Hospital, Innsbruck, Austria
    Cancer 97:1564-72. 2003
    ..The main focus of the current study was to assess fatigue in these patients and to investigate the impact of fatigue and other clinical and psychosocial variables on their quality of life (QOL)...
  66. ncbi Neural correlates of episodic encoding and recognition of words in unmedicated patients during an acute episode of schizophrenia: a functional MRI study
    Alex Hofer
    Department of Biological Psychiatry, Innsbruck University Clinics, Austria
    Am J Psychiatry 160:1802-8. 2003
    ..The same procedure was used in this study to investigate unmedicated patients during an acute episode of schizophrenia...
  67. ncbi Olfactory functions and volumetric measures of orbitofrontal and limbic regions in schizophrenia
    Claudia I Rupp
    Department of Psychiatry, Medical University Innsbruck, Austria
    Schizophr Res 74:149-61. 2005
    ..In this study, we examined the relationship between different olfactory functions and volumes of the hippocampus-amygdala complex (HAC) and the orbitofrontal brain region using magnetic resonance imaging (MRI)...
  68. ncbi Executive function and memory in relation to olfactory deficits in alcohol-dependent patients
    Claudia I Rupp
    Department of Psychiatry, Innsbruck Medical University, Innsbruck, Austria
    Alcohol Clin Exp Res 30:1355-62. 2006
    ....
  69. ncbi Osteoporosis in patients with schizophrenia
    Martina Hummer
    Department of Biological Psychiatry, Innsbruck University Hospital, Austria
    Am J Psychiatry 162:162-7. 2005
    ..The authors' goals were to investigate the association between schizophrenia and a decrease in bone mineral density and to get more insight into potential underlying pathophysiological mechanisms...
  70. ncbi [The role of alcohol and/or benzodiazepines in occupational accidents compared to accidents due to other causes]
    Ilsemarie Kurzthaler
    Abteilung für Biologische Psychiatrie, Universitätsklinik für Psychiatrie, Innsbruck, Osterreich
    Wien Med Wochenschr 154:482-8. 2004
    ..76 +/- 0.58 g/l) compared to other injuries (1.63 g/l +/- 0.74 g/l). No correlations were found concerning benzodiazepine use and demographic variables and all measured benzodiazepine plasma levels were within the therapeutic range...
  71. ncbi The safety of clozapine in the treatment of first- and multiple-episode patients with treatment-resistant schizophrenia
    Alex Hofer
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    Int J Neuropsychopharmacol 6:201-6. 2003
    ..With regard to side-effects, we could not find any significant difference between groups. Altogether, response and side-effects to clozapine treatment do not seem to be determined by the chronicity of the disorder...
  72. ncbi The effects of second-generation antipsychotics on cognitive functioning and psychosocial outcome in schizophrenia
    Elisabeth M Weiss
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck University Clinics, Anichtrasse 35, 6020 Innsbruck, Austria
    Psychopharmacology (Berl) 162:11-7. 2002
    ..In this context it also addresses several methodological and conceptional issues that limited the comparison of these studies...
  73. ncbi Brain activation patterns during a verbal fluency test-a functional MRI study in healthy volunteers and patients with schizophrenia
    Elisabeth M Weiss
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck, Austria
    Schizophr Res 70:287-91. 2004
    ..These data indicate that high-functioning schizophrenia patients show a reduced language lateralization of the frontal cortex compared to healthy controls...
  74. ncbi Quality of life in schizophrenia: the impact of psychopathology, attitude toward medication, and side effects
    Alex Hofer
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    J Clin Psychiatry 65:932-9. 2004
    ..Factors deemed relevant in this context include severity of symptoms, antipsychotic-induced side effects, sociodemographic variables, and patients' subjective response to medication...
