Michael N Dworzak

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Prognostic significance and modalities of flow cytometric minimal residual disease detection in childhood acute lymphoblastic leukemia
    Michael N Dworzak
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Blood 99:1952-8. 2002
  2. ncbi request reprint Flow cytometric detection of minimal residual disease in acute lymphoblastic leukemia
    Michael N Dworzak
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Leuk Lymphoma 44:1445-55. 2003
  3. ncbi request reprint Bone marrow assessment in Langerhans cell histiocytosis
    Milen Minkov
    St Anna Children s Hospital, Vienna, Austria
    Pediatr Blood Cancer 49:694-8. 2007
  4. pmc CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: setting the stage for anti-CD20 directed immunotherapy
    Michael N Dworzak
    Children s Cancer Research Institute, Vienna, Austria
    Blood 112:3982-8. 2008
  5. doi request reprint Prognostic relevance of dic(9;20)(p11;q13) in childhood B-cell precursor acute lymphoblastic leukaemia treated with Berlin-Frankfurt-Münster (BFM) protocols containing an intensive induction and post-induction consolidation therapy
    Herbert Pichler
    Department of Paediatric Haematology and Oncology, St Anna Children s Hospital, Vienna, Austria
    Br J Haematol 149:93-100. 2010
  6. ncbi request reprint CD99 (MIC2) expression in paediatric B-lineage leukaemia/lymphoma reflects maturation-associated patterns of normal B-lymphopoiesis
    M N Dworzak
    Children s Cancer Research Institute, St Anna Kinderspital, Vienna, Austria
    Br J Haematol 105:690-5. 1999
  7. ncbi request reprint CD99 expression in T-lineage ALL: implications for flow cytometric detection of minimal residual disease
    M N Dworzak
    Children s Cancer Research Institute, St Anna Children s Hospital, Vienna, Austria
    Leukemia 18:703-8. 2004
  8. ncbi request reprint Immunological detection of minimal residual disease in acute lymphoblastic leukemia
    M N Dworzak
    Forschungsinstitut für krebskranke Kinder, St Anna Kinderspital, Wien, Austria
    Onkologie 24:442-8. 2001
  9. ncbi request reprint Detection of residual disease in pediatric B-cell precursor acute lymphoblastic leukemia by comparative phenotype mapping: method and significance
    M N Dworzak
    Children s Cancer Research Institute, St Anna Kinderspital, Vienna, Austria
    Leuk Lymphoma 38:295-308. 2000
  10. doi request reprint The inferior prognosis of adolescents with acute lymphoblastic leukaemia (ALL) is caused by a higher rate of treatment-related mortality and not an increased relapse rate--a population-based analysis of 25 years of the Austrian ALL-BFM (Berlin-Frankfurt-M
    Herbert Pichler
    Paediatric Haematology and Oncology, St Anna Children s Hospital, Department of Paediatrics, Medical University of Vienna, Vienna, Austria
    Br J Haematol 161:556-65. 2013

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Prognostic significance and modalities of flow cytometric minimal residual disease detection in childhood acute lymphoblastic leukemia
    Michael N Dworzak
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Blood 99:1952-8. 2002
    ..Standardization regarding absolute quantification on the basis of NCs and assessment during periods of continuous treatment promise to increase the accuracy, simplicity, and cost efficiency of the approach...
  2. ncbi request reprint Flow cytometric detection of minimal residual disease in acute lymphoblastic leukemia
    Michael N Dworzak
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Leuk Lymphoma 44:1445-55. 2003
    ....
  3. ncbi request reprint Bone marrow assessment in Langerhans cell histiocytosis
    Milen Minkov
    St Anna Children s Hospital, Vienna, Austria
    Pediatr Blood Cancer 49:694-8. 2007
    ..The aim of the present study was to characterize the bone marrow changes in LCH patients and to ascertain their relation to disease severity...
  4. pmc CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: setting the stage for anti-CD20 directed immunotherapy
    Michael N Dworzak
    Children s Cancer Research Institute, Vienna, Austria
    Blood 112:3982-8. 2008
    ..This study was registered at http://www.clinicaltrials.gov as #NCT00430118...
  5. doi request reprint Prognostic relevance of dic(9;20)(p11;q13) in childhood B-cell precursor acute lymphoblastic leukaemia treated with Berlin-Frankfurt-Münster (BFM) protocols containing an intensive induction and post-induction consolidation therapy
    Herbert Pichler
    Department of Paediatric Haematology and Oncology, St Anna Children s Hospital, Vienna, Austria
    Br J Haematol 149:93-100. 2010
    ....
