B Bohle

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Allergen-specific T lymphocytes as targets for specific immunotherapy: striking at the roots of type I allergy
    Barbara Bohle
    Department of Pathophysiology, University of Vienna, Austria
    Arch Immunol Ther Exp (Warsz) 50:233-41. 2002
  2. ncbi request reprint CpG motifs as possible adjuvants for the treatment of allergic diseases
    Barbara Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, Austria
    Int Arch Allergy Immunol 129:198-203. 2002
  3. ncbi request reprint AIC. Dynavax
    Barbara Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, AKH EBO 3Q, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Curr Opin Investig Drugs 4:603-7. 2003
  4. ncbi request reprint Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level
    Barbara Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, Vienna, Austria
    Eur J Immunol 33:3303-10. 2003
  5. ncbi request reprint Improving diagnostic tests for food allergy with recombinant allergens
    Barbara Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, General Hospital Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Methods 32:292-9. 2004
  6. ncbi request reprint A novel approach to specific allergy treatment: the recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v 1) combines reduced allergenicity with immunomodulating capacity
    Barbara Bohle
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Immunol 172:6642-8. 2004
  7. ncbi request reprint Oligodeoxynucleotides containing CpG motifs induce low levels of TNF-alpha in human B lymphocytes: possible adjuvants for Th1 responses
    B Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, Vienna, Austria
    J Immunol 166:3743-8. 2001
  8. ncbi request reprint Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice
    U Wiedermann
    Department of Clinical Pharmacology, University of Vienna, Austria
    Int Arch Allergy Immunol 126:68-77. 2001
  9. ncbi request reprint Absence of systemic immunologic changes during dose build-up phase and early maintenance period in effective specific sublingual immunotherapy in children
    E Dehlink
    Department of Pediatrics and Juvenile Medicine and Department of Pathophysiology, Centre for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 36:32-9. 2006
  10. ncbi request reprint Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy
    Y Ma
    Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    Clin Exp Allergy 36:1087-96. 2006

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Allergen-specific T lymphocytes as targets for specific immunotherapy: striking at the roots of type I allergy
    Barbara Bohle
    Department of Pathophysiology, University of Vienna, Austria
    Arch Immunol Ther Exp (Warsz) 50:233-41. 2002
    ..Both approaches promise to be capable of adjusting the pathological Th2 immune response...
  2. ncbi request reprint CpG motifs as possible adjuvants for the treatment of allergic diseases
    Barbara Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, Austria
    Int Arch Allergy Immunol 129:198-203. 2002
    ..This article discusses how the use of CpG ODN in immunotherapeutics could improve the treatment of type I allergy...
  3. ncbi request reprint AIC. Dynavax
    Barbara Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, AKH EBO 3Q, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Curr Opin Investig Drugs 4:603-7. 2003
    ..By May 2001, phase II/III trials were underway in Canada and the US, and by March 2002, phase II trials were underway in France. In October 2002, Dynavax expected to commence a phase III trial in 2003...
  4. ncbi request reprint Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level
    Barbara Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, Vienna, Austria
    Eur J Immunol 33:3303-10. 2003
    ..The activation of Bet v 1-specific Th2 cells by Api g 1, in particular outside the pollen season, may have consequences for birch pollen-allergic individuals...
  5. ncbi request reprint Improving diagnostic tests for food allergy with recombinant allergens
    Barbara Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, General Hospital Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Methods 32:292-9. 2004
    ..First experiments with recombinant food allergens in this respect appear very promising...
  6. ncbi request reprint A novel approach to specific allergy treatment: the recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v 1) combines reduced allergenicity with immunomodulating capacity
    Barbara Bohle
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Immunol 172:6642-8. 2004
    ..The strategy described in this work may be generally applied to design vaccines for specific immunotherapy of type I allergy with improved efficacy and safety...
  7. ncbi request reprint Oligodeoxynucleotides containing CpG motifs induce low levels of TNF-alpha in human B lymphocytes: possible adjuvants for Th1 responses
    B Bohle
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, Vienna, Austria
    J Immunol 166:3743-8. 2001
    ..In conclusion, our findings indicate that certain CpG-ODN induce low amounts of TNF-alpha in human B lymphocytes and may therefore be used to modulate Th2-biased immune responses in allergic patients...
