Sabine Eichinger

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden
    S Eichinger
    Department of Internal Medicine I, University Vienna, Austria
    Thromb Haemost 82:1232-6. 1999
  2. ncbi The risk of recurrent venous thromboembolism in heterozygous carriers of factor V Leiden and a first spontaneous venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, Division of Hematology and Hemostasis, University of Vienna, Waehringer Guertel 18 20, 1090 Wien, Austria
    Arch Intern Med 162:2357-60. 2002
  3. ncbi D-dimer levels and risk of recurrent venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, University of Vienna, Austria
    JAMA 290:1071-4. 2003
  4. ncbi Thrombin-activatable fibrinolysis inhibitor and the risk for recurrent venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Blood 103:3773-6. 2004
  5. ncbi Prevention of deep vein thrombosis in orthopedic surgery
    Sabine Eichinger
    Dept of Internal Medicine I, Div of Hematology and Hemostasis, Medical University of Vienna, Austria
    Eur J Med Res 9:112-8. 2004
  6. doi Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model
    Sabine Eichinger
    Department of Internal Medicine I, the Karl Landsteiner Institut für Klinische Thromboseforschung, Wien, Austria
    Circulation 121:1630-6. 2010
  7. doi ProCGlobal and endogenous thrombin potential during pregnancy
    Gregor Hron
    Division of Hematology and Hemostasis, Department of Medicine I, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Am J Obstet Gynecol 203:463.e1-6. 2010
  8. ncbi Family history for venous thromboembolism and the risk for recurrence
    Gregor Hron
    Department of Internal Medicine I, Division of Angiology, Medical University of Vienna, Vienna, Austria
    Am J Med 119:50-3. 2006
  9. ncbi Prediction of recurrent venous thromboembolism by measuring ProC Global
    Sabine Eichinger
    Dept of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Thromb Haemost 98:1232-6. 2007
  10. ncbi Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation
    Gregor Hron
    Department of Internal Medicine I, Medical University of Vienna, Austria
    JAMA 296:397-402. 2006

Collaborators

Detail Information

Publications46

  1. ncbi Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden
    S Eichinger
    Department of Internal Medicine I, University Vienna, Austria
    Thromb Haemost 82:1232-6. 1999
    ..Higher levels of D-Dimer in women with FVL than in women with wildtype factor V at baseline as well as during pregnancy indicate increased fibrinolytic system activation in carriers of the mutation...
  2. ncbi The risk of recurrent venous thromboembolism in heterozygous carriers of factor V Leiden and a first spontaneous venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, Division of Hematology and Hemostasis, University of Vienna, Waehringer Guertel 18 20, 1090 Wien, Austria
    Arch Intern Med 162:2357-60. 2002
    ..Factor V (FV) Leiden is a risk factor for venous thrombosis (VT). Data on its influence on the risk of recurrent venous thromboembolism (VTE) are controversial owing to different study designs and patient cohorts...
  3. ncbi D-dimer levels and risk of recurrent venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, University of Vienna, Austria
    JAMA 290:1071-4. 2003
    ..Because of the increasing number of risk factors, assessing the risk of recurrence in an individual patient is intricate; therefore, a laboratory method that measures multifactorial thrombophilia is required...
  4. ncbi Thrombin-activatable fibrinolysis inhibitor and the risk for recurrent venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Blood 103:3773-6. 2004
    ..9; 95% CI, 1.3-6.9), high factor VIII (RR, 6.5; 95% CI, 2.9-14.8), or high factor IX (RR, 2.0; 95% CI, 1.0-3.9) levels compared with patients with low levels of TAFI and one of these factors...
  5. ncbi Prevention of deep vein thrombosis in orthopedic surgery
    Sabine Eichinger
    Dept of Internal Medicine I, Div of Hematology and Hemostasis, Medical University of Vienna, Austria
    Eur J Med Res 9:112-8. 2004
    ..g., an increased bleeding risk) and high costs the role of these new drugs in the prophylaxis of VTE in patients undergoing major orthopedic surgery of the lower extremities remains to be established...
  6. doi Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model
    Sabine Eichinger
    Department of Internal Medicine I, the Karl Landsteiner Institut für Klinische Thromboseforschung, Wien, Austria
    Circulation 121:1630-6. 2010
    ..Predicting the risk of recurrent venous thromboembolism (VTE) in an individual patient is often not feasible. We aimed to develop a simple risk assessment model that improves prediction of the recurrence risk...