  6. ncbi request reprint CD99 (MIC2) expression in paediatric B-lineage leukaemia/lymphoma reflects maturation-associated patterns of normal B-lymphopoiesis
    M N Dworzak
    Children s Cancer Research Institute, St Anna Kinderspital, Vienna, Austria
    Br J Haematol 105:690-5. 1999
    ..In summary, we found that paediatric B-lineage malignancies display remarkable synchrony regarding the levels of CD99 expression compared to their putative normal counterparts...
  7. ncbi request reprint CD99 expression in T-lineage ALL: implications for flow cytometric detection of minimal residual disease
    M N Dworzak
    Children s Cancer Research Institute, St Anna Children s Hospital, Vienna, Austria
    Leukemia 18:703-8. 2004
    ..002% of nucleated BM cells in patients with non-T ALL). We conclude that CD99 is a highly informative tool for MRD detection in T-ALL, bearing the advantage of surface expression in contrast to TdT...
  8. ncbi request reprint Immunological detection of minimal residual disease in acute lymphoblastic leukemia
    M N Dworzak
    Forschungsinstitut für krebskranke Kinder, St Anna Kinderspital, Wien, Austria
    Onkologie 24:442-8. 2001
    ..Concluding remarks further relate to technical issues which may allow to simplify the approach in the future which should augment also its economic efficiency...
  9. ncbi request reprint Detection of residual disease in pediatric B-cell precursor acute lymphoblastic leukemia by comparative phenotype mapping: method and significance
    M N Dworzak
    Children s Cancer Research Institute, St Anna Kinderspital, Vienna, Austria
    Leuk Lymphoma 38:295-308. 2000
    ....
  10. doi request reprint The inferior prognosis of adolescents with acute lymphoblastic leukaemia (ALL) is caused by a higher rate of treatment-related mortality and not an increased relapse rate--a population-based analysis of 25 years of the Austrian ALL-BFM (Berlin-Frankfurt-M
    Herbert Pichler
    Paediatric Haematology and Oncology, St Anna Children s Hospital, Department of Paediatrics, Medical University of Vienna, Vienna, Austria
    Br J Haematol 161:556-65. 2013
    ....
  11. doi request reprint Asparagine and aspartic acid concentrations in bone marrow versus peripheral blood during Berlin-Frankfurt-Münster-based induction therapy for childhood acute lymphoblastic leukemia
    Manuel Steiner
    Department of Pediatric Hematology and Oncology, St Anna Children s Hospital, Medical University of Vienna, Vienna, Austria
    Leuk Lymphoma 53:1682-7. 2012
    ....
  12. doi request reprint Outcome of children and adolescents with a second or third relapse of acute lymphoblastic leukemia (ALL): a population-based analysis of the Austrian ALL-BFM (Berlin-Frankfurt-Münster) study group
    Bettina Reismüller
    Pediatric Hematology and Oncology, Department of Pediatrics, St Anna Children s Hospital, Medical University of Vienna, Austria
    J Pediatr Hematol Oncol 35:e200-4. 2013
    ..Conclusively, patients with a second ALL relapse are ideal candidates for phase I/II trials exploring new innovative drugs. ..
  13. doi request reprint Modulation of antigen expression in B-cell precursor acute lymphoblastic leukemia during induction therapy is partly transient: evidence for a drug-induced regulatory phenomenon. Results of the AIEOP-BFM-ALL-FLOW-MRD-Study Group
    Michael N Dworzak
    Laboratory of Immunological Diagnostics, Children s Cancer Research Institute, Vienna, Austria
    Cytometry B Clin Cytom 78:147-53. 2010
    ..Many markers used for phenotyping and minimal residual disease (MRD) monitoring are affected. Glucocorticoid (GC)-induced expression modulation has been causally suspected, however, subclone selection may also cause the phenomenon...
  14. ncbi request reprint Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity
    Andishe Attarbaschi
    Department of Hematology and Oncology, St Anna Children s Hospital, Vienna, Austria
    Clin Cancer Res 12:2988-94. 2006
    ..However, the incidence and type of MLL rearrangements have not been determined in common ALL (cALL) and CD10+ or CD10- pre-B ALL...
  15. ncbi request reprint Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian children
    Leo Kager
    Department of Hematology and Oncology, St Anna Children s Hospital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Haematologica 92:1561-4. 2007
    ..These data document that contemporary ALL-BFM treatment is highly effective in children with TCF3-PBX1 ALL. Implementation of early dose-intensified remission induction may be an essential treatment component...