  8. ncbi request reprint Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice
    U Wiedermann
    Department of Clinical Pharmacology, University of Vienna, Austria
    Int Arch Allergy Immunol 126:68-77. 2001
    ..The major birch pollen allergen Bet v 1 represents one of the most prevalent environmental allergens responsible for allergic airway inflammation...
  9. ncbi request reprint Absence of systemic immunologic changes during dose build-up phase and early maintenance period in effective specific sublingual immunotherapy in children
    E Dehlink
    Department of Pediatrics and Juvenile Medicine and Department of Pathophysiology, Centre for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 36:32-9. 2006
    ..Sublingual immunotherapy (SLIT) has been reported to be a safe treatment for inhalant allergies in children. Yet the immunologic mechanisms resulting in clinical improvement are poorly understood...
  10. ncbi request reprint Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy
    Y Ma
    Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    Clin Exp Allergy 36:1087-96. 2006
    ..Profilins are ubiquitous panallergens that have been extensively characterized; yet, their clinical relevance is still unclear...
  11. ncbi request reprint Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens
    B Bohle
    Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 35:1392-9. 2005
    ..g. apples, carrots and hazelnuts. In a high number of tree pollen-allergic individuals, this cross-reactivity causes clinical symptoms, commonly known as the 'birch-fruit-syndrome'...
  12. pmc Hydrocortisone enhances total IgE levels--but not the synthesis of allergen-specific IgE--in a monocyte-dependent manner
    B Bohle
    Institute of General and Experimental Pathology, University of Vienna, Austria
    Clin Exp Immunol 101:474-9. 1995
    ..Therefore we conclude that newly synthesized IgE is not specific for allergens, but that sequential isotype switching in human B cells leads to increased polyclonal IgE production...
  13. ncbi request reprint Peptide mimotopes displayed by phage inhibit antibody binding to bet v 1, the major birch pollen allergen, and induce specific IgG response in mice
    E Jensen-Jarolim
    Department of General and Experimental Pathology, University of Vienna, Austria
    FASEB J 12:1635-42. 1998
    ..We conclude that peptide mimotopes, when displayed on phages, may induce a protective IgG response preventing IgE-mediated allergic reactions, suggesting a possible clinical application...
  14. doi request reprint A hypoallergenic variant of the major birch pollen allergen shows distinct characteristics in antigen processing and T-cell activation
    C Kitzmuller
    Department of Pathophysiology and Allergy Research, Christian Doppler Laboratory for Immunomodulation, Medical University of Vienna, Vienna, Austria
    Allergy 67:1375-82. 2012
    ..The aim of this study was to elucidate possible differences between BM4 and Bet v 1 in internalization, antigen processing, and presentation...
  15. ncbi request reprint Natural and recombinant molecules of the cherry allergen Pru av 2 show diverse structural and B cell characteristics but similar T cell reactivity
    H C Fuchs
    Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 36:359-68. 2006
    ..Pru av 2, identified as a thaumatin-like protein (TLP) from sweet cherry, was recognized by the majority of cherry-allergic patients in immunoblotting...
  16. pmc Allergen specific responses in cord and adult blood are differentially modulated in the presence of endotoxins
    T Eiwegger
    Department of Pediatrics, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 38:1627-34. 2008
    ..Endotoxins are common contaminants in allergen preparations and affect antigen-specific cellular responses. Distinct effects of endotoxin on cells in human umbilical cord and adult blood are poorly defined...
  17. ncbi request reprint Characterization of the human T cell response to antigen 5 from Vespula vulgaris (Ves v 5)
    B Bohle
    Department of Pathophysiology, Medical University of Vienna, VA 1090 Vienna, Austria
    Clin Exp Allergy 35:367-73. 2005
    ..The T cell reactivity to the major allergen of bee venom, phospholipase A2, has been thoroughly characterized. In contrast, only little is known about the human cellular response to major allergens from wasp venom...
  18. doi request reprint Human blood basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1
    C Kitzmuller
    Christian Doppler Laboratory for Immunomodulation, Medical University of Vienna, Vienna, Austria
    Allergy 67:593-600. 2012
    ..The aim of this study was to investigate whether human basophils function as APC for the major birch pollen allergen Bet v 1...
