M Busslinger

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. pmc Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation
    Fabio Savarese
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Mol Cell Biol 26:7167-77. 2006
  2. ncbi request reprint Reversion of B cell commitment upon loss of Pax5 expression
    Ingvild Mikkola
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 297:110-3. 2002
  3. ncbi request reprint Transcriptional control of early B cell development
    Meinrad Busslinger
    Research Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Annu Rev Immunol 22:55-79. 2004
  4. ncbi request reprint Lineage commitment in lymphopoiesis
    M Busslinger
    Research Institute of Molecular Pathology, Vienna, A 1030, Austria
    Curr Opin Immunol 12:151-8. 2000
  5. ncbi request reprint Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development
    M Bouchard
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 127:3703-13. 2000
  6. ncbi request reprint Independent regulation of the two Pax5 alleles during B-cell development
    S L Nutt
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Genet 21:390-5. 1999
  7. ncbi request reprint Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis
    S L Nutt
    Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Int Rev Immunol 20:65-82. 2001
  8. ncbi request reprint Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
    S L Nutt
    Research Institute of Molecular Pathology, Vienna, Austria
    Nature 401:556-62. 1999
  9. pmc Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties
    Z Kozmik
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 13:6024-35. 1993
  10. ncbi request reprint Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary
    P L Pfeffer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 127:1017-28. 2000

Collaborators

Detail Information

Publications64

  1. pmc Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation
    Fabio Savarese
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Mol Cell Biol 26:7167-77. 2006
    ..This suggests that Xist function is restricted in development by the limited activity of epigenetic pathways rather than by a change in the responsiveness of chromatin between embryonic and differentiated cell types...
  2. ncbi request reprint Reversion of B cell commitment upon loss of Pax5 expression
    Ingvild Mikkola
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 297:110-3. 2002
    ..Hence, Pax5 expression is continuously required to maintain B cell lineage commitment, because its loss converts committed pro-B cells into hematopoietic progenitors with multilineage potential...
  3. ncbi request reprint Transcriptional control of early B cell development
    Meinrad Busslinger
    Research Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Annu Rev Immunol 22:55-79. 2004
    ..Finally, IRF4 and IRF8 together control the termination of pre-B cell receptor signaling and thus promote differentiation to small pre-B cells undergoing light-chain gene rearrangements...
  4. ncbi request reprint Lineage commitment in lymphopoiesis
    M Busslinger
    Research Institute of Molecular Pathology, Vienna, A 1030, Austria
    Curr Opin Immunol 12:151-8. 2000
    ..In contrast, loss- and gain-of-function analyses have implicated the Notch1 receptor in the specification of the T cell fate, which may thus be controlled by instructive signals in the thymus...
  5. ncbi request reprint Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development
    M Bouchard
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 127:3703-13. 2000
    ..Together these data demonstrate that the transcription factors Pax2 and Pax5 have maintained equivalent biochemical functions since their divergence early in vertebrate evolution...
  6. ncbi request reprint Independent regulation of the two Pax5 alleles during B-cell development
    S L Nutt
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Genet 21:390-5. 1999
    ..Similar allele-specific regulation may be a common mechanism causing the haploinsufficiency and frequent association of other Pax genes with human disease...
  7. ncbi request reprint Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis
    S L Nutt
    Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Int Rev Immunol 20:65-82. 2001
    ..Once committed to the B-lineage, B cells require Pax5 function to maintain their B-lymphoid identity throughout B cell development...
  8. ncbi request reprint Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
    S L Nutt
    Research Institute of Molecular Pathology, Vienna, Austria
    Nature 401:556-62. 1999
    ..Pax5 therefore plays an essential role in B-lineage commitment by suppressing alternative lineage choices...
  9. pmc Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties
    Z Kozmik
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 13:6024-35. 1993
    ..Hence, alternative splicing of Pax-8 gene transcripts not only generates six different Pax-8 variants but is also temporally and spatially regulated during early mouse development...
  10. ncbi request reprint Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary
    P L Pfeffer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 127:1017-28. 2000
    ..Together these data indicate that Pax2 and homeodomain proteins directly bind to and cooperatively regulate the mhb enhancer of Pax5...
  11. pmc The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle
    T Ellis
    Research Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 15:2307-19. 2001
    ..These data implicate CDP in cell-lineage specification during hair follicle morphogenesis, which resembles the role of the related Cut protein in specifying cell fates during Drosophila development...
  12. pmc Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments
    S L Nutt
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    EMBO J 17:2319-33. 1998
    ....
  13. ncbi request reprint Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis
    M Horcher
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 14:779-90. 2001
    ..These data demonstrate that Pax5 is essential for maintaining the identity and function of B cells during late B lymphopoiesis...
