Research Topics
| W DrexlerSummaryAffiliation: University of Vienna Country: Austria Publications
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Detail Information
Publications
Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomographyWolfgang Drexler
Department of Medical Physics, University of Vienna, Christian Doppler Laboratory, Austria
Arch Ophthalmol 121:695-706. 2003....- Partial coherence interferometry: a novel approach to biometry in cataract surgeryW Drexler
Institut für Medizinische Physik, Universitat Wien, Vienna, Austria
Am J Ophthalmol 126:524-34. 1998.... - Ultrahigh-resolution optical coherence tomographyWolfgang Drexler
Department of Medical Physics, Christian Doppler Laboratory, University of Vienna, Vienna, Austria
J Biomed Opt 9:47-74. 2004.... - Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomographyA Unterhuber
Department of Medical Physics, Medical University of Vienna and Christian Doppler Laboratory, A-1090 Vienna, Austria
Phys Med Biol 49:1235-46. 2004.... - Improved prediction of intraocular lens power using partial coherence interferometryO Findl
Department of Ophthalmology, Vienna General Hospital, Vienna, Austria
J Cataract Refract Surg 27:861-7. 2001..Further improvement can be achieved by applying PCI to a modified SRK/T formula that predicts the postoperative ACD using PCI biometry data... - Adaptive-optics ultrahigh-resolution optical coherence tomographyB Hermann
Department of Medical Physics, Christian Doppler Laboratory, Medical University of Vienna, Austria
Opt Lett 29:2142-4. 2004..A significant signal-to-noise ratio improvement of up to 9 dB in corrected compared with uncorrected OCT tomograms is also achieved... - Investigation of dispersion effects in ocular media by multiple wavelength partial coherence interferometryW Drexler
Institut für Medizinische Physik, Universitat Wien, Wahringer Strasse 13, Wien, A 1090, Austria
Exp Eye Res 66:25-33. 1998.... 
Optophysiology: depth-resolved probing of retinal physiology with functional ultrahigh-resolution optical coherence tomographyK Bizheva
Center for Biomedical Engineering and Physics/Christian Doppler Laboratory, University of Vienna, A-1090 Vienna, Austria
Proc Natl Acad Sci U S A 103:5066-71. 2006....- Compact, low-cost Ti:Al2O3 laser for in vivo ultrahigh-resolution optical coherence tomographyA Unterhuber
Department of Medical Physics, Christian Doppler Laboratory, University of Vienna, Vienna A-1090, Austria
Opt Lett 28:905-7. 2003.... - Stimulus-driven versus pilocarpine-induced biometric changes in pseudophakic eyesK Kriechbaum
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
Ophthalmology 112:453-9. 2005..However, it may be helpful to evaluate the maximum potential of an accommodating IOL... - Effects of change in intraocular pressure on axial eye length and lens positionC Leydolt
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
Eye (Lond) 22:657-61. 2008.... - Compact, broad-bandwidth fiber laser for sub-2-microm axial resolution optical coherence tomography in the 1300-nm wavelength regionK Bizheva
Department of Medical Physics, Christian Doppler Laboratory, University of Vienna, Waehringer Strasse 13, Vienna, Austria
Opt Lett 28:707-9. 2003..4-microm axial and approximately 3-microm lateral resolution and 95-dB sensitivity, demonstrating the great potential for clinical OCT applications of this stable, low-cost, and turn-on-key fiber laser... - Optical biometry of the anterior eye segment: interexaminer and intraexaminer reliability of ACMasterStefan Sacu
Department of Ophthalmology, Section of Clinical Biometrics, Medical University of Vienna, Vienna, Austria
J Cataract Refract Surg 31:2334-9. 2005..However, lens thickness measurements in cataract eyes were often difficult... - Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseasesAndre J Witkin
New England Eye Center, Tufts-New England Medical Center, Tufts University, Boston, Massachusetts 0211, USA
Am J Ophthalmol 142:945-52. 2006..FOSPET was statistically thinner in patients with RP and related diseases than in normal eyes and showed correlation with logMAR visual acuity. FOSPET appears to be a probable predictor of visual acuity in RP... - Ultrahigh resolution optical coherence tomography in macular dystrophyMatthias G Wirtitsch
Department of Ophthalmology, Medical University of Vienna, , 1090 Vienna, Austria
Am J Ophthalmol 140:976-983. 2005.... - Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repairTony H Ko
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Ophthalmology 111:2033-43. 2004..The ability to visualize photoreceptors and their integrity or impairment is an indicator of macular hole progression and surgical outcome... - Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomographyLelia A Paunescu
New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA
Ophthalmology 113:48-57. 2006.... - Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomographyErdem Ergun
Department of Ophthalmology, General Hospital of Vienna, Vienna, Austria