  19. doi request reprint Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut
    V Schulten
    Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria
    Allergy 66:1005-13. 2011
    ..Often, patients allergic to the nsLTP in peach suffer from allergy to hazelnuts. We aimed to analyse the T-cell response to Cor a 8, the nsLTP in hazelnut and its immunological cross-reactivity with the nsLTP in peach, Pru p 3...
  20. doi request reprint Genetic allergen modification in the development of novel approaches to specific immunotherapy
    S Mutschlechner
    Christian Doppler Laboratory for Immunomodulation, Department of Pathophysiology, Center for Physiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 39:1635-42. 2009
    ..This review will introduce different concepts of allergen modification using genetic engineering to improve vaccines for SIT of Type I allergy...
  21. ncbi request reprint Characterization of recombinant cat albumin
    R Reininger
    Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
    Clin Exp Allergy 33:1695-702. 2003
    ..Indoor allergens derived from animals and mites often contribute to exacerbation of skin manifestations in atopic dermatitis (AD) patients...
  22. pmc Influence of the route of sensitization on local and systemic immune responses in a murine model of type I allergy
    A Repa
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Immunol 137:12-8. 2004
    ....
  23. ncbi request reprint The impact of pollen-related food allergens on pollen allergy
    B Bohle
    Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Allergy 62:3-10. 2007
    ..We speculate that symptom-free consumption of pollen-related food allergens may have implications for the pollen-specific immune response of allergic individuals...
  24. ncbi request reprint Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen-specific serum immunoglobulin E
    B Jahn-Schmid
    Institute of Pathophysiology, University of Vienna, Vienna, Austria
    Clin Exp Allergy 33:1443-9. 2003
    ..The availability of recombinant allergens and recent advances in biochip technology led to the development of a novel test system for the detection of allergen-specific IgE...
  25. ncbi request reprint Allergy to millet: another risk for atopic bird keepers
    B Bohle
    Department of Pathophysiology, University of Vienna, Vienna, Austria
    Allergy 58:325-8. 2003
    ..Millet has been reported to induce not very frequent but severe anaphylactic reactions following ingestion. Seven individuals who all kept cage birds experienced allergic reactions after ingestion of millet-containing food...
  26. ncbi request reprint Materno-fetal passage of nutritive and inhalant allergens across placentas of term and pre-term deliveries perfused in vitro
    C Loibichler
    Department of Paediatrics, University of Vienna, Austria
    Clin Exp Allergy 32:1546-51. 2002
    ..Although T cell reactivity of fetal origin to a range of common allergens is present in most cord blood samples, the immunological basis remains unclear...
  27. ncbi request reprint Alpha-Gal on bioprostheses: xenograft immune response in cardiac surgery
    K Z Konakci
    Medizinische Universität Wien, Vienna, Austria
    Eur J Clin Invest 35:17-23. 2005
    ..We sought to investigate whether a specific alpha-Gal immune response may play a role in this clinical scenario...
  28. ncbi request reprint A recombinant bacterial cell surface (S-layer)-major birch pollen allergen-fusion protein (rSbsC/Bet v1) maintains the ability to self-assemble into regularly structured monomolecular lattices and the functionality of the allergen
    Andreas Breitwieser
    Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Agricultural Sciences, Gregor Mendelstrasse 33, 1180 Vienna, Austria
    Protein Eng 15:243-9. 2002
    ..This is the first S-layer fusion protein described that had retained the specific properties of the S-layer protein moiety in addition to those of the fused functional peptide sequence...
  29. ncbi request reprint Allergy multivaccines created by DNA shuffling of tree pollen allergens
    Michael Wallner
    Christian Doppler Laboratory of Allergy Diagnosis and Therapy, University of Salzburg, Austria
    J Allergy Clin Immunol 120:374-80. 2007
    ..Members of the Fagales order have distinct geographic distribution, and it is expected that depending on the exposure pattern of the individual, inclusion of other Bet v 1 family members might increase the efficacy of the treatment...
  30. ncbi request reprint Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation
    Barbara Bohle
    Department of Pathophysiology, Center for Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 120:707-13. 2007
    ..The immunologic mechanisms underlying sublingual immunotherapy (SLIT) are still unclear, particularly the role of regulatory T cells...