  14. pmc Cooperation of Pax2 and Pax5 in midbrain and cerebellum development
    P Urbanek
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 94:5703-8. 1997
    ..5. On the basis of these data, we propose that the cooperation of Pax2 and Pax5 is essential for normal functioning of the organizing center at the midbrain-hindbrain junction...
  15. pmc Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor
    G Bergers
    Research Institute of Molecular Pathology, Vienna, Austria
    EMBO J 13:1176-88. 1994
    ..Differential regulation of two distinct promoters is thus used to determine the ratio between secreted and membrane-bound forms of Fit-1 (T1/ST2) which may modulate signaling in response to IL-1...
  16. ncbi request reprint Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9
    P Stapleton
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Genet 3:292-8. 1993
    ..PAX-1 and PAX-7 map to chromosomal regions containing previously assigned disease loci...
  17. ncbi request reprint Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function
    P L Pfeffer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 125:3063-74. 1998
    ..Consequently, the noi mutation of zebrafish is equivalent to combined inactivation of the mouse Pax2 and Pax5 genes with regard to the loss of midbrain-hindbrain boundary development...
  18. pmc Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis
    C Thevenin
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    J Exp Med 188:735-44. 1998
    ..Together, these data demonstrate that the absence of Pax5 arrests adult B lymphopoiesis at an early developmental stage that is unresponsive to pre-BCR signaling...
  19. ncbi request reprint The characterization of novel Pax genes of the sea urchin and Drosophila reveal an ancient evolutionary origin of the Pax2/5/8 subfamily
    T Czerny
    Research Institute of Molecular Pathology, Vienna, Austria
    Mech Dev 67:179-92. 1997
    ..During Drosophila embryogenesis, the Pax258 gene is shown to be expressed in the precursor cells of the external sensory organs, thus suggesting a role for Pax258 in the early development of the peripheral nervous system of insects...
  20. pmc Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma
    M Busslinger
    Research Institute of Molecular Pathology, Vienna, Austria
    Proc Natl Acad Sci U S A 93:6129-34. 1996
    ..These data suggest that deregulation of PAX-5 gene transcription by the t(9;14)(pl3;q32) translocation contributes to the pathogenesis of small lymphocytic lymphomas with plasmacytoid differentiation...
  21. ncbi request reprint Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
    B Adams
    Institute of Molecular Pathology, Vienna, Austria
    Genes Dev 6:1589-607. 1992
    ..All of this evidence indicates that the transcription factor BSAP may not only play an important role in B-cell differentiation but also in neural development and spermatogenesis...
  22. ncbi request reprint Essential functions of Pax-5 (BSAP) in pro-B cell development
    S L Nutt
    Research Institute of Molecular Pathology, Vienna, Austria
    Immunobiology 198:227-35. 1997
    ..Together these data demonstrate therefore that B cell development in the Pax-5 deficient bone marrow is arrested at an early pro-B cell stage which is not yet responsive to pre-B cell receptor signaling...
  23. ncbi request reprint twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development
    T Czerny
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell 3:297-307. 1999
    ..Toy is therefore required for initiation of ey expression in the embryo and acts through Ey to activate the eye developmental program...
  24. ncbi request reprint Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
    S L Nutt
    Research Institute of Molecular Pathology, Vienna, Austria
    Genes Dev 11:476-91. 1997
    ..In contrast, V(H)-to-D(H)J(H) rearrangements were reduced approximately 50-fold in Pax5-deficient pre-BI cells, suggesting a role for Pax5 in the developmental pathway controlling V-to-DJ recombination...
  25. pmc Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
    D Eberhard
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria and Departamento de Biologia Molecular i Cellular, CID CSIC, Jordi Girona 18 26, 08034 Barcelona, Spain
    EMBO J 19:2292-303. 2000
    ..These data indicate that Pax proteins can be converted from transcriptional activators to repressors through interaction with corepressors of the Groucho protein family...
  26. ncbi request reprint Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
    P Urbanek
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 79:901-12. 1994
    ..These data define a key role for Pax5 in early B lymphopoiesis and midbrain patterning...
  27. ncbi request reprint DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site
    T Czerny
    Research Institute of Molecular Pathology, Vienna, Austria
    Genes Dev 7:2048-61. 1993
    ....
  28. ncbi request reprint The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins
    D Eberhard
    Research Institute of Molecular Pathology, Vienna, Austria
    Cancer Res 59:1716s-1724s; discussion 1724s-1725s. 1999
    ..These data indicate that Pax-5 is able to contact the basal transcription machinery through the TBP-containing initiation factor TFIID, and that its activity can be controlled by the cell cycle-regulated association with Rb...