  7. doi ProCGlobal and endogenous thrombin potential during pregnancy
    Gregor Hron
    Division of Hematology and Hemostasis, Department of Medicine I, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Am J Obstet Gynecol 203:463.e1-6. 2010
    ....
  8. ncbi Family history for venous thromboembolism and the risk for recurrence
    Gregor Hron
    Department of Internal Medicine I, Division of Angiology, Medical University of Vienna, Vienna, Austria
    Am J Med 119:50-3. 2006
    ..The relevance of a family history for venous thromboembolism with regard to the likelihood for recurrence is unknown...
  9. ncbi Prediction of recurrent venous thromboembolism by measuring ProC Global
    Sabine Eichinger
    Dept of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Thromb Haemost 98:1232-6. 2007
    ..4% in patients with a lower ratio (p = 0.006). Patients with a high ProC Global NR have a low risk of recurrent VTE. ProC Global NR can be used to stratify patients with a first unprovoked VTE according to their risk of recurrence...
  10. ncbi Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation
    Gregor Hron
    Department of Internal Medicine I, Medical University of Vienna, Austria
    JAMA 296:397-402. 2006
    ..Because of the large number of risk factors, assessing the risk of recurrence in an individual patient is complex. A method covering multicausal thrombophilia is therefore required...
  11. ncbi Tissue factor pathway inhibitor and the risk of recurrent venous thromboembolism
    Matthias Hoke
    Department of Internal Medicine I, Div of Hematology Hemostasis, Medical University of Vienna, Austria
    Thromb Haemost 94:787-90. 2005
    ..8 (95% CI 0.6-9.5)]. We conclude that thrombosis patients with low levels of free TFPI are at an increased risk of recurrent VTE...
  12. ncbi Superficial thrombophlebitis and risk for recurrent venous thromboembolism
    Verena Schönauer
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Vienna University Hospital, Vienna, Austria
    J Vasc Surg 37:834-8. 2003
    ..Data on risk factors and incidence rates for ST are scarce. It is also unknown whether ST is a risk factor for recurrence of VTE...
  13. doi Risk assessment for recurrent venous thrombosis
    Paul Alexander Kyrle
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Lancet 376:2032-9. 2010
    ..Analysis of preliminary data suggests that risk assessment can also be refined through integration of prothrombotic coagulation changes and clinical risk factors...
  14. ncbi Circulating P-selectin and the risk of recurrent venous thromboembolism
    Paul A Kyrle
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Haemost 97:880-3. 2007
    ..7-fold (95% CI 1.0-2.9, p = 0.045) increased among patients with P-selectin levels exceeding the 75(th) percentile. We conclude that high circulating P-selectin is a risk factor of recurrent VTE...
  15. doi Overweight, obesity, and the risk of recurrent venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Arch Intern Med 168:1678-83. 2008
    ..Excess body weight is a risk factor for a first venous thromboembolism. The impact of excess body weight on risk of recurrent venous thrombosis is uncertain...
  16. doi Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer
    Sabine Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Clin Chem 54:2042-8. 2008
    ..We investigated the relation between endogenous thrombin potential (ETP) and risk of recurrent venous thromboembolism and evaluated whether prediction of recurrence can be improved by a combined analysis of ETP and D-dimer...
  17. ncbi High-density lipoprotein and the risk of recurrent venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Circulation 115:1609-14. 2007
    ..High-density lipoprotein (HDL) protects against arterial atherothrombosis, but it is unknown whether it protects against recurrent venous thromboembolism...
  18. ncbi The risk of recurrent venous thromboembolism in men and women
    Paul A Kyrle
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Ludwig Boltzmann Institut fur Thromboseforschung, Vienna, Austria
    N Engl J Med 350:2558-63. 2004
    ..Whether a patient's sex is associated with the risk of recurrent venous thromboembolism is unknown...
  19. pmc Hematocrit and the risk of recurrent venous thrombosis: a prospective cohort study
    Lisbeth Eischer
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e38705. 2012
    ..Venous thromboembolism (VTE) is a multicausal disease which recurs. Hematocrit is associated with a thrombotic risk. We aimed to investigate if hematocrit is associated with the recurrence risk...
  20. ncbi Tissue factor-positive microparticles: cellular origin and association with coagulation activation in patients with colorectal cancer
    Gregor Hron
    Dept of Internal Medicine I, Medical University Vienna, Austria
    Thromb Haemost 97:119-23. 2007
    ..017). TF (+) MPs correlated with D-dimer ( ? = 0.48, p = 0.002). High levels of TF (+) MPs in cancer patients and their correlation with D-dimer suggest that TF (+) MPs might be involved in hemostasis activation in cancer patients...