  75. ncbi [Pathophysiology of schizophrenia and its impact on pharmacotherapy]
    C G Widschwendter
    Abteilung für Biologische Psychiatrie, Universitätsklinik für Psychiatrie, Medizinische Universität Innsbruck Osterreich
    Fortschr Neurol Psychiatr 73:S32-7. 2005
    ..This article reviews the pathophysiological background of the disorder, its implications for pharmacological treatment and possible directions for future research...
  76. ncbi Treatment of severe clozapine-induced neutropenia with granulocyte colony-stimulating factor (G-CSF). Remission despite continuous treatment with clozapine
    B Sperner-Unterweger
    Innsbruck University Clinics, Department of Biological Psychiatry, Austria
    Br J Psychiatry 172:82-4. 1998
    ..Discontinuation of clozapine led to an acute psychotic relapse. During clozapine treatment the patient developed severe neutropenia...
  77. ncbi Comorbid somatic illnesses in patients with severe mental disorders: clinical, policy, and research challenges
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    J Clin Psychiatry 69:514-9. 2008
    ....
  78. ncbi Olanzapine-induced weight gain and disturbances of lipid and glucose metabolism
    Ursula eder-Ischia
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    Essent Psychopharmacol 6:112-7. 2005
    ..Clinicians should take these risks seriously in prescribing these antipsychotics and employ intelligent safeguards if and when they use them...
  79. ncbi Aripiprazole
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Austria
    Expert Opin Pharmacother 6:2091-101. 2005
    ..Further studies in other indications and clinical trials that confirm results from the Phase II and III clinical development programme are eagerly awaited...
  80. ncbi Olanzapine impairs glycogen synthesis and insulin signaling in L6 skeletal muscle cells
    J Engl
    Clinical Department of Internal Medicine, Clinical Division of General Internal Medicine, Innsbruck, Austria
    Mol Psychiatry 10:1089-96. 2005
    ..We conclude that olanzapine impairs glycogen synthesis via inhibition of the classical insulin-signaling cascade and that this inhibitory effect may lead to the induction of insulin resistance in olanzapine-treated patients...
  81. ncbi Differential diagnosis of depressed mood in patients with schizophrenia: a diagnostic algorithm based on a review
    A Hausmann
    Department of General Psychiatry, Innsbruck University Hospital, Innsbruck, Austria
    Acta Psychiatr Scand 106:83-96. 2002
    ..To review the available literature on depressive symptomatology in schizophrenia in order to establish a diagnostic algorithm of depressive syndromes in schizophrenia...
  82. ncbi Trends in the pharmacological treatment of patients with schizophrenia over a 12 year observation period
    Monika Edlinger
    Department of Biological Psychiatry, Medical University Innsbruck Anichstrasse 35 A 6020, Austria
    Schizophr Res 77:25-34. 2005
    ..All in all, the pharmacological management of schizophrenia patients is increasingly in tune with current treatment guidelines...
  83. doi Antipsychotics in the early stage of development
    Falko Biedermann
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Tyrol, Austria
    Curr Opin Psychiatry 22:326-30. 2009
    ....
  84. ncbi Experimental antipsychotics and metabolic adverse effects--findings from clinical trials
    Alexander Tschoner
    Department of Internal Medicine I, Medical University Innsbruck, Center of Internal Medicine, 6020 Innsbruck, Austria
    Curr Opin Investig Drugs 10:1041-8. 2009
    ..This review discusses some of the most recently developed antipsychotic compounds that have undergone clinical assessment from the perspective of their metabolic impact...
  85. doi Second-generation antipsychotic long-acting injections: systematic review
    W Wolfgang Fleischhacker
    Medical University Innsbruck, Department of Psychiatry and Psychotherapy, Anichstrasse 35, A 6020 Innsbruck, Austria
    Br J Psychiatry Suppl 52:S29-36. 2009
    ..Second-generation antipsychotics (SGAs) represent an advance in the long-term management of schizophrenia...