  29. pmc Deregulated expression of PAX5 in medulloblastoma
    Z Kozmik
    Research Institute of Molecular Pathology, Vienna, Austria
    Proc Natl Acad Sci U S A 92:5709-13. 1995
    ..These data suggest that deregulated expression of PAX5 correlates positively with cell proliferation and inversely with neuronal differentiation in desmoplastic medulloblastoma...
  30. pmc Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron
    G Bergers
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 15:3748-58. 1995
    ..Together, these data identify fra-1 as a unique member of the fos gene family which is under positive control by AP-1 activity...
  31. ncbi request reprint A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation
    A Barberis
    Institute of Molecular Pathology, Vienna, Austria
    Genes Dev 4:849-59. 1990
    ....
  32. pmc The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP
    Z Kozmik
    Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 12:2662-72. 1992
    ..In addition, BSAP was found to be the only abundant DNA-binding activity of B-cell nuclear extracts that interacts with the CD19 promoter. Together, this evidence strongly implicates BSAP in the regulation of the CD19 gene...
  33. ncbi request reprint Transcriptional control of B-cell development
    Michael Schebesta
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Opin Immunol 14:216-23. 2002
    ..One emerging theme is that negative regulatory networks play an important role in suppressing alternative gene programs and their corresponding cell fates throughout B-cell development...
  34. ncbi request reprint Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus
    Abdallah Souabni
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Blood 109:281-9. 2007
    ..These data identify Pax5 as a potent oncogene and demonstrate that the T-lymphoid lineage is particularly sensitive to the oncogenic action of Pax5...
  35. ncbi request reprint Pax5: the guardian of B cell identity and function
    Cesar Cobaleda
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Immunol 8:463-70. 2007
    ..PAX5 has also been implicated in human B cell malignancies, as it is deregulated by chromosomal translocations in a subset of acute lymphoblastic leukemias and non-Hodgkin lymphomas...
  36. ncbi request reprint Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function
    Martin Fuxa
    Research Institute of Molecular Pathology, Vienna Biocenter, Austria
    J Immunol 178:8222-8. 2007
    ..Hence, the transcriptional initiation and B cell-specific expression of Pax5 is entirely consistent with its B cell lineage commitment function...
  37. ncbi request reprint Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function
    Alexandra Schebesta
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 27:49-63. 2007
    ....
  38. ncbi request reprint Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function
    Martin Fuxa
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Immunol 178:3031-7. 2007
    ..Hence, the transcriptional initiation and B cell-specific expression of Pax5 is entirely consistent with its B cell lineage commitment function...
  39. ncbi request reprint Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
    Cesar Cobaleda
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 449:473-7. 2007
    ..Hence, the complete loss of Pax5 in late B cells could initiate lymphoma development and uncovered an extraordinary plasticity of mature peripheral B cells despite their advanced differentiation stage...
  40. pmc Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
    Stephen Malin
    Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
    Nat Immunol 11:171-9. 2010
    ..Hence, STAT5 and IL-7 signaling control cell survival and the developmental ordering of immunoglobulin gene rearrangements by suppressing premature Igk recombination in pro-B cells...
  41. ncbi request reprint Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells
    Alessio Delogu
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 24:269-81. 2006
    ....
  42. pmc Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors
    Barry Heavey
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    EMBO J 22:3887-97. 2003
    ..The same regulators were unable to induce a myeloid lineage switch in Pax5(+/+) pro-B cells, indicating that Pax5 dominates over myeloid transcription factors in B-lymphocytes...
  43. pmc Nephric lineage specification by Pax2 and Pax8
    Maxime Bouchard
    Research Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 16:2958-70. 2002
    ..Together, these data identify Pax2 and Pax8 as critical regulators that specify the nephric lineage...
  44. ncbi request reprint Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1
    Abdallah Souabni
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 17:781-93. 2002
    ..Pax5 thereby interfered with T lineage commitment and early thymocyte development by repressing the transcription of the T cell specification gene Notch1...
  45. ncbi request reprint Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors
    Sonja Höflinger
    Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
    J Immunol 173:3935-44. 2004
    ..These data suggest that Notch1 acts upstream of GATA3 and Tcf1 in early T cell development and regulates Vbeta-DJbeta rearrangements by controlling the chromatin accessibility of Vbeta genes at the TCRbeta locus...
  46. ncbi request reprint Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene
    Michael Schebesta
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 17:473-85. 2002
    ..The pre-BCR was shown to execute its checkpoint function by regulating genes involved in cell proliferation, intracellular signaling, growth factor responsiveness, and V(D)J recombination...
  47. doi request reprint Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
    Kyongrim Kwon
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 28:751-62. 2008
    ....