  21. doi Genetic variation in heme oxygenase 1 (HMOX1) and the risk of recurrent venous thromboembolism
    Stefan Mustafa
    Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    J Vasc Surg 47:566-70. 2008
    ..We hypothesize that these long alleles are associated with decreased HO1 anticoagulant activity and, thus, an increased risk of thrombosis....
  22. ncbi Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolism
    Sabine Eichinger
    Division of Hematology and Hemostasis, Department of Internal Medicine I, University of Vienna, Vienna, Austria
    Arch Intern Med 164:92-6. 2004
    ..We therefore investigated the risk of recurrence among patients with spontaneous symptomatic PE and among those with deep vein thrombosis (DVT) without symptoms of PE...
  23. ncbi The risk of recurrent venous thromboembolism: the Austrian Study on Recurrent Venous Thromboembolism
    Paul Alexander Kyrle
    Division of Hematology and Hemostasis, Ludwig Boltzmann Institute for Thrombosis Research, Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria
    Wien Klin Wochenschr 115:471-4. 2003
    ....
  24. pmc Prediction of recurrent venous thromboembolism by clot lysis time: a prospective cohort study
    Ludwig Traby
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e51447. 2012
    ..No association between CLT and recurrence risk was found in men. Hypofibrinolysis as assessed by CLT confers a moderate increase in the risk of recurrent VTE. A weak association between CLT and risk of recurrence was found in women only...
  25. ncbi Novel anticoagulants for the prevention and treatment of venous thromboembolism
    Ansgar Weltermann
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Wien Med Wochenschr 153:426-33. 2003
    ..This article reviews mechanisms and sites of action, and the current state of preclinical and clinical research of these and various other agents with respect to the prevention and treatment of venous thromboembolism)...
  26. doi Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism
    Gottfried Novacek
    Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Gastroenterology 139:779-87, 787.e1. 2010
    ..We performed a cohort study to determine the risk for recurrent VTE among patients with IBD compared with subjects without IBD...
  27. doi Medical therapy in venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Semin Respir Crit Care Med 33:186-90. 2012
    ..Models that combine clinical characteristics and laboratory markers further improve prediction of the recurrence risk in individual patients, but these models await validation before they can be applied in routine care...
  28. doi Duration of anticoagulation after venous thrombosis
    Sabine Eichinger
    Department of Medicine I, Medical University of Vienna, Austria
    Vasa 41:11-7. 2012
    ..New oral anticoagulants have been studied for treatment of patients with VTE. However, more data on the bleeding risk during extended thromboprophylaxis are needed to decide which patients may indeed benefit from these novel agents...
  29. doi The effects of low-molecular-weight heparin at two different dosages on thrombin generation in cancer patients. A randomised controlled trial
    Ludwig Traby
    Department of Internal Medicine I, Division of Hematology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Thromb Haemost 104:92-9. 2010
    ..Peak thrombin levels are sensitive to the anticoagulant effects of LMWH at different dosages. The prothrombotic state is substantially attenuated by higher LMWH doses...
  30. ncbi Homozygosity in the single nucleotide polymorphism Ser128Arg in the E-selectin gene associated with recurrent venous thromboembolism
    Bernd Jilma
    Department of Clinical Pharmacology, and Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Arch Intern Med 166:1655-9. 2006
    ..As this SNP enhances tissue factor-triggered coagulation in humans during systemic inflammation, we hypothesized that it may also predispose for the development of recurrent venous thromboembolism (VTE)...
  31. ncbi Marburg I polymorphism of factor VII-activating protease and risk of recurrent venous thromboembolism
    Talin Gulesserian
    Department of Pediatric and Adolescent Medicine, Medical University of Vienna, Austria
    Thromb Haemost 95:65-7. 2006
    ..3) after adjustment for potentially confounding factors. We conclude that FSAP Marburg I is, if at all, only a mild factor for recurrent VTE. Patients with FSAP Marburg I most probably will not benefit from extended anticoagulation...
  32. ncbi Prospective evaluation of coagulation activation in pregnant women receiving low-molecular weight heparin
    Matthias Hoke
    Department of Internal Medicine I, Division of Haematology Haemostaseology, University Vienna, Austria
    Thromb Haemost 91:935-40. 2004
    ..Levels of F1+2 significantly increased while the APC-ratio significantly decreased during pregnancy among patients and controls. Despite LMWH, pregnancy is accompanied by a substantial activation of the coagulation system...