Invest Ophthalmol Vis Sci 46:310-6. 2005..Therefore, UHR-OCT could be of future use in judging patients' prognoses in Stargardt's disease... - Local corneal thickness changes after small-incision cataract surgeryMatthias Bolz
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
J Cataract Refract Surg 32:1667-71. 2006..The prolonged corneal thickening at 3.0 mm eccentricity temporally could be a result of the proximity to the incision site... - Comparison of partial coherence interferometers: Acmaster versus laboratory prototypeKatharina Kriechbaum
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
J Refract Surg 22:811-6. 2006..CONCLUSIONS: The ACMaster is a user-friendly device that enables axial anterior segment biometry using the partial coherence interferometry technique with a reproducibility similar to that of the original laboratory prototype... - Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseasesUrsula Schmidt-Erfurth
Department of Ophthalmology, General Hospital of Vienna, Medical University of Vienna, Waehringer Strasse 13, A-1090 Vienna, Austria
Invest Ophthalmol Vis Sci 46:3393-402. 2005..A complete 3-D data set of the macular layers allows a comprehensive analysis of focal and diffuse diseases, as well as identification of dynamic pathomechanisms... - Influence of severity of nuclear cataract on optical biometryAna Prinz
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
J Cataract Refract Surg 32:1161-5. 2006..Furthermore, it was found that AL in the phakic eye was overestimated by about 0.07 mm because of a slightly too low value of the group refractive index used for the crystalline lens... - Biometry of cataractous eyes using partial coherence interferometry: clinical feasibility study of a commercial prototype IBarbara Kiss
, Allgemeines Krankenhaus Wien, Vienna, Austria
J Cataract Refract Surg 28:224-9. 2002..However, the difference between the PCI and IUS in axial length measurement must be considered when using the constants supplied by intraocular lens (IOL) manufacturers for IOL power calculations... - Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomographyMartin Gloesmann
Institutes of Physiology, University of Vienna, Vienna, Austria
Invest Ophthalmol Vis Sci 44:1696-703. 2003..The specific assignment of OCT signal patterns to retinal substructures provides a basis for improved interpretation of in vivo ophthalmic OCT tomograms of high clinical relevance... - Inherent homogenous media dispersion compensation in frequency domain optical coherence tomography by accurate k-samplingAlexandre R Tumlinson
Division of Biomedical Engineering, University of Arizona, Tucson 85721, USA
Appl Opt 47:687-93. 2008.... - Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patientsBoris Povazay
Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales, CF24 4LU, United Kingdom
J Biomed Opt 12:041211. 2007..Results achieved with 3-D OCT at 1050 nm reveal, for the first time, decisive improvements in image quality for patients with retinal pathologies and clinically significant cataract... - Optical biometry in cataract surgeryOliver Findl
, Allgemeines Krankenhaus Wien, Austria
Dev Ophthalmol 34:131-40. 2002 - Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathologyTony H Ko
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Ophthalmology 112:1922.e1-15. 2005..In addition, UHR OCT can provide additional information on macular disease morphology that promises to improve understanding of disease progression and management... - Refractive outcome of cataract surgery using partial coherence interferometry and ultrasound biometry: clinical feasibility study of a commercial prototype IIBarabara Kiss
, Allegemeines Krankenhaus Wien, Vienna, Austria
J Cataract Refract Surg 28:230-4. 2002..However, the difference in axial length measured by the ALM compared to that measured by IUS must be considered when using the IOL A-constants supplied by the manufacturers... - Lack of fundus autofluorescence to 488 nanometers from childhood on in patients with early-onset severe retinal dystrophy associated with mutations in RPE65Birgit Lorenz
Department of Paediatric Ophthalmology and Ophthalmogenetics, University of Regensburg, Germany
Ophthalmology 111:1585-94. 2004..This study was conducted to evaluate fundus autofluorescence in patients with early-onset severe retinal dystrophy (EOSRD, or early-onset rod-cone dystrophy) associated with mutations on both alleles of RPE65... - Intraocular lens movement caused by ciliary muscle contractionOliver Findl
Department of Ophthalmology, University of Vienna, Austria
J Cataract Refract Surg 29:669-76. 2003..To investigate intraocular lens (IOL) movement, measured as a change in anterior chamber depth (ACD) caused by pilocarpine-induced ciliary muscle contraction... - Ultrahigh-resolution optical coherence tomography of surgically closed macular holesTony H Ko
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Mass, USA