  16. doi request reprint Minimal residual disease values discriminate between low and high relapse risk in children with B-cell precursor acute lymphoblastic leukemia and an intrachromosomal amplification of chromosome 21: the Austrian and German acute lymphoblastic leukemia Berl
    Andishe Attarbaschi
    Department of Pediatric Hematology and Oncology, St Anna Children s Hospital, Vienna, Austria
    J Clin Oncol 26:3046-50. 2008
    ..We aimed to identify relapse predictors in children with a B-cell precursor acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21), a novel genetic entity associated with poor outcome...
  17. doi request reprint Death induction by CD99 ligation in TEL/AML1-positive acute lymphoblastic leukemia and normal B cell precursors
    Zvenyslava Husak
    St Anna Kinderkrebsforschung, Children s Cancer Research Institute, Zimmermannplatz 10, A 1090 Vienna, Austria
    J Leukoc Biol 88:405-12. 2010
    ..We consider our results as an indication that CD99 may play a physiologic role in the clonal deletion processes necessary for B-lymphoid selection...
  18. doi request reprint Long-term outcome of initially homogenously treated and relapsed childhood acute lymphoblastic leukaemia in Austria--a population-based report of the Austrian Berlin-Frankfurt-Münster (BFM) Study Group
    Bettina Reismüller
    Department of Paediatric Haematology and Oncology, St Anna Children s Hospital, Vienna, Austria
    Br J Haematol 144:559-70. 2009
    ..Additionally, a Cox regression model demonstrated that allogeneic SCT after first relapse was associated with a superior EFS compared with chemo/radiotherapy only (hazard ratio = 0.254; P = 0.0017)...
  19. ncbi request reprint Near-tetraploidy in childhood B-cell precursor acute lymphoblastic leukemia is a highly specific feature of ETV6/RUNX1-positive leukemic cases
    Andishe Attarbaschi
    St Anna Children s Hospital, Vienna, Austria
    Genes Chromosomes Cancer 45:608-11. 2006
    ..After a median follow-up of 11.4 years, none of the patients has relapsed or died. Thus, near-tetraploidy appears to be a specific feature of ETV6/RUNX1+ BCP ALL cases that in turn may explain its excellent outcome...
  20. doi request reprint Thiamine-responsive megaloblastic anemia (TRMA) in an Austrian boy with compound heterozygous SLC19A2 mutations
    Herbert Pichler
    Pediatric Hematology and Oncology, St Anna Children s Hospital, Department of Pediatrics, Medical University of Vienna, Vienna, Austria
    Eur J Pediatr 171:1711-5. 2012
    ..An early molecular genetic verification of the diagnosis provides a sound basis for a successful and simple treatment that helps to prevent severe sequelae...
  21. ncbi request reprint Philadelphia chromosome-positive mature B-cell (Burkitt cell) leukaemia
    Georg Mann
    Children s Cancer Research Institute, St Anna Children s Hospital, Kinderspitalgasse 6, 1090 Vienna, Austria
    Br J Haematol 118:559-62. 2002
    ..The occurrence of Ph+ Burkitt's leukaemia might reflect multiple-step cancer development...
  22. ncbi request reprint Screening for NUP98 rearrangements in hematopoietic malignancies by fluorescence in situ hybridization
    Karin Nebral
    Children s Cancer Research Institute, Vienna, Austria
    Haematologica 90:746-52. 2005
    ..This aim was achieved using a fluorescence in situ hybridization (FISH) assay that allows the detection of NUP98 aberrations independently of the partner gene involved...
  23. doi request reprint Prednisone induces immunophenotypic modulation of CD10 and CD34 in nonapoptotic B-cell precursor acute lymphoblastic leukemia cells
    Giuseppe Gaipa
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza, MI, Italy
    Cytometry B Clin Cytom 74:150-5. 2008
    ..Immunophenotypic modulation is induced by steroids in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients during remission induction therapy...
  24. ncbi request reprint Expression of CD58 in normal, regenerating and leukemic bone marrow B cells: implications for the detection of minimal residual disease in acute lymphocytic leukemia
    Marinella Veltroni
    Dipartimento di Pediatria, Universita di Padova, Padua, Italy
    Haematologica 88:1245-52. 2003
    ..To assess the reliability and accuracy of CD58 for this purpose, we studied its expression in a large series of normal and ALL bone marrow (BM) samples using quantitative FC...