T Decker

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression
    T Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    J Interferon Cytokine Res 17:121-34. 1997
  2. pmc IFNs and STATs in innate immunity to microorganisms
    Thomas Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    J Clin Invest 109:1271-7. 2002
  3. ncbi request reprint Jaks, Stats and the immune system
    T Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    Immunobiology 198:99-111. 1997
  4. ncbi request reprint Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins
    T Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    Cell Mol Life Sci 55:1535-46. 1999
  5. pmc Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
    P Kovarik
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    EMBO J 20:91-100. 2001
  6. pmc Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons
    A Meinke
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    Mol Cell Biol 16:6937-44. 1996
  7. ncbi request reprint The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3
    I Woldman
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr. Bohr-Gasse 9, A1030 Vienna, Austria
    J Biol Chem 276:45722-8. 2001
  8. pmc Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
    M Kieslinger
    Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 14:232-44. 2000
  9. ncbi request reprint Serine phosphorylation of STATs
    T Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    Oncogene 19:2628-37. 2000
  10. ncbi request reprint Jak2-Stat5 interactions analyzed in yeast
    F Barahmand-Pour
    Institute of Microbiology and Genetics, Vienna Biocenter, University of Vienna, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    J Biol Chem 273:12567-75. 1998

Collaborators

  • S Akira
  • Pavel Kovarik
  • M Muller
  • D E Levy
  • B Groner
  • Peter Murray
  • Stephen E Girardin
  • Almudena Porras
  • Dana J Philpott
  • Christian Bogdan
  • Silvia Stockinger
  • Katrin Ramsauer
  • Marina Karaghiosoff
  • Thomas Kolbe
  • Andreas Pilz
  • Didier Soulat
  • Catherine Werts
  • Christian Schindler
  • I Woldman
  • Gordin Zupkovitz
  • Iwona Sadzak
  • Louisa Varinou
  • Tilo Materna
  • Florian Lordick
  • Ralf Steinborn
  • F Barahmand-Pour
  • M Kieslinger
  • A Meinke
  • Keiryn L Bennett
  • Adrijana Stefanovic
  • Giulio Superti-Furga
  • Tilmann Burckstummer
  • Angela Bauch
  • Sandra Westermayer
  • Adriana Goncalves
  • Oliver Hantschel
  • Jianguo Liu
  • Michel Chignard
  • Leticia A Carneiro
  • Xiaojing Ma
  • Lionel Le Bourhis
  • Viviane Balloy
  • Joao G Magalhaes
  • Jörg H Fritz
  • Gerda Egger
  • Susanna Chiocca
  • Christian Seiser
  • Norbert Schweifer
  • Julia Tischler
  • Markus Posch
  • Reinhard Grausenburger
  • Sylvia Brunner
  • Tadatsugu Taniguchi
  • Carola Schellack
  • Benjamin Reutterer
  • Barbara Schaljo
  • Masahiro Yamamoto
  • Reiner Hartenstein
  • Markus Hentrich
  • Michael Leitges
  • Hans Pohlmann
  • Manuela Baccarini
  • Ursula Reichart
  • Tomas Leanderson
  • Hamid Heidari
  • Klaus Pfeffer
  • Michael Hennig
  • Christian Peschel
  • Birgit Donabauer
  • Gernot Kriegshäuser
  • Trinad Chakraborty
  • Angel R Nebreda
  • Dagmar Stoiber
  • Lourdes Bayr
  • Hermann Unger
  • K Ramsauer
  • L Varinou
  • B Rapp
  • R Moriggl
  • J N Ihle
  • J Hofmann
  • H Beug
  • J C Marine
  • S Wohrl
  • D Stoiber