  31. ncbi request reprint B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines
    Charlotte Admyre
    Department of Medicine, Clinical Allergy Research Unit, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 120:1418-24. 2007
    ..Exosomes from antigen-presenting cells carry immunorelevant molecules like MHC class I and II and costimulatory molecules and thus are suggested to have a role in immune modulation...
  32. ncbi request reprint A novel approach to specific allergy treatment: the recombinant allergen-S-layer fusion protein rSbsC-Bet v 1 matures dendritic cells that prime Th0/Th1 and IL-10-producing regulatory T cells
    Marianne Gerstmayr
    Department of Pathophysiology, Center for Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
    J Immunol 179:7270-5. 2007
    ..These data further support that the concept of conjugating allergens to bacterial agents is a promising approach to improve vaccines for specific immunotherapy of atopic allergies...
  33. ncbi request reprint Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes
    Victoria M Leb
    Institute of Immunology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 121:64-71. 2008
    ..Sixty-nine percent of patients recognizing the single immunodominant T-cell epitope Art v 1(25-36) have an HLA-DRB1*01 phenotype...
  34. ncbi request reprint The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma
    Irene Mittermann
    Division of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Invest Dermatol 128:1451-9. 2008
    ..Our data demonstrate that the Hom s 2 autoantigen can cause IFN-gamma-mediated cell damage...
  35. ncbi request reprint Assessment of Bet v 1-specific CD4+ T cell responses in allergic and nonallergic individuals using MHC class II peptide tetramers
    Laurence Van Overtvelt
    Recherche et Developpement, Stallergenes SA, Antony, France
    J Immunol 180:4514-22. 2008
    ..Allergy vaccines should be designed to recapitulate such naturally protective Th1/regulatory T cell responses observed in healthy individuals...
  36. ncbi request reprint T cell responses during allergen-specific immunotherapy of Type I allergy
    Barbara Bohle
    Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Front Biosci 13:6079-85. 2008
    ..In view of very recent data indicating that both mechanisms may occur consecutively during allergy treatment this review summarizes the current understanding of the immunological mechanisms involved in allergy vaccination...
  37. ncbi request reprint Characterization of HLA class II/peptide-TCR interactions of the immunodominant T cell epitope in Art v 1, the major mugwort pollen allergen
    Beatrice Jahn-Schmid
    Institute of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    J Immunol 181:3636-42. 2008
    ....
  38. ncbi request reprint The T cell response to Art v 1, the major mugwort pollen allergen, is dominated by one epitope
    Beatrice Jahn-Schmid
    Department of Pathophysiology, Division of Immunopathology, University of Vienna, AKH 3Q, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Immunol 169:6005-11. 2002
    ..Therefore, mugwort allergy may be an ideal candidate for a peptide-based immunotherapy approach...
  39. ncbi request reprint Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis
    Ruth Fritsch
    Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    J Immunol 169:1068-76. 2002
    ..Taken together, the presence of autoreactive Th1-like cells in RA patients in conjunction with synovial overexpression of A2/RA33 may indicate potential involvement of this autoantigen in the pathogenesis of RA...
  40. ncbi request reprint Regulation of cytokine production in human peripheral blood mononuclear cells and allergen-specific th cell clones by 1alpha,25-dihydroxyvitamin D3
    Xiahoui Rausch-Fan
    Institute of Pathophysiology, University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 128:33-41. 2002
    ..These effects may be exerted through the control of protooncogenes and the regulation of cytokine production...
  41. ncbi request reprint T lymphocytes and food allergy
    Barbara Bohle
    Department of Pathophysiology, Medical University of Vienna, Austria
    Mol Nutr Food Res 48:424-33. 2004
    ..Recent data provide evidence that in addition to IgE-mediated inflammation, food allergen-specific T lymphocytes may also cause inflammatory responses independently of IgE-mediated mechanisms...
  42. ncbi request reprint Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods
    Montserrat Fernandez-Rivas
    Allergy Unit, Fundacion Hospital Alcorcon, Madrid
    J Allergy Clin Immunol 118:481-8. 2006
    ..Allergy to a plant food can either result from direct sensitization to that food or from primary sensitization to pollen, latex, or another food...
  43. ncbi request reprint Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01
    Beatrice Jahn-Schmid
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 115:399-404. 2005
    ..In contrast to other common pollen allergens that contain multiple T-cell epitopes, Art v 1 contains only 1 immunodominant T-cell epitope (Art v 1 25-36 )...
