Research Topics
Genomes and Genes
| Frank EisenhaberSummaryAffiliation: University of Vienna Country: Austria Publications
| Collaborators
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Detail Information
Publications
TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1Hartmut C Vodermaier
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
Curr Biol 13:1459-68. 2003..The APC is a ubiquitin ligase composed of at least 11 subunits. The interaction of APC2 and APC11 with E2 enzymes is sufficient for ubiquitination reactions, but the functions of most other subunits are unknown...- Prediction of sequence signals for lipid post-translational modifications: insights from case studiesBirgit Eisenhaber
Research Institute of Molecular Pathology, Vienna, Republic of Austria
Proteomics 4:1614-25. 2004..Finally, we discuss the usage of evolutionary information in evaluating the functional importance of predicted PTMs in cases of motif conservation within sequence families... 
Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1Frank Eisenhaber
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Republic of Austria
Nucleic Acids Res 31:3631-4. 2003..Guidelines for application of the three WWW-based predictors (http://mendel.imp.univie.ac.at/) and for the interpretation of their output are described...- Refinement and prediction of protein prenylation motifsSebastian Maurer-Stroh
IMP Research Institute of Molecular Pathology, Dr, Bohr Gasse 7, A 1030 Vienna, Austria
Genome Biol 6:R55. 2005..PrePS can predict partially overlapping substrate specificities, which is of medical importance in the case of understanding cellular action of FT inhibitors as anticancer and anti-parasite agents... - Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) familyMaria Novatchkova
Gregor Mendel Institut GMI, Austrian Academy of Sciences, Vienna Biocenter, A 1030 Vienna, Austria
BMC Bioinformatics 6:22. 2005..Recent findings point at the importance of SUMO-mediated histone NAD-dependent deacetylase (HDAC) recruitment in transcriptional regulation... - N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequenceSebastian Maurer-Stroh
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, A 1030, Austria
J Mol Biol 317:541-57. 2002..Analyses of complete eukaryote genomes indicate that about 0.5 % of all encoded proteins are apparent NMT substrates except for a higher fraction in Arabidopsis thaliana ( approximately 0.8 %)... - The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substratesClaudine Kraft
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Mol Cell 18:543-53. 2005..Our data imply that APC/C is activated by the association of Cdh1 with Cdc27, which enables APC/C to recognize the D box of substrates via Cdh1's propeller domain... - Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequenceGeorg Neuberger
Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
J Mol Biol 328:581-92. 2003..The predicted presence of a PTS1 signal implies peroxisomal localisation in the absence of N-terminal targeting sequences such as the mitochondrial import signal... - A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombeBirgit Eisenhaber
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
J Mol Biol 337:243-53. 2004..Lists of potentially GPI lipid anchored proteins for five fungal proteomes have been generated and the hits have been functionally classified. The fungal big-Pi prediction WWW server as well as precursor lists are available at.. - Towards complete sets of farnesylated and geranylgeranylated proteinsSebastian Maurer-Stroh
Research Institute of Molecular Pathology, Vienna, Austria
PLoS Comput Biol 3:e66. 2007..Experimental evidence is presented for the selective farnesylation of targets with an evolutionary conserved modification site... - Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteinsBirgit Eisenhaber
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Republic Austria
Bioessays 25:367-85. 2003..This structural proposal would explain the paradoxical properties of the GPI lipid anchor signal motif and of PIG-K/GPI8 orthologs without membrane insertion regions in some species... - Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noiseNedim Mujezinovic
Research Institute of Molecular Pathology, Vienna, Austria
Proteomics 6:5117-31. 2006..The approach is based on numerical spectral analysis and signal detection methods. The algorithm has been implemented in a stand-alone computer program called MS Cleaner that can be obtained from the authors upon request... - N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differencesSebastian Maurer-Stroh
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, A 1030, Austria
J Mol Biol 317:523-40. 2002..An exhaustive search for NMT-homologues led to the discovery of two putative entomopoxviral NMTs... - Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differencesGeorg Neuberger
Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