Arch Ophthalmol 124:827-36. 2006..Thin epiretinal membranes do not seem to decrease visual acuity and may play a role in reestablishing foveal anatomy after surgery... - Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retinaEnrique J Fernandez
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Wales, UK
Opt Express 16:11083-94. 2008..The presented technique has the potential to unveil photoreceptor development and pathogenesis as well as improved therapy monitoring of numerous retinal diseases... - Linear relationship of refractive and biometric lenticular changes during accommodation in emmetropic and myopic eyesMatthias Bolz
Department of Ophthalmology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Br J Ophthalmol 91:360-5. 2007..Furthermore, differences in these relationships between young, healthy emmetropic and myopic subjects were analyzed... - Cellular and functional optical coherence tomography of the human retina: the Cogan lectureWolfgang Drexler
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom
Invest Ophthalmol Vis Sci 48:5339-51. 2007 - State-of-the-art retinal optical coherence tomographyWolfgang Drexler
Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, CF24 4LU, Wales, United Kingdom
Prog Retin Eye Res 27:45-88. 2008..Functional OCT promises to enable the differentiation of retinal pathologies via localized, functional retinal response or metabolic properties. These advances promise to have a powerful impact on fundamental as well as clinical studies... - Effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttataMatthias G Wirtitsch
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
Arch Ophthalmol 125:1345-50. 2007..To investigate the effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata... - Minimum distance mapping using three-dimensional optical coherence tomography for glaucoma diagnosisBoris Povazay
Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales CF24 4LU, United Kingdom
J Biomed Opt 12:041204. 2007..For the purposes of this pilot study, we present data from a normal subject and from two patients with characteristic optic nerve and retinal nerve fiber layer changes secondary to glaucoma... - Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomographyLida P Hariri
Division of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
Cancer Biol Ther 6:1753-62. 2007.... - Ultrahigh resolution optical coherence tomography of macular holesChristoph Scholda
Department of Ophthalmology, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria
Retina 26:1034-41. 2006..Hence, UHR OCT could lead to better understanding of macular hole pathogenesis and to more accurate disease prognosis... - In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscopeAlexandre R Tumlinson
University of Arizona, Division of Biomedical Engineering, Tucson, Arizona 85721, USA
J Biomed Opt 11:064003. 2006..Resolution near the cellular level is potentially capable of identifying abnormal crypt formation and dysplastic cellular organization... - Comparison of three methods of measuring corneal thickness and anterior chamber depthWolf Buehl
Department of Ophthalmology, Medical University of Vienna, , A-1090 Vienna, Austria
Am J Ophthalmol 141:7-12. 2006..Larger differences occurred only when measuring peripheral CT values, especially between AC-Master and the other two methods... - Comparison of anterior chamber depth measurement methods in phakic and pseudophakic eyesKatharina Kriechbaum
Department of Ophthalmology, University of Vienna, Vienna, Austria
J Cataract Refract Surg 29:89-94. 2003..21; P >.2). CONCLUSIONS: In phakic eyes, the difference between IOLMaster and PCI measurements was small and not statistically significant. In pseudophakic eyes, the difference was larger and the methods did not correlate... - Short-term effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttataMatthias G Wirtitsch
Department of Ophthalmology, University of Vienna, Austria
Arch Ophthalmol 121:621-5. 2003..3 micro m (95% CI, -0.1 to 2.6 microm), respectively. CONCLUSION: Application of dorzolamide for 1 day results in a slight but statistically significant thickening of central corneal thickness in patients with cornea guttata... - Influence of operator experience on the performance of ultrasound biometry compared to optical biometry before cataract surgeryOliver Findl
Department of Ophthalmology, University of Vienna, Vienna, Austria
J Cataract Refract Surg 29:1950-5. 2003..The noncontact optical method, which is essentially operator independent, gave significantly more reliable biometry before cataract surgery, especially in the case of less experienced operators... - Postoperative change in effective lens position of a 3-piece acrylic intraocular lensChristina Koeppl
Department of Ophthalmology, University of Vienna, Vienna, Austria
J Cataract Refract Surg 29:1974-9. 2003..Although the change in refraction was small, there was variability among patients. The sharp posterior optic edge design did not affect the IOL's movement in the capsular bag... - Determining postoperative anterior chamber depthKatharina Kriechbaum
Department of Ophthalmology, University of Vienna, Vienna, Austria