  33. doi Clinical scores to predict recurrence risk of venous thromboembolism
    Paul A Kyrle
    Dept of Medicine I, Medical University of Vienna, Vienna, Austria
    Thromb Haemost 108:1061-4. 2012
    ..The aim of this report is to describe currently available scoring systems in more detail...
  34. doi Regulation of PAR-1 in patients undergoing percutaneous coronary intervention: effects of unfractionated heparin and bivalirudin
    Roza Badr Eslam
    Department of Internal Medicine 2, Division of Cardiology, Medical University of Vienna, Vienna, Austria
    Eur Heart J 30:1831-6. 2009
    ..002). Conclusion Heparin has stronger inhibitory effects on thrombin-dependent PAR-1 cleavage and internalization, thus providing a biological explanation for lower clinical bleeding rates with bivalirudin...
  35. doi The emotional impact of genetic testing and aspects of counseling prior to prescription of oral contraceptives
    Verena Gartner
    Department of Internal Medicine I, Medical University of Vienna, Vienna, 1090, Austria
    Contraception 78:392-8. 2008
    ..Oral contraceptives increase the thrombotic risk in women with factor V Leiden. Emotional aspects of genetic testing prior to the prescription of oral contraceptives (OC), aspects of counseling and referral patterns are widely unknown...
  36. ncbi Treatment of venous thromboembolism
    Sabine Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Wien Med Wochenschr 155:7-10. 2005
    ..Several new antithrombotics with potential advantages over heparin and VKA have been evaluated in phase II and III trials, but are currently not licensed for the treatment of venous thromboembolic events...
  37. doi New diagnostic strategies for pulmonary embolism
    Paul A Kyrle
    Department of Medicine, Medical University of Vienna, 1090 Vienna, Austria
    Lancet 371:1312-5. 2008
  38. ncbi D-dimer testing in pregnancy
    Sabine Eichinger
    Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    Semin Vasc Med 5:375-8. 2005
    ....
  39. doi Age at first venous thromboembolism and risk of recurrence: a prospective cohort study
    Lisbeth Eischer
    Department of Medicine I, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Medicine (Baltimore) 88:366-70. 2009
    ..5).Our results show that in patients with first unprovoked proximal DVT and/or PE, risk of recurrence is not related to age at first VTE. Regardless of age, these patients have a high risk of recurrence...
  40. ncbi D-dimer testing in pregnancy
    Sabine Eichinger
    Dept of Internal Medicine I, Div of Hematology and Hemostasis, Allgemeines Krankenhaus Wien, Austria
    Pathophysiol Haemost Thromb 33:327-9. 2003
    ....
  41. ncbi Homocysteine, vitamin B6 and the risk of recurrent venous thromboembolism
    Sabine Eichinger
    Dept of Internal Medicine I, Div of Hematology and Hemostasis, Allgemeines Krankenhaus Wien, Austria
    Pathophysiol Haemost Thromb 33:342-4. 2003
    ..Low vitamin B6 levels are associated with an increased risk of a first venous thrombosis. We currently investigate whether or not low plasma levels of PLP are associated with a heightened risk for recurrent VTE...
  42. doi D-dimer levels over time and the risk of recurrent venous thromboembolism: an update of the Vienna prediction model
    Sabine Eichinger
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Am Heart Assoc 3:e000467. 2014
    ..We aimed to expand the model to also assess the recurrence risk from later points on...
  43. ncbi Deep vein thrombosis
    Paul A Kyrle
    Medical University of Vienna, Department of Internal Medicine I, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Lancet 365:1163-74. 2005
    ..Women seem to have a lower thrombosis risk than men, but pregnancy or use of oral contraceptives or hormone replacement therapy represent important risk factors...
  44. doi Diagnostic issues of VTE in pregnancy
    Sabine Eichinger
    Dept of Internal Medicine I, Medical University of Vienna, Austria
    Thromb Res 123:S38-40. 2009
    ..The role of magnetic resonance imaging for the diagnosis of venous thromboembolism during pregnancy is uncertain and contraindications particularly to contrast media have to be considered...
  45. ncbi Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial
    Martin den Heijer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 109:139-44. 2007
    ..65-1.98) in the hyperhomocysteinemic group and 0.58 (95% CI, 0.31-1.07) in the normohomocysteinemic group. The results of our study do not show that homocysteine lowering by B vitamin supplementation prevents recurrent venous thrombosis...
  46. ncbi Low vitamin B6 levels and the risk of recurrent venous thromboembolism
    Gregor Hron
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Milano, Italy
    Haematologica 92:1250-3. 2007
    ..01). Patients with PLP ''23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE...