Frank Eisenhaber

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1
    Hartmut C Vodermaier
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 13:1459-68. 2003
  2. ncbi request reprint Prediction of sequence signals for lipid post-translational modifications: insights from case studies
    Birgit Eisenhaber
    Research Institute of Molecular Pathology, Vienna, Republic of Austria
    Proteomics 4:1614-25. 2004
  3. pmc Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1
    Frank Eisenhaber
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Republic of Austria
    Nucleic Acids Res 31:3631-4. 2003
  4. pmc Refinement and prediction of protein prenylation motifs
    Sebastian Maurer-Stroh
    IMP Research Institute of Molecular Pathology, Dr, Bohr Gasse 7, A 1030 Vienna, Austria
    Genome Biol 6:R55. 2005
  5. pmc Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family
    Maria Novatchkova
    Gregor Mendel Institut GMI, Austrian Academy of Sciences, Vienna Biocenter, A 1030 Vienna, Austria
    BMC Bioinformatics 6:22. 2005
  6. ncbi request reprint N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, A 1030, Austria
    J Mol Biol 317:541-57. 2002
  7. ncbi request reprint The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates
    Claudine Kraft
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mol Cell 18:543-53. 2005
  8. ncbi request reprint Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence
    Georg Neuberger
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    J Mol Biol 328:581-92. 2003
  9. ncbi request reprint A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe
    Birgit Eisenhaber
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Mol Biol 337:243-53. 2004
  10. pmc Towards complete sets of farnesylated and geranylgeranylated proteins
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Vienna, Austria
    PLoS Comput Biol 3:e66. 2007