J Cataract Refract Surg 29:2122-6. 2003..The refractive outcome of cataract surgery can be improved by combining preoperative high-precision PCI biometry and numerical ray tracing for IOL power calculations... - Effect of accommodation and pupil size on the movement of a posterior chamber lens in the phakic eyeVanessa Petternel
Department of Ophthalmology, University of Vienna, Vienna, Austria
Ophthalmology 111:325-31. 2004..This mechanism might cause inadequate aqueous circulation in the prelenticular space and might be one of the causes of subcapsular opacification in some of the eyes after ICL implantation... - Analysis of nonlinear systems to estimate intraocular lens position after cataract surgeryOliver Findl
Department of Ophthalmology, Medical University of Vienna, , 1090 Vienna, Austria
J Cataract Refract Surg 30:863-6. 2004..68 for the MLP; however, this difference was not statistically significant. CONCLUSION: The prediction of postoperative ACD with the MLP was not significantly better than the prediction using linear regression... - Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sectionsElisabeth M Anger
Department of Physiology, Medical University of Vienna, Vienna, Austria
Exp Eye Res 78:1117-25. 2004..Such correlation will facilitate the extraction of structural information from in vivo ultrahigh resolution OCT images in clinical and experimental applications... - Central corneal thickness measurements with partial coherence interferometry, ultrasound, and the Orbscan systemGeorg Rainer
Department of Ophthalmology, University of Vienna, Vienna, Austria
Ophthalmology 111:875-9. 2004..To compare the reliability of central corneal thickness measurements (CCT) obtained with partial coherence interferometry (PCI), ultrasound pachymetry, and the Orbscan system... - Imaging ex vivo and in vitro brain morphology in animal models with ultrahigh resolution optical coherence tomographyKostadinka Bizheva
Department of Medical Physics, Medical University of Vienna and Christian Doppler Laboratory, Vienna A-1090, Austria
J Biomed Opt 9:719-24. 2004..In addition, the OCT image penetration depth and the scattering properties of gray and white brain matter were evaluated in tissue samples from the visual cortex of a fixed monkey brain... - Laserinterferometric assessment of pilocarpine-induced movement of an accommodating intraocular lens: a randomized trialOliver Findl
Department of Ophthalmology, University of Vienna, Austria
Ophthalmology 111:1515-21. 2004..To measure the axial movement of an accommodating intraocular lens (IOL) induced by ciliary muscle contraction after application of pilocarpine... - Ultrahigh-resolution optical coherence tomography in glaucomaGadi Wollstein
New England Eye Center, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Ophthalmology 112:229-37. 2005..CONCLUSIONS: Ultrahigh-resolution OCT provides high-resolution images of the ocular posterior segment, which improves the ability to detect retinal abnormalities due to glaucoma... - Change in IOL position and capsular bag size with an angulated intraocular lens early after cataract surgeryChristina Koeppl
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
J Cataract Refract Surg 31:348-53. 2005..Loss of haptic memory seemed to be the most likely cause. Myopic eyes with large capsular bags showed less IOL shift in the early postoperative period than hyperopic eyes with smaller capsular bags... - Imaging ex vivo healthy and pathological human brain tissue with ultra-high-resolution optical coherence tomographyKostadinka Bizheva
Medical University of Vienna and Christian Doppler Laboratory, Center for Biomedical Engineering and Physics, Vienna A-1090, Austria
J Biomed Opt 10:11006. 2005.... - Intraocular lens-capsular bag imaging with ultrahigh-resolution optical coherence tomography Pseudophakic human autopsy eyesReijo J Linnola
PlusHealth-Doctors Ltd, Vaasa, Finland
J Cataract Refract Surg 31:818-23. 2005..Ultrahigh-resolution OCT may also help in determining the area of origin of PCO after cataract surgery... - Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using a liquid crystal spatial light modulatorEnrique J Fernandez
Center for Biomedical Engineering and Physics, Vienna University of Medicine, Austria
Vision Res 45:3432-44. 2005..Volumetric UHR OCT of the living retina, obtained with up 25,000A-scans/s and high resolution enables visualization of retinal features that might correspond to groups of terminal bars of photoreceptors at the external limiting membrane... - Comparison of ultrasound pachymetry and partial coherence interferometry in the measurement of central corneal thicknessGeorg Rainer
Department of Ophthalmology, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Cataract Refract Surg 28:2142-5. 2002..To compare central corneal thickness (CCT) measurements obtained with 3 ultrasound pachymeters and with partial coherence interferometry (PCI) and evaluate the effect of repeated contact by a pachymetry probe on corneal thickness...