Detail Information

Publications23

  1. ncbi request reprint GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression
    T Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    J Interferon Cytokine Res 17:121-34. 1997
    ..This review focuses on the identification and definition of GAS elements, their interaction with Stat transcription factors, and their contribution to the specificity of cytokine-induced gene expression...
  2. pmc IFNs and STATs in innate immunity to microorganisms
    Thomas Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    J Clin Invest 109:1271-7. 2002
  3. ncbi request reprint Jaks, Stats and the immune system
    T Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    Immunobiology 198:99-111. 1997
    ..Here we give a brief overview of both recent progress and open questions concerning the Jak and Stat molecules, their regulation, and the biological implications of their activity...
  4. ncbi request reprint Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins
    T Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    Cell Mol Life Sci 55:1535-46. 1999
    ..The basis, background, and implications of these molecular events will be summarized and discussed...
  5. pmc Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
    P Kovarik
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    EMBO J 20:91-100. 2001
    ....
  6. pmc Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons
    A Meinke
    Vienna Biocenter, Institute of Microbiology and Genetics, Austria
    Mol Cell Biol 16:6937-44. 1996
    ..Moreover, they suggest that Stat5 might be part of the differentiation response of myeloid cells...
  7. ncbi request reprint The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3
    I Woldman
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr. Bohr-Gasse 9, A1030 Vienna, Austria
    J Biol Chem 276:45722-8. 2001
    ..In IFN-gamma-treated, Stat1-deficient fibroblasts Stat5 was inefficient in inducing transcription of a Stat-dependent reporter gene, suggesting it does not per se make a major contribution to the expression of IFN-gamma-responsive genes...
  8. pmc Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
    M Kieslinger
    Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 14:232-44. 2000
    ..Taken together, our findings suggest that Stat5 may promote cytokine-dependent survival and proliferation of differentiating myeloid progenitor cells in stress or pathological situations, such as inflammation...
  9. ncbi request reprint Serine phosphorylation of STATs
    T Decker
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    Oncogene 19:2628-37. 2000
    ..The biochemical and biological consequences of STAT serine phosphorylation are discussed. Oncogene (2000)...
  10. ncbi request reprint Jak2-Stat5 interactions analyzed in yeast
    F Barahmand-Pour
    Institute of Microbiology and Genetics, Vienna Biocenter, University of Vienna, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    J Biol Chem 273:12567-75. 1998
    ..Therefore, the Jak kinase domain may be all that is needed to cause Stat phosphorylation in situations where receptor docking is dispensable...
  11. pmc Sepsis: avoiding its deadly toll
    Thomas Decker
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Vienna, Austria
    J Clin Invest 113:1387-9. 2004
    ..A new study reports a successful attempt to inhibit systemic inflammation in mice by disrupting the formation of complexes between Gram-positive bacteria and their cognate receptor, TLR2...
  12. ncbi request reprint Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity
    Louisa Varinou
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Dr Bohr Gasse 9 4, A1030 Vienna, Austria
    Immunity 19:793-802. 2003
    ..Our data demonstrate that the increase in transcription factor activity caused by Stat serine phosphorylation contributes to macrophage activation and to IFN-gamma-dependent immune responses in vivo...
  13. ncbi request reprint Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
    Marina Karaghiosoff
    Institute of Animal Breeding and Genetics, Veterinary University of Vienna, A 1210 Vienna, Austria
    Nat Immunol 4:471-7. 2003
    ..IFN-beta-null but not STAT1-null mice were also resistant to high dose LPS treatment. Together, these data suggest that Tyk2 and IFN-beta are essential effectors in LPS induced lethality...
  14. ncbi request reprint The yin and yang of type I interferon activity in bacterial infection
    Thomas Decker
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria
    Nat Rev Immunol 5:675-87. 2005
    ..Strikingly, their activity can be either favourable or detrimental, and can influence various immune effector mechanisms...
  15. ncbi request reprint IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism
    Silvia Stockinger
    Max F Perutz Laboratories, University Department at the Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Austria
    J Immunol 173:7416-25. 2004
    ..monocytogenes stimulates a novel TLR- and Nod2-independent pathway to target IRF3 and the type I IFN genes...
  16. ncbi request reprint JAK-STAT signaling: from interferons to cytokines
    Christian Schindler
    Departments of Microbiology and Medicine, Columbia University, New York, NY 10032, USA
    J Biol Chem 282:20059-63. 2007
  17. ncbi request reprint Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway
    Catherine Werts
    Unité de Recherche Réponses Précoces aux Parasites et Immunopathologie, Institut Pasteur, Paris, France
    Eur J Immunol 37:2499-508. 2007
    ..Together, these results identify a novel target downstream of Nod1 and Nod2, which is likely to play a key role in orchestrating the global Nod-dependent immune defense during bacterial infections...
  18. pmc Negative and positive regulation of gene expression by mouse histone deacetylase 1
    Gordin Zupkovitz
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
    Mol Cell Biol 26:7913-28. 2006
    ..Our study reveals a regulatory cross talk between HDAC1 and HDAC2 and a novel function for HDAC1 as a transcriptional coactivator...
  19. pmc Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons
    Andreas Pilz
    Institute of Microbiology and Genetics, Vienna Biocenter, Vienna, Austria
    EMBO Rep 4:368-73. 2003
    ..Our data suggest an important contribution of the Stat1 C terminus and its phosphorylation at Ser727 to the transcriptional activities of the Stat1 dimer and the Isgf3 complex...
  20. ncbi request reprint Ultrasound screening for internal jugular vein thrombosis aids the detection of central venous catheter-related infections in patients with haemato-oncological diseases: a prospective observational study
    Florian Lordick
    Third Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Germany
    Br J Haematol 120:1073-8. 2003
    ..These findings could be clinically useful for the handling of central venous catheters in patients with an elevated risk of infectious complications...
  21. ncbi request reprint Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes
    Silvia Stockinger
    Vienna Biocenter and University of Vienna, Institute of Microbiology and Genetics, Austria
    J Immunol 169:6522-9. 2002
    ..The data stress the importance of type I IFN for the course of infections with intracellular bacteria and suggest that factors other than listeriolysin O contribute to macrophage death during Listeria infection...
  22. pmc p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation
    Katrin Ramsauer
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 99:12859-64. 2002
    ..Taken together, these results demonstrate an interaction between IFN-gamma signaling and the p38 pathway that leads to increased transcriptional activation by STAT1 independently of phosphorylation at Ser-727...
  23. pmc The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
    Didier Soulat
    Department of Infection Biology, Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    EMBO J 27:2135-46. 2008
    ..Phosphorylation-deficient mutants of DDX3X failed to synergize with TBK1 in their ability to stimulate the IFN promoter. Overall, our data imply that DDX3X is a critical effector of TBK1 that is necessary for type I IFN induction...