Detail Information

Publications29

  1. ncbi request reprint TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1
    Hartmut C Vodermaier
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 13:1459-68. 2003
    ..The APC is a ubiquitin ligase composed of at least 11 subunits. The interaction of APC2 and APC11 with E2 enzymes is sufficient for ubiquitination reactions, but the functions of most other subunits are unknown...
  2. ncbi request reprint Prediction of sequence signals for lipid post-translational modifications: insights from case studies
    Birgit Eisenhaber
    Research Institute of Molecular Pathology, Vienna, Republic of Austria
    Proteomics 4:1614-25. 2004
    ..Finally, we discuss the usage of evolutionary information in evaluating the functional importance of predicted PTMs in cases of motif conservation within sequence families...
  3. pmc Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1
    Frank Eisenhaber
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Republic of Austria
    Nucleic Acids Res 31:3631-4. 2003
    ..Guidelines for application of the three WWW-based predictors (http://mendel.imp.univie.ac.at/) and for the interpretation of their output are described...
  4. pmc Refinement and prediction of protein prenylation motifs
    Sebastian Maurer-Stroh
    IMP Research Institute of Molecular Pathology, Dr, Bohr Gasse 7, A 1030 Vienna, Austria
    Genome Biol 6:R55. 2005
    ..PrePS can predict partially overlapping substrate specificities, which is of medical importance in the case of understanding cellular action of FT inhibitors as anticancer and anti-parasite agents...
  5. pmc Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family
    Maria Novatchkova
    Gregor Mendel Institut GMI, Austrian Academy of Sciences, Vienna Biocenter, A 1030 Vienna, Austria
    BMC Bioinformatics 6:22. 2005
    ..Recent findings point at the importance of SUMO-mediated histone NAD-dependent deacetylase (HDAC) recruitment in transcriptional regulation...
  6. ncbi request reprint N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, A 1030, Austria
    J Mol Biol 317:541-57. 2002
    ..Analyses of complete eukaryote genomes indicate that about 0.5 % of all encoded proteins are apparent NMT substrates except for a higher fraction in Arabidopsis thaliana ( approximately 0.8 %)...
  7. ncbi request reprint The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates
    Claudine Kraft
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mol Cell 18:543-53. 2005
    ..Our data imply that APC/C is activated by the association of Cdh1 with Cdc27, which enables APC/C to recognize the D box of substrates via Cdh1's propeller domain...
  8. ncbi request reprint Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence
    Georg Neuberger
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    J Mol Biol 328:581-92. 2003
    ..The predicted presence of a PTS1 signal implies peroxisomal localisation in the absence of N-terminal targeting sequences such as the mitochondrial import signal...
  9. ncbi request reprint A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe
    Birgit Eisenhaber
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Mol Biol 337:243-53. 2004
    ..Lists of potentially GPI lipid anchored proteins for five fungal proteomes have been generated and the hits have been functionally classified. The fungal big-Pi prediction WWW server as well as precursor lists are available at..
  10. pmc Towards complete sets of farnesylated and geranylgeranylated proteins
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Vienna, Austria
    PLoS Comput Biol 3:e66. 2007
    ..Experimental evidence is presented for the selective farnesylation of targets with an evolutionary conserved modification site...
  11. ncbi request reprint Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins
    Birgit Eisenhaber
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Republic Austria
    Bioessays 25:367-85. 2003
    ..This structural proposal would explain the paradoxical properties of the GPI lipid anchor signal motif and of PIG-K/GPI8 orthologs without membrane insertion regions in some species...
  12. ncbi request reprint Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noise
    Nedim Mujezinovic
    Research Institute of Molecular Pathology, Vienna, Austria
    Proteomics 6:5117-31. 2006
    ..The approach is based on numerical spectral analysis and signal detection methods. The algorithm has been implemented in a stand-alone computer program called MS Cleaner that can be obtained from the authors upon request...
  13. ncbi request reprint N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, A 1030, Austria
    J Mol Biol 317:523-40. 2002
    ..An exhaustive search for NMT-homologues led to the discovery of two putative entomopoxviral NMTs...
  14. ncbi request reprint Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences
    Georg Neuberger
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    J Mol Biol 328:567-79. 2003
    ..Specificity differences are confined to taxonomic subgroups (metazoa and fungi) and are connected with amino acid type preferences in region 1 and deviating hydrophobicity patterns in region 2...
  15. ncbi request reprint Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners
    Alexander Schleiffer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mol Cell 11:571-5. 2003
    ..Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure. Since these are the only domains conserved among kleisins, we suggest that ring formation with SMC proteins may define this family...
  16. pmc Application of a sensitive collection heuristic for very large protein families: evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases
    Georg Schneider
    IMP Research Institute of Molecular Pathology, Dr, Bohr Gasse 7, A 1030 Vienna, Republic of Austria
    BMC Bioinformatics 7:164. 2006
    ..The unclear evolutionary relationship between classical mammalian lipases and the recently discovered human adipose triglyceride lipase (ATGL; a patatin family member) is an exemplary case for such a problem...
  17. ncbi request reprint Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II
    Kirsten P Rabitsch
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 14:287-301. 2004
    ..Segregation during the second division depends on retention of sister chromatid cohesion between centromeres until the onset of anaphase II, which in Drosophila melanogaster depends on a protein called Mei-S332 that binds to centromeres...
  18. pmc Hidden localization motifs: naturally occurring peroxisomal targeting signals in non-peroxisomal proteins
    Georg Neuberger
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Genome Biol 5:R97. 2004
    ....
  19. pmc DOUTfinder--identification of distant domain outliers using subsignificant sequence similarity
    Maria Novatchkova
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nucleic Acids Res 34:W214-8. 2006
    ..DOUTfinder is available at http://mendel.imp.ac.at/dout/...
  20. pmc Reannotation of the CELO genome characterizes a set of previously unassigned open reading frames and points to novel modes of host interaction in avian adenoviruses
    Stefan Washietl
    Research Institute of Molecular Pathology, Dr, Bohrgasse 7, A 1030 Vienna, Austria
    BMC Bioinformatics 4:55. 2003
    ..We conducted a systematic reannotation and in-depth sequence analysis of the CELO genome...
  21. pmc Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes
    Robert Kurzbauer
    Institute for Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 101:10984-9. 2004
    ..Taken together, the presented work provides insight into the spatial regulation of MAPK signaling, illustrating how p14 and MP1 collaborate as an endosomal adaptor/scaffold complex...
  22. ncbi request reprint Protein prenyltransferases: anchor size, pseudogenes and parasites
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Biol Chem 384:977-89. 2003
    ....
  23. pmc Protein prenyltransferases
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Genome Biol 4:212. 2003
    ..The effects of these inhibitors are complicated, however, by the overlapping substrate specificities of geranylgeranyltransferase I and farnesyltransferase...
  24. pmc Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo
    Wolfgang Benetka
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    BMC Biochem 7:6. 2006
    ....
  25. ncbi request reprint Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?
    Birgit Eisenhaber
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Protein Pept Sci 8:197-203. 2007
    ..Surprisingly, some proteins carry sequence signals for posttranslational modification or translocation that remain hidden in the normal biological context but can become fully functional in certain conditions...
  26. pmc A CH domain-containing N terminus in NuMA?
    Maria Novatchkova
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Protein Sci 11:2281-4. 2002
    ....
  27. pmc Glycosylphosphatidylinositol lipid anchoring of plant proteins. Sensitive prediction from sequence- and genome-wide studies for Arabidopsis and rice
    Birgit Eisenhaber
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Plant Physiol 133:1691-701. 2003
    ..imp.univie.ac.at/gpi/plants/gpi_plants.html. Arabidopsis and rice protein hits have been functionally classified. Several GPI lipid-anchored arabinogalactan-related proteins have been identified in rice...
  28. ncbi request reprint The STIR-domain superfamily in signal transduction, development and immunity
    Maria Novatchkova
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Trends Biochem Sci 28:226-9. 2003
    ..By analogy, we suggest that SEFIR-domain proteins function as signalling components of Toll/IL-1R-similar pathways and that their SEFIR domain mediates physical protein-protein interactions between pathway components...
  29. ncbi request reprint Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion
    Dmitri Ivanov
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:323-8. 2002
    ..In vitro Eco1 acetylates itself and components of the cohesin complex but not histones. Thus, the establishment of cohesion between sister chromatids appears to be regulated, directly or indirectly, by a specific acetyltransferase...