J Mol Biol 328:567-79. 2003..Specificity differences are confined to taxonomic subgroups (metazoa and fungi) and are connected with amino acid type preferences in region 1 and deviating hydrophobicity patterns in region 2... - Kleisins: a superfamily of bacterial and eukaryotic SMC protein partnersAlexander Schleiffer
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
Mol Cell 11:571-5. 2003..Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure. Since these are the only domains conserved among kleisins, we suggest that ring formation with SMC proteins may define this family... - Application of a sensitive collection heuristic for very large protein families: evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipasesGeorg Schneider
IMP Research Institute of Molecular Pathology, Dr, Bohr Gasse 7, A 1030 Vienna, Republic of Austria
BMC Bioinformatics 7:164. 2006..The unclear evolutionary relationship between classical mammalian lipases and the recently discovered human adipose triglyceride lipase (ATGL; a patatin family member) is an exemplary case for such a problem... - Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and IIKirsten P Rabitsch
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Curr Biol 14:287-301. 2004..Segregation during the second division depends on retention of sister chromatid cohesion between centromeres until the onset of anaphase II, which in Drosophila melanogaster depends on a protein called Mei-S332 that binds to centromeres... - Hidden localization motifs: naturally occurring peroxisomal targeting signals in non-peroxisomal proteinsGeorg Neuberger
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Genome Biol 5:R97. 2004.... - DOUTfinder--identification of distant domain outliers using subsignificant sequence similarityMaria Novatchkova
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nucleic Acids Res 34:W214-8. 2006..DOUTfinder is available at http://mendel.imp.ac.at/dout/... - Reannotation of the CELO genome characterizes a set of previously unassigned open reading frames and points to novel modes of host interaction in avian adenovirusesStefan Washietl
Research Institute of Molecular Pathology, Dr, Bohrgasse 7, A 1030 Vienna, Austria
BMC Bioinformatics 4:55. 2003..We conducted a systematic reannotation and in-depth sequence analysis of the CELO genome... - Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomesRobert Kurzbauer
Institute for Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Proc Natl Acad Sci U S A 101:10984-9. 2004..Taken together, the presented work provides insight into the spatial regulation of MAPK signaling, illustrating how p14 and MP1 collaborate as an endosomal adaptor/scaffold complex... - Protein prenyltransferases: anchor size, pseudogenes and parasitesSebastian Maurer-Stroh
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Biol Chem 384:977-89. 2003.... - Protein prenyltransferasesSebastian Maurer-Stroh
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Genome Biol 4:212. 2003..The effects of these inhibitors are complicated, however, by the overlapping substrate specificities of geranylgeranyltransferase I and farnesyltransferase... - Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivoWolfgang Benetka
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
BMC Biochem 7:6. 2006.... - Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?Birgit Eisenhaber
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Curr Protein Pept Sci 8:197-203. 2007..Surprisingly, some proteins carry sequence signals for posttranslational modification or translocation that remain hidden in the normal biological context but can become fully functional in certain conditions... - A CH domain-containing N terminus in NuMA?Maria Novatchkova
Research Institute of Molecular Pathology, A 1030 Vienna, Austria
Protein Sci 11:2281-4. 2002.... - Glycosylphosphatidylinositol lipid anchoring of plant proteins. Sensitive prediction from sequence- and genome-wide studies for Arabidopsis and riceBirgit Eisenhaber
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Plant Physiol 133:1691-701. 2003..imp.univie.ac.at/gpi/plants/gpi_plants.html. Arabidopsis and rice protein hits have been functionally classified. Several GPI lipid-anchored arabinogalactan-related proteins have been identified in rice... - The STIR-domain superfamily in signal transduction, development and immunityMaria Novatchkova
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Trends Biochem Sci 28:226-9. 2003..By analogy, we suggest that SEFIR-domain proteins function as signalling components of Toll/IL-1R-similar pathways and that their SEFIR domain mediates physical protein-protein interactions between pathway components... - Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesionDmitri Ivanov
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
Curr Biol 12:323-8. 2002..In vitro Eco1 acetylates itself and components of the cohesin complex but not histones. Thus, the establishment of cohesion between sister chromatids appears to be regulated, directly or indirectly, by a specific acetyltransferase...