  48. doi request reprint Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis
    Thorsten Decker
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 30:508-20. 2009
    ..These experiments demonstrate a stepwise activation of Pax5 in early lymphopoiesis and provide mechanistic insights into the process of B cell commitment...
  49. pmc Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene
    Martin Fuxa
    Research Institute of Molecular Pathology, Vienna Biocente, A 1030 Vienna, Austria
    Genes Dev 18:411-22. 2004
    ..Pax5 subsequently activates locus contraction and distal VH-DJH rearrangements in collaboration with an unknown factor that is present in pro-B cells, but absent in thymocytes...
  50. doi request reprint STAT5 in B cell development and leukemia
    Stephen Malin
    Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
    Curr Opin Immunol 22:168-76. 2010
    ....
  51. pmc The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction
    Hiromi Tagoh
    Division of Experimental Haematology, LIMM, University of Leeds, St James s University Hospital, Leeds, UK
    EMBO J 25:1070-80. 2006
    ..Our results support a model by which Pax5 does not lead to major alterations in chromatin modification, but inhibits transcription by interfering with the action of myeloid transcription factors...
  52. doi request reprint B young again
    Thomas Graf
    Center for Genomic Regulation, Carrer Dr Aiguader 88, E 08003 Barcelona, Spain
    Immunity 28:606-8. 2008
    ..Hanna et al. (2008) report in a recent issue of Cell that a defined set of transcription factors can reprogram mature B cells back to pluripotent stem cells...
  53. doi request reprint Developmental plasticity of lymphocytes
    Cesar Cobaleda
    Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Curr Opin Immunol 20:139-48. 2008
    ..Together these experiments have uncovered an unanticipated developmental plasticity of lymphocytes, which may account for lineage switches observed in human malignancies...
  54. doi request reprint Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis
    Feng Guo
    Research Group Immunology, Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Blood 112:551-9. 2008
    ..Thus, tightly controlled p100 processing and RelB activation is essential for normal B lymphopoiesis and lymphoid/myeloid lineage decision in bone marrow...
  55. pmc Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    Derk Amsen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:89-99. 2007
    ..Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch...
  56. pmc Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow
    Rosana Pelayo
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13 St, Oklahoma City, OK 73104, USA
    Blood 105:4407-15. 2005
    ..Thus, 2 functionally specialized subsets of pDCs arise in bone marrow from progenitors that diverge from B, T, and NK lineages at an early stage...
  57. pmc Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible
    Hiromi Tagoh
    Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
    EMBO J 23:4275-85. 2004
    ..However, even at mature B cell stages, c-fms chromatin is still in a poised conformation and c-fms expression can be re-activated by conditional deletion of the transcription factor Pax5...
  58. ncbi request reprint Postnatal development of the murine cerebellar cortex: formation and early dispersal of basket, stellate and Golgi neurons
    Gunnar Weisheit
    Anatomisches Institut, Anatomie and Zellbiologie, University of Bonn, Bonn, Germany
    Eur J Neurosci 24:466-78. 2006
    ....
  59. ncbi request reprint Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
    Leping Cheng
    The Dana Farber Cancer Institute, and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 7:510-7. 2004
    ..Finally, excess GABA-mediated inhibition caused dysfunction of central respiratory circuits in Tlx3 mutant mice...
  60. ncbi request reprint In vitro differentiation of murine embryonic stem cells toward a renal lineage
    Stephen J Bruce
    Department of Anatomy and Cell Biology School of Biomedical Sciences Monash University Melbourne, Vic, Australia
    Differentiation 75:337-49. 2007
    ..This induction assay and these unique ES cell lines will be useful for the generation of mesoderm-derived cell populations with implications for future cell therapeutic/integration assays...
  61. ncbi request reprint Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes
    Jane A Skok
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Nat Immunol 8:378-87. 2007
    ..Hence, pericentromeric recruitment and locus 'decontraction' seem to contribute to the initiation and maintenance of allelic exclusion at the Tcrb locus...
  62. pmc Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes
    Ylva Linderson
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm Sweden
    EMBO Rep 5:291-6. 2004
    ..1/Grg4. These data indicate that Pax5 depends on PU.1, acting in cis, for stable recruitment of Grg co-repressors to B-cell-specific genes...
  63. ncbi request reprint Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells
    Laurence Ardouin
    Centre d immunologie de Marseille Luminy, INSERM, CNRS, Universite de la Mediterranee, Marseille, France
    Eur J Immunol 35:977-86. 2005
    ..Therefore, it constitutes a powerful first-line screen for mutations worth fastidious knock-in approaches...
  64. ncbi request reprint Life beyond cleavage: the case of Ago2 and hematopoiesis
    Javier Martinez
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, A 1030 Vienna, Austria
    Genes Dev 21:1983-8. 2007