Research Topics
| Robert EferlSummaryAffiliation: University of Vienna Country: Austria Publications
| Collaborators
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Detail Information
Publications
AP-1: a double-edged sword in tumorigenesisRobert Eferl
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A-1030 Vienna, Austria
Nat Rev Cancer 3:859-68. 2003- Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53Robert Eferl
Research Institute of Molecular Pathology IMP, Dr Bohrgasse 7, A 1030, Vienna, Austria
Cell 112:181-92. 2003..These data indicate that c-Jun prevents apoptosis by antagonizing p53 activity, illustrating a mechanism that might contribute to the early stages of human HCC development... 
Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin diseaseRainer Zenz
Ludwig Boltzmann Institute for Cancer Research, Währinger Strasse 13a, A 1090 Vienna, Austria
Arthritis Res Ther 10:201. 2008..These new data provide a better molecular understanding of disease pathways and should pave the road for the discovery of new targets for therapeutic applications...- Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiationLatifa Bakiri
Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
Bone 40:867-75. 2007..We propose that Fra1 together with a dimerization partner different from Jun proteins can rescue osteoclast differentiation in c-Fos-deficient precursors... - Fos/AP-1 proteins in bone and the immune systemErwin F Wagner
Research Institute of Molecular Pathology IMP, Vienna, Austria
Immunol Rev 208:126-40. 2005..We also attempt to put potential therapeutic strategies for inflammatory bone diseases in perspective... - Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1Robert Eferl
Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, A 1030 Vienna, Austria
Proc Natl Acad Sci U S A 105:10525-30. 2008.... - The Fos-related antigen Fra-1 is an activator of bone matrix formationRobert Eferl
Research Institute of Molecular Pathology IMP, Vienna, Austria
EMBO J 23:2789-99. 2004..These results uncover a novel function of Fra-1 in regulating bone mass through bone matrix production by osteoblasts and chondrocytes... - Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defectsLukas Kenner
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
J Cell Biol 164:613-23. 2004..Thus, these data reveal a novel function of JunB as a positive regulator controlling primarily osteoblast as well as osteoclast activity... - Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogeneAlexander Fleischmann
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Cancer Cell 4:477-82. 2003..Moreover, Fos is able to repress Pax7 expression in rhabdomyosarcoma cell lines and primary myoblasts, suggesting a molecular link to genetic alterations involved in human rhabdomyosarcomas... - The AP1 transcription factor Fra2 is required for efficient cartilage developmentFlorian Karreth
Research Institute of Molecular Pathology I M P Vienna, Austria
Development 131:5717-25. 2004..In addition, these mice suffer from a kyphosis-like phenotype, an abnormal bending of the spine. Hence, Fra2 is a novel transcription factor important for skeletogenesis by affecting chondrocyte differentiation... - Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteinsRainer Zenz
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nature 437:369-75. 2005..Thus, these data support the hypothesis that epidermal alterations are sufficient to initiate both skin lesions and arthritis in psoriasis... - c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activityEwa Stepniak
Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
Genes Dev 20:2306-14. 2006..These data demonstrate that c-Jun/AP-1 regulates liver regeneration through a novel molecular pathway that involves p53, p21, and the stress kinase p38alpha... - c-Jun regulates eyelid closure and skin tumor development through EGFR signalingRainer Zenz
Research Institute of Molecular Pathology IMP, A 1030, Vienna, Austria
Dev Cell 4:879-89. 2003..Thus, using three experimental systems, we show that EGFR and HB-EGF are regulated by c-Jun, which controls eyelid development, keratinocyte proliferation, and skin tumor formation... - Induction of DNA synthesis in primary mouse hepatocytes is associated with nuclear pro-transforming growth factor alpha and erbb-1 and is independent of c-junElisabeth Schausberger
, University of Vienna, Borschkegasse 8a, Austria
Carcinogenesis 24:835-41. 2003.... 
Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxiaAline Bozec
Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nature 454:221-5. 2008..Thus placenta-induced hypoxia during embryogenesis leads to the formation of giant osteoclasts in young pups. These findings offer potential targets for the treatment of syndromes associated with increased osteoclastogenesis...- Distinct functions of junD in cardiac hypertrophy and heart failureRomeo Ricci
Institute of Molecular Pathology, A 1030 Vienna, Austria
Genes Dev 19:208-13. 2005..These data suggest that junD promotes both adaptive-protective and maladaptive hypertrophy in heart, depending on its expression levels...