  44. ncbi request reprint Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy
    Thierry Batard
    Stallergènes, R and D, Antony, France
    Int Arch Allergy Immunol 136:239-49. 2005
    ..We describe the production in Escherichia coli as a recombinant protein of clinical grade wild-type Bet v 1a (rBet v 1a), to be used as a candidate vaccine against birch pollen allergy...
  45. ncbi request reprint FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Allergy Clin Immunol 113:949-57. 2004
    ....
  46. ncbi request reprint IFN-gamma-enhanced allergen penetration across respiratory epithelium augments allergic inflammation
    Jürgen Reisinger
    Department of Otorhinolaryngology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 115:973-81. 2005
    ..Respiratory allergen contact is the critical event in the elicitation and boosting of allergen-specific immune responses, as well as in the induction of immediate and late inflammatory reactions...
  47. ncbi request reprint IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA
    Moritz Wagner
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Ziemssenstrasse 1, 80336 Munich, Germany
    J Immunol 172:954-63. 2004
    ..Our findings provide a molecular basis for the potent adjuvant activity of CpG ODN to support humoral immune responses observed in vivo, and for the limited value of LPS...
  48. ncbi request reprint Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens
    Beatrice Jahn-Schmid
    Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 116:213-9. 2005
    ....
  49. ncbi request reprint Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity
    Karl J Aichberger
    Division of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Vienna General Hospital, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Immunol 175:1286-94. 2005
    ..It may thus contribute to chronic skin inflammation in atopic as well as in nonatopic persons...
  50. ncbi request reprint Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1
    Yan Ma
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 139:53-62. 2006
    ..The objective of the present study was to evaluate whether this concept was applicable for the Bet v 1-homologous apple allergen, Mal d 1...
  51. ncbi request reprint Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator-releasing, but not T cell-activating, capacity
    Eva Maria Schimek
    Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 116:1327-33. 2005
    ..In addition, T lymphocytes specific for Bet v 1 also cross-react with these dietary proteins...
  52. ncbi request reprint T-cell epitopes of food allergens
    Barbara Bohle
    Center for Physiology and Pathophysiology, Department of Pathophysiology, Medical University of Vienna, Austria
    Clin Rev Allergy Immunol 30:97-108. 2006
    ..Results obtained from such studies may not only contribute to the understanding of cellular mechanisms underlying different types of food allergy but also to the development of novel strategies for immunotherapy of food allergy...
  53. ncbi request reprint Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo
    Barbara Bohle
    Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Allergy Clin Immunol 118:242-9. 2006
    ..To avoid this food, allergy allergologists and guidebooks advise patients to consume birch pollen-related foods after heating...
  54. ncbi request reprint Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1
    Tamar Kinaciyan
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 119:937-43. 2007
    ..Cross-reactivity between the major birch pollen allergen, Bet v 1, and the apple protein, Mal d 1, frequently causes food allergy...
  55. ncbi request reprint TGF-beta1 impairs homocysteine metabolism in human renal cells: possible implications for transplantation
    Gürkan Sengoelge
    Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Transpl Int 16:843-8. 2003
    ..We demonstrated that the release of Hcy from huRPTECs is enhanced by TGF-beta1, but that TGF-beta1 plasma levels in renal graft recipients show no independent relationship with hyperhomocysteinemia...
  56. ncbi request reprint Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles
    Franziska Roth-Walter
    Center of Physiology and Pathophysiology, Medical University of Vienna, AKH 3Q, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Immunol Lett 100:182-8. 2005
    ..We conclude that AAL-coated microparticles may have the potential to target entrapped antigens to human M-cells for oral vaccination...
  57. ncbi request reprint Biodegradable PLGA particles for improved systemic and mucosal treatment of Type I allergy
    Isabella Schöll
    Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Immunol Allergy Clin North Am 26:349-64, ix. 2006
    ..The authors suggest that biocompatible PLGA nano- or microparticles can be useful tools for upgrading therapy of type I allergy...
  58. ncbi request reprint IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone
    Martin Himly
    Institute of Genetics, University of Salzburg
    J Allergy Clin Immunol 111:882-8. 2003
    ..Presently, there are no useful in vitro test systems available for the detection of antibodies directed against analgesic drugs...