  86. ncbi Off-label use of antipsychotic drugs
    E Weiss
    Department of Biological Psychiatry, University of Innsbruck, Austria
    J Clin Psychopharmacol 20:695-8. 2000
    ..In classical indications, clozapine was used more frequently (50%) than other antipsychotics. Melperone was primarily prescribed for off-label use...
  87. ncbi Sex differences in brain activation pattern during a visuospatial cognitive task: a functional magnetic resonance imaging study in healthy volunteers
    E Weiss
    Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria
    Neurosci Lett 344:169-72. 2003
    ..Our results point to gender specific differences in the neuropsychological processes involved in mental rotation tasks...
  88. ncbi The impact of hemoglobin levels on fatigue and quality of life in cancer patients
    B Holzner
    Department of Biological Psychiatry, Innsbruck University Hospital, Austria
    Ann Oncol 13:965-73. 2002
    ..The objective of the present study was to investigate the relationship between hemoglobin (Hb) levels and the subjective experience of fatigue and quality of life in cancer patients with mild or no anemia undergoing chemotherapy...
  89. ncbi Switching between second-generation antipsychotics: why and how?
    Monika Edlinger
    Department of Biological Psychiatry, Innsbruck Medical University, Innsbruck, A 6020, Austria
    CNS Drugs 19:27-42. 2005
    ..We review the available evidence concerning techniques, problems and consequences when switching from one second-generation antipsychotic agent to another and discuss potential difficulties...
  90. doi Tolerability of antipsychotics: recent controversies and future management
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University of Innsbruck, Austria
    J Clin Psychiatry 70:e06. 2009
    ....
  91. ncbi Attitudes toward antipsychotics among outpatient clinic attendees with schizophrenia
    Alex Hofer
    Department of Biologic Psychiatry, University Clinics Innsbruck, Austria
    J Clin Psychiatry 63:49-53. 2002
    ..A cross-sectional study was conducted in patients with schizophrenia who regularly attended an outpatient clinic to examine the impact of psychopathology, side effects, and sociodemographic factors on attitudes toward antipsychotics...
  92. ncbi Improvement of cognitive dysfunction after treatment with second-generation antipsychotics
    Elisabeth Weiss
    Arch Gen Psychiatry 59:572-3; author reply 573-5. 2002
  93. ncbi The soluble leptin receptor in olanzapine-induced weight gain: results from a prospective study
    Christoph Ebenbichler
    Schizophr Res 75:143-6. 2005
  94. ncbi Worsening of psychosis after replacement of adjunctive valproate with topiramate in a schizophrenia patient
    Alex Hofer
    J Clin Psychiatry 64:1267-8. 2003
  95. ncbi Treatment of antipsychotic-associated hyperglycemia with pioglitazone: a case series
    Monika Edlinger
    J Clin Psychopharmacol 27:403-4. 2007
  96. ncbi Transient hyperproinsulinemia during treatment with clozapine and amisulpride
    Maria A Rettenbacher
    J Clin Psychiatry 65:878-9. 2004
  97. ncbi Longitudinal volumetric MRI study in first- and multiple-episode male schizophrenia patients
    Alexandra B Whitworth
    Psychiatry Res 140:225-37. 2005
    ..Our results do not support the hypothesis that schizophrenia leads to progressive volume reduction in these areas, although there may be a subset of patients with morphologically visible disease progression...
  98. ncbi Attitudes towards medication in patients with schizophrenia
    Alex Hofer
    Acta Psychiatr Scand 113:161-2. 2006
  99. ncbi Second-generation antipsychotics: discrepancies between licensed indications, evidence base and actual use
    W Wolfgang Fleischhacker
    Psychopharmacology (Berl) 169:207-10. 2003
  100. doi Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial
    Rene S Kahn
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet 371:1085-97. 2008
    ..We aimed to compare the effectiveness of second-generation antipsychotic drugs with that of a low dose of haloperidol, in first-episode schizophrenia...
  101. ncbi Second generation antipsychotics
    W Wolfgang Fleischhacker
    Psychopharmacology (Berl) 162:90